ATE200677T1 - Substituierte tetra- und pentapeptid hemmstoffe der farnesyl protein transferase - Google Patents

Substituierte tetra- und pentapeptid hemmstoffe der farnesyl protein transferase

Info

Publication number
ATE200677T1
ATE200677T1 AT94931425T AT94931425T ATE200677T1 AT E200677 T1 ATE200677 T1 AT E200677T1 AT 94931425 T AT94931425 T AT 94931425T AT 94931425 T AT94931425 T AT 94931425T AT E200677 T1 ATE200677 T1 AT E200677T1
Authority
AT
Austria
Prior art keywords
inhibitors
pentapetide
protein transferase
farnesyl protein
substituted tetra
Prior art date
Application number
AT94931425T
Other languages
English (en)
Inventor
Gary Louis Bolton
Alfred Campbell
Richard Gowan
John Cooke Hodges
Donald Hupe
Daniele Leonard
Tomi Sawyer
Judith Sebolt-Leopold
Francis J Tinney
Original Assignee
Parke Davis & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Parke Davis & Co filed Critical Parke Davis & Co
Application granted granted Critical
Publication of ATE200677T1 publication Critical patent/ATE200677T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
AT94931425T 1993-10-25 1994-10-21 Substituierte tetra- und pentapeptid hemmstoffe der farnesyl protein transferase ATE200677T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14275693A 1993-10-25 1993-10-25
US30963594A 1994-09-23 1994-09-23
PCT/US1994/012060 WO1995011917A1 (en) 1993-10-25 1994-10-21 Substituted tetra- and pentapeptide inhibitors of protein:farnesyl transferase

Publications (1)

Publication Number Publication Date
ATE200677T1 true ATE200677T1 (de) 2001-05-15

Family

ID=26840404

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94931425T ATE200677T1 (de) 1993-10-25 1994-10-21 Substituierte tetra- und pentapeptid hemmstoffe der farnesyl protein transferase

Country Status (15)

Country Link
EP (1) EP0725790B1 (de)
JP (1) JPH09504295A (de)
KR (1) KR100378615B1 (de)
AT (1) ATE200677T1 (de)
AU (1) AU682906B2 (de)
CA (1) CA2173590A1 (de)
DE (1) DE69427127T2 (de)
DK (1) DK0725790T3 (de)
ES (1) ES2157994T3 (de)
FI (1) FI961621A0 (de)
GR (1) GR3036188T3 (de)
LV (1) LV12771B (de)
NZ (1) NZ275037A (de)
PT (1) PT725790E (de)
WO (1) WO1995011917A1 (de)

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US5631280A (en) * 1995-03-29 1997-05-20 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5534537A (en) * 1995-03-29 1996-07-09 Merck & Co., Inc. Prodrugs of inhibitors of farnesyl-protein transferase
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US5578629A (en) * 1995-03-29 1996-11-26 Merck & Co., Inc. Benzamide-containing inhibitors of farnesyl-protein transferase
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US5972984A (en) * 1995-06-06 1999-10-26 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
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US6117641A (en) 1996-04-11 2000-09-12 Mitotix, Inc. Assays and reagents for identifying anti-fungal agents and uses related thereto
DE69713759T2 (de) 1996-04-11 2003-03-13 Mitotix Inc Assays und reaganzien zur identifizierung von fungiziden wirkstoffen und ihre verwendungen
US6727082B1 (en) 1996-04-11 2004-04-27 Gpc Biotech Inc. Assays and reagents for identifying anti-fungal agents, and uses related thereto
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US7226991B1 (en) 1999-03-23 2007-06-05 United States Of America, Represented By The Secretary, Department Of Health And Human Services Phenylalanine derivatives
US7871981B2 (en) 1999-10-22 2011-01-18 The United States Of America As Represented By The Department Of Health And Human Services Inhibition of cell motility, angiogenesis, and metastasis
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Also Published As

Publication number Publication date
DE69427127T2 (de) 2001-10-04
KR100378615B1 (ko) 2003-10-10
FI961621A (fi) 1996-04-12
GR3036188T3 (en) 2001-10-31
JPH09504295A (ja) 1997-04-28
FI961621A0 (fi) 1996-04-12
WO1995011917A1 (en) 1995-05-04
NZ275037A (en) 1998-01-26
LV12771A (lv) 2001-12-20
EP0725790A1 (de) 1996-08-14
LV12771B (en) 2002-03-20
DE69427127D1 (de) 2001-05-23
AU682906B2 (en) 1997-10-23
EP0725790B1 (de) 2001-04-18
ES2157994T3 (es) 2001-09-01
CA2173590A1 (en) 1995-05-04
DK0725790T3 (da) 2001-06-11
PT725790E (pt) 2001-08-30
AU8051394A (en) 1995-05-22

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee