ATE185146T1 - Verfahren zur entfernung von n-terminalem methionin - Google Patents

Verfahren zur entfernung von n-terminalem methionin

Info

Publication number
ATE185146T1
ATE185146T1 AT97303856T AT97303856T ATE185146T1 AT E185146 T1 ATE185146 T1 AT E185146T1 AT 97303856 T AT97303856 T AT 97303856T AT 97303856 T AT97303856 T AT 97303856T AT E185146 T1 ATE185146 T1 AT E185146T1
Authority
AT
Austria
Prior art keywords
terminal
removal
terminal methionine
methionine residue
peptide
Prior art date
Application number
AT97303856T
Other languages
English (en)
Inventor
Osamu Nishimura
Masato Suenaga
Mae Hiroaki Oh
Shinji Tsuji
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of ATE185146T1 publication Critical patent/ATE185146T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/246—IL-2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • External Artificial Organs (AREA)
  • Forging (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
AT97303856T 1996-06-14 1997-06-05 Verfahren zur entfernung von n-terminalem methionin ATE185146T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15463496 1996-06-14

Publications (1)

Publication Number Publication Date
ATE185146T1 true ATE185146T1 (de) 1999-10-15

Family

ID=15588495

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97303856T ATE185146T1 (de) 1996-06-14 1997-06-05 Verfahren zur entfernung von n-terminalem methionin

Country Status (11)

Country Link
US (2) US6066470A (de)
EP (1) EP0812856B1 (de)
KR (1) KR100478747B1 (de)
CN (1) CN1158303C (de)
AT (1) ATE185146T1 (de)
CA (1) CA2207723C (de)
DE (1) DE69700561T2 (de)
DK (1) DK0812856T3 (de)
ES (1) ES2136458T3 (de)
GR (1) GR3032139T3 (de)
IL (1) IL121053A (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2768743B1 (fr) * 1997-09-23 2001-09-14 Bio Merieux Procede de lyse de micro-organisme
AU6002199A (en) * 1998-10-05 2000-04-26 Takeda Chemical Industries Ltd. Process for eliminating n-terminal methionine
EP1138772A4 (de) * 1998-12-11 2005-04-06 Takeda Chemical Industries Ltd Verfahren zur herstellung von apelin
AU2002221067A1 (en) * 2000-12-07 2002-06-18 Takeda Chemical Industries Ltd. Process for producing rfrp
EP1352964A4 (de) * 2000-12-22 2005-02-16 Nippon Soda Co Verfahren zur herstellung einer substanz unter verwendung eines mikrobiellen katalysators
EP2460530A3 (de) * 2002-12-31 2012-08-29 Althea Technologies, Inc. Kristalle des menschlichen Wachstumshormons und Verfahren zu ihrer Herstellung
DE10353973B4 (de) * 2003-11-19 2006-08-17 Beru Ag Verfahren zum Herstellen eines keramischen Glühstiftes für eine keramische Glühkerze
EP1976551A4 (de) * 2005-12-23 2009-12-30 Altus Pharmaceuticals Inc Zusammensetzungen mit polykation-komplex-proteinkristallen und behandlungsverfahren damit
JP5649825B2 (ja) 2007-01-31 2015-01-07 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド 安定化させたｐ５３ペプチドおよびその使用法
KR20160061439A (ko) 2007-03-28 2016-05-31 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 스티칭된 폴리펩티드
KR102104762B1 (ko) 2010-08-13 2020-04-24 에일러론 테라퓨틱스 인코포레이티드 펩티도미메틱 거대고리
KR20140100937A (ko) 2011-10-18 2014-08-18 에일러론 테라퓨틱스 인코포레이티드 펩티도미메틱 거대고리
CN104144695A (zh) 2012-02-15 2014-11-12 爱勒让治疗公司 ***交联的和硫醚交联的拟肽大环化合物
CN107216380A (zh) 2012-02-15 2017-09-29 爱勒让治疗公司 拟肽大环化合物
KR20150082307A (ko) 2012-11-01 2015-07-15 에일러론 테라퓨틱스 인코포레이티드 이치환 아미노산 및 이의 제조 및 사용 방법
EA201690264A1 (ru) * 2013-08-21 2016-06-30 Кадила Хелзкэр Лимитед Способ очистки pth
BR112017005598A2 (pt) 2014-09-24 2017-12-12 Aileron Therapeutics Inc macrociclos peptidomiméticos e usos dos mesmos
EP3294318A4 (de) 2015-03-20 2019-04-03 Aileron Therapeutics, Inc. Peptidomimetische makrozyklen und verwendungen davon

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986007380A1 (en) 1985-06-04 1986-12-18 Takeda Chemical Industries, Ltd. Process for preparing polypeptide
IT1219454B (it) * 1988-02-17 1990-05-18 Serono Cesare Ist Ricerca Metodo di rottura alla metionina di polipeptidi contenenti pontidisolfuro
JPH06316557A (ja) * 1993-03-06 1994-11-15 Fuji Kagaku Kogyo Kk アルキルチオ脂肪酸誘導体、製造法及びその肝臓疾患、腎臓疾患、膵臓疾患及び脳疾患用剤

Also Published As

Publication number Publication date
ES2136458T3 (es) 1999-11-16
IL121053A (en) 2000-12-06
CA2207723A1 (en) 1997-12-14
DK0812856T3 (da) 2000-01-03
EP0812856B1 (de) 1999-09-29
KR100478747B1 (ko) 2005-09-08
EP0812856A1 (de) 1997-12-17
KR980002062A (ko) 1998-03-30
GR3032139T3 (en) 2000-04-27
DE69700561D1 (de) 1999-11-04
CN1158303C (zh) 2004-07-21
DE69700561T2 (de) 2000-05-04
US6066470A (en) 2000-05-23
US6309859B1 (en) 2001-10-30
CN1178798A (zh) 1998-04-15
IL121053A0 (en) 1997-11-20
CA2207723C (en) 2006-12-12

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee