ATE182152T1 - GROWTH FACTOR LIGAND THAT BINDS TO THE ERBB-2 RECEPTOR AND INDUCES CELLULAR RESPONSES - Google Patents

GROWTH FACTOR LIGAND THAT BINDS TO THE ERBB-2 RECEPTOR AND INDUCES CELLULAR RESPONSES

Info

Publication number
ATE182152T1
ATE182152T1 AT92903981T AT92903981T ATE182152T1 AT E182152 T1 ATE182152 T1 AT E182152T1 AT 92903981 T AT92903981 T AT 92903981T AT 92903981 T AT92903981 T AT 92903981T AT E182152 T1 ATE182152 T1 AT E182152T1
Authority
AT
Austria
Prior art keywords
erbb
growth factor
receptor
binds
cellular responses
Prior art date
Application number
AT92903981T
Other languages
German (de)
Inventor
Marc E Lippman
Ruth Lupu
Original Assignee
Univ Georgetown
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Georgetown filed Critical Univ Georgetown
Application granted granted Critical
Publication of ATE182152T1 publication Critical patent/ATE182152T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/4756—Neuregulins, i.e. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08—RNA viruses
    • C07K14/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus human T-cell leukaemia-lymphoma virus
    • C07K14/155—Lentiviridae, e.g. visna-maedi virus, equine infectious virus, FIV, SIV
    • C07K14/16—HIV-1 ; HIV-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

The present invention relates to erbB-2 ligands and function derivatives thereof which are capable of binding to the erbB-2 transmembrane protein but fail to bind to epidermal growth factor receptor. The present invention further pertains to anti-ligand molecules capable of recognizing and binding to the erbB-2 ligand molecule and to screening assays for such ligands. The present invention additionally relates to uses for the erbB-2 ligand, the anti-ligand molecules and the screening assays.
AT92903981T 1991-01-14 1992-01-13 GROWTH FACTOR LIGAND THAT BINDS TO THE ERBB-2 RECEPTOR AND INDUCES CELLULAR RESPONSES ATE182152T1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US64049791A 1991-01-14 1991-01-14

Publications (1)

Publication Number Publication Date
ATE182152T1 true ATE182152T1 (en) 1999-07-15

Family

ID=24568503

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92903981T ATE182152T1 (en) 1991-01-14 1992-01-13 GROWTH FACTOR LIGAND THAT BINDS TO THE ERBB-2 RECEPTOR AND INDUCES CELLULAR RESPONSES

Country Status (9)

Country Link
EP (1) EP0574414B1 (en)
JP (1) JPH06505011A (en)
KR (1) KR930703359A (en)
AT (1) ATE182152T1 (en)
AU (2) AU1227792A (en)
CA (1) CA2100549A1 (en)
DE (2) DE69229597D1 (en)
NZ (1) NZ241292A (en)
WO (1) WO1992012174A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5530109A (en) 1991-04-10 1996-06-25 Ludwig Institute For Cancer Research DNA encoding glial mitogenic factors
US7094749B1 (en) 1991-04-10 2006-08-22 Acorda Therapeutics, Inc. Glial mitogenic factors, their preparation and use
US7115554B1 (en) 1993-05-06 2006-10-03 Acorda Therapeutics, Inc. Methods of increasing myotube formation or survival or muscle cell mitogenesis differentiation or survival using neuregulin GGF III
US7285531B1 (en) 1991-04-10 2007-10-23 Acorda Therapeutics, Inc. Method for prophylaxis or treatment of a nervous system, pathophysiological condition involving a glial growth factor sensitive cell by administration of a glial growth factor
US7135456B1 (en) 1991-04-10 2006-11-14 Acorda Therapeutics, Inc. Glial mitogenic factors, their preparation and use
US7319019B1 (en) 1991-04-10 2008-01-15 Acorda Therapeutics, Inc. Glial mitogenic factors lacking an N-terminal signal sequence
IL101943A0 (en) * 1991-05-24 1992-12-30 Genentech Inc Structure,production and use of heregulin
US5367060A (en) * 1991-05-24 1994-11-22 Genentech, Inc. Structure, production and use of heregulin
US5834229A (en) * 1991-05-24 1998-11-10 Genentech, Inc. Nucleic acids vectors and host cells encoding and expressing heregulin 2-α
AU693767B2 (en) * 1992-08-10 1998-07-09 Cambridge Neuroscience, Inc. Inhibitors of cell proliferation, their preparation and use
GB9217316D0 (en) * 1992-08-14 1992-09-30 Ludwig Inst Cancer Res Schwann cell mitogenic factor,its preparation and use
US5770567A (en) * 1994-11-14 1998-06-23 Genentech, Inc. Sensory and motor neuron derived factor (SMDF)
US5912326A (en) * 1995-09-08 1999-06-15 President And Fellows Of Harvard College Cerebellum-derived growth factors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5030565A (en) * 1983-08-17 1991-07-09 Scripps Clinic And Research Foundation Polypeptide-induced monoclonal receptors to protein ligands
CA2079585C (en) * 1990-04-06 1997-01-07 Mark I. Greene Ligand for the neu gene product

Also Published As

Publication number Publication date
AU5601896A (en) 1996-08-29
CA2100549A1 (en) 1992-07-15
JPH06505011A (en) 1994-06-09
DE69229597T4 (en) 2000-08-17
DE69229597D1 (en) 1999-08-19
KR930703359A (en) 1993-11-29
NZ241292A (en) 1994-04-27
EP0574414B1 (en) 1999-07-14
EP0574414A1 (en) 1993-12-22
DE69229597T2 (en) 2000-05-04
EP0574414A4 (en) 1994-12-21
WO1992012174A1 (en) 1992-07-23
AU1227792A (en) 1992-08-17

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