ATE182137T1 - Peptidylderivate als inhibitoren von metalloproteinase - Google Patents

Peptidylderivate als inhibitoren von metalloproteinase

Info

Publication number
ATE182137T1
ATE182137T1 AT94913709T AT94913709T ATE182137T1 AT E182137 T1 ATE182137 T1 AT E182137T1 AT 94913709 T AT94913709 T AT 94913709T AT 94913709 T AT94913709 T AT 94913709T AT E182137 T1 ATE182137 T1 AT E182137T1
Authority
AT
Austria
Prior art keywords
pct
inhibitors
derivatives
metalloproteinase
sec
Prior art date
Application number
AT94913709T
Other languages
English (en)
Inventor
Richard John Morphy
Andrew Thomas Millican
Original Assignee
Celltech Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939308696A external-priority patent/GB9308696D0/en
Application filed by Celltech Therapeutics Ltd filed Critical Celltech Therapeutics Ltd
Application granted granted Critical
Publication of ATE182137T1 publication Critical patent/ATE182137T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/38—Eight-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C317/50—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/61—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
AT94913709T 1993-04-27 1994-04-27 Peptidylderivate als inhibitoren von metalloproteinase ATE182137T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939308696A GB9308696D0 (en) 1993-04-27 1993-04-27 Peptidyl derivatives
ZA948169A ZA948169B (en) 1993-04-27 1994-10-18 Peptidyl derivatives and processes for their preparation

Publications (1)

Publication Number Publication Date
ATE182137T1 true ATE182137T1 (de) 1999-07-15

Family

ID=26302820

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94913709T ATE182137T1 (de) 1993-04-27 1994-04-27 Peptidylderivate als inhibitoren von metalloproteinase

Country Status (10)

Country Link
US (1) US5714491A (de)
EP (1) EP0648205B1 (de)
JP (1) JPH08500124A (de)
AT (1) ATE182137T1 (de)
AU (1) AU6575394A (de)
CA (1) CA2139128A1 (de)
DE (1) DE69419473T2 (de)
ES (1) ES2134939T3 (de)
WO (1) WO1994025434A1 (de)
ZA (1) ZA948169B (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6037472A (en) * 1993-11-04 2000-03-14 Syntex (U.S.A.) Inc. Matrix metalloprotease inhibitors
GB2315750B (en) * 1994-01-22 1998-07-01 British Biotech Pharm Metalloproteinase inhibitors
JP3827324B2 (ja) * 1994-01-22 2006-09-27 ブリテッシュ バイオテック ファーマシューティカルズ リミテッド 金属タンパク質分解酵素阻害剤
GB9423914D0 (en) * 1994-11-26 1995-01-11 British Biotech Pharm Polyether derivatives as metalloproteinase inhibitors
US5917090A (en) * 1995-06-30 1999-06-29 British Biotech Pharmaceuticals Ltd. Matrix metalloproteinase inhibitors
DE69615058T2 (de) 1995-11-23 2002-06-27 British Biotech Pharm Metalloproteinase inhibitoren
US6500948B1 (en) 1995-12-08 2002-12-31 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors-compositions, uses preparation and intermediates thereof
ATE225343T1 (de) * 1995-12-20 2002-10-15 Hoffmann La Roche Matrix-metalloprotease inhibitoren
WO1997031892A1 (fr) * 1996-03-01 1997-09-04 Sankyo Company, Limited Derives d'acide hydroxamique
US6037138A (en) * 1996-04-26 2000-03-14 The Children's Medical Center Corp. Enzyme screen for breast cancer
US6811995B1 (en) 1996-04-26 2004-11-02 Children's Medical Center Corporation Non-invasive enzyme screen for cancer
US6462023B1 (en) 1996-09-10 2002-10-08 British Biotech Pharmaceuticals, Ltd. Cytostatic agents
ATE220660T1 (de) 1996-09-10 2002-08-15 British Biotech Pharm Cytostatische hydroxamsäurederivate
US6174915B1 (en) 1997-03-25 2001-01-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
US6008243A (en) * 1996-10-24 1999-12-28 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use
US20020099004A1 (en) * 1996-12-06 2002-07-25 Lund Leif Roge Inhibition of invasive remodelling
US5952320A (en) * 1997-01-07 1999-09-14 Abbott Laboratories Macrocyclic inhibitors of matrix metalloproteinases and TNFα secretion
WO1998039024A1 (en) * 1997-03-03 1998-09-11 Darwin Discovery Limited Selective mmp inhibitors having reduced side-effects
US5985900A (en) * 1997-04-01 1999-11-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
GB9707333D0 (en) 1997-04-11 1997-05-28 British Biotech Pharm Metalloproteinase inhibitors
WO1999021583A1 (en) * 1997-10-29 1999-05-06 Warner-Lambert Company Method of inhibiting metastases of cancer cells
NZ504683A (en) 1998-01-09 2002-06-28 Pfizer Amide derivatives and pharmaceutical compositions thereof and their use as matrix metalloprotease inhibitors
GB9803005D0 (en) 1998-02-12 1998-04-08 British Biotech Pharm Anti-inflammatory agents
US6329418B1 (en) 1998-04-14 2001-12-11 The Procter & Gamble Company Substituted pyrrolidine hydroxamate metalloprotease inhibitors
US6696456B1 (en) * 1999-10-14 2004-02-24 The Procter & Gamble Company Beta disubstituted metalloprotease inhibitors
CA2404131A1 (en) 2000-03-21 2001-09-27 The Procter & Gamble Company Heterocyclic side chain containing, n-substituted metalloprotease inhibitors
WO2001070693A2 (en) * 2000-03-21 2001-09-27 The Procter & Gamble Company Difluorobutyric acid derivatives and their use as metalloprotease inhibitors
CA2403778A1 (en) * 2000-03-21 2001-09-27 The Procter & Gamble Company Carbocyclic side chain containing metalloprotease inhibitors
PT1406893E (pt) 2001-06-15 2007-07-12 Vicuron Pharm Inc Compostos bicíclicos de pirrolidina
AR036053A1 (es) 2001-06-15 2004-08-04 Versicor Inc Compuestos de n-formil-hidroxilamina, un proceso para su preparacion y composiciones farmaceuticas
US20040192658A1 (en) * 2002-12-27 2004-09-30 Angiotech International Ag Compositions and methods of using collajolie

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8919251D0 (en) * 1989-08-24 1989-10-04 British Bio Technology Compounds
HUT61973A (en) * 1990-12-03 1993-03-29 Celltech Ltd Process for producing peptidyl derivatives and pharmaceutical compositions comprising such compounds as active ingredient

Also Published As

Publication number Publication date
ES2134939T3 (es) 1999-10-16
AU6575394A (en) 1994-11-21
DE69419473T2 (de) 2000-03-16
DE69419473D1 (de) 1999-08-19
EP0648205A1 (de) 1995-04-19
CA2139128A1 (en) 1994-11-10
WO1994025434A1 (en) 1994-11-10
EP0648205B1 (de) 1999-07-14
ZA948169B (en) 1996-04-18
US5714491A (en) 1998-02-03
JPH08500124A (ja) 1996-01-09

Similar Documents

Publication Publication Date Title
DE69419473D1 (de) Peptidylderivate als inhibitoren von metalloproteinase
NZ516562A (en) Pyrimidine-2,4,6-trione metalloproteinase inhibitors
DK0971713T3 (da) Anvendelse af cholinesteraseinhibitorer til behandling af opmærksomhedsforstyrrelser
TR200102499T2 (tr) Neoplazi tedavisinde bir kombinasyon terapisi olarak bir siklooksijenaz-2 inhibitörü ve bir veya daha fazla antineoplastik ajan kullanma yöntemi
NZ335981A (en) Ketobenzamides as calpain inhibitors
ATE230757T1 (de) Verabreichung von peptidylheterocyclen zur behandlung von thrombin in zusammenhang stehenden krankheiten
DK0728144T3 (da) Peptidylforbindelser og deres terapeutiske anvendelse som inhibitorer af metalloproteinaser
ATE233738T1 (de) Kleine moleküle anwendbar in der behandlung von entzündgskrankheiten
DE69624262T2 (de) Sulfonamidinhibitoren von matrix metalloproteinasen
NO308794B1 (no) Farmakologisk aktive pyridin-derivater, preparater inneholdende forbindelsene samt forbindelsenes anvendelse
DE69111077T2 (de) Chinazolinderivate um die antitumorwirkung zu verbessern.
AP2001002318A0 (en) Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors
TR199800818A2 (xx) �kame edilmi� diaminokarbonik asitler.
DE69022150D1 (de) Neue Peptidasen und Isomerasen-Inhibitoren.
HUP9802971A1 (hu) Az MMP-inhibitorok alkalmazása a szemben történő érképződés kezelésére
DE69811111D1 (de) Hydroxamsäure- und carbonsäurederivate mit mmp und tnf hemmender wirkung
NO972391L (no) 2-substituerte 1,2,5-tiadiazolidin-3-on 1,1-dioksider og preparater og metoder for anvendelse derav
NZ331484A (en) Serine protease inhibitors having an alkynylamino side chain for use in treatment of thrombin related diseases
DE69935853D1 (de) Anwendung von alfa1beta1 integrinrezeptorinhibitoren und tgf-beta1-inhibitoren zur behandlung von nierenkrankheiten
YU49422B (sh) Upotreba inhibitora ugljenične anhidraze za proizvodnju medikamenata za tretiranje makularnog edema ili makularne degeneracije izazvane starošću
DE60033809D1 (de) Inhibitoren von metalloproteinasen
DE69912743D1 (de) Behandlung von follikulären lymphomen unter verwendung von inhibitoren des lymphotoxin (lt)-aktivierungsweges
TR200000954T2 (tr) Mikrodolaşım hastalıklarının tedavisi ve önlenmesi için madde.
LV11593A (lv) Dimetikona pielietojums aizcietejumu arstesana
DK1042288T3 (da) Tripeptidyl-peptidase inhibitorer

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties