ATE165810T1 - N-substituierte derivate des n-methyl-3-(p- trifluormethylphenoxy)-3-phenylpropylamins und verfahren zu deren herstellung - Google Patents
N-substituierte derivate des n-methyl-3-(p- trifluormethylphenoxy)-3-phenylpropylamins und verfahren zu deren herstellungInfo
- Publication number
- ATE165810T1 ATE165810T1 AT94101743T AT94101743T ATE165810T1 AT E165810 T1 ATE165810 T1 AT E165810T1 AT 94101743 T AT94101743 T AT 94101743T AT 94101743 T AT94101743 T AT 94101743T AT E165810 T1 ATE165810 T1 AT E165810T1
- Authority
- AT
- Austria
- Prior art keywords
- methyl
- substituted derivatives
- phenylpropylamine
- trifluoromethylphenoxy
- alkylaril
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- RTHCYVBBDHJXIQ-UHFFFAOYSA-N N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine Chemical class C=1C=CC=CC=1C(CCNC)OC1=CC=C(C(F)(F)F)C=C1 RTHCYVBBDHJXIQ-UHFFFAOYSA-N 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000006503 p-nitrobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1[N+]([O-])=O)C([H])([H])* 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004429 atom Chemical group 0.000 abstract 2
- QULYNCCPRWKEMF-UHFFFAOYSA-N parachlorobenzotrifluoride Chemical compound FC(F)(F)C1=CC=C(Cl)C=C1 QULYNCCPRWKEMF-UHFFFAOYSA-N 0.000 abstract 2
- XXSDCGNHLFVSET-UHFFFAOYSA-N 3-(methylamino)-1-phenylpropan-1-ol Chemical class CNCCC(O)C1=CC=CC=C1 XXSDCGNHLFVSET-UHFFFAOYSA-N 0.000 abstract 1
- 230000003197 catalytic effect Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- AOGYCOYQMAVAFD-UHFFFAOYSA-N chlorocarbonic acid Chemical compound OC(Cl)=O AOGYCOYQMAVAFD-UHFFFAOYSA-N 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000007327 hydrogenolysis reaction Methods 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/06—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton from hydroxy amines by reactions involving the etherification or esterification of hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/48—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/48—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HR930130A HRP930130B1 (en) | 1993-02-05 | 1993-02-05 | New process for the preparation of n-methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine |
| HR930129A HRP930129B1 (en) | 1993-02-05 | 1993-02-05 | N-substituted derivatives of n-methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine and procedure for their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE165810T1 true ATE165810T1 (de) | 1998-05-15 |
Family
ID=26316866
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94101743T ATE165810T1 (de) | 1993-02-05 | 1994-02-04 | N-substituierte derivate des n-methyl-3-(p- trifluormethylphenoxy)-3-phenylpropylamins und verfahren zu deren herstellung |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5618968A (de) |
| EP (1) | EP0617006B1 (de) |
| AT (1) | ATE165810T1 (de) |
| DE (1) | DE69410005T2 (de) |
| ES (1) | ES2118988T3 (de) |
| SI (1) | SI9400049B (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2120368B1 (es) * | 1996-06-14 | 1999-07-01 | Almirall Prodesfarma Sa | Procedimiento de obtencion de n-metil-3-(p-trifluorometilfenoxi)-3-fenilpropilamina y sus sales farmaceuticamente aceptables. |
| IT1283141B1 (it) * | 1996-07-11 | 1998-04-07 | Laporte Organics Francis S P A | Procedimento per la preparazione di n-metil-3-(p-trifluorometilfenossi)-3-fenilpropilamina e dei suoi |
| HU226690B1 (en) * | 1996-09-10 | 2009-06-29 | Egis Gyogyszergyar Nyilvanosan | Process for producing fluoxetin |
| US5936124A (en) * | 1998-06-22 | 1999-08-10 | Sepacor Inc. | Fluoxetine process from benzoylpropionic acid |
| US6025517A (en) * | 1998-08-03 | 2000-02-15 | Sepracor Inc. | Fluoxetine process from benzoylacetonitrile |
| US20030064429A1 (en) * | 1999-08-24 | 2003-04-03 | Agouron Pharmaceuticals, Inc. | Efficient methods for the preparation of rhinovirus protease inhibitors, key intermediates and a continuous membrane reactor useful for preparing the same |
| US6355807B1 (en) | 1999-08-24 | 2002-03-12 | Agouron Pharmaceuticals, Inc. | Efficient synthetic routes for the preparation of rhinovirus protease inhibitors and key intermediates |
| US6774243B2 (en) | 1999-08-24 | 2004-08-10 | Agouron Pharmaceuticals, Inc. | Efficient synthetic routes for the preparation of rhinovirus protease inhibitors and key intermediates |
| US6258853B1 (en) | 2001-01-31 | 2001-07-10 | Grayson Walker Stowell | Form a of fluoxetine hydrochloride |
| US6316672B1 (en) | 2001-01-31 | 2001-11-13 | Grayson Walker Stowell | Form a of fluoxetine hydrochloride |
| US6313350B1 (en) | 2001-01-31 | 2001-11-06 | Grayson Walker Stowell | Form a of fluoxetine hydrochloride |
| US6310250B1 (en) | 2001-01-31 | 2001-10-30 | Grayson Walker Stowell | Form A of fluoxetine hydrochloride |
| US6310251B1 (en) | 2001-01-31 | 2001-10-30 | Grayson Walker Stowell | Form a of fluoxetine hydrochloride |
| US20130053579A1 (en) | 2010-05-18 | 2013-02-28 | Arch Pharmalabs Limited | Process for the preparation of n-methyl-o-aryloxy propanamine derivatives and pharmaceutically acceptable salt thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1228209B (it) * | 1989-01-10 | 1991-06-05 | Grato Magnone | Procedimento per la preparazione di fluoxetina cloridrato. |
| FI81083C (fi) * | 1989-03-03 | 1990-09-10 | Orion Yhtymae Oy | Ett foerbaettrat foerfarande foer framstaellning av n-metyl-3-(p-trifluormetylfenoxi)-3-fenylpropylamin hydroklorid. |
| IL99316A (en) * | 1991-08-27 | 1995-03-15 | Teva Pharma | Production of fluoxetine and new intermediates |
-
1993
- 1993-11-03 US US08/145,141 patent/US5618968A/en not_active Expired - Fee Related
-
1994
- 1994-02-01 SI SI9400049A patent/SI9400049B/sl not_active IP Right Cessation
- 1994-02-04 AT AT94101743T patent/ATE165810T1/de not_active IP Right Cessation
- 1994-02-04 DE DE69410005T patent/DE69410005T2/de not_active Expired - Fee Related
- 1994-02-04 EP EP94101743A patent/EP0617006B1/de not_active Expired - Lifetime
- 1994-02-04 ES ES94101743T patent/ES2118988T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69410005T2 (de) | 1998-11-12 |
| EP0617006B1 (de) | 1998-05-06 |
| DE69410005D1 (de) | 1998-06-10 |
| ES2118988T3 (es) | 1998-10-01 |
| SI9400049A (en) | 1994-09-30 |
| EP0617006A1 (de) | 1994-09-28 |
| SI9400049B (en) | 2001-06-30 |
| US5618968A (en) | 1997-04-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |