ATE160351T1 - Verfahren zur herstellung von 7-trialkylsilyl baccatin iii - Google Patents

Verfahren zur herstellung von 7-trialkylsilyl baccatin iii

Info

Publication number: ATE160351T1
Authority: AT; Austria
Prior art keywords: pct; symbols; date oct; producing; sec
Prior art date: 1994-04-05

Application number

AT95916696T

Other languages

English (en)

Inventor

Jean-Pierre Bastart

Jean-Pierre Leconte

Original Assignee

Rhone Poulenc Rorer Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-04-05

Filing date

1995-04-03

Publication date

1997-12-15

1995-04-03 Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa

1997-12-15 Application granted granted Critical

1997-12-15 Publication of ATE160351T1 publication Critical patent/ATE160351T1/de

Links

OVMSOCFBDVBLFW-VHLOTGQHSA-N 5beta,20-epoxy-1,7beta,13alpha-trihydroxy-9-oxotax-11-ene-2alpha,4alpha,10beta-triyl 4,10-diacetate 2-benzoate Chemical compound O([C@@H]1[C@@]2(C[C@H](O)C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)O)C(=O)C1=CC=CC=C1 OVMSOCFBDVBLFW-VHLOTGQHSA-N 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
YWLXLRUDGLRYDR-ZHPRIASZSA-N 5beta,20-epoxy-1,7beta,10beta,13alpha-tetrahydroxy-9-oxotax-11-ene-2alpha,4alpha-diyl 4-acetate 2-benzoate Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](O)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 YWLXLRUDGLRYDR-ZHPRIASZSA-N 0.000 abstract 2
-1 alkyl radicals Chemical class 0.000 abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 2
CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical compound C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C07F7/1872—Preparation; Treatments not provided for in C07F7/20
- C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C07F7/1872—Preparation; Treatments not provided for in C07F7/20
- C07F7/188—Preparation; Treatments not provided for in C07F7/20 by reactions involving the formation of Si-O linkages

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Epoxy Compounds (AREA)
Crystals, And After-Treatments Of Crystals (AREA)
Silicon Compounds (AREA)
Saccharide Compounds (AREA)
Liquid Deposition Of Substances Of Which Semiconductor Devices Are Composed (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Cephalosporin Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Magnetic Resonance Imaging Apparatus (AREA)
Internal Circuitry In Semiconductor Integrated Circuit Devices (AREA)
Processes Of Treating Macromolecular Substances (AREA)
Silicon Polymers (AREA)
Steroid Compounds (AREA)

AT95916696T 1994-04-05 1995-04-03 Verfahren zur herstellung von 7-trialkylsilyl baccatin iii ATE160351T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9403979A FR2718137B1 (fr)	1994-04-05	1994-04-05	Procédé de préparation de trialcoylsilyl-7 baccatine III.

Publications (1)

Publication Number	Publication Date
ATE160351T1 true ATE160351T1 (de)	1997-12-15

Family

ID=9461745

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95916696T ATE160351T1 (de)	1994-04-05	1995-04-03	Verfahren zur herstellung von 7-trialkylsilyl baccatin iii

Country Status (33)

Country	Link
US (1)	US5670658A (de)
EP (1)	EP0754185B1 (de)
JP (1)	JP3718225B2 (de)
KR (1)	KR100399246B1 (de)
CN (1)	CN1058497C (de)
AT (1)	ATE160351T1 (de)
AU (1)	AU683560B2 (de)
BG (1)	BG62735B1 (de)
BR (1)	BR9507444A (de)
CA (1)	CA2186916C (de)
CZ (1)	CZ288397B6 (de)
DE (1)	DE69501080T2 (de)
DK (1)	DK0754185T3 (de)
EE (1)	EE03240B1 (de)
ES (1)	ES2109103T3 (de)
FI (1)	FI115970B (de)
FR (1)	FR2718137B1 (de)
GE (1)	GEP19991537B (de)
GR (1)	GR3025448T3 (de)
HU (1)	HU214158B (de)
LT (1)	LT4185B (de)
LV (1)	LV11691B (de)
MX (1)	MX9604466A (de)
NO (1)	NO305839B1 (de)
NZ (1)	NZ284490A (de)
PL (1)	PL316588A1 (de)
RO (1)	RO115631B1 (de)
RU (1)	RU2127729C1 (de)
SK (1)	SK280448B6 (de)
TW (1)	TW284765B (de)
UA (1)	UA44730C2 (de)
WO (1)	WO1995026967A1 (de)
ZA (1)	ZA952733B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5973160A (en) *	1992-12-23	1999-10-26	Poss; Michael A.	Methods for the preparation of novel sidechain-bearing taxanes
US7288665B1 (en) *	1997-08-18	2007-10-30	Florida State University	Process for selective derivatization of taxanes
EP1019347B1 (de) *	1997-08-21	2003-03-19	Florida State University	Verfahren zur synthese von taxanen
CA2422964A1 (en) *	2000-09-22	2002-03-28	Bristol Myers Squibb Company	Method for reducing toxicity of combined chemotherapies
WO2004033442A2 (en) *	2002-10-09	2004-04-22	Chatham Biotec Ltd.	Novel taxanes and methods related to use and preparation thereof
US7202370B2 (en) *	2003-10-27	2007-04-10	Conor Medsystems, Inc.	Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
WO2005113528A1 (en) *	2004-05-14	2005-12-01	Immunogen, Inc.	A facile method for synthesizing baccatin iii compounds
CZ298333B6 (cs) *	2005-09-26	2007-08-29	Zentiva, A. S	Zpusob prípravy 7-trialkylsilylbaccatinu III
KR101671537B1 (ko)	2008-08-11	2016-11-01	넥타르 테라퓨틱스	다분지형 중합체 알카노에이트 컨쥬게이트
US10894087B2 (en)	2010-12-22	2021-01-19	Nektar Therapeutics	Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds
WO2012088422A1 (en)	2010-12-22	2012-06-28	Nektar Therapeutics	Multi-arm polymeric prodrug conjugates of taxane-based compounds
WO2012088391A1 (en)	2010-12-22	2012-06-28	Nektar Therapeutics	Non-ring hydroxy substituted taxanes and methods for synthesizing the same

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4823167A (en) *	1986-12-16	1989-04-18	Baxter International Inc.	Catheter calibration device
FR2629818B1 (fr) *	1988-04-06	1990-11-16	Centre Nat Rech Scient	Procede de preparation du taxol
MX9102128A (es)	1990-11-23	1992-07-08	Rhone Poulenc Rorer Sa	Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
US5229526A (en) *	1991-09-23	1993-07-20	Florida State University	Metal alkoxides
US5597931A (en) *	1992-03-30	1997-01-28	Sloan-Kettering Institute For Cancer Research	Total synthesis of taxol and analogues thereof
US5475011A (en) *	1993-03-26	1995-12-12	The Research Foundation Of State University Of New York	Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
US5405972A (en) *	1993-07-20	1995-04-11	Florida State University	Synthetic process for the preparation of taxol and other tricyclic and tetracyclic taxanes
US5449790A (en) *	1994-04-06	1995-09-12	Hauser Chemical Research, Inc.	Preparation of 10-deacetylbaccatin III and 7-protected-10-deacetylbaccatin III derivatives from 10-deacetyl taxol A, 10-deacetyl taxol B, and 10-deacetyl taxol C

1994
- 1994-04-05 FR FR9403979A patent/FR2718137B1/fr not_active Expired - Fee Related
1995
- 1995-03-22 TW TW084102793A patent/TW284765B/zh not_active IP Right Cessation
- 1995-04-03 BR BR9507444A patent/BR9507444A/pt not_active IP Right Cessation
- 1995-04-03 AT AT95916696T patent/ATE160351T1/de active
- 1995-04-03 HU HU9602735A patent/HU214158B/hu unknown
- 1995-04-03 EE EE9600143A patent/EE03240B1/xx unknown
- 1995-04-03 SK SK1265-96A patent/SK280448B6/sk not_active IP Right Cessation
- 1995-04-03 US US08/722,103 patent/US5670658A/en not_active Expired - Lifetime
- 1995-04-03 GE GEAP19953433A patent/GEP19991537B/en unknown
- 1995-04-03 RO RO96-01921A patent/RO115631B1/ro unknown
- 1995-04-03 MX MX9604466A patent/MX9604466A/es unknown
- 1995-04-03 ES ES95916696T patent/ES2109103T3/es not_active Expired - Lifetime
- 1995-04-03 EP EP95916696A patent/EP0754185B1/de not_active Expired - Lifetime
- 1995-04-03 CA CA002186916A patent/CA2186916C/fr not_active Expired - Lifetime
- 1995-04-03 AU AU23096/95A patent/AU683560B2/en not_active Expired
- 1995-04-03 JP JP52546695A patent/JP3718225B2/ja not_active Expired - Lifetime
- 1995-04-03 ZA ZA952733A patent/ZA952733B/xx unknown
- 1995-04-03 WO PCT/FR1995/000419 patent/WO1995026967A1/fr active IP Right Grant
- 1995-04-03 RU RU96120192/04A patent/RU2127729C1/ru active
- 1995-04-03 DE DE69501080T patent/DE69501080T2/de not_active Expired - Lifetime
- 1995-04-03 PL PL95316588A patent/PL316588A1/xx unknown
- 1995-04-03 CN CN95192429A patent/CN1058497C/zh not_active Expired - Lifetime
- 1995-04-03 CZ CZ19962900A patent/CZ288397B6/cs not_active IP Right Cessation
- 1995-04-03 KR KR1019960705642A patent/KR100399246B1/ko not_active IP Right Cessation
- 1995-04-03 UA UA96093735A patent/UA44730C2/uk unknown
- 1995-04-03 NZ NZ284490A patent/NZ284490A/en not_active IP Right Cessation
- 1995-04-03 DK DK95916696.8T patent/DK0754185T3/da active
1996
- 1996-09-24 LT LT96-137A patent/LT4185B/lt not_active IP Right Cessation
- 1996-09-27 NO NO964103A patent/NO305839B1/no not_active IP Right Cessation
- 1996-10-04 FI FI964001A patent/FI115970B/fi not_active IP Right Cessation
- 1996-10-04 BG BG100886A patent/BG62735B1/bg unknown
- 1996-10-07 LV LVP-96-392A patent/LV11691B/lv unknown
1997
- 1997-11-20 GR GR970401504T patent/GR3025448T3/el unknown

Also Published As

Publication number	Publication date
FR2718137A1 (fr)	1995-10-06
RO115631B1 (ro)	2000-04-28
HU9602735D0 (en)	1996-11-28
DK0754185T3 (da)	1998-01-26
DE69501080T2 (de)	1998-04-02
ZA952733B (en)	1996-01-09
NO964103D0 (no)	1996-09-27
UA44730C2 (uk)	2002-03-15
EP0754185B1 (de)	1997-11-19
EP0754185A1 (de)	1997-01-22
AU683560B2 (en)	1997-11-13
GEP19991537B (en)	1999-03-05
SK280448B6 (sk)	2000-02-14
HU214158B (hu)	1998-01-28
NO305839B1 (no)	1999-08-02
EE03240B1 (et)	1999-12-15
KR100399246B1 (ko)	2004-02-11
LT96137A (en)	1997-02-25
CA2186916A1 (fr)	1995-10-12
JP3718225B2 (ja)	2005-11-24
SK126596A3 (en)	1997-04-09
NZ284490A (en)	1998-08-26
LV11691A (lv)	1997-02-20
CN1058497C (zh)	2000-11-15
AU2309695A (en)	1995-10-23
CN1145073A (zh)	1997-03-12
FI964001A0 (fi)	1996-10-04
TW284765B (de)	1996-09-01
DE69501080D1 (de)	1998-01-02
CZ288397B6 (en)	2001-06-13
JPH09512522A (ja)	1997-12-16
FI964001A (fi)	1996-10-04
LT4185B (en)	1997-07-25
RU2127729C1 (ru)	1999-03-20
FI115970B (fi)	2005-08-31
PL316588A1 (en)	1997-01-20
HUT76035A (en)	1997-06-30
WO1995026967A1 (fr)	1995-10-12
MX9604466A (es)	1997-07-31
LV11691B (en)	1997-06-20
BR9507444A (pt)	1997-09-16
ES2109103T3 (es)	1998-01-01
CZ290096A3 (en)	1997-01-15
FR2718137B1 (fr)	1996-04-26
NO964103L (no)	1996-09-27
US5670658A (en)	1997-09-23
CA2186916C (fr)	2004-05-25
BG62735B1 (bg)	2000-06-30
BG100886A (en)	1998-01-30
GR3025448T3 (en)	1998-02-27

Legal Events

Date	Code	Title	Description
1998-06-15	UEP	Publication of translation of european patent specification
2005-03-15	EEFA	Change of the company name

Publication	Publication Date	Title
DE59108707D1 (de)	1997-06-26	Verfahren zur Herstellung von Oxetanonen
ATE160351T1 (de)	1997-12-15	Verfahren zur herstellung von 7-trialkylsilyl baccatin iii
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ATE215071T1 (de)	2002-04-15	Verfahren zur herstellung von prostaglandin e1