ATE15368T1 - Prostaglandin-analoga und verfahren zu ihrer herstellung. - Google Patents

Prostaglandin-analoga und verfahren zu ihrer herstellung.

Info

Publication number: ATE15368T1
Authority: AT; Austria
Prior art keywords: prostaglandin analogues; epoxy; prostanoids; olefins; members
Prior art date: 1981-03-02

Application number

AT82200192T

Other languages

English (en)

Inventor

Edward David Mihelich

Original Assignee

Procter & Gamble

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-03-02

Filing date

1982-02-18

Publication date

1985-09-15

1982-02-18 Application filed by Procter & Gamble filed Critical Procter & Gamble

1985-09-15 Application granted granted Critical

1985-09-15 Publication of ATE15368T1 publication Critical patent/ATE15368T1/de

Links

229940006138 antiglaucoma drug and miotics prostaglandin analogues Drugs 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 3
150000001336 alkenes Chemical class 0.000 abstract 2
LPIQUOYDBNQMRZ-UHFFFAOYSA-N cyclopentene Chemical compound C1CC=CC1 LPIQUOYDBNQMRZ-UHFFFAOYSA-N 0.000 abstract 2
229940127293 prostanoid Drugs 0.000 abstract 2
150000003814 prostanoids Chemical class 0.000 abstract 2
NEMITCBDWZCQGL-UHFFFAOYSA-N 6-oxabicyclo[3.1.0]hexan-2-ol Chemical compound OC1CCC2OC12 NEMITCBDWZCQGL-UHFFFAOYSA-N 0.000 abstract 1
VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 abstract 1
MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
239000004593 Epoxy Substances 0.000 abstract 1
-1 VIB transition metal Chemical class 0.000 abstract 1
150000001298 alcohols Chemical class 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
229910052804 chromium Inorganic materials 0.000 abstract 1
239000011651 chromium Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000001120 cytoprotective effect Effects 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
230000003647 oxidation Effects 0.000 abstract 1
238000007254 oxidation reaction Methods 0.000 abstract 1
RGSFGYAAUTVSQA-UHFFFAOYSA-N pentamethylene Natural products C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 abstract 1
239000007858 starting material Substances 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1
238000006257 total synthesis reaction Methods 0.000 abstract 1
229910052723 transition metal Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0025—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/14—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by free hydroxyl radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Compounds (AREA)
Catalysts (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AT82200192T 1981-03-02 1982-02-18 Prostaglandin-analoga und verfahren zu ihrer herstellung. ATE15368T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/239,765 US4345984A (en)	1981-03-02	1981-03-02	Novel prostaglandin analogues and process for making same
EP82200192A EP0061209B1 (de)	1981-03-02	1982-02-18	Prostaglandin-Analoga und Verfahren zu ihrer Herstellung

Publications (1)

Publication Number	Publication Date
ATE15368T1 true ATE15368T1 (de)	1985-09-15

Family

ID=22903636

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT82200192T ATE15368T1 (de)	1981-03-02	1982-02-18	Prostaglandin-analoga und verfahren zu ihrer herstellung.

Country Status (12)

Country	Link
US (1)	US4345984A (de)
EP (1)	EP0061209B1 (de)
JP (1)	JPS57206654A (de)
AT (1)	ATE15368T1 (de)
AU (2)	AU548052B2 (de)
CA (1)	CA1210016A (de)
DE (1)	DE3265945D1 (de)
ES (3)	ES510008A0 (de)
IE (1)	IE52623B1 (de)
MX (1)	MX7354E (de)
NZ (1)	NZ199807A (de)
ZA (1)	ZA821102B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4383904A (en) *	1981-09-21	1983-05-17	Celanese Corporation	Photochemical epoxidation
US4576962A (en) *	1983-10-19	1986-03-18	The Procter & Gamble Company	Prostaglandin analogues
IL75230A (en) *	1984-05-18	1989-07-31	Glaxo Group Ltd	Aminocyclopentyl ethers and their preparation and pharmaceutical formulation
US4851555A (en) *	1984-10-25	1989-07-25	Scientific Design Company, Inc.	Process for preparing alkylene oxides from alkylene carbonates
IL84414A0 (en) *	1986-11-14	1988-04-29	Ciba Geigy Ag	N9-cyclopentyl-substituted adenine derivatives
WO1994006736A1 (de) *	1992-09-16	1994-03-31	Hoechst Aktiengesellschaft	Verfahren zur sensibilisierten photooxygenierung von ungesättigten verbindungen
US6674781B1 (en) *	2002-08-19	2004-01-06	The Boeing Company	Method and system for fueling a closed cycle chemical oxygen iodine laser
EP2266998B1 (de) *	2009-06-16	2013-07-24	Crystal Pharma, S.A.U.	Verfahren zum Erhalten von 17-Spirolactonen in Steroiden

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE640204A (de) *	1962-11-20
US4175201A (en) *	1973-05-18	1979-11-20	University Of Chicago	Chemical synthesis
US4021369A (en) *	1973-06-29	1977-05-03	Sun Ventures, Inc.	Ion-exchanged transition metal catalysts for the direct oxidation of olefins to epoxyalcohols
US4123445A (en) *	1974-11-13	1978-10-31	Sun Ventures, Inc.	Novel homogeneous transition-metal catalyzed geometric isomerization of cyclic epoxy alcohols
US4180672A (en) *	1976-08-13	1979-12-25	Teijin Limited	2-Organothio-2-cyclopentenones, organothio-cyclopentanes derived therefrom

1981
- 1981-03-02 US US06/239,765 patent/US4345984A/en not_active Expired - Lifetime
1982
- 1982-02-18 AT AT82200192T patent/ATE15368T1/de not_active IP Right Cessation
- 1982-02-18 EP EP82200192A patent/EP0061209B1/de not_active Expired
- 1982-02-18 DE DE8282200192T patent/DE3265945D1/de not_active Expired
- 1982-02-19 ZA ZA821102A patent/ZA821102B/xx unknown
- 1982-02-19 AU AU80632/82A patent/AU548052B2/en not_active Ceased
- 1982-02-23 NZ NZ199807A patent/NZ199807A/en unknown
- 1982-03-01 MX MX829947U patent/MX7354E/es unknown
- 1982-03-01 IE IE450/82A patent/IE52623B1/en unknown
- 1982-03-01 CA CA000397348A patent/CA1210016A/en not_active Expired
- 1982-03-01 ES ES510008A patent/ES510008A0/es active Granted
- 1982-03-02 JP JP57032953A patent/JPS57206654A/ja active Pending
1983
- 1983-02-18 ES ES519903A patent/ES8500224A1/es not_active Expired
- 1983-02-18 ES ES519902A patent/ES8403451A1/es not_active Expired
1985
- 1985-08-22 AU AU46558/85A patent/AU4655885A/en not_active Abandoned

Also Published As

Publication number	Publication date
US4345984A (en)	1982-08-24
EP0061209B1 (de)	1985-09-04
AU548052B2 (en)	1985-11-21
IE820450L (en)	1982-09-02
ES519903A0 (es)	1984-10-01
ES519902A0 (es)	1984-03-16
AU4655885A (en)	1985-12-05
ES8403451A1 (es)	1984-03-16
JPS57206654A (en)	1982-12-18
NZ199807A (en)	1985-11-08
MX7354E (es)	1988-07-19
ES8307738A1 (es)	1983-07-01
AU8063282A (en)	1982-09-09
IE52623B1 (en)	1988-01-06
ES510008A0 (es)	1983-07-01
ZA821102B (en)	1983-01-26
CA1210016A (en)	1986-08-19
ES8500224A1 (es)	1984-10-01
DE3265945D1 (en)	1985-10-10
EP0061209A1 (de)	1982-09-29

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Legal Events

Date	Code	Title	Description
1986-01-15	UEP	Publication of translation of european patent specification
1989-11-15	REN	Ceased due to non-payment of the annual fee