ATE152615T1 - Verfahren und vorrichtung zur herstellung von liposomen - Google Patents

Verfahren und vorrichtung zur herstellung von liposomen

Info

Publication number
ATE152615T1
ATE152615T1 AT94917485T AT94917485T ATE152615T1 AT E152615 T1 ATE152615 T1 AT E152615T1 AT 94917485 T AT94917485 T AT 94917485T AT 94917485 T AT94917485 T AT 94917485T AT E152615 T1 ATE152615 T1 AT E152615T1
Authority
AT
Austria
Prior art keywords
critical
liposomes
supercritical
producing liposomes
methods
Prior art date
Application number
AT94917485T
Other languages
English (en)
Inventor
Trevor P Castor
Original Assignee
Aphios Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aphios Corp filed Critical Aphios Corp
Application granted granted Critical
Publication of ATE152615T1 publication Critical patent/ATE152615T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT94917485T 1993-05-28 1994-05-26 Verfahren und vorrichtung zur herstellung von liposomen ATE152615T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/069,134 US5554382A (en) 1993-05-28 1993-05-28 Methods and apparatus for making liposomes

Publications (1)

Publication Number Publication Date
ATE152615T1 true ATE152615T1 (de) 1997-05-15

Family

ID=22086969

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94917485T ATE152615T1 (de) 1993-05-28 1994-05-26 Verfahren und vorrichtung zur herstellung von liposomen

Country Status (11)

Country Link
US (1) US5554382A (de)
EP (1) EP0703778B1 (de)
JP (1) JP3742427B2 (de)
KR (1) KR960702748A (de)
AT (1) ATE152615T1 (de)
AU (1) AU6919094A (de)
CA (1) CA2163903A1 (de)
DE (1) DE69403077T2 (de)
FI (1) FI115115B (de)
NO (1) NO954756L (de)
WO (1) WO1994027581A1 (de)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6582728B1 (en) 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
US6509006B1 (en) 1992-07-08 2003-01-21 Inhale Therapeutic Systems, Inc. Devices compositions and methods for the pulmonary delivery of aerosolized medicaments
WO1995035157A1 (fr) * 1994-06-20 1995-12-28 Nippon Shinyaku Co., Ltd. Procede de fabrication d'emulsion et emulsificateur
GB9413202D0 (en) * 1994-06-30 1994-08-24 Univ Bradford Method and apparatus for the formation of particles
US6290991B1 (en) 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
ATE223205T1 (de) * 1994-11-18 2002-09-15 Aphios Corp Verfahren zur herstellung von liposomen, die hydrophobische artzneistoffe enthalten
DE4445341A1 (de) * 1994-12-19 1996-06-20 Basf Ag Verfahren und Vorrichtung zur Herstellung wirkstoffhaltiger Dispersionen
US5795587A (en) 1995-01-23 1998-08-18 University Of Pittsburgh Stable lipid-comprising drug delivery complexes and methods for their production
US6008202A (en) * 1995-01-23 1999-12-28 University Of Pittsburgh Stable lipid-comprising drug delivery complexes and methods for their production
GB9703673D0 (en) * 1997-02-21 1997-04-09 Bradford Particle Design Ltd Method and apparatus for the formation of particles
US6740335B1 (en) * 1997-09-16 2004-05-25 Osi Pharmaceuticals, Inc. Liposomal camptothecin formulations
AU751439B2 (en) * 1997-09-16 2002-08-15 Osi Pharmaceuticals, Inc. Liposomal camptothecin formulations
CA2304096C (en) 1997-09-18 2003-09-09 Skyepharma Inc. Sustained-release liposomal anesthetic compositions
NZ504188A (en) * 1997-11-14 2001-10-26 Skyepharma Inc Emulsification process for preparing multivesicular liposomes
US5994855A (en) 1998-05-07 1999-11-30 Optiva Corporation Automatic power adjustment system for introductory use of a vibrating device on a human body
GB9810559D0 (en) * 1998-05-15 1998-07-15 Bradford Particle Design Ltd Method and apparatus for particle formation
US7314637B1 (en) 1999-06-29 2008-01-01 Neopharm, Inc. Method of administering liposomal encapsulated taxane
US6461637B1 (en) * 2000-09-01 2002-10-08 Neopharm, Inc. Method of administering liposomal encapsulated taxane
US6855296B1 (en) 1998-11-13 2005-02-15 Optime Therapeutics, Inc. Method and apparatus for liposome production
AU756196B2 (en) * 1998-11-13 2003-01-09 Optime Therapeutics, Inc. Method and apparatus for liposome production
US6040330A (en) * 1999-01-08 2000-03-21 Bionumerik Pharmaceuticals, Inc. Pharmaceutical formulations of taxanes
GB9915975D0 (en) * 1999-07-07 1999-09-08 Bradford Particle Design Ltd Method for the formation of particles
US6521258B1 (en) * 2000-09-08 2003-02-18 Ferro Corporation Polymer matrices prepared by supercritical fluid processing techniques
US20040099976A1 (en) * 2000-10-13 2004-05-27 Katsuto Otake Process for producing liposome and apparatus therefor
GB0027357D0 (en) 2000-11-09 2000-12-27 Bradford Particle Design Plc Particle formation methods and their products
US7708915B2 (en) 2004-05-06 2010-05-04 Castor Trevor P Polymer microspheres/nanospheres and encapsulating therapeutic proteins therein
US20020130430A1 (en) * 2000-12-29 2002-09-19 Castor Trevor Percival Methods for making polymer microspheres/nanospheres and encapsulating therapeutic proteins and other products
JP2004535388A (ja) * 2001-04-30 2004-11-25 ターゲティッド ジェネティクス コーポレイション 脂質含有薬物送達複合体およびそれらの生成方法
GB0117696D0 (en) * 2001-07-20 2001-09-12 Bradford Particle Design Plc Particle information
US7029707B2 (en) * 2001-10-03 2006-04-18 Herbalscience, Llc Method of producing a processed kava product having an altered kavalactone distribution and processed kava products produced using the same
US20050069596A1 (en) * 2001-10-03 2005-03-31 Gow Robert T. Compositions and methods comprising kava and anti-anxiety compounds
US7291352B2 (en) 2001-10-03 2007-11-06 Herbalscience Llc Methods and compositions for oral delivery of Areca and mate' or theobromine
US7105185B2 (en) 2001-10-03 2006-09-12 Herbalscience, Llc Kavalactone profile
US7001620B2 (en) 2001-10-03 2006-02-21 Herbal Science, Llc Kavalactone product
US7037524B2 (en) * 2001-10-03 2006-05-02 Herbalscience, Llc Oral delivery of a botanical
DE10205130A1 (de) * 2002-02-07 2003-08-28 Air Liquide Gmbh Verfahren zum unterbrechungsfreien Bereitstellen von flüssigem, unterkühltem Kohlendioxid bei konstantem Druck oberhalb von 40 bar sowie Versorgungssystem
GB0216562D0 (en) 2002-04-25 2002-08-28 Bradford Particle Design Ltd Particulate materials
US9339459B2 (en) 2003-04-24 2016-05-17 Nektar Therapeutics Particulate materials
US6966990B2 (en) 2002-10-11 2005-11-22 Ferro Corporation Composite particles and method for preparing
JP4711947B2 (ja) * 2003-02-03 2011-06-29 ネオファーム、インコーポレイティッド 安定な濾過滅菌性リポソームに被包化されたタキサン及び他の抗腫瘍剤
US7083748B2 (en) * 2003-02-07 2006-08-01 Ferro Corporation Method and apparatus for continuous particle production using supercritical fluid
US6931888B2 (en) * 2003-02-07 2005-08-23 Ferro Corporation Lyophilization method and apparatus for producing particles
US20060008531A1 (en) * 2003-05-08 2006-01-12 Ferro Corporation Method for producing solid-lipid composite drug particles
BRPI0409962A (pt) * 2003-05-08 2006-04-25 Nektar Therapeutics Uk Ltd co-formulação particulada de uma substáncia ativa e um excipiente, composição farmacêutica ou nutricêutrica, produto farmacêutico ou nutricêutico, método para preparar uma co-formulação particulada de uma substáncia ativa e um excipiente, e, uso de uma substáncia ativa e um excipiente
JP2005170923A (ja) * 2003-10-21 2005-06-30 Konica Minolta Medical & Graphic Inc リポソーム含有ｘ線造影剤およびその製造方法
US7294353B2 (en) * 2003-10-24 2007-11-13 Herbalscience, Llc Methods and compositions comprising ilex
CN1917892A (zh) * 2003-10-24 2007-02-21 草本制药科学有限责任公司 包含冬青的方法和组合物
JP4595319B2 (ja) * 2003-12-03 2010-12-08 コニカミノルタエムジー株式会社 リポソーム用脂質、リポソームおよびそれらの製造方法
JP2005162702A (ja) * 2003-12-04 2005-06-23 Konica Minolta Medical & Graphic Inc リポソーム製剤の製造方法、リポソーム製剤およびその製造装置
JP4649841B2 (ja) * 2004-02-18 2011-03-16 コニカミノルタエムジー株式会社 リポソーム含有製剤の製造方法、およびリポソーム含有製剤
JPWO2006009022A1 (ja) * 2004-07-21 2008-05-01 コニカミノルタエムジー株式会社 リポソーム含有ｘ線造影剤およびその製造方法
JP5176320B2 (ja) * 2004-08-11 2013-04-03 コニカミノルタエムジー株式会社 リポソーム含有製剤の製造方法
JP2006056807A (ja) * 2004-08-18 2006-03-02 Konica Minolta Medical & Graphic Inc 光線力学療法製剤
JP4715133B2 (ja) * 2004-08-26 2011-07-06 コニカミノルタエムジー株式会社 抗腫瘍リポソーム製剤およびその製造方法
JP2006069929A (ja) * 2004-08-31 2006-03-16 Konica Minolta Medical & Graphic Inc 真菌症治療製剤およびその製造方法
ES2265262B1 (es) * 2005-01-31 2008-03-01 Activery Biotech, S.L.(Titular Al 50%) Procedimiento para la obtencion de sistemas micro- y nanodispersos.
US20060239925A1 (en) * 2005-04-21 2006-10-26 Konica Minolta Medical & Graphic, Inc. Method of manufacturing pharmaceutical preparation containing liposomes
DK1888033T3 (da) * 2005-06-09 2014-05-26 Meda Ab Fremgangsmåde og sammensætning til behandling af inflammatoriske sygdomme
ES2292300B1 (es) * 2005-07-19 2009-02-16 Sociedad Española De Carburos Metalicos, S.A.(Titular Al 50%) Procedimiento para la obtencion de un material compuesto.
EP1920765A1 (de) * 2006-11-07 2008-05-14 Medigene AG Single-Pass Verfahren zur Liposomherstellung
KR100811447B1 (ko) * 2006-12-05 2008-03-11 재단법인서울대학교산학협력재단 초임계 유체를 이용한 세라마이드 나노입자 제조방법
JP5532921B2 (ja) * 2007-05-14 2014-06-25 コニカミノルタ株式会社 リポソーム
AU2008331967B2 (en) * 2007-12-07 2012-10-25 Xspray Microparticles Ab Method and arrangement for the production of particles
US8637074B2 (en) * 2009-03-31 2014-01-28 Aphios Corporation Methods for co-encapsulation of combination drugs and co-encapsulated combination drug product
KR101102834B1 (ko) * 2010-02-24 2012-01-05 충남대학교산학협력단 신규한 리포좀 제조 방법 및 장치
CN104922071A (zh) 2010-04-09 2015-09-23 帕西拉制药有限公司 用于配制大直径合成膜囊泡的方法
KR101795019B1 (ko) * 2010-06-16 2017-12-01 초임계연구소 주식회사 봉입물질의 열변성을 방지하는 저온 리포좀 제조방법
KR101047873B1 (ko) * 2010-06-23 2011-07-08 주식회사 에프씨비투웰브 인체유래 줄기세포 배양액 추출물을 포접시킨 리포좀을 함유하는 화장료 조성물
US9981238B2 (en) * 2010-08-25 2018-05-29 Aphios Corporation Apparatus and methods for making nanosomes loaded with nucleic acid
CA2767773C (en) 2011-02-11 2015-11-24 Grain Processing Corporation Composition comprising a salt and a crystallization interrupter
DK2729127T3 (en) 2011-07-04 2018-08-06 Statens Seruminstitut METHODS FOR LIPOSOMES PREPARATION
RU2659729C2 (ru) 2012-07-30 2018-07-03 Матинас Биофарма Нанотекнолоджис, Инк. Кохлеаты, полученные с использованием фосфатидилсерина сои
JP6373749B2 (ja) 2014-12-19 2018-08-15 富士フイルム株式会社 リポソームの製造方法及びリポソーム製造装置
CN109291298B (zh) * 2018-09-30 2024-03-29 苏州艾特森制药设备有限公司 一种微量脂质体高压挤出装置
US11278494B1 (en) 2021-01-22 2022-03-22 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11033495B1 (en) 2021-01-22 2021-06-15 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11357727B1 (en) 2021-01-22 2022-06-14 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
DE102021130372A1 (de) 2021-11-19 2023-05-25 Deutsches Zentrum für Luft- und Raumfahrt e.V. Verfahren und Anordnung zur Herstellung eines Treibstoffgemisches

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2521565B1 (fr) * 1982-02-17 1985-07-05 Dior Sa Parfums Christian Melange pulverulent de constituants lipidiques et de constituants hydrophobes, procede pour le preparer, phases lamellaires lipidiques hydratees et procede de fabrication, compositions pharmaceutiques ou cosmetiques comportant des phases lamellaires lipidiques hydratees
FR2543018B1 (fr) * 1983-03-22 1985-07-26 Oreal Procede de preparation de vesicules lipidiques par vaporisation de solvants
GB8613811D0 (en) * 1986-06-06 1986-07-09 Phares Pharm Res Nv Composition & method
US5141674A (en) * 1984-03-08 1992-08-25 Phares Pharmaceutical Research N.V. Methods of preparing pro-liposome dispersions and aerosols
GB8423436D0 (en) * 1984-09-17 1984-10-24 Riker Laboratories Inc Preparation of liposomes
GB8502892D0 (en) * 1985-02-05 1985-03-06 Sterwin Ag Aerosol composition
US5192528A (en) * 1985-05-22 1993-03-09 Liposome Technology, Inc. Corticosteroid inhalation treatment method
US4752425A (en) * 1986-09-18 1988-06-21 Liposome Technology, Inc. High-encapsulation liposome processing method
WO1988001864A1 (en) * 1986-09-18 1988-03-24 Liposome Technology, Inc. High-concentration liposome processing method
DE3812816A1 (de) * 1988-04-16 1989-11-02 Lawaczeck Ruediger Dipl Phys P Verfahren zur solubilisierung von liposomen und/oder biologischer membranen sowie deren verwendung
US5088499A (en) * 1989-12-22 1992-02-18 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5305757A (en) * 1989-12-22 1994-04-26 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents

Also Published As

Publication number Publication date
US5554382A (en) 1996-09-10
FI955727A0 (fi) 1995-11-28
JP3742427B2 (ja) 2006-02-01
EP0703778A1 (de) 1996-04-03
AU6919094A (en) 1994-12-20
FI955727A (fi) 1996-01-26
EP0703778B1 (de) 1997-05-07
NO954756L (no) 1996-01-26
NO954756D0 (no) 1995-11-24
CA2163903A1 (en) 1994-12-08
KR960702748A (ko) 1996-05-23
FI115115B (fi) 2005-03-15
DE69403077D1 (de) 1997-06-12
JPH09502644A (ja) 1997-03-18
WO1994027581A1 (en) 1994-12-08
DE69403077T2 (de) 1997-11-13

Similar Documents

Publication Publication Date Title
ATE152615T1 (de) Verfahren und vorrichtung zur herstellung von liposomen
ATE223205T1 (de) Verfahren zur herstellung von liposomen, die hydrophobische artzneistoffe enthalten
DE69426374D1 (de) Aroma- oder Parfümkonzentrat für Mundwasser in Form einer Öl-in-Wasser Mikroemulsion, und Verfahren zur Herstellung derselben
DE59606677D1 (de) Verfahren und vorrichtung zur vereinheitlichten, kontinuierlichen herstellung von polyamiden
DE59108720D1 (de) Verfahren und Vorrichtung zur kontinuierlichen Intensivbefeuchtung von Flächengebilden, insbesondere bahnförmigen Textilien u. dgl.
ATE95581T1 (de) Verfahren und vorrichtung zur formung von dreidimensional zusammengesetzten bahnen.
DE69903970D1 (de) Verfahren und vorrichtung zur vorbeugung von kleinen lechern im zone-laminats
DE69435288D1 (de) Verfahren und Vorrichtung zur Herstellung von Dünnfilmen
DE69509219D1 (de) Schleifartikel, verfahren zur herstellung desselben, und schleifmaschine
DE69501872D1 (de) Wässrige fluorpolymeremulsion und verfahren zu dessen herstellung
DE69409618D1 (de) Verfahren und Vorrichtung zur Herstellung von mehrschichtigen, unter niedrigen Druck imprägnierten Gegenständen, insbesondere mit tiefen Ünterschneidungen
SG90008A1 (en) Oil-in-water type emulsion and process for producing the same
DE59104082D1 (de) Verfahren zur herstellung von öl-in-wasser-cremes.
DE59203503D1 (de) Verfahren zur herstellung von öl-in-wasser-emulsionen.
DE69606294D1 (de) Vorrichtung und verfahren zur herstellung von polstermaterial mit heftperforationen
ATE290003T1 (de) Verfahren zur herstellung von pyrazolo-(4,3- d)pyrimidin-7-ones und zwischenprodukte davon
DE69505539D1 (de) Sicherheitsprodukt, film und verfahren zur herstellung eines sicherheitsprodukts
DE59105631D1 (de) Verfahren zur herstellung von flächen- und im querschnitt ringförmigen extrudaten sowie vorrichtung zur durchführung des verfahrens.
DE69840926D1 (de) Verfahren und vorrichtung zur herstellung von profilen und laminaten
DE59105668D1 (de) Verfahren und Vorrichtung zum Herstellen von Druckbehältern sowie Druckbehälter.
DE69521349D1 (de) Verfahren und vorrichtung zur herstellung von aufgussbeuteln
ATE148067T1 (de) Behälter zum verstäuben von flüssigkeiten und verfahren zur herstellung desselben
DE69202227D1 (de) Vorrichtung zur Herstellung von Sojabohnen-Quark und dessen Plazierung in Behältern.
DE69419666D1 (de) Vorrichtung zum Verhindern der Schaumbildung bei den extrakorporalen Blutbehandlung und Verfahren zur Herstellung der Vorrichtung
DE69604213D1 (de) Mikrowellenfeste Lebensmittelverpackung sowie Verfahren zur Herstellen derselben

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties