ATE149T1 - 2-(N-(2'-CHLORO-4'-METHYLTHIENYL-3')-N-(CYCLOPROPYL-METHYL)-AMINO)-IMIDAZOLINE-(2), ITS ACID ADDITION SALTS, MEDICINAL PRODUCT CONTAINING THIS AND PROCESS FOR ITS PREPARATION. - Google Patents
2-(N-(2'-CHLORO-4'-METHYLTHIENYL-3')-N-(CYCLOPROPYL-METHYL)-AMINO)-IMIDAZOLINE-(2), ITS ACID ADDITION SALTS, MEDICINAL PRODUCT CONTAINING THIS AND PROCESS FOR ITS PREPARATION.Info
- Publication number
- ATE149T1 ATE149T1 AT79101859T AT79101859T ATE149T1 AT E149 T1 ATE149 T1 AT E149T1 AT 79101859 T AT79101859 T AT 79101859T AT 79101859 T AT79101859 T AT 79101859T AT E149 T1 ATE149 T1 AT E149T1
- Authority
- AT
- Austria
- Prior art keywords
- methyl
- imidazoline
- cyclopropyl
- chloro
- amino
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- 229940126601 medicinal product Drugs 0.000 title 1
- 230000000059 bradycardiac effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
2-[N-(Cyclopropyl-methyl)-N-(2'-chloro-4'-methyl-thienyl-3')-amino]-2- imidazoline and non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds are useful as bradycardiacs.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19782830279 DE2830279A1 (en) | 1978-07-10 | 1978-07-10 | 2-CORNER CLAMP ON N- (2'-CHLOR-4'-METHYL-THIENYL-3 ') - N- (CYCLOPROPYLMETHYL) - AMINO CORNER CLAMP ON-IMIDAZOLINE- (2), THE ACID ADDITION SALTS THAT IT INCLUDES HIS PRODUCTION |
EP79101859A EP0007007B1 (en) | 1978-07-10 | 1979-06-11 | 2-(n-(2'chloro-4'-methyl-thienyl-3')-n-(cyclopropylmethyl)-amino) imidazoline (2), its acid addition salts, pharmaceutical preparations containing them and process for their preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE149T1 true ATE149T1 (en) | 1981-09-15 |
Family
ID=6043997
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT79101859T ATE149T1 (en) | 1978-07-10 | 1979-06-11 | 2-(N-(2'-CHLORO-4'-METHYLTHIENYL-3')-N-(CYCLOPROPYL-METHYL)-AMINO)-IMIDAZOLINE-(2), ITS ACID ADDITION SALTS, MEDICINAL PRODUCT CONTAINING THIS AND PROCESS FOR ITS PREPARATION. |
Country Status (5)
Country | Link |
---|---|
US (1) | US4215133A (en) |
EP (1) | EP0007007B1 (en) |
JP (1) | JPS5513285A (en) |
AT (1) | ATE149T1 (en) |
DE (2) | DE2830279A1 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2951601A1 (en) * | 1979-12-21 | 1981-07-02 | C.H. Boehringer Sohn, 6507 Ingelheim | NEW SUBSTITUTED 2-PHENYLAMINOIMIDAZOLINE (2), THE ACID ADDITION SALTS THEREOF, THE MEDICINAL PRODUCTS CONTAINING THE SAME AND METHOD FOR THE PRODUCTION THEREOF |
GB8304593D0 (en) * | 1983-02-18 | 1983-03-23 | Beecham Group Plc | Amidines |
US7049333B2 (en) * | 2002-06-04 | 2006-05-23 | Sanofi-Aventis Deutschland Gmbh | Substituted thiophenes: compositions, processes of making, and uses in disease treatment and diagnosis |
DE10224892A1 (en) * | 2002-06-04 | 2003-12-18 | Aventis Pharma Gmbh | Substituted thiophenes, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3746724A (en) * | 1970-04-13 | 1973-07-17 | Ciba Geigy Corp | 3-guanidinoalkyl-thiophenes |
DE2308883C3 (en) * | 1973-02-23 | 1978-05-24 | C.H. Boehringer Sohn, 6507 Ingelheim | 2-Phenylamino-thienylmethyl-imidazoline- (2), process for the preparation of the same and medicaments containing them |
DE2636732A1 (en) * | 1976-08-14 | 1978-02-16 | Boehringer Sohn Ingelheim | NEW SUBSTITUTED 2-PHENYLAMINO IMIDAZOLINE (2), THE ACID ADDITION SALTS THEREOF, THE MEDICINAL PRODUCTS CONTAINING THE SAME AND METHOD FOR THE PRODUCTION THEREOF |
-
1978
- 1978-07-10 DE DE19782830279 patent/DE2830279A1/en not_active Withdrawn
-
1979
- 1979-06-11 EP EP79101859A patent/EP0007007B1/en not_active Expired
- 1979-06-11 AT AT79101859T patent/ATE149T1/en not_active IP Right Cessation
- 1979-06-11 DE DE7979101859T patent/DE2960627D1/en not_active Expired
- 1979-07-05 US US06/054,850 patent/US4215133A/en not_active Expired - Lifetime
- 1979-07-09 JP JP8600579A patent/JPS5513285A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
JPS5513285A (en) | 1980-01-30 |
US4215133A (en) | 1980-07-29 |
EP0007007A1 (en) | 1980-01-23 |
EP0007007B1 (en) | 1981-08-12 |
DE2830279A1 (en) | 1980-01-31 |
DE2960627D1 (en) | 1981-11-12 |
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REN | Ceased due to non-payment of the annual fee |