ATE149505T1 - Verfahren zur trennung von 2-deoxy-2,2-difluor-d- ribofuranosyl-alkyl-sulfonat-anomeren - Google Patents
Verfahren zur trennung von 2-deoxy-2,2-difluor-d- ribofuranosyl-alkyl-sulfonat-anomerenInfo
- Publication number
- ATE149505T1 ATE149505T1 AT93304821T AT93304821T ATE149505T1 AT E149505 T1 ATE149505 T1 AT E149505T1 AT 93304821 T AT93304821 T AT 93304821T AT 93304821 T AT93304821 T AT 93304821T AT E149505 T1 ATE149505 T1 AT E149505T1
- Authority
- AT
- Austria
- Prior art keywords
- ribofuranosyl
- deoxy
- separating
- difluorene
- anomers
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/902,303 US5256797A (en) | 1992-06-22 | 1992-06-22 | Process for separating 2-deoxy-2,2-difluoro-D-ribofuranosyl alkylsulfonate anomers |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE149505T1 true ATE149505T1 (de) | 1997-03-15 |
Family
ID=25415647
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT93304821T ATE149505T1 (de) | 1992-06-22 | 1993-06-21 | Verfahren zur trennung von 2-deoxy-2,2-difluor-d- ribofuranosyl-alkyl-sulfonat-anomeren |
Country Status (17)
Country | Link |
---|---|
US (1) | US5256797A (de) |
EP (1) | EP0576232B1 (de) |
JP (1) | JPH0656867A (de) |
KR (1) | KR100302087B1 (de) |
AT (1) | ATE149505T1 (de) |
BR (1) | BR9302426A (de) |
CA (1) | CA2098888C (de) |
CY (1) | CY2091B1 (de) |
DE (1) | DE69308391T2 (de) |
DK (1) | DK0576232T3 (de) |
ES (1) | ES2100462T3 (de) |
GR (1) | GR3023060T3 (de) |
HK (1) | HK1006022A1 (de) |
HU (1) | HU217976B (de) |
IL (1) | IL106074A (de) |
MX (1) | MX9303714A (de) |
TW (1) | TW233300B (de) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0576231B1 (de) * | 1992-06-22 | 1997-05-28 | Eli Lilly And Company | Verfahren zur Herstellung von mit Alpha-Anomeren angereicherten 1-Halogen-2-Deoxy-2,2-Difluor-D-Ribofuranosyl-Derivaten |
MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
KR20030036189A (ko) | 2000-05-26 | 2003-05-09 | 이데닉스(케이만)리미티드 | 플라비바이러스 및 페스티바이러스의 치료방법 및 조성물 |
US7608600B2 (en) * | 2002-06-28 | 2009-10-27 | Idenix Pharmaceuticals, Inc. | Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections |
AU2003248748A1 (en) | 2002-06-28 | 2004-01-19 | Idenix (Cayman) Limited | 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
KR20050088079A (ko) | 2002-11-15 | 2005-09-01 | 이데닉스 (케이만) 리미티드 | 2'-분지형 뉴클레오시드 및 플라비비리다에 돌연변이 |
EP2319853B1 (de) | 2002-12-12 | 2014-03-12 | IDENIX Pharmaceuticals, Inc. | Verfahren zur Herstellung von 2 -verzweigten Nucleosiden |
BRPI0512360A (pt) * | 2004-06-23 | 2008-03-11 | Idenix Cayman Ltd | derivados de 5-aza-7-deazapurina para o tratamento de flaviviridae |
US7214791B2 (en) * | 2004-07-01 | 2007-05-08 | Shenzhen Hande Technology Co., Ltd. | Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material |
AT502221A1 (de) * | 2005-07-20 | 2007-02-15 | Pharmacon Forschung & Beratung Gmbh | Homogemcitabine, verfahren zu ihrer herstellung sowie deren verwendung |
US7781576B2 (en) | 2005-12-23 | 2010-08-24 | Idenix Pharmaceuticals, Inc. | Process for preparing a synthetic intermediate for preparation of branched nucleosides |
US20070191598A1 (en) * | 2006-02-07 | 2007-08-16 | Chemagis Ltd. | Process for Preparing Gemcitabine and Associated Intermediates |
US20070249823A1 (en) * | 2006-04-20 | 2007-10-25 | Chemagis Ltd. | Process for preparing gemcitabine and associated intermediates |
US20080262215A1 (en) * | 2007-04-23 | 2008-10-23 | Chemagis Ltd. | Gemcitabine production process |
GB0812895D0 (en) * | 2008-07-15 | 2008-08-20 | Glycom As | Crystalline carbohydrate derivative |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4526988A (en) * | 1983-03-10 | 1985-07-02 | Eli Lilly And Company | Difluoro antivirals and intermediate therefor |
DE3856330T2 (de) * | 1987-08-28 | 1999-09-30 | Lilly Co Eli | Verfahren zur selektiven Isolierung von beta-2'-desoxy-2'2'-difluorocytidin oder seiner Salze |
US4965374A (en) * | 1987-08-28 | 1990-10-23 | Eli Lilly And Company | Process for and intermediates of 2',2'-difluoronucleosides |
-
1992
- 1992-06-22 US US07/902,303 patent/US5256797A/en not_active Expired - Lifetime
-
1993
- 1993-06-21 EP EP93304821A patent/EP0576232B1/de not_active Expired - Lifetime
- 1993-06-21 AT AT93304821T patent/ATE149505T1/de active
- 1993-06-21 IL IL106074A patent/IL106074A/en not_active IP Right Cessation
- 1993-06-21 DK DK93304821.7T patent/DK0576232T3/da active
- 1993-06-21 BR BR9302426A patent/BR9302426A/pt not_active Application Discontinuation
- 1993-06-21 MX MX9303714A patent/MX9303714A/es unknown
- 1993-06-21 KR KR1019930011306A patent/KR100302087B1/ko not_active IP Right Cessation
- 1993-06-21 CA CA002098888A patent/CA2098888C/en not_active Expired - Lifetime
- 1993-06-21 DE DE69308391T patent/DE69308391T2/de not_active Expired - Lifetime
- 1993-06-21 JP JP5149152A patent/JPH0656867A/ja active Pending
- 1993-06-21 ES ES93304821T patent/ES2100462T3/es not_active Expired - Lifetime
- 1993-06-21 HU HU9301826A patent/HU217976B/hu not_active IP Right Cessation
- 1993-06-22 TW TW082104993A patent/TW233300B/zh not_active IP Right Cessation
-
1997
- 1997-04-08 GR GR970400728T patent/GR3023060T3/el unknown
-
1998
- 1998-06-12 HK HK98105211A patent/HK1006022A1/xx not_active IP Right Cessation
- 1998-06-18 CY CY9800012A patent/CY2091B1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
DE69308391T2 (de) | 1997-07-17 |
DE69308391D1 (de) | 1997-04-10 |
HUT64551A (en) | 1994-01-28 |
TW233300B (de) | 1994-11-01 |
HU9301826D0 (en) | 1993-09-28 |
HU217976B (hu) | 2000-05-28 |
KR100302087B1 (ko) | 2001-10-22 |
HK1006022A1 (en) | 1999-02-05 |
EP0576232A1 (de) | 1993-12-29 |
CA2098888A1 (en) | 1993-12-23 |
CY2091B1 (en) | 2002-04-05 |
IL106074A0 (en) | 1993-10-20 |
JPH0656867A (ja) | 1994-03-01 |
EP0576232B1 (de) | 1997-03-05 |
KR940000473A (ko) | 1994-01-03 |
US5256797A (en) | 1993-10-26 |
MX9303714A (es) | 1994-01-31 |
CA2098888C (en) | 2003-07-29 |
BR9302426A (pt) | 1994-01-11 |
ES2100462T3 (es) | 1997-06-16 |
IL106074A (en) | 1998-02-22 |
DK0576232T3 (da) | 1997-07-21 |
GR3023060T3 (en) | 1997-07-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |