ATE148698T1 - Dihydropyridine zur anwendung in der antitumor- therapie - Google Patents
Dihydropyridine zur anwendung in der antitumor- therapieInfo
- Publication number
- ATE148698T1 ATE148698T1 AT92308561T AT92308561T ATE148698T1 AT E148698 T1 ATE148698 T1 AT E148698T1 AT 92308561 T AT92308561 T AT 92308561T AT 92308561 T AT92308561 T AT 92308561T AT E148698 T1 ATE148698 T1 AT E148698T1
- Authority
- AT
- Austria
- Prior art keywords
- chem
- alkoxy
- group
- alkyl optionally
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Saccharide Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB919119983A GB9119983D0 (en) | 1991-09-19 | 1991-09-19 | Dihydropyridine derivatives useful in antitumor therapy |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE148698T1 true ATE148698T1 (de) | 1997-02-15 |
Family
ID=10701636
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT92308561T ATE148698T1 (de) | 1991-09-19 | 1992-09-18 | Dihydropyridine zur anwendung in der antitumor- therapie |
Country Status (21)
Country | Link |
---|---|
US (1) | US5362729A (de) |
EP (1) | EP0533504B1 (de) |
JP (1) | JPH05213935A (de) |
KR (1) | KR930006002A (de) |
AT (1) | ATE148698T1 (de) |
AU (1) | AU651001B2 (de) |
CA (1) | CA2078606A1 (de) |
DE (1) | DE69217308T2 (de) |
DK (1) | DK0533504T3 (de) |
ES (1) | ES2099800T3 (de) |
FI (1) | FI98215C (de) |
GB (1) | GB9119983D0 (de) |
GR (1) | GR3022988T3 (de) |
HU (1) | HUT61994A (de) |
IL (1) | IL103019A (de) |
MX (1) | MX9205207A (de) |
MY (1) | MY129935A (de) |
NZ (1) | NZ244280A (de) |
RU (1) | RU2086548C1 (de) |
TW (1) | TW283147B (de) |
ZA (1) | ZA927115B (de) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5508410A (en) * | 1993-11-30 | 1996-04-16 | Reilly Industries, Inc. | Process for preparing 2-halo-5-substituted pyridines |
US5554621A (en) * | 1995-06-07 | 1996-09-10 | Bristol-Myers Squibb Company | Dihydropyridine NPY antagonists: nitrogen heterocyclic derivatives |
US5668151A (en) * | 1995-06-07 | 1997-09-16 | Bristol-Myers Squibb Company | Dihydropyridine NPY antagonists: piperidine derivatives |
GB9515445D0 (en) * | 1995-07-27 | 1995-09-27 | Pharmacia Spa | Dihydropyridine and pyridine derivatives and process for their preparation |
GB2310136A (en) * | 1996-02-16 | 1997-08-20 | Pharmacia Spa | Dihydropyridine derivatives as aromatase inhibitors |
US5889016A (en) * | 1997-06-26 | 1999-03-30 | Bristol-Myers Squibb Company | Dihydropyrimidone derivatives as NPY antagonists |
ES2151850B1 (es) * | 1998-10-26 | 2001-08-16 | Esteve Quimica Sa | Intermedio para la sintesis de amlodipino para su obtencion y utilizacion correspondiente. |
US6177429B1 (en) | 1999-06-21 | 2001-01-23 | Bristol-Myers Squibb Company | Dihydropyrazine derivatives as NPY antagonists |
US6693099B2 (en) | 2000-10-17 | 2004-02-17 | The Procter & Gamble Company | Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance |
US6376514B1 (en) | 2000-10-17 | 2002-04-23 | The Procter & Gamble Co. | Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof |
US8906392B2 (en) * | 2005-12-16 | 2014-12-09 | University Of Kansas | Nanocluster compositions and methods |
WO2010009146A1 (en) * | 2008-07-15 | 2010-01-21 | University Of Kansas | Nanoclusters for delivery of poorly water soluble drug nanoparticles |
EP2782573B1 (de) | 2011-11-24 | 2019-10-09 | Richter Gedeon Nyrt. | 1,4-dihydropyridin-derivate mit hsp-modulierender aktivität |
CN105175326B (zh) * | 2015-08-19 | 2018-02-27 | 四川国康药业有限公司 | 5‑甲基‑2(1h)吡啶酮衍生物及其制备方法和用途 |
KR102528669B1 (ko) * | 2016-06-10 | 2023-05-04 | 엘지전자 주식회사 | 식기 세척기 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1670827C3 (de) * | 1967-03-20 | 1974-10-24 | Bayer Ag, 5090 Leverkusen | 4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridin |
DE2508181A1 (de) * | 1975-02-26 | 1976-09-09 | Bayer Ag | 1,4-dihydropyridincarbonsaeurearal- kylester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
SU725406A1 (ru) * | 1978-08-08 | 1981-07-30 | Ордена Трудового Красного Знамениинститут Органического Синтеза Ah Латвий-Ской Ccp | Эфиры диметил дигидропиридин диКАРбОНОВОй КиСлОТы,ОблАдАющиЕ АНТи-МЕТАСТАТичЕСКОй АКТиВНОСТью |
JPS58159490A (ja) * | 1982-02-23 | 1983-09-21 | Nikken Kagaku Kk | 1,4−ジヒドロピリジン化合物 |
ES8601891A1 (es) * | 1983-03-04 | 1985-11-01 | Nikken Chemicals Co Ltd | Un metodo para preparar compuestos de 1, 4-dihidropiridina |
US4906646A (en) * | 1983-03-31 | 1990-03-06 | Board Of Governors Of Wayne State University | Method and composition for the treatment of tumors by administering a platinum coordination compound and a calcium channel blocker compound of the dihydropyridine class |
US4690935A (en) * | 1983-03-31 | 1987-09-01 | Wayne State University | Inhibition of tumor growth and metastasis with calcium channel blocker compounds |
DE3326384A1 (de) * | 1983-07-22 | 1985-01-31 | Bayer Ag, 5090 Leverkusen | 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
SU1125957A1 (ru) * | 1983-10-20 | 1986-03-23 | Ордена Трудового Красного Знамени Институт Органического Синтеза Ан Латвсср | 4-(3-Метилпиразолил-4)-2,6-диметил-3,5-диэтоксикарбонил-1,4-дигидропиридин ,об ладающий гепатопротекторной активностью |
IT1201454B (it) * | 1985-08-19 | 1989-02-02 | Boehringer Biochemia Srl | 1,4-diidropiridine-2-sostituite |
DE3601196A1 (de) * | 1986-01-17 | 1987-07-23 | Merck Patent Gmbh | 1,4-dihydropyridine |
IT1204459B (it) * | 1986-02-20 | 1989-03-01 | Glaxo Spa | Derivati eterociclici |
JPS63135381A (ja) * | 1986-11-26 | 1988-06-07 | Kyorin Pharmaceut Co Ltd | 多剤耐性癌細胞に対する感受性増強剤及びその製造方法 |
DE3711991A1 (de) * | 1987-04-09 | 1988-10-20 | Bayer Ag | Dihydropyridinamide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
JPH02167262A (ja) * | 1988-06-05 | 1990-06-27 | Taisho Pharmaceut Co Ltd | 1,4―ジヒドロピリジン誘導体 |
JP2640245B2 (ja) * | 1988-07-28 | 1997-08-13 | 日研化学株式会社 | 1,4−ジヒドロピリジン誘導体 |
ES2059767T3 (es) * | 1988-07-28 | 1994-11-16 | Nikken Chemicals Co Ltd | Derivado de 1,4-dihidropiridina. |
IL92646A0 (en) * | 1988-12-15 | 1990-08-31 | Erba Carlo Spa | Imidazolyl and pyridyl derivatives of phenyl substituted 1,4-dihydropyridines,their preparation and pharmaceutical compositions containing them |
-
1991
- 1991-09-19 GB GB919119983A patent/GB9119983D0/en active Pending
-
1992
- 1992-09-01 US US07/937,681 patent/US5362729A/en not_active Expired - Fee Related
- 1992-09-02 IL IL10301992A patent/IL103019A/en not_active IP Right Cessation
- 1992-09-07 TW TW081107052A patent/TW283147B/zh not_active IP Right Cessation
- 1992-09-10 NZ NZ244280A patent/NZ244280A/en unknown
- 1992-09-11 MX MX9205207A patent/MX9205207A/es unknown
- 1992-09-14 HU HU9202934A patent/HUT61994A/hu unknown
- 1992-09-14 AU AU23593/92A patent/AU651001B2/en not_active Ceased
- 1992-09-14 FI FI924110A patent/FI98215C/fi not_active IP Right Cessation
- 1992-09-17 ZA ZA927115A patent/ZA927115B/xx unknown
- 1992-09-18 MY MYPI92001674A patent/MY129935A/en unknown
- 1992-09-18 RU SU925052896A patent/RU2086548C1/ru active
- 1992-09-18 JP JP4249635A patent/JPH05213935A/ja active Pending
- 1992-09-18 DE DE69217308T patent/DE69217308T2/de not_active Expired - Fee Related
- 1992-09-18 EP EP92308561A patent/EP0533504B1/de not_active Expired - Lifetime
- 1992-09-18 KR KR1019920016987A patent/KR930006002A/ko not_active Application Discontinuation
- 1992-09-18 CA CA002078606A patent/CA2078606A1/en not_active Abandoned
- 1992-09-18 ES ES92308561T patent/ES2099800T3/es not_active Expired - Lifetime
- 1992-09-18 AT AT92308561T patent/ATE148698T1/de not_active IP Right Cessation
- 1992-09-18 DK DK92308561.7T patent/DK0533504T3/da active
-
1997
- 1997-04-01 GR GR970400662T patent/GR3022988T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
NZ244280A (en) | 1995-02-24 |
FI924110A (fi) | 1993-03-20 |
KR930006002A (ko) | 1993-04-20 |
MY129935A (en) | 2007-05-31 |
HU9202934D0 (en) | 1992-11-30 |
IL103019A (en) | 1996-10-31 |
GR3022988T3 (en) | 1997-07-30 |
MX9205207A (es) | 1993-03-01 |
ES2099800T3 (es) | 1997-06-01 |
HUT61994A (en) | 1993-03-29 |
IL103019A0 (en) | 1993-02-21 |
EP0533504B1 (de) | 1997-02-05 |
FI98215C (fi) | 1997-05-12 |
DK0533504T3 (da) | 1997-04-07 |
DE69217308D1 (de) | 1997-03-20 |
DE69217308T2 (de) | 1997-05-28 |
AU651001B2 (en) | 1994-07-07 |
JPH05213935A (ja) | 1993-08-24 |
FI924110A0 (fi) | 1992-09-14 |
AU2359392A (en) | 1993-03-25 |
US5362729A (en) | 1994-11-08 |
ZA927115B (en) | 1993-03-22 |
TW283147B (de) | 1996-08-11 |
EP0533504A1 (de) | 1993-03-24 |
FI98215B (fi) | 1997-01-31 |
RU2086548C1 (ru) | 1997-08-10 |
CA2078606A1 (en) | 1993-03-20 |
GB9119983D0 (en) | 1991-11-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69217308D1 (de) | Dihydropyridine zur Anwendung in der Antitumor-Therapie | |
ATE211735T1 (de) | 1-phenyl-pyrazolderivate und ihr verwendung als schädlingsbekämpfungsmittel | |
DE69919897D1 (en) | 4-oxo-1,4-dihydro-3-chinolincarboxamide als antivirale mittel | |
ATE119774T1 (de) | Imidazopyridinderivate und ihre verwendung. | |
ES2167371T3 (es) | Derivados de 1h-3-aril-pirrolidin-2,4-diona espirociclicos substituidos. | |
BG102792A (en) | Substituted derivatives of 4-hydroxyphenylalkane acids having antagonists activity to ppar-gama. | |
NO20034595D0 (no) | Kinolin- og kinazolinderivater med azolylgruppe | |
BG104287A (en) | Halogensubstituted tetracyclic derivatives of tetrahydrofuran | |
FR2619111B1 (fr) | Derives de (piperidinyl-4)methyl-2 tetrahydro-1,2,3,4 9h-pyrido (3,4-b) indole, leur preparation et leur application en therapeutique | |
DE122011100040I2 (de) | Zusammensetzung, verfahren und instrument zur potenzierung der antitumoraktivitat und zur behandlungvon tumoren. | |
CA2207784A1 (en) | Certain pyrrolopyridine derivatives; novel crf1 specific ligands | |
ATE263771T1 (de) | Totalsynthese von acylfulvenen mit antitumorwirkung | |
IL119828A0 (en) | Substituted triazine derivatives their preparation and use | |
DE3575140D1 (de) | Dreizyklische oxindole als antientzuendungsmittel. | |
MY131762A (en) | Pharmaceutical compounds | |
ATE173733T1 (de) | Antimikrobielle carbapenem-derivate, ihre herstellung und ihre therapeutische verwendung | |
DE69910568D1 (de) | Furopyridinderivate und ihre therapeutische verwendung | |
ATE134607T1 (de) | Tetrahydronaphtalenderivate, ihre herstellung und ihre therapeutische verwendung | |
DK0516486T3 (da) | Azetidinonderivater egnede til fremstilling af carbapenemantibiotika | |
CA2272136A1 (en) | Pyrazole derivatives having crf antagonist activity |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |