ATE148168T1 - MONOCLONAL ANTIBODIES - Google Patents

MONOCLONAL ANTIBODIES

Info

Publication number
ATE148168T1
ATE148168T1 AT90916718T AT90916718T ATE148168T1 AT E148168 T1 ATE148168 T1 AT E148168T1 AT 90916718 T AT90916718 T AT 90916718T AT 90916718 T AT90916718 T AT 90916718T AT E148168 T1 ATE148168 T1 AT E148168T1
Authority
AT
Austria
Prior art keywords
rhesus
antibody molecules
monoclonal antibodies
chimeric antibody
antibodies
Prior art date
Application number
AT90916718T
Other languages
German (de)
Inventor
Nevin Campbell Hughes-Jones
Original Assignee
Nat Blood Authority
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nat Blood Authority filed Critical Nat Blood Authority
Application granted granted Critical
Publication of ATE148168T1 publication Critical patent/ATE148168T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/34—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood group antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention provides DNA sequences encoding complementarity determining regions of variable domains of human anti-RhD antibodies and their use in the production of recombinant chimeric antibody molecules. Chimeric antibody molecules against the Rhesus (D) antigen or an antigen binding fragment thereof, as well as anti-Rhesus (D) reagents and pharmaceutical compositions comprising said chimeric antibodies are also provided.
AT90916718T 1989-11-13 1990-11-13 MONOCLONAL ANTIBODIES ATE148168T1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898925590A GB8925590D0 (en) 1989-11-13 1989-11-13 Monoclonal antibodies

Publications (1)

Publication Number Publication Date
ATE148168T1 true ATE148168T1 (en) 1997-02-15

Family

ID=10666204

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90916718T ATE148168T1 (en) 1989-11-13 1990-11-13 MONOCLONAL ANTIBODIES

Country Status (11)

Country Link
US (2) US5831063A (en)
EP (1) EP0500659B1 (en)
AT (1) ATE148168T1 (en)
AU (1) AU647054B2 (en)
CA (1) CA2068222C (en)
DE (1) DE69029808T2 (en)
DK (1) DK0500659T3 (en)
ES (1) ES2098274T3 (en)
GB (1) GB8925590D0 (en)
GR (1) GR3022847T3 (en)
WO (1) WO1991007492A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5495002A (en) * 1984-01-31 1996-02-27 Akzo N.V. Tumor associated monoclonal antibody 123AV16
GB9020282D0 (en) 1990-09-17 1990-10-31 Gorman Scott D Altered antibodies and their preparation
US6326488B1 (en) 1990-10-19 2001-12-04 Board Of Trustees Of University Of Illinois Gene and genetic elements associated with sensitivity to chemotherapeutic drugs
WO1994004679A1 (en) * 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
WO1992022653A1 (en) 1991-06-14 1992-12-23 Genentech, Inc. Method for making humanized antibodies
US6800738B1 (en) 1991-06-14 2004-10-05 Genentech, Inc. Method for making humanized antibodies
EP0523949B1 (en) * 1991-07-15 2003-06-25 The Wellcome Foundation Limited Production of antibodies
FR2724182B1 (en) * 1994-09-02 1996-12-13 Pasteur Institut OBTAINING A RECOMBINANT MONOCLONAL ANTIBODY FROM A HUMAN ANTI-RHESUS D MONOCLONAL ANTIBODY, ITS PRODUCTION IN INSECT CELLS, AND USES THEREOF
NZ333329A (en) * 1996-06-24 2000-07-28 Rotkreuzstiftung Zentrallab Polypeptides capable of forming antigen binding structures with specificity for rhesus d antigens
ATE414151T1 (en) 2000-03-03 2008-11-15 Cambridge Antibody Tech ANTIBODIES TO EOTAXIN AND THEIR USE
US6946546B2 (en) 2000-03-06 2005-09-20 Cambridge Antibody Technology Limited Human antibodies against eotaxin
FR2807767B1 (en) 2000-04-12 2005-01-14 Lab Francais Du Fractionnement MONOCLONAL ANTIBODIES ANTI-D
JP4307079B2 (en) * 2001-01-26 2009-08-05 セレキス エスアー Matrix attachment region and method of use
WO2003000908A1 (en) * 2001-06-21 2003-01-03 Ecole Polytechnique Federale De Lausanne A method for introducing a nucleic acid into a eukaryotic cell
US7521053B2 (en) 2001-10-11 2009-04-21 Amgen Inc. Angiopoietin-2 specific binding agents
US7658924B2 (en) * 2001-10-11 2010-02-09 Amgen Inc. Angiopoietin-2 specific binding agents
GB0324368D0 (en) * 2003-10-17 2003-11-19 Univ Cambridge Tech Polypeptides including modified constant regions
CA2535836C (en) 2003-10-24 2014-02-04 Nicolas Mermod High efficiency gene transfer and expression in mammalian cells by a multiple transfection procedure of mar sequences
AR069290A1 (en) * 2007-11-13 2010-01-13 Evec Inc MONOCLONAL ANTIBODIES THAT JOIN THE HGM -CSF (STIMULATING FACTOR OF THE COLONY OF GRANULOCITOS-MACROFAGOS) AND THE MEDICAL COMPOSITIONS THAT UNDERSTAND THEM
JO2913B1 (en) 2008-02-20 2015-09-15 امجين إنك, Antibodies directed to angiopoietin-1 and angiopoietin-2 and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8607679D0 (en) * 1986-03-27 1986-04-30 Winter G P Recombinant dna product
GB8610106D0 (en) * 1986-04-25 1986-05-29 Central Blood Lab Authority Human igm-producing heterohybridoma
AU623345B2 (en) * 1987-09-18 1992-05-14 National Blood Authority Human anti-rh(d) monoclonal antibodies
AU622417B2 (en) * 1987-09-18 1992-04-09 National Blood Authority Human anti-rh(d) monoclonal antibodies

Also Published As

Publication number Publication date
DE69029808D1 (en) 1997-03-06
AU647054B2 (en) 1994-03-17
AU6721490A (en) 1991-06-13
DK0500659T3 (en) 1997-07-14
ES2098274T3 (en) 1997-05-01
EP0500659A1 (en) 1992-09-02
CA2068222A1 (en) 1991-05-14
US5919910A (en) 1999-07-06
CA2068222C (en) 1999-05-11
WO1991007492A1 (en) 1991-05-30
US5831063A (en) 1998-11-03
EP0500659B1 (en) 1997-01-22
DE69029808T2 (en) 1997-07-10
GB8925590D0 (en) 1990-01-04
GR3022847T3 (en) 1997-06-30

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee