ATE144976T1 - Phenylalkansäurederivat, seine herstellung und die trennung seiner optischen isomere - Google Patents
Phenylalkansäurederivat, seine herstellung und die trennung seiner optischen isomereInfo
- Publication number
- ATE144976T1 ATE144976T1 AT92916116T AT92916116T ATE144976T1 AT E144976 T1 ATE144976 T1 AT E144976T1 AT 92916116 T AT92916116 T AT 92916116T AT 92916116 T AT92916116 T AT 92916116T AT E144976 T1 ATE144976 T1 AT E144976T1
- Authority
- AT
- Austria
- Prior art keywords
- acid derivative
- optical isomers
- phenylalkanic
- separation
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
- C07C45/562—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with nitrogen as the only hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
- C07C49/697—Unsaturated compounds containing a keto groups being part of a ring containing halogen containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
- C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/54—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings and other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/72—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings and other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/88—Unsaturated compounds containing keto groups containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP22500091 | 1991-08-10 | ||
JP22499991 | 1991-08-10 | ||
JP23114991 | 1991-08-20 | ||
PCT/JP1992/000995 WO1993002999A1 (en) | 1991-08-10 | 1992-08-04 | Phenylalkanoic acid derivative, production thereof, and separation of optical isomers thereof |
US08/193,081 US5434292A (en) | 1991-08-10 | 1994-02-04 | Phenylalkanoic acid derivatives, process for producing the same and process for separating optical isomers thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE144976T1 true ATE144976T1 (de) | 1996-11-15 |
Family
ID=27477153
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT92916116T ATE144976T1 (de) | 1991-08-10 | 1992-08-04 | Phenylalkansäurederivat, seine herstellung und die trennung seiner optischen isomere |
Country Status (10)
Country | Link |
---|---|
US (1) | US5434292A (de) |
EP (1) | EP0641760B1 (de) |
JP (1) | JP2745436B2 (de) |
KR (1) | KR0141507B1 (de) |
CN (1) | CN1033086C (de) |
AT (1) | ATE144976T1 (de) |
AU (1) | AU656411B2 (de) |
CA (1) | CA2115256A1 (de) |
DE (1) | DE69215108T2 (de) |
WO (1) | WO1993002999A1 (de) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6190691B1 (en) | 1994-04-12 | 2001-02-20 | Adolor Corporation | Methods for treating inflammatory conditions |
US5962477A (en) * | 1994-04-12 | 1999-10-05 | Adolor Corporation | Screening methods for cytokine inhibitors |
US6573282B1 (en) | 1995-09-12 | 2003-06-03 | Adolor Corporation | Peripherally active anti-hyperalgesic opiates |
US5849761A (en) | 1995-09-12 | 1998-12-15 | Regents Of The University Of California | Peripherally active anti-hyperalgesic opiates |
JPH0990573A (ja) * | 1995-09-28 | 1997-04-04 | Konica Corp | ハロゲン化銀写真感光材料の処理用固体現像補充剤及び現像処理方法 |
JP2010024239A (ja) * | 1998-05-06 | 2010-02-04 | Kowa Co | 消化管運動抑制剤 |
US6635674B1 (en) | 1998-11-06 | 2003-10-21 | Bristol-Myers Squibb Co. | Pharmaceutical preparations for external use containing non-steroidal anti-inflammatory and analgesic agents |
JP2000143540A (ja) * | 1998-11-06 | 2000-05-23 | Bristol Myers Squibb Co | 非ステロイド系消炎鎮痛薬含有外用剤 |
DE19935159A1 (de) * | 1999-07-27 | 2001-02-22 | Schuster Wolfgang | Mittel zur Muskelentspannung |
AU7998800A (en) * | 1999-10-04 | 2001-05-10 | R. Steven Marcus | Medical cutting tool lubricant composition |
JP4195178B2 (ja) * | 1999-11-10 | 2008-12-10 | 東興薬品工業株式会社 | 消炎鎮痛外用剤 |
US6497859B1 (en) * | 2000-11-17 | 2002-12-24 | Noville Inc. | Cooling agents, pharmaceutical compositions having cooling agents and processes for making and using same |
US20030225031A1 (en) * | 2002-05-21 | 2003-12-04 | Quay Steven C. | Administration of acetylcholinesterase inhibitors to the cerebral spinal fluid |
US6852713B2 (en) * | 2003-04-16 | 2005-02-08 | Adolor Corporation | Lactam derivatives and methods of their use |
US7034051B2 (en) * | 2003-08-28 | 2006-04-25 | Adolor Corporation | Fused bicyclic carboxamide derivatives and methods of their use |
US7160902B2 (en) * | 2003-11-14 | 2007-01-09 | Adolor Corporation | Amide derivatives and methods of their use |
TW200827343A (en) | 2006-09-11 | 2008-07-01 | Fuji Yakuhin Co Ltd | Novel phenylacetic acid derivative |
JP5390883B2 (ja) * | 2009-02-26 | 2014-01-15 | 国立大学法人 熊本大学 | ロキソプロフェン誘導体及びそれを含有する医薬 |
JP5770621B2 (ja) | 2011-12-27 | 2015-08-26 | 株式会社Lttバイオファーマ | 2−フルオロフェニルプロピオン酸誘導体 |
CN109134262A (zh) * | 2017-06-15 | 2019-01-04 | 北京蓝丹医药科技有限公司 | 一种洛索洛芬衍生物 |
CN109134261A (zh) * | 2017-06-15 | 2019-01-04 | 北京蓝丹医药科技有限公司 | 一种洛索洛芬衍生物 |
CN110041191A (zh) * | 2019-04-30 | 2019-07-23 | 湖南九典宏阳制药有限公司 | 一种培比洛芬的纯化方法 |
CN114746394B (zh) * | 2020-09-09 | 2024-02-02 | 南京海融医药科技股份有限公司 | 一种芳基丙酸衍生物、药物组合物及其制备方法和应用 |
CN115836047B (zh) * | 2021-12-24 | 2024-02-13 | 南京海融医药科技股份有限公司 | 一种芳基丙酸衍生物及其乳状制剂 |
CN117682966A (zh) * | 2022-04-19 | 2024-03-12 | 石家庄迪斯凯威医药科技有限公司 | 一种手性芳基丙酸衍生物及其药物组合物和用途 |
CN115161847A (zh) * | 2022-07-05 | 2022-10-11 | 晋江康邦拓新材料科技有限公司 | 一种抗菌防臭鞋材内里衬布及其加工方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS584699B2 (ja) * | 1977-04-05 | 1983-01-27 | 三共株式会社 | 置換フエニル酢酸誘導体及びその製法 |
DD141422A5 (de) * | 1978-01-27 | 1980-04-30 | Schering Ag | Verfahren zur herstellung von phenylessigsaeure-derivaten |
JPS574919A (en) * | 1980-06-09 | 1982-01-11 | Sankyo Co Ltd | Anti-inflammatory for external use |
JPS59196839A (ja) * | 1983-04-21 | 1984-11-08 | Sankyo Co Ltd | フエニル酢酸誘導体 |
-
1992
- 1992-08-04 AT AT92916116T patent/ATE144976T1/de active
- 1992-08-04 EP EP92916116A patent/EP0641760B1/de not_active Expired - Lifetime
- 1992-08-04 JP JP5503475A patent/JP2745436B2/ja not_active Expired - Lifetime
- 1992-08-04 WO PCT/JP1992/000995 patent/WO1993002999A1/ja active IP Right Grant
- 1992-08-04 DE DE69215108T patent/DE69215108T2/de not_active Expired - Fee Related
- 1992-08-04 AU AU23909/92A patent/AU656411B2/en not_active Ceased
- 1992-08-04 CA CA002115256A patent/CA2115256A1/en not_active Abandoned
- 1992-08-10 CN CN92109051.XA patent/CN1033086C/zh not_active Expired - Fee Related
-
1994
- 1994-02-04 US US08/193,081 patent/US5434292A/en not_active Expired - Fee Related
- 1994-02-07 KR KR1019940700344A patent/KR0141507B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE69215108T2 (de) | 1997-03-20 |
JP2745436B2 (ja) | 1998-04-28 |
CN1033086C (zh) | 1996-10-23 |
AU2390992A (en) | 1993-03-02 |
DE69215108D1 (de) | 1996-12-12 |
CN1069484A (zh) | 1993-03-03 |
EP0641760A4 (de) | 1994-12-01 |
AU656411B2 (en) | 1995-02-02 |
KR0141507B1 (ko) | 1998-07-01 |
EP0641760B1 (de) | 1996-11-06 |
CA2115256A1 (en) | 1993-02-18 |
WO1993002999A1 (en) | 1993-02-18 |
EP0641760A1 (de) | 1995-03-08 |
US5434292A (en) | 1995-07-18 |
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