ATE124725T1 - Verbessertes verfahren zur herstellung von faktor viii:c-typ-proteinen. - Google Patents
Verbessertes verfahren zur herstellung von faktor viii:c-typ-proteinen.Info
- Publication number
- ATE124725T1 ATE124725T1 AT88903710T AT88903710T ATE124725T1 AT E124725 T1 ATE124725 T1 AT E124725T1 AT 88903710 T AT88903710 T AT 88903710T AT 88903710 T AT88903710 T AT 88903710T AT E124725 T1 ATE124725 T1 AT E124725T1
- Authority
- AT
- Austria
- Prior art keywords
- improved method
- factor viii
- type proteins
- producing factor
- phospholipid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3488287A | 1987-04-06 | 1987-04-06 | |
US6886587A | 1987-07-02 | 1987-07-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE124725T1 true ATE124725T1 (de) | 1995-07-15 |
Family
ID=26711519
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT88903710T ATE124725T1 (de) | 1987-04-06 | 1988-04-06 | Verbessertes verfahren zur herstellung von faktor viii:c-typ-proteinen. |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0362218B2 (de) |
JP (1) | JPH02503744A (de) |
AT (1) | ATE124725T1 (de) |
CA (1) | CA1331157C (de) |
DE (1) | DE3854125T3 (de) |
WO (1) | WO1988008035A1 (de) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5595886A (en) * | 1986-01-27 | 1997-01-21 | Chiron Corporation | Protein complexes having Factor VIII:C activity and production thereof |
US6060447A (en) * | 1987-05-19 | 2000-05-09 | Chiron Corporation | Protein complexes having Factor VIII:C activity and production thereof |
CA1340740C (en) * | 1987-12-08 | 1999-09-14 | Eileen R. Mulvihill | Co-expression in eukaryotic cells |
US5648254A (en) * | 1988-01-15 | 1997-07-15 | Zymogenetics, Inc. | Co-expression in eukaryotic cells |
US5811523A (en) | 1988-11-10 | 1998-09-22 | Trinchieri; Giorgio | Antibodies to natural killer stimulatory factor |
US7247475B2 (en) | 1989-07-28 | 2007-07-24 | Wyeth | Method for producing monoclonal antibodies |
US6475787B1 (en) | 1989-07-28 | 2002-11-05 | Wyeth | Method for producing monoclonal antibodies |
US5563045A (en) | 1992-11-13 | 1996-10-08 | Genetics Institute, Inc. | Chimeric procoagulant proteins |
AU7254894A (en) * | 1993-07-23 | 1995-02-20 | Baxter International Inc. | Activated human factor viii and method of preparation |
US5576291A (en) * | 1993-09-13 | 1996-11-19 | Baxter International Inc. | Activated factor VIII as a therapeutic agent and method of treating factor VIII deficiency |
AU6486196A (en) * | 1995-07-11 | 1997-02-10 | Chiron Corporation | Novel factor viii:c polypeptide analogs with altered protease sites |
US8183344B2 (en) | 1996-04-24 | 2012-05-22 | University Of Michigan | Inactivation resistant factor VIII |
EP1754718B1 (de) | 1996-04-24 | 2011-03-23 | The Regents Of The University Of Michigan | Gegen Inaktivierung resistenter Faktor VIII |
US6475725B1 (en) | 1997-06-20 | 2002-11-05 | Baxter Aktiengesellschaft | Recombinant cell clones having increased stability and methods of making and using the same |
ES2182501T3 (es) | 1998-03-12 | 2003-03-01 | Inst Genetics Llc | Metodos mejorados para producir proteinas del factor viii. |
US7820796B2 (en) | 1998-03-12 | 2010-10-26 | Genetics Institute, Llc. | Methods for producing Factor VIII proteins |
EP1154796B1 (de) | 1999-02-22 | 2007-06-20 | University of Connecticut | Neue albuminfreie faktor viii formulierungen |
AU2002248329B2 (en) | 2001-01-12 | 2007-06-28 | The American National Red Cross | Methods and compositions for reducing heparan sulfate proteoglycan-mediated clearance of factor VIII |
US7211559B2 (en) | 2003-10-31 | 2007-05-01 | University Of Maryland, Baltimore | Factor VIII compositions and methods |
EP2035572A4 (de) | 2006-06-30 | 2010-01-06 | Univ Michigan | Verfahren zur herstellung von faktor-viii-proteinen durch rekombinationsverfahren |
EP1988101A1 (de) | 2007-05-04 | 2008-11-05 | Novo Nordisk A/S | Verbesserung von Faktor-VIII-Polypeptid-Titern in Zellkulturen |
US20120263701A1 (en) | 2009-08-24 | 2012-10-18 | Volker Schellenberger | Coagulation factor vii compositions and methods of making and using same |
HUE036233T2 (hu) | 2009-12-06 | 2018-06-28 | Bioverativ Therapeutics Inc | VIII-FC Faktor kimérás és hibrid polipeptidek, és ezek használati módszerei |
EP3508573A1 (de) | 2010-07-09 | 2019-07-10 | Bioverativ Therapeutics Inc. | Systeme für faktor viii-verarbeitung und verfahren davon |
ES2556454T3 (es) | 2010-10-05 | 2016-01-18 | Novo Nordisk Health Care Ag | Proceso para producción de proteínas |
EP3527218A1 (de) | 2011-06-10 | 2019-08-21 | Bioverativ Therapeutics Inc. | Gerinnungsfördernde verbindungen und verfahren zur verwendung davon |
EP4169525A1 (de) | 2011-07-08 | 2023-04-26 | Bioverativ Therapeutics Inc. | Chimäre und hybride faktor-viii-polypeptide und verfahren zur verwendung davon |
US10656167B2 (en) | 2011-07-25 | 2020-05-19 | Bioverativ Therapeutics Inc. | Assays to monitor bleeding disorders |
CN104271150A (zh) | 2012-01-12 | 2015-01-07 | 比奥根艾迪克Ma公司 | 嵌合因子viii多肽及其用途 |
EA029560B1 (ru) | 2012-01-12 | 2018-04-30 | Байоджен Эмэй Инк. | Применение химерного фактора свертывания крови для уменьшения ингибирующего иммунного ответа у субъекта |
LT2814840T (lt) | 2012-02-15 | 2020-02-25 | Bioverativ Therapeutics Inc. | Faktoriaus viii kompozicijos ir jų gavimo ir naudojimo būdai |
EP2822577B1 (de) | 2012-02-15 | 2019-02-06 | Bioverativ Therapeutics Inc. | Rekombinante faktor-viii-proteine |
EP3404105A1 (de) | 2012-07-06 | 2018-11-21 | Bioverativ Therapeutics Inc. | Einkettige faktor-viii-polypeptide exprimierende zelllinie und verwendungen davon |
PT2882450T (pt) | 2012-07-11 | 2020-02-19 | Bioverativ Therapeutics Inc | Complexo de fator viii com xten e a proteína fator de von willebrand, e utilizações do mesmo |
US10001495B2 (en) | 2012-07-25 | 2018-06-19 | Bioverativ Therapeutics Inc. | Blood factor monitoring assay and uses thereof |
EP2908847B1 (de) | 2012-10-18 | 2022-03-30 | Bioverativ Therapeutics Inc. | Verfahren zur verwendung einer festgelegten dosis eines blutgerinnungsfaktors |
EP2914293A4 (de) | 2012-10-30 | 2016-04-20 | Biogen Ma Inc | Verfahren zur verwendung von fviii-polypeptid |
JP6330026B2 (ja) | 2013-03-15 | 2018-05-23 | バイオベラティブ セラピューティクス インコーポレイテッド | 第viii因子ポリペプチド製剤 |
MX2015016567A (es) | 2013-06-28 | 2016-03-31 | Biogen Ma Inc | Enlazador escindible por trombina con xten y usos del mismo. |
EP3043813B1 (de) | 2013-08-08 | 2021-01-13 | Bioverativ Therapeutics Inc. | Reinigung von chimären fviii-molekülen |
EP3033097B1 (de) | 2013-08-14 | 2021-03-10 | Bioverativ Therapeutics Inc. | Faktor viii-xten fusionen sowie ihre verwendungen. |
WO2015070014A1 (en) | 2013-11-08 | 2015-05-14 | Biogen Idec Ma Inc. | Procoagulant fusion compound |
US10325687B2 (en) | 2013-12-06 | 2019-06-18 | Bioverativ Therapeutics Inc. | Population pharmacokinetics tools and uses thereof |
DK4176894T3 (da) | 2014-01-10 | 2024-05-27 | Bioverativ Therapeutics Inc | Kimære faktor viii-proteiner og anvendelser deraf |
AU2016301303B2 (en) | 2015-08-03 | 2021-10-07 | Bioverativ Therapeutics Inc. | Factor IX fusion proteins and methods of making and using same |
AU2019270184A1 (en) | 2018-05-18 | 2020-11-26 | Bioverativ Therapeutics Inc. | Methods of treating hemophilia A |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5813389A (ja) * | 1981-07-16 | 1983-01-25 | Kyowa Hakko Kogyo Co Ltd | 細胞培養用培地 |
JPS5823784A (ja) * | 1981-08-04 | 1983-02-12 | Ajinomoto Co Inc | 哺乳動物細胞用培地 |
US4560655A (en) * | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
EP0162067B1 (de) * | 1983-10-28 | 1992-07-15 | Genetics Institute, Inc. | Herstellung des faktors viii und damit verwandte erzeugnisse |
JP2525022B2 (ja) * | 1986-01-03 | 1996-08-14 | ジェネティックス・インスチチュ−ト・インコ−ポレ−テッド | ▲VIII▼:c因子型タンパク質の改良生産方法 |
EP0251843A1 (de) * | 1986-06-06 | 1988-01-07 | Transgene S.A. | Verfahren zur Herstellung von Faktor VIII aus Säugerzellen |
AU606925B2 (en) * | 1987-01-30 | 1991-02-21 | Biogen, Inc. | A method for producing factor viii in high yield |
-
1988
- 1988-04-05 CA CA000563248A patent/CA1331157C/en not_active Expired - Lifetime
- 1988-04-06 AT AT88903710T patent/ATE124725T1/de not_active IP Right Cessation
- 1988-04-06 JP JP63503436A patent/JPH02503744A/ja active Pending
- 1988-04-06 WO PCT/US1988/001114 patent/WO1988008035A1/en active IP Right Grant
- 1988-04-06 DE DE3854125T patent/DE3854125T3/de not_active Expired - Lifetime
- 1988-04-06 EP EP88903710A patent/EP0362218B2/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CA1331157C (en) | 1994-08-02 |
EP0362218B2 (de) | 2000-04-12 |
WO1988008035A1 (en) | 1988-10-20 |
EP0362218B1 (de) | 1995-07-05 |
JPH02503744A (ja) | 1990-11-08 |
DE3854125T3 (de) | 2000-10-12 |
DE3854125D1 (de) | 1995-08-10 |
EP0362218A1 (de) | 1990-04-11 |
EP0362218A4 (en) | 1990-09-19 |
DE3854125T2 (de) | 1996-01-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
UEP | Publication of translation of european patent specification | ||
EEFA | Change of the company name | ||
EELA | Cancelled due to lapse of time |