ATE119547T1 - Oligosaccharide mit antiatherosclerotischer wirkung. - Google Patents
Oligosaccharide mit antiatherosclerotischer wirkung.Info
- Publication number
- ATE119547T1 ATE119547T1 AT90900186T AT90900186T ATE119547T1 AT E119547 T1 ATE119547 T1 AT E119547T1 AT 90900186 T AT90900186 T AT 90900186T AT 90900186 T AT90900186 T AT 90900186T AT E119547 T1 ATE119547 T1 AT E119547T1
- Authority
- AT
- Austria
- Prior art keywords
- oligosaccharides
- mucopolysaccharides
- antiatherosclerotic
- antiatherosclerotic effect
- antithrombotic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
- C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
- C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
- C08B37/0078—Degradation products
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Polymers & Plastics (AREA)
- Animal Behavior & Ethology (AREA)
- Materials Engineering (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT8822386A IT1230582B (it) | 1988-10-21 | 1988-10-21 | Oliogosaccaridi di dermatan solfato ed eparina aventi attivita' antiaterosclerotica |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE119547T1 true ATE119547T1 (de) | 1995-03-15 |
Family
ID=11195576
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT90900186T ATE119547T1 (de) | 1988-10-21 | 1989-10-13 | Oligosaccharide mit antiatherosclerotischer wirkung. |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0439555B1 (de) |
JP (1) | JP2960158B2 (de) |
KR (1) | KR0148799B1 (de) |
AT (1) | ATE119547T1 (de) |
AU (1) | AU639427B2 (de) |
DE (1) | DE68921633T2 (de) |
ES (1) | ES2021905A6 (de) |
IT (1) | IT1230582B (de) |
WO (1) | WO1990004607A2 (de) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5707973A (en) * | 1991-04-23 | 1998-01-13 | Rhone-Poulenc Rorer S.A. | Sulfated polysaccharids for treatment or prevention of thromboses |
IT1251182B (it) * | 1991-08-28 | 1995-05-04 | Opocrin Spa | Oligosaccaridi di dermatan solfato, processo per la loro produzione e relative composizioni farmaceutiche. |
US5849721A (en) * | 1992-02-07 | 1998-12-15 | Rhone-Poulenc Rorer S.A. | Sulfated polysaccharides obtained from heparin, preparation process, pharmaceutical composition and use thereof |
IT1264709B1 (it) * | 1993-07-12 | 1996-10-04 | Italfarmaco Spa | Derivati eparinici ad attivita' antimetastatica |
AU2560995A (en) * | 1994-06-06 | 1996-01-04 | Per Bjorn Ostergaard | A pharmaceutical composition comprising oligosaccharides binding to lipoprotein lipase |
US6001820A (en) * | 1995-03-31 | 1999-12-14 | Hamilton Civic Hospitals Research Development Inc. | Compositions and methods for inhibiting thrombogenesis |
US5763427A (en) * | 1995-03-31 | 1998-06-09 | Hamilton Civic Hospitals Research Development Inc. | Compositions and methods for inhibiting thrombogenesis |
US5744457A (en) * | 1995-03-31 | 1998-04-28 | Hamilton Civic Hospitals Research Development Inc. | Compositions and methods for inhibiting thrombogenesis |
US5821020A (en) * | 1995-07-14 | 1998-10-13 | Nhh Biologics | Vitamin D assay |
US5980865A (en) * | 1995-08-18 | 1999-11-09 | Baker Norton Pharmaceuticals, Inc. | Method for treating late phase allergic reactions and inflammatory diseases |
US5767269A (en) * | 1996-10-01 | 1998-06-16 | Hamilton Civic Hospitals Research Development Inc. | Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics |
GB9711443D0 (en) | 1997-06-03 | 1997-07-30 | Leo Pharm Prod Ltd | Chemical suppositions |
AUPO888497A0 (en) * | 1997-09-01 | 1997-09-25 | Australian National University, The | Use of sulfated oligosaccharides as inhibitors of cardiovascular disease |
EP1344781A1 (de) | 2002-03-12 | 2003-09-17 | Laboratori Derivati Organici S.P.A. | Verfahren zur Depolymerisierung von Glykosaminoglykanen und so hergestellte Produkte |
ITMI20021372A1 (it) | 2002-06-21 | 2003-12-22 | Derivati Organici Lab | Processo per la depolimerizzazione fisica dei glicosamminogliacani e prodotti da esso ottenuti |
EP1475391A1 (de) * | 2003-05-09 | 2004-11-10 | Laboratori Derivati Organici S.P.A. | Verfahren zur physikalischen Depolymerisation von Glykosaminoglykanen und dadurch erhaltene Produkte |
GB0509433D0 (en) * | 2005-05-09 | 2005-06-15 | Uni For Milj Og Biovitenskap | Method |
ATE552004T1 (de) | 2005-11-30 | 2012-04-15 | Istituto G Ronzoni | Oral verabreichbare heparinderivate |
WO2009007224A1 (en) * | 2007-07-10 | 2009-01-15 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Low molecular weight heparin derivatives having neuroprotective activity |
DE102011077393A1 (de) | 2011-06-10 | 2012-12-13 | Johannes Reinmüller | Antiinfektives Mittel |
ITLO20130005A1 (it) * | 2013-10-31 | 2015-05-01 | He E Biochimiche G Ronzonr S R | Derivati di glucosamminoglicani n-desolfatati e loro uso come farmaci |
ITLO20130006A1 (it) | 2013-11-06 | 2015-05-07 | He E Biochimiche G Ronzoni S R | Derivati carbossilati di glucosamminoglicani e loro uso come farmaci |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4500519A (en) | 1978-11-06 | 1985-02-19 | Choay S.A. | Mucopolysaccharides having biological properties, preparation and method of use |
FR2478646A2 (fr) | 1980-03-20 | 1981-09-25 | Choay Sa | Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir |
CA1136620A (en) | 1979-01-08 | 1982-11-30 | Ulf P.F. Lindahl | Heparin fragments having selective anticoagulation activity |
IL61201A (en) | 1979-10-05 | 1984-09-30 | Choay Sa | Oligosaccharides having no more than 8 saccharide moieties,their obtention from heparin and pharmaceutical compositions containing them |
DE2945212A1 (de) | 1979-11-09 | 1981-05-27 | C.H. Boehringer Sohn, 6507 Ingelheim | Vorrichtung und verfahren zur abfuellung kleinster pulvermengen |
US4281108A (en) | 1980-01-28 | 1981-07-28 | Hepar Industries, Inc. | Process for obtaining low molecular weight heparins endowed with elevated pharmacological properties, and product so obtained |
FR2482611B1 (fr) | 1980-05-14 | 1986-03-07 | Pharmindustrie | Nouveaux polysaccharides sulfates, procedes pour leur preparation et leur utilisation comme medicaments |
FR2482603A1 (fr) | 1980-05-14 | 1981-11-20 | Pharmindustrie | Nouveaux esters d'heparine utilisables pour la preparation de medicaments, et procedes pour leur preparation |
US4351938A (en) | 1980-05-19 | 1982-09-28 | Riker Laboratories, Inc. | Anticoagulant substance |
CA1171375A (en) | 1980-09-15 | 1984-07-24 | Ulf P.F. Lindahl | Oligosaccharides having selective anticoagulation activity |
US4687765A (en) | 1983-07-25 | 1987-08-18 | Choay S.A. | Method and composition for thrombolytic treatment |
IT1214609B (it) * | 1985-05-17 | 1990-01-18 | Opocrin Spa | Esosaminoglicani solfati depolimerizzati ad attivita'antitrombotica, fibrinolitica, antinfiammatoria, loro procedimento di preparazione e composizioni farmaceutiche che li contengono. |
-
1988
- 1988-10-21 IT IT8822386A patent/IT1230582B/it active
-
1989
- 1989-10-13 JP JP2500512A patent/JP2960158B2/ja not_active Expired - Lifetime
- 1989-10-13 DE DE68921633T patent/DE68921633T2/de not_active Expired - Fee Related
- 1989-10-13 EP EP90900186A patent/EP0439555B1/de not_active Expired - Lifetime
- 1989-10-13 AU AU48012/90A patent/AU639427B2/en not_active Ceased
- 1989-10-13 AT AT90900186T patent/ATE119547T1/de not_active IP Right Cessation
- 1989-10-13 WO PCT/EP1989/001214 patent/WO1990004607A2/en active IP Right Grant
- 1989-10-20 ES ES8903550A patent/ES2021905A6/es not_active Expired - Fee Related
- 1989-10-21 KR KR1019900701324A patent/KR0148799B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JPH04502928A (ja) | 1992-05-28 |
WO1990004607A3 (en) | 1990-05-31 |
DE68921633D1 (de) | 1995-04-13 |
KR900701851A (ko) | 1990-12-04 |
ES2021905A6 (es) | 1991-11-16 |
EP0439555B1 (de) | 1995-03-08 |
DE68921633T2 (de) | 1995-10-19 |
AU639427B2 (en) | 1993-07-29 |
AU4801290A (en) | 1990-05-14 |
JP2960158B2 (ja) | 1999-10-06 |
KR0148799B1 (ko) | 1998-08-17 |
EP0439555A1 (de) | 1991-08-07 |
IT1230582B (it) | 1991-10-28 |
WO1990004607A2 (en) | 1990-05-03 |
IT8822386A0 (it) | 1988-10-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE119547T1 (de) | Oligosaccharide mit antiatherosclerotischer wirkung. | |
US4933326A (en) | Oligosaccharides obtained by heparin depolymerization having antiatherosclerotic activity | |
ATE131176T1 (de) | Sulfatierte polysaccharide, antikoagulierungs- und antikomplementärmittel, hergestellt aus fukanen aus braunen algen, und verfahren zu deren herstellung. | |
ZA839652B (en) | Process for the depolymerisation and sulfation of polysaccharides | |
SE9101957L (sv) | Blandningar av polysackarider med laag molekylvikt samt framstaellning och anvaendning av desamma | |
DE69012154D1 (de) | Heparinderivate und Verfahren zu ihrer Herstellung. | |
EP0970130B1 (de) | Glykosaminoglykane mit hoher antithrombotischer wirkung | |
ES2007422A6 (es) | Un metodo para modificar alginatos u otros compuestos que contienen acido uronico. | |
AU550317B2 (en) | Polysaccharide anti-thromboticum | |
EP0973526A1 (de) | Sulfatierte oligosaccharide die anticoagulierende und antithrombotische reigenschaften besitzen | |
ATE154615T1 (de) | Halbsynthetische glykosaminoglykane, die in 3- position mit nukleophilen radikalen substituierte alpha-l-galakturonsäure enthalten | |
RU2216548C2 (ru) | Смесь линейных олигосахаридов, полученная из дерматансульфата, фармацевтическая композиция, обладающая антитромботическим действием, и способ лечения | |
AU2396392A (en) | Oligosaccharides of dermatan sulphate, process for their production, and associated pharmaceutical compositions | |
DE69313826D1 (de) | Sulfatierte polysaccharide, verfahren zu deren herstellung, pharmazeutische zusammensetzung und ihre verwendung | |
NO934044L (no) | Genetisk kontroll av acetylering og pyruvylering av xantanbaserte poly-sakkaridpolymerer | |
ATE138938T1 (de) | Sulfatiertes polysaccharid, dessen pharmazeutisch verträgliche salze, dessen herstellung und medikament, das dieses als wirksstoff enthält | |
NO903283L (no) | Xanthan-baserte polysakkaridpolymerer og fremgangsmaate til deres fremstilling. | |
PT95511A (pt) | Processo de producao de glicosaminoglicuronano sulfato e de composicoes farmaceuticas | |
Raake et al. | Anticoagulant and antithrombotic properties of synthetic sulfated bis-lactobionic acid amides | |
WO2001015654A3 (fr) | Polysaccharide antithrombotique de bas poids moleculaire | |
KR890001589A (ko) | 올리고당 또는 다당류를 함유하는 약학 조성물 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |