ATE115562T1 - Neue vitamin d derivate. - Google Patents

Neue vitamin d derivate.

Info

Publication number: ATE115562T1
Authority: AT; Austria
Prior art keywords: derivatives; derivs; substd; opt; deuterium
Prior art date: 1990-08-15

Application number

AT91914384T

Other languages

English (en)

Inventor

Claus Aage Svensgaard Bretting

Original Assignee

Leo Pharm Prod Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-08-15

Filing date

1991-07-11

Publication date

1994-12-15

1991-07-11 Application filed by Leo Pharm Prod Ltd filed Critical Leo Pharm Prod Ltd

1994-12-15 Application granted granted Critical

1994-12-15 Publication of ATE115562T1 publication Critical patent/ATE115562T1/de

Links

150000003710 vitamin D derivatives Chemical class 0.000 title abstract 2
YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 abstract 2
229910052805 deuterium Inorganic materials 0.000 abstract 2
125000000743 hydrocarbylene group Chemical group 0.000 abstract 2
239000004215 Carbon black (E152) Substances 0.000 abstract 1
229910019142 PO4 Inorganic materials 0.000 abstract 1
229930003316 Vitamin D Natural products 0.000 abstract 1
QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000002837 carbocyclic group Chemical group 0.000 abstract 1
229930195733 hydrocarbon Natural products 0.000 abstract 1
150000002430 hydrocarbons Chemical class 0.000 abstract 1
125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
238000001727 in vivo Methods 0.000 abstract 1
239000010452 phosphate Substances 0.000 abstract 1
-1 phosphate ester Chemical class 0.000 abstract 1
235000019166 vitamin D Nutrition 0.000 abstract 1
239000011710 vitamin D Substances 0.000 abstract 1
229940046008 vitamin d Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Diabetes (AREA)
Obesity (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Nutrition Science (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Steroid Compounds (AREA)

AT91914384T 1990-08-15 1991-07-11 Neue vitamin d derivate. ATE115562T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB909017890A GB9017890D0 (en)	1990-08-15	1990-08-15	Chemical compounds i

Publications (1)

Publication Number	Publication Date
ATE115562T1 true ATE115562T1 (de)	1994-12-15

Family

ID=10680686

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91914384T ATE115562T1 (de)	1990-08-15	1991-07-11	Neue vitamin d derivate.

Country Status (20)

Country	Link
US (1)	US5447924A (de)
EP (1)	EP0543864B1 (de)
JP (1)	JP3246914B2 (de)
KR (1)	KR100203227B1 (de)
AT (1)	ATE115562T1 (de)
AU (1)	AU636510B2 (de)
CA (1)	CA2078555C (de)
CZ (1)	CZ286485B6 (de)
DE (1)	DE69105981T2 (de)
DK (1)	DK0543864T3 (de)
ES (1)	ES2068601T3 (de)
FI (1)	FI103791B1 (de)
GB (1)	GB9017890D0 (de)
GR (1)	GR3014922T3 (de)
IE (1)	IE66241B1 (de)
LT (1)	LT3666B (de)
LV (1)	LV10089B (de)
RU (1)	RU2126384C1 (de)
SK (1)	SK281443B6 (de)
WO (1)	WO1992003414A1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2062520C (en) *	1991-03-11	1998-08-11	Hector F. Deluca	Synthesis of 1-alpha-hydroxy-secosterol compounds
US5486509A (en) *	1991-06-28	1996-01-23	University Of Miami	Method of preventing and treating chemotherapy-induced alopecia
GB9206648D0 (en) *	1992-03-26	1992-05-06	Leo Pharm Prod Ltd	Chemical compounds
GB9214202D0 (en) *	1992-07-03	1992-08-12	Leo Pharm Prod Ltd	Chemical compounds
GB9226860D0 (en) *	1992-12-23	1993-02-17	Leo Pharm Prod Ltd	Novel treatment
US5449668A (en) *	1993-06-04	1995-09-12	Duphar International Research B.V.	Vitamin D compounds and method of preparing these compounds
US6291444B1 (en)	1993-06-16	2001-09-18	Wisconsin Alumni Research Foundation	Treatment of t-cell immunodeficiencies with vitamin D compounds
US5880114A (en) *	1993-06-16	1999-03-09	Wisconsin Alumni Research Foundation	Treatment of immune deficiency with vitamin D compounds
US5552392A (en) *	1993-11-03	1996-09-03	Wisconsin Alumni Research Foundation	Method of treating hypoparathyroidism with (20S) vitamin D compounds
US5384314B1 (en) *	1994-03-11	1997-08-05	Hoffmann La Roche	1alpha-fluoro-25-hydroxy-16-ene-23-yne-cholecalciferol
US5661140A (en) *	1994-11-21	1997-08-26	Wisconsin Alumni Research Foundation	18-nor-vitamin D compounds
DE19519273A1 (de) *	1995-05-22	1996-11-28	Schering Ag	Topisch applizierbare Mittel zur Behandlung und Prophylaxe der Alopezie
NO971934L (no) *	1996-05-23	1997-11-24	Hoffmann La Roche	Flourinerte vitamin D3 -analoger
US5939408A (en)	1996-05-23	1999-08-17	Hoffman-La Roche Inc.	Vitamin D3 analogs
SG70009A1 (en) *	1996-05-23	2000-01-25	Hoffmann La Roche	Vitamin d3 analogs
GB9622590D0 (en)	1996-10-30	1997-01-08	Leo Pharm Prod Ltd	Chemical compounds
MA26481A1 (fr) *	1997-04-21	2004-12-20	Hoffmann La Roche	Derives d'arylsecocholadiene
WO1999003828A1 (en) *	1997-07-17	1999-01-28	F.Hoffmann-La Roche Ag	Dihomo-seco-cholestanes with two unsaturated bones in the side chain
JP4219553B2 (ja) *	1997-09-08	2009-02-04	エフ．ホフマン−ラロシュアーゲー	１，３−ジヒドロキシ−２０，２０−ジアルキル−ビタミンｄ３類似体
US20030220234A1 (en) *	1998-11-02	2003-11-27	Selvaraj Naicker	Deuterated cyclosporine analogs and their use as immunodulating agents
EP2340840B1 (de)	1998-03-27	2012-08-29	Oregon Health Sciences University	Gepulste Dose von einem Vitamin D Wirkstoff zur Behandlung von hyperproliferativen Hauterkrankungen
AU2002331509B2 (en)	2001-10-19	2007-12-06	Aurinia Pharmaceuticals Inc.	Synthesis of cyclosporin analogs
RU2320644C2 (ru) *	2002-10-23	2008-03-27	Лео Фарма А/С	Аналоги витамина d, композиции, содержащие указанные аналоги, и их применение
AR041696A1 (es)	2002-10-23	2005-05-26	Leo Pharm Prod Ltd	Compuestos analogos de vitamina d, composiciones que comprenden dichos compuestos analogos y su uso
AU2003291810A1 (en) *	2002-11-18	2004-06-15	Teva Pharmaceutical Industries Ltd.	A crystallization method for purification of calcipotriene
ES2233209B1 (es)	2003-11-28	2006-04-01	Laboratorios Viñas S.A.	Compuestos monohalogenovinilderivados de vitamina d.
ES2234423B1 (es) *	2003-12-05	2006-03-01	Laboratorios Viñas, S.A.	Procedimiento para la obtencion de derivados de vitamina d a partir de compuestos monohalogenovinilicos.
EP1879595B1 (de) *	2005-05-10	2014-09-24	Dermipsor Ltd	Zusammensetzungen und verfahren zur behandlung von hyperproliferativen epidermalen erkrankungen
EP1879449A4 (de) *	2005-05-10	2009-12-16	Dermipsor Ltd	Hautpflege-zusammensetzungen und -verfahren
CA2670425A1 (en) *	2006-08-29	2008-03-06	Teva Pharmaceutical Industries Ltd.	Pharmaceutical compositions including vitamin d and corticosteroid
CN102341110B (zh)	2009-01-27	2017-04-12	博格有限责任公司	用于减轻与化疗有关的副作用的维生素d3及其类似物
SG10201404883YA (en)	2009-08-14	2014-10-30	Berg Llc	Vitamin d3 and analogs thereof for treating alopecia
PT2634171E (pt) *	2010-10-25	2015-09-16	Teijin Pharma Ltd	Derivado de 23-ino-vitamina d3
CN112156097A (zh)	2013-05-29	2021-01-01	博格有限责任公司	使用维生素d预防或减轻化疗诱发的脱发
WO2017209934A1 (en)	2016-05-13	2017-12-07	Case Western Reserve University	Autophagy activators for treating or preventing skin injury

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4594432A (en) *	1983-01-28	1986-06-10	Hoffman-La Roche Inc.	Process for the synthesis of 1α,23(S),25-trihydroxycholecalciferol and 1α,23(R),25-trihydroxycholecalciferol
US4719205A (en) *	1984-01-30	1988-01-12	Wisconsin Alumini Research Foundation	Side-chain unsaturated 1-hydroxyvitamin D compounds
JPS6144860A (ja) *	1984-08-10	1986-03-04	Taisho Pharmaceut Co Ltd	１α．２５−ジヒドロキシ−２６．２７−ジメチルビタミンＤ↓３
JPS6172652A (ja) *	1984-09-14	1986-04-14	Asahi Glass Co Ltd	歯科材料用リン酸カルシウム系結晶性ガラス
US4612308A (en) *	1984-11-29	1986-09-16	Hoffmann-La Roche Inc.	25,26-Dehydro-1α,23(S,R)-dihydroxycholecalciferol and its epimers
ATE45347T1 (de) *	1985-05-30	1989-08-15	Taisho Pharmaceutical Co Ltd	Vitamin d3-derivate.
EP0227826B1 (de)	1985-08-02	1989-10-25	Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab)	Neue vitamin-d-analoga
EP0245524B1 (de) *	1985-11-21	1991-04-17	Taisho Pharmaceutical Co. Ltd	Vitamin d3-abkömmling
US4804502A (en) *	1988-01-20	1989-02-14	Hoffmann-La Roche Inc.	Vitamin D compounds
WO1989010351A1 (en)	1988-04-21	1989-11-02	Leo Pharmaceutical Products Ltd. A/S (Løvens Kemis	Novel vitamin d analogues
US4851401A (en) *	1988-07-14	1989-07-25	Wisconsin Alumni Research Foundation	Novel cyclopentano-vitamin D analogs
US5053401A (en)	1989-02-28	1991-10-01	Chugai Seiyaku Kabushiki Kaisha	Osteogenesis promotion with use of vitamin d derivatives
US4948789A (en)	1989-03-28	1990-08-14	Chugai Seiyaku Kabushiki Kaisha	Suppression of parathyroid hormone synthesis and secretion
DE69005897D1 (de) *	1989-05-18	1994-02-24	Hoffmann La Roche	Dehydrocholecalciferolderivate.
GB8914963D0 (en) *	1989-06-29	1989-08-23	Leo Pharm Prod Ltd	Chemical compounds
GB8915770D0 (en) *	1989-07-10	1989-08-31	Leo Pharm Prod Ltd	Chemical compounds
US5260290A (en) *	1990-02-14	1993-11-09	Wisconsin Alumni Research Foundation	Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives
DE4011682A1 (de) *	1990-04-06	1991-10-10	Schering Ag	24-oxa-derivate in der vitamin d-reihe
US5200536A (en) *	1992-02-10	1993-04-06	Daikin Industries Ltd.	Fluorine-containing vitamin D3 analogues
US5194431A (en) *	1992-07-08	1993-03-16	Wisconsin Alumni Research Foundation	24-cyclopropane vitamin D derivatives

1990
- 1990-08-15 GB GB909017890A patent/GB9017890D0/en active Pending
1991
- 1991-07-11 ES ES91914384T patent/ES2068601T3/es not_active Expired - Lifetime
- 1991-07-11 WO PCT/DK1991/000200 patent/WO1992003414A1/en active IP Right Grant
- 1991-07-11 DK DK91914384.2T patent/DK0543864T3/da active
- 1991-07-11 DE DE69105981T patent/DE69105981T2/de not_active Expired - Fee Related
- 1991-07-11 CA CA002078555A patent/CA2078555C/en not_active Expired - Fee Related
- 1991-07-11 JP JP51385491A patent/JP3246914B2/ja not_active Expired - Fee Related
- 1991-07-11 AT AT91914384T patent/ATE115562T1/de not_active IP Right Cessation
- 1991-07-11 EP EP91914384A patent/EP0543864B1/de not_active Expired - Lifetime
- 1991-07-11 AU AU84223/91A patent/AU636510B2/en not_active Ceased
- 1991-07-11 RU RU92016313A patent/RU2126384C1/ru not_active IP Right Cessation
- 1991-07-15 IE IE246291A patent/IE66241B1/en not_active IP Right Cessation
1992
- 1992-09-22 US US07/927,420 patent/US5447924A/en not_active Expired - Fee Related
- 1992-09-30 KR KR1019920702385A patent/KR100203227B1/ko not_active IP Right Cessation
- 1992-12-07 FI FI925547A patent/FI103791B1/fi active
- 1992-12-17 CZ CZ19923726A patent/CZ286485B6/cs not_active IP Right Cessation
- 1992-12-17 SK SK3726-92A patent/SK281443B6/sk unknown
1993
- 1993-02-15 LV LVP-93-243A patent/LV10089B/en unknown
- 1993-09-10 LT LTIP965A patent/LT3666B/lt not_active IP Right Cessation
1995
- 1995-02-01 GR GR950400186T patent/GR3014922T3/el unknown

Also Published As

Publication number	Publication date
RU2126384C1 (ru)	1999-02-20
EP0543864B1 (de)	1994-12-14
KR100203227B1 (ko)	1999-06-15
DE69105981D1 (de)	1995-01-26
DE69105981T2 (de)	1995-04-20
FI103791B (fi)	1999-09-30
FI925547A (fi)	1992-12-07
LV10089A (lv)	1994-05-10
DK0543864T3 (da)	1995-05-08
LTIP965A (en)	1995-03-27
JPH06500089A (ja)	1994-01-06
WO1992003414A1 (en)	1992-03-05
FI103791B1 (fi)	1999-09-30
LV10089B (en)	1994-10-20
AU636510B2 (en)	1993-04-29
CZ286485B6 (en)	2000-04-12
JP3246914B2 (ja)	2002-01-15
LT3666B (en)	1996-01-25
GR3014922T3 (en)	1995-05-31
AU8422391A (en)	1992-03-17
CZ372692A3 (en)	1993-05-12
SK281443B6 (sk)	2001-03-12
US5447924A (en)	1995-09-05
IE912462A1 (en)	1992-02-26
CA2078555C (en)	2002-11-26
ES2068601T3 (es)	1995-04-16
IE66241B1 (en)	1995-12-13
FI925547A0 (fi)	1992-12-07
CA2078555A1 (en)	1992-02-16
GB9017890D0 (en)	1990-09-26
SK372692A3 (en)	1995-04-12
EP0543864A1 (de)	1993-06-02

Legal Events

Date	Code	Title	Description
1995-06-15	UEP	Publication of translation of european patent specification
2004-04-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69105981D1 (de)	1995-01-26	Neue vitamin d derivate.
MY100740A (en)	1991-01-31	Spiro-substituted glutaramide diuretic agents.
MX9202996A (es)	1992-07-01	Diazabiciclo-(3-3-1)nonanos.
MX9302214A (es)	1993-10-01	Derivados de taxol y proceso para su preparacion
YU149791A (sh)	1994-01-20	Mometason, furoat monohidrat i postupak za njegovo dobijanje
ES2186677T3 (es)	2003-05-16	Derivados de deuteroporfirina sustituidos en las posiciones 3 y 8, agentes farmaceuticos que contienen estos derivados y procedimientos para su preparacion.
SE8207302D0 (sv)	1982-12-21	Nya 2-pyrrolidonforeningar och forfarande for framstellning av desamma
ES2110213T3 (es)	1998-02-01	Derivado de n-acilglutamina.
IT1155850B (it)	1987-01-28	Procedimento per l'estrazione di camomilla mediante gas ipercritici
JPS5239653A (en)	1977-03-28	Process for preparing antibiotics of 3',4'-dideoxykanamycin b derivati ves
DK299584A (da)	1984-12-24	Hidtil ukendte prostacyklinderivater, fremgangsmaade til deres fremstilling og deres anvendelse som laegemidler
BG35749A3 (en)	1984-06-15	Method for preparing 20- dihydro- 20, 23- dideoxytilonolide
GB2020659B (en)	1982-08-25	Derivatives of 1,5-dimethylbicyclo (3.2.1) octane
ATE40693T1 (de)	1989-02-15	Neue thyroninderivate.
GB1466411A (en)	1977-03-09	Sulphur-containing hydroxy aliphatic compounds
ES474052A1 (es)	1979-04-16	Procedimiento para la obtencion de 1,4-dihidropiridazinas 1-n-sustituidas.
JPS5257209A (en)	1977-05-11	Lubricating oil
JPS5283753A (en)	1977-07-12	Benzotriazole
IT8260902V0 (it)	1982-01-20	Cavalletto per la revisione di motori di autocarro o similari.
JPS52137522A (en)	1977-11-17	Safety gear of gas bearing turbine
JPS5259188A (en)	1977-05-16	Preparation of novel alkoxyt-substituted putterioine derivatives
ATE13876T1 (de)	1985-07-15	Verfahren zur herstellung von cycloalkenonderivaten.
JPS51120402A (en)	1976-10-21	Driving system for fire extinguisher pump
JPS5226406A (en)	1977-02-28	Propelling guide apparatus of linear motor
JPS5429416A (en)	1979-03-05	Apparatus for preventing axile weight of locomotive from displacememt