ATE103332T1 - Modifizierter gewebeplasminogenaktivator. - Google Patents
Modifizierter gewebeplasminogenaktivator.Info
- Publication number
- ATE103332T1 ATE103332T1 AT88870156T AT88870156T ATE103332T1 AT E103332 T1 ATE103332 T1 AT E103332T1 AT 88870156 T AT88870156 T AT 88870156T AT 88870156 T AT88870156 T AT 88870156T AT E103332 T1 ATE103332 T1 AT E103332T1
- Authority
- AT
- Austria
- Prior art keywords
- plasminogen activator
- tissue plasminogen
- modified tissue
- kringles
- sequence
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10770887A | 1987-10-09 | 1987-10-09 | |
EP88870156A EP0311589B1 (de) | 1987-10-09 | 1988-10-07 | Modifizierter Gewebeplasminogenaktivator |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE103332T1 true ATE103332T1 (de) | 1994-04-15 |
Family
ID=22318035
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT88870156T ATE103332T1 (de) | 1987-10-09 | 1988-10-07 | Modifizierter gewebeplasminogenaktivator. |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0311589B1 (de) |
JP (1) | JPH01132377A (de) |
AT (1) | ATE103332T1 (de) |
AU (1) | AU605364B2 (de) |
DE (1) | DE3888619D1 (de) |
ZA (1) | ZA887556B (de) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL88247A0 (en) * | 1987-11-06 | 1989-06-30 | Genentech Inc | Novel human tissue-type plasminogen activator variant |
DK176140B1 (da) * | 1988-07-20 | 2006-09-25 | Schering Ag Patentabteilung | Flagermusspyt-plasminogenaktivatorer |
GB9023149D0 (en) * | 1990-10-24 | 1990-12-05 | British Bio Technology | Proteins and nucleic acids |
US5242688A (en) * | 1990-12-24 | 1993-09-07 | Eli Lilly And Company | Method of treating thromboembolic disorders by administration of diglycosylated t-pa variants |
DE19950043A1 (de) | 1999-10-16 | 2001-07-12 | Degussa | Pigmentpräparationen, Verfahren zu ihrer Herstellung und Verwendung |
US7553930B2 (en) | 2003-01-06 | 2009-06-30 | Xencor, Inc. | BAFF variants and methods thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1987003906A1 (en) * | 1985-12-20 | 1987-07-02 | The Upjohn Company | Tissue plasminogen activator (tpa) analogs |
EP0227462B1 (de) * | 1985-12-23 | 1992-04-01 | Chiron Corporation | Peptidplasminogenaktivatoren |
EP0234051B1 (de) * | 1986-02-17 | 1991-12-11 | Stichting Centraal Laboratorium van de Bloedtransfusiedienst van het Nederlandse Rode Kruis | Gewebeplasminogen-Aktivator-Mutant, dafür kodierende rekombinante genetische Information und Verfahren zur Herstellung dieser Mutanten, deren Verwendung und pharmazeutische Zusammensetzungen |
-
1988
- 1988-10-07 ZA ZA887556A patent/ZA887556B/xx unknown
- 1988-10-07 AU AU23536/88A patent/AU605364B2/en not_active Ceased
- 1988-10-07 AT AT88870156T patent/ATE103332T1/de not_active IP Right Cessation
- 1988-10-07 EP EP88870156A patent/EP0311589B1/de not_active Expired - Lifetime
- 1988-10-07 DE DE88870156T patent/DE3888619D1/de not_active Expired - Lifetime
- 1988-10-07 JP JP63253660A patent/JPH01132377A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AU2353688A (en) | 1989-06-22 |
JPH01132377A (ja) | 1989-05-24 |
DE3888619D1 (de) | 1994-04-28 |
EP0311589A1 (de) | 1989-04-12 |
AU605364B2 (en) | 1991-01-10 |
EP0311589B1 (de) | 1994-03-23 |
ZA887556B (en) | 1989-07-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |