ATE102041T1 - Ghilanten: antimetastatischer wirkstoff aus dem suedamerikanischen blutegel haementeria ghilianii. - Google Patents

Ghilanten: antimetastatischer wirkstoff aus dem suedamerikanischen blutegel haementeria ghilianii.

Info

Publication number
ATE102041T1
ATE102041T1 AT90111551T AT90111551T ATE102041T1 AT E102041 T1 ATE102041 T1 AT E102041T1 AT 90111551 T AT90111551 T AT 90111551T AT 90111551 T AT90111551 T AT 90111551T AT E102041 T1 ATE102041 T1 AT E102041T1
Authority
AT
Austria
Prior art keywords
ghilanten
south american
haementeria ghilianii
antimetastatic agent
leech haementeria
Prior art date
Application number
AT90111551T
Other languages
English (en)
Inventor
Alan D Cardin
Sai Prasad Sunkara
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Application granted granted Critical
Publication of ATE102041T1 publication Critical patent/ATE102041T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A61K38/58—Protease inhibitors from animals; from humans from leeches, e.g. hirudin, eglin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/855—Proteins from animals other than mammals or birds
    • Y10S530/856—Snakes; venom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/855—Proteins from animals other than mammals or birds
    • Y10S530/858—Proteins from animals other than mammals or birds insects; venom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Road Paving Structures (AREA)
AT90111551T 1989-06-20 1990-06-19 Ghilanten: antimetastatischer wirkstoff aus dem suedamerikanischen blutegel haementeria ghilianii. ATE102041T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36861689A 1989-06-20 1989-06-20
US43836589A 1989-12-14 1989-12-14

Publications (1)

Publication Number Publication Date
ATE102041T1 true ATE102041T1 (de) 1994-03-15

Family

ID=27004258

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90111551T ATE102041T1 (de) 1989-06-20 1990-06-19 Ghilanten: antimetastatischer wirkstoff aus dem suedamerikanischen blutegel haementeria ghilianii.

Country Status (10)

Country Link
US (1) US5447911A (de)
EP (1) EP0404055B1 (de)
JP (1) JP2947882B2 (de)
KR (1) KR0185973B1 (de)
AT (1) ATE102041T1 (de)
AU (1) AU624962B2 (de)
DE (1) DE69006931T2 (de)
DK (1) DK0404055T3 (de)
ES (1) ES2052105T3 (de)
IE (1) IE63540B1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2047527A1 (en) * 1990-07-24 1992-01-25 Christopher Dunwiddie Method for administering a therapeutic anticoagulant
EP0662514A1 (de) * 1994-01-07 1995-07-12 Ciba-Geigy Ag Hirustasin, ein Serinprotease-Inhibitor des Antistasintyps aus Hiruda
NZ270194A (en) * 1994-01-07 1996-05-28 Ciba Geigy Ag Hirustasin, a serine protease inhibitor from hirudo medicinalis
TW586934B (en) * 1997-05-19 2004-05-11 Sumitomo Pharma Immunopotentiating composition
GB9930564D0 (en) * 1999-12-23 2000-02-16 Evolutec Limited Screening method
US8004538B2 (en) 2007-09-21 2011-08-23 Global Oled Technology Llc Preferential tone scale for electronic displays
US8784896B2 (en) 2012-09-17 2014-07-22 Biopep Solutions, Inc Antioxidant therapy with a whole, leech saliva extract
JP2016529279A (ja) * 2013-08-29 2016-09-23 第一三共株式会社 がんの治療又は予防のための剤

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4390630A (en) * 1980-10-28 1983-06-28 The Regents Of The University Of California Hementin--a fibrinolytic agent
US4588587A (en) * 1983-03-01 1986-05-13 Pennsylvania Hospital Method of treatment to inhibit metastasis
NO170430C (no) * 1986-09-18 1992-10-14 Pennsylvania Hospital Fremgangsmaate for fremstilling av et protein som har antikoagulerende og anti-metastatiske egenskaper
US4832849A (en) * 1988-06-16 1989-05-23 Merrell Dow Pharmaceuticals Inc. Extraction and purification of an anticoagulant principle from the south american leech, haementeria ghilianii

Also Published As

Publication number Publication date
EP0404055A1 (de) 1990-12-27
JP2947882B2 (ja) 1999-09-13
JPH03128326A (ja) 1991-05-31
EP0404055B1 (de) 1994-03-02
AU624962B2 (en) 1992-06-25
KR0185973B1 (ko) 1999-05-01
IE902212L (en) 1990-12-20
ES2052105T3 (es) 1994-07-01
DK0404055T3 (da) 1994-03-28
US5447911A (en) 1995-09-05
IE902212A1 (en) 1991-01-16
IE63540B1 (en) 1995-05-17
DE69006931T2 (de) 1994-08-18
KR910000172A (ko) 1991-01-29
AU5753890A (en) 1991-01-03
DE69006931D1 (de) 1994-04-07

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee