AT379815B - Verfahren zur herstellung von (e)-5(2-bromvinyl)- uridins und seiner derivate - Google Patents

Verfahren zur herstellung von (e)-5(2-bromvinyl)- uridins und seiner derivate

Info

Publication number
AT379815B
AT379815B AT0333882A AT333882A AT379815B AT 379815 B AT379815 B AT 379815B AT 0333882 A AT0333882 A AT 0333882A AT 333882 A AT333882 A AT 333882A AT 379815 B AT379815 B AT 379815B
Authority
AT
Austria
Prior art keywords
uridins
bromvinyl
derivatives
producing
Prior art date
Application number
AT0333882A
Other languages
English (en)
Other versions
ATA333882A (de
Inventor
Anna Dr Szabolcs
Laszlo Dr Oetvoes
Janos Dr Sagi
Attila Dr Szemzoe
Maria Dr Peredy
Istvan Dr Horvath
Istvan Dr Koczka
Csilla Rethati
Pal Ivan
Ildiko Fritzsche
Janos Nagy
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of ATA333882A publication Critical patent/ATA333882A/de
Application granted granted Critical
Publication of AT379815B publication Critical patent/AT379815B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
AT0333882A 1981-09-07 1982-09-07 Verfahren zur herstellung von (e)-5(2-bromvinyl)- uridins und seiner derivate AT379815B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU812571A HU183567B (en) 1981-09-07 1981-09-07 Process for preparing /e/-5-/2-bromo-vinyl/-uridine and derivatives thereof

Publications (2)

Publication Number Publication Date
ATA333882A ATA333882A (de) 1985-07-15
AT379815B true AT379815B (de) 1986-03-10

Family

ID=10960052

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0333882A AT379815B (de) 1981-09-07 1982-09-07 Verfahren zur herstellung von (e)-5(2-bromvinyl)- uridins und seiner derivate

Country Status (15)

Country Link
US (1) US4544740A (de)
JP (1) JPS5888398A (de)
AT (1) AT379815B (de)
BE (1) BE894294A (de)
CA (1) CA1207760A (de)
CH (1) CH653340A5 (de)
CS (1) CS228939B2 (de)
DE (1) DE3233198A1 (de)
FR (1) FR2513252A1 (de)
GB (1) GB2106107B (de)
HU (1) HU183567B (de)
NL (1) NL8203476A (de)
PL (1) PL137818B1 (de)
SE (1) SE8205056L (de)
SU (1) SU1240363A3 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU187736B (en) * 1982-08-04 1986-02-28 Mta Koezponti Kemiai Kutato Intezet,Hu Process for producing /e/ -5-/2-bromovinyl/-2-comma above-deoxyuridine and o-acyl derivatives
FR2531962B1 (fr) * 1982-08-17 1986-11-14 Sandoz Sa Nouveaux derives de la desoxyuridine, leur preparation et leur utilisation comme medicaments
AU575022B2 (en) * 1982-09-17 1988-07-21 Glaxo Group Limited Antiviral 5-halovinyl-2'-deoxyuridines
US4658044A (en) * 1983-09-16 1987-04-14 Glaxo Group Limited Intermediates for uracil derivatives
GB8517402D0 (en) * 1985-07-10 1985-08-14 Wellcome Found Treatment of viral infections
GB8912972D0 (en) * 1989-06-06 1989-07-26 Wellcome Found Therapeutic nucleosides
US5446031A (en) * 1991-04-24 1995-08-29 Yamasa Shuyu Kabushiki Kaisha 1-β-D-arabinofuranosyl-(E)-5-(2-halogenovinyl)uracil derivatives
DE102006037786A1 (de) 2006-08-11 2008-03-20 Resprotect Gmbh Nukleoside, diese enthaltendes Arzneimittel und deren Verwendung
AU2009223453B2 (en) 2008-03-03 2014-05-01 Tosk, Inc. Methotrexate adjuvants to reduce toxicity and methods for using the same

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3002197A1 (de) * 1980-01-22 1981-07-23 Robugen Gmbh Pharmazeutische Fabrik Esslingen A.N., 7300 Esslingen 5-alkylsubstituierte pyrimidin-nukleoside, verfahren zu deren herstellung und daraus hergestellte virostatische und cytostatische mittel

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1601020A (en) * 1978-04-24 1981-10-21 Stichting Grega Vzw 2'-deoxy-5 (2-halogenovinyl)-uridines
US4247544A (en) * 1979-07-02 1981-01-27 The Regents Of The University Of California C-5 Substituted uracil nucleosides
GB2060604B (en) * 1979-10-03 1983-11-23 Univ Birmingham And Stichting E15-(2-halogenovinyl)-2'-deoxycytidines
JPS5687599A (en) * 1979-12-19 1981-07-16 Yamasa Shoyu Co Ltd E 55 22halogenovinyl arabinofuranosyluracil and its preparation
EP0060099A1 (de) * 1981-03-11 1982-09-15 Beecham Group Plc Antivirale Verbindungen, ihre Herstellung und Verwendung
NZ199764A (en) * 1981-03-20 1984-08-24 Beecham Group Plc 5-(2-halogenovinyl)-2'-deoxyuridine derivatives and pharmaceutical compositions

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3002197A1 (de) * 1980-01-22 1981-07-23 Robugen Gmbh Pharmazeutische Fabrik Esslingen A.N., 7300 Esslingen 5-alkylsubstituierte pyrimidin-nukleoside, verfahren zu deren herstellung und daraus hergestellte virostatische und cytostatische mittel

Also Published As

Publication number Publication date
SU1240363A3 (ru) 1986-06-23
CH653340A5 (de) 1985-12-31
CS228939B2 (en) 1984-05-14
US4544740A (en) 1985-10-01
GB2106107B (en) 1985-06-12
FR2513252B1 (de) 1985-02-15
HU183567B (en) 1984-05-28
GB2106107A (en) 1983-04-07
DE3233198A1 (de) 1983-03-17
NL8203476A (nl) 1983-04-05
JPS5888398A (ja) 1983-05-26
BE894294A (fr) 1983-03-03
ATA333882A (de) 1985-07-15
SE8205056L (sv) 1983-03-08
CA1207760A (en) 1986-07-15
PL238159A1 (en) 1984-02-13
PL137818B1 (en) 1986-07-31
SE8205056D0 (sv) 1982-09-06
FR2513252A1 (fr) 1983-03-25

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Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee
ELJ Ceased due to non-payment of the annual fee