AT356270B - Verfahren zum herstellen von neuen heteromono- cyclischen und heterobicyclischen derivaten ungesaettigter 7-acylamido-3-cephem-4-carbon- saeuren, ihren salzen und isomeren - Google Patents

Verfahren zum herstellen von neuen heteromono- cyclischen und heterobicyclischen derivaten ungesaettigter 7-acylamido-3-cephem-4-carbon- saeuren, ihren salzen und isomeren

Info

Publication number
AT356270B
AT356270B AT32778A AT32778A AT356270B AT 356270 B AT356270 B AT 356270B AT 32778 A AT32778 A AT 32778A AT 32778 A AT32778 A AT 32778A AT 356270 B AT356270 B AT 356270B
Authority
AT
Austria
Prior art keywords
heteromonocyclic
acylamido
cephem
isomers
unsaturated
Prior art date
Application number
AT32778A
Other languages
English (en)
Other versions
ATA32778A (de
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Priority to AT324379A priority Critical patent/AT360158B/de
Priority to AT324179A priority patent/AT360156B/de
Priority to AT324279A priority patent/AT360157B/de
Publication of ATA32778A publication Critical patent/ATA32778A/de
Application granted granted Critical
Publication of AT356270B publication Critical patent/AT356270B/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D501/00Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/207-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/247-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/28Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by an aliphatic carboxylic acid, which is substituted by hetero atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D501/00Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/207-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/247-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36Methylene radicals, substituted by sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT32778A 1977-02-11 1978-01-17 Verfahren zum herstellen von neuen heteromono- cyclischen und heterobicyclischen derivaten ungesaettigter 7-acylamido-3-cephem-4-carbon- saeuren, ihren salzen und isomeren AT356270B (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AT324379A AT360158B (de) 1977-02-11 1979-04-30 Verfahren zum herstellen von neuen heteromono- cyclischen und heterobicyclischen derivaten ungesaettigter 7-acylamido-3-cephem-4-carbon- saeuren, ihren salzen und isomeren
AT324179A AT360156B (de) 1977-02-11 1979-04-30 Verfahren zum herstellen von neuen heteromono- cyclischen und heterobicyclischen derivaten ungesaettigter 7-acylamido-3-cehpem-4-carbon- saeuren, ihren salzen und isomeren
AT324279A AT360157B (de) 1977-02-11 1979-04-30 Verfahren zum herstellen von neuen heteromono- cyclischen und heterobicyclischen derivaten ungesaettigter 7-acylamido-3-cephem-4-carbon- saeuren, ihren salzen und isomren

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT20173/77A IT1075277B (it) 1977-02-11 1977-02-11 Derivati insaturi e epossidici dell'acio 7-acilamido-3-cefem-4-carbossilico e procedimento per la loro preparazione

Publications (2)

Publication Number Publication Date
ATA32778A ATA32778A (de) 1979-09-15
AT356270B true AT356270B (de) 1980-04-25

Family

ID=11164407

Family Applications (2)

Application Number Title Priority Date Filing Date
AT585677A AT355206B (de) 1977-02-11 1977-08-11 Verfahren zum herstellen von neuen derivaten der 7-acylamido-3-cephem-4-carbonsaeure und ihren salzen
AT32778A AT356270B (de) 1977-02-11 1978-01-17 Verfahren zum herstellen von neuen heteromono- cyclischen und heterobicyclischen derivaten ungesaettigter 7-acylamido-3-cephem-4-carbon- saeuren, ihren salzen und isomeren

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT585677A AT355206B (de) 1977-02-11 1977-08-11 Verfahren zum herstellen von neuen derivaten der 7-acylamido-3-cephem-4-carbonsaeure und ihren salzen

Country Status (29)

Country Link
US (3) US4154830A (de)
JP (2) JPS5398991A (de)
AT (2) AT355206B (de)
AU (2) AU512934B2 (de)
BE (2) BE858433A (de)
CA (2) CA1103237A (de)
CH (3) CH632513A5 (de)
CS (3) CS196381B2 (de)
CY (1) CY1234A (de)
DE (2) DE2736471A1 (de)
DK (2) DK155944C (de)
FI (2) FI65259C (de)
FR (3) FR2380285A1 (de)
GB (4) GB1590610A (de)
GR (2) GR71901B (de)
HK (1) HK55284A (de)
HU (2) HU177596B (de)
IL (3) IL52708A0 (de)
IT (1) IT1075277B (de)
MY (1) MY8500446A (de)
NL (2) NL7708943A (de)
NO (4) NO152654C (de)
NZ (2) NZ184889A (de)
PH (1) PH16946A (de)
SE (4) SE7709002L (de)
SG (1) SG9484G (de)
SU (4) SU845788A3 (de)
YU (1) YU40307B (de)
ZA (2) ZA774835B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1075277B (it) * 1977-02-11 1985-04-22 Erba Carlo Spa Derivati insaturi e epossidici dell'acio 7-acilamido-3-cefem-4-carbossilico e procedimento per la loro preparazione
JPS5593413A (en) * 1979-01-11 1980-07-15 Osaka Gas Co Ltd Lining method for inner surface of pipe
US4331666A (en) * 1979-05-11 1982-05-25 Farmitalia Carlo Erba S.P.A. 3-[(8-Carboxy-6-tetrazolo[1,5-b]pyridazinyl)-thiomethyl]-7-[2-(2-amino-4-thiazolyl)-2-methoxyimino-acetamido]-3-cephem-4-carboxylic acid
US4420477A (en) * 1979-11-30 1983-12-13 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
US4405617A (en) * 1980-02-11 1983-09-20 Fujisawa Pharmaceutical Co., Ltd. 3-(Propynyltetrazol)thiomethyl-3-cephems
GB2076803B (en) * 1980-05-16 1984-02-08 Erba Farmitalia Substituted 7-(a-oxy-imino-acetamido)-cephalosporins and process for their preparation
GB2186875A (en) * 1983-10-31 1987-08-26 Fujisawa Pharmaceutical Co New cephem compounds and processes for preparation thereof
EP0225634B1 (de) * 1985-12-13 1994-04-06 Takeda Chemical Industries, Ltd. Antibakterielle Verbindungen, ihre Herstellung und Verwendung
JPH0544294Y2 (de) * 1986-06-10 1993-11-10
US5198445A (en) * 1990-01-12 1993-03-30 The Dow Chemical Company Composition and use of substituted 3-thio-2-propynenitriles as industrial antimicrobials
US5126349A (en) * 1990-01-12 1992-06-30 The Dow Chemical Company Composition and use of substituted 3-thio-2-propynenitriles as an industrial antimicrobial
CA2073458A1 (en) * 1990-01-12 1991-07-13 Connie I. Deford Composition and use of substituted 3-thio-2-propynenitriles as an industrial antimicrobial
US5155119A (en) * 1992-03-05 1992-10-13 The Dow Chemical Company 3-(2-pyridinylthio)-N-oxide, 2-halo-2-propenenitrile compounds useful as antimicrobials
US5157051A (en) * 1992-03-05 1992-10-20 The Dow Chemical Company Composition and use of 3-thiocyano-2-halo-2-propenenitriles as antimicrobial agents
US5206227A (en) * 1992-06-02 1993-04-27 The Dow Chemical Company Composition and use of phosphonic acid, (2-halo-2-cyanoethenyl)-dialkyl esters as antimicrobials
JP3115455B2 (ja) * 1992-12-18 2000-12-04 明治製菓株式会社 新規セファロスポリン誘導体
SE9802974D0 (sv) * 1998-09-03 1998-09-03 Astra Ab New crystalline forms

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1075277B (it) * 1977-02-11 1985-04-22 Erba Carlo Spa Derivati insaturi e epossidici dell'acio 7-acilamido-3-cefem-4-carbossilico e procedimento per la loro preparazione
GB1478055A (en) * 1973-07-27 1977-06-29 Erba Carlo Spa Cephalosporin compounds
US3883520A (en) * 1973-08-17 1975-05-13 Smithkline Corp Substituted mercaptoacetamidocephalosporins
FI761035A (de) * 1975-04-21 1976-10-22 Erba Carlo Spa
ZA767084B (en) * 1975-12-16 1977-10-26 Erba Carlo Spa Thiadiazolyl derivatives of 7-acylamido 3-cephem-4-carboxylic acid and process for their preparation
US4057631A (en) * 1976-09-02 1977-11-08 Smithkline Corporation 7-(α-Substituted phenylacetamido)-3-(1-carboxymethylthioethyltetrazolyl-5-thiomethyl)-3-cephem-4-carboxylic acids
US4079134A (en) * 1976-09-24 1978-03-14 Smithkline Corporation 7-Acylamino-3-(5-sulfomethyl-1,3,4-thiadiazol-2-ylthiomethyl)-3-cephem-4-carboxylic acids

Also Published As

Publication number Publication date
CS196381B2 (en) 1980-03-31
ATA32778A (de) 1979-09-15
FR2380285B1 (de) 1981-10-23
JPS6153359B2 (de) 1986-11-17
SU904524A3 (ru) 1982-02-07
SE8000110L (sv) 1980-01-08
CA1103237A (en) 1981-06-16
IL59527A0 (en) 1980-06-30
DE2736471C2 (de) 1988-09-22
NO772779L (no) 1978-08-14
NO800239L (no) 1978-08-14
YU210977A (en) 1982-10-31
NO794101L (no) 1978-08-14
CA1108603A (en) 1981-09-08
NO780074L (no) 1978-08-14
GB1597261A (en) 1981-09-03
SE7709002L (sv) 1978-08-12
FI772411A (fi) 1978-08-12
CY1234A (en) 1984-06-29
AU2786577A (en) 1979-02-15
GR72589B (de) 1983-11-18
GR71901B (de) 1983-08-11
AU513444B2 (en) 1980-12-04
HU177596B (en) 1981-11-28
BE863625A (fr) 1978-08-03
DK155944B (da) 1989-06-05
NO152654C (no) 1985-10-30
US4172892A (en) 1979-10-30
DK353577A (da) 1978-08-12
NZ186236A (en) 1980-05-08
HK55284A (en) 1984-07-27
IL53830A (en) 1982-07-30
YU40307B (en) 1985-12-31
AU3247678A (en) 1979-07-26
AT355206B (de) 1980-02-25
IT1075277B (it) 1985-04-22
CS199713B2 (en) 1980-07-31
MY8500446A (en) 1985-12-31
CH634330A5 (de) 1983-01-31
ATA585677A (de) 1979-07-15
BE858433A (fr) 1978-01-02
PH16946A (en) 1984-04-24
IL52708A0 (en) 1977-10-31
FI780437A (fi) 1978-08-12
CS199714B2 (en) 1980-07-31
FI65259C (fi) 1984-04-10
CH632513A5 (de) 1982-10-15
FR2384783B1 (de) 1982-12-03
SU753361A3 (ru) 1980-07-30
HU178918B (en) 1982-07-28
FR2380285A1 (fr) 1978-09-08
SG9484G (en) 1984-08-03
SU856388A3 (ru) 1981-08-15
SE7800292L (sv) 1978-08-12
SE446536B (sv) 1986-09-22
NZ184889A (en) 1979-07-11
DE2736471A1 (de) 1978-08-17
FR2445834A1 (fr) 1980-08-01
ZA774835B (en) 1978-07-26
DK11578A (da) 1978-08-12
FR2384783A1 (fr) 1978-10-20
IL53830A0 (en) 1978-04-30
GB1582295A (en) 1981-01-07
GB1590610A (en) 1981-06-03
NL7800443A (nl) 1978-08-15
NO152654B (no) 1985-07-22
US4154830A (en) 1979-05-15
NL7708943A (nl) 1978-08-15
DE2801644A1 (de) 1978-08-17
FR2445834B1 (de) 1983-10-21
DK155944C (da) 1989-12-04
JPS53121788A (en) 1978-10-24
FI65259B (fi) 1983-12-30
ZA78181B (en) 1979-08-29
CH636359A5 (de) 1983-05-31
SE8002904L (sv) 1980-04-18
US4388314A (en) 1983-06-14
GB1597262A (en) 1981-09-03
JPS5398991A (en) 1978-08-29
AU512934B2 (en) 1980-11-06
SU845788A3 (ru) 1981-07-07

Similar Documents

Publication Publication Date Title
AT371813B (de) Verfahren zum herstellen von neuen substituierten propanolamin- und morpholinderivaten und von deren isomeren und salzen
AT356270B (de) Verfahren zum herstellen von neuen heteromono- cyclischen und heterobicyclischen derivaten ungesaettigter 7-acylamido-3-cephem-4-carbon- saeuren, ihren salzen und isomeren
AT355029B (de) Verfahren zum herstellen von neuen 3,4-dihydro- chinazolinen und ihren salzen und isomeren
AT355566B (de) Verfahren zum herstellen von neuen amino- alkohol-derivaten
AT356652B (de) Verfahren zum herstellen von neuen spiro-(1,3- -dioxolan-4,3') chinuclidinen, ihren salzen und isomeren
AT368512B (de) Verfahren zum herstellen von neuen heterocyclischen derivaten von oxyiminosubstituierten cephalosporinen, ihren salzen und ihren isomeren
AT351041B (de) Verfahren zum herstellen von neuen cyclischen derivaten von 1,4-benzoxazinen und 1,4-benzo- thiazinen sowie von deren salzen und stereo- isomeren
AT370095B (de) Verfahren zum herstellen von neuen 1-aryl-alkyl-imidazolderivaten und deren salzen
AT361921B (de) Verfahren zum herstellen von neuen chromen- derivaten
AT360158B (de) Verfahren zum herstellen von neuen heteromono- cyclischen und heterobicyclischen derivaten ungesaettigter 7-acylamido-3-cephem-4-carbon- saeuren, ihren salzen und isomeren
AT360156B (de) Verfahren zum herstellen von neuen heteromono- cyclischen und heterobicyclischen derivaten ungesaettigter 7-acylamido-3-cehpem-4-carbon- saeuren, ihren salzen und isomeren
AT363931B (de) Verfahren zum herstellen von neuen substituierten 2-cyclopropyl-chromonen, ihren salzen und isomeren
AT360157B (de) Verfahren zum herstellen von neuen heteromono- cyclischen und heterobicyclischen derivaten ungesaettigter 7-acylamido-3-cephem-4-carbon- saeuren, ihren salzen und isomren
ATA869078A (de) Verfahren zum herstellen von hohlkoerpern
AT379591B (de) Verfahren zur herstellung von neuen thiazolidinderivaten und von deren salzen und isomeren
AT352721B (de) Verfahren zum herstellen von neuen substi- tuierten 2-vinyl-chromonen ihren salzen und isomeren
AT355212B (de) Verfahren zum herstellen von neuen derivaten der 7-acylamido-3-cephem-4-carbonsaeure und ihren salzen
ATA426081A (de) Verfahren zum herstellen von neuen heterocyclischen derivaten von oxyiminosubstituierten cephalosporinen, ihren salzen und ihren isomeren
ATA426181A (de) Verfahren zum herstellen von neuen heterocyclischen derivaten von oxyiminosubstituierten cephalosporinen, ihren salzen und ihren isomeren
AT371809B (de) Verfahren zum herstellen von neuen chinazolinen und ihren salzen
ATA303380A (de) Verfahren zum herstellen von neuen substi- tuierten 2-cyclopropyl-chromonen ihren salzen und isomeren
ATA105179A (de) Verfahren zum herstellen von neuen spiro-(1,3- dioxolan-4,3')chinuclidinen, ihren salzen und isomeren
ATA485081A (de) Verfahren zum herstellen von neuen chinazolinen und ihren salzen
ATA419781A (de) Verfahren zum herstellen von neuen substituierten morpholinderivaten und von deren isomeren und salzen
ATA246479A (de) Verfahren zum herstellen von neuen 3,4-dihydro- chinazolinen und ihren salzen und isomeren

Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee