AR247572A1 - Competitive genadoliberin antagonists - Google Patents
Competitive genadoliberin antagonistsInfo
- Publication number
- AR247572A1 AR247572A1 AR89315650A AR31565089A AR247572A1 AR 247572 A1 AR247572 A1 AR 247572A1 AR 89315650 A AR89315650 A AR 89315650A AR 31565089 A AR31565089 A AR 31565089A AR 247572 A1 AR247572 A1 AR 247572A1
- Authority
- AR
- Argentina
- Prior art keywords
- ser
- phe
- rha
- nal
- leu
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE UN PEPTIDO DE FORMULA: AC-D-NAL(2)-D- PHE-D-PHE-SER-X-D-SER(RHA)-LEU-ARG-PRO-Y EN DONDE AC ES ACETILO, D-NAL(2) ES 3-(2-NAFTIL)-D-ALANINA, D-PHE ES D-FENILALANINA, SER ES L-SERINA, X ES L TIROSINA (TYR) O L-HISTIDINA (HIS), D-SER(RHA) ES 0-(ALFA-L-RAMNOPIRANOSIL) D-SERINA, LEU ES L-LEUCINA, ARG ES L-ARGININA, PRO ES L-PROLINA E Y ES GLICINAMIDA (GLY-NH2), D-ALANINA (D-ALA-NH2), AZAGLICINAMIDA (AZGLY-NH2) O NH-C2H5, ASI COMO SUS SALES FISIOLOGICAMENTE COMPATIBLES, DONDE UN FRAGMENTO CON UN GRUPO AMINO LIBRE EN EL N-TERMINAL SE CONDENSA CON UN GRUPO CARBOXILO LIBRE EN EL C-TERMINAL, SE SEPARAN UNO O VARIOS GRUPOS PROTECTORES, EVENTUALMENTE INCORPORADOS DE MANERA PROVISIONAL PARA LA PROTECCION DE GRUPOS FUNCIONALES, Y EL PEPTIDO, ASI OBTENIDO SE TRANSFORMA EVENTUALMENTE EN SU SAL FISIOLOGICAMENTE COMPATIBLE.PROCEDURE FOR THE PREPARATION OF A FORMULA PEPTIDE: AC-D-NAL (2) -D- PHE-D-PHE-SER-XD-SER (RHA) -LEU-ARG-PRO-Y WHERE AC IS ACETILO, D -NAL (2) ES 3- (2-NAFTIL) -D-ALANINA, D-PHE ES D-FENILALANINA, SER ES L-SERINA, X ES L TIROSINA (TYR) O L-HISTIDINA (HIS), D-SER (RHA) IS 0- (ALPHA-L-RAMNOPYRANOSIL) D-SERINE, LEU IS L-LEUCIN, ARG IS L-ARGININE, PRO IS L-PROLIN E AND IS GLYCINAMIDE (GLY-NH2), D-ALANINE (D-ALA -NH2), AZAGLYCINAMIDE (AZGLY-NH2) OR NH-C2H5, AS WELL AS THEIR PHYSIOLOGICALLY COMPATIBLE SALTS, WHERE A FRAGMENT WITH A FREE AMINO GROUP IN THE N-TERMINAL CONDENSES WITH A FREE CARBOXYL GROUP IN THE C-TERMINAL, ONE OR SEVERAL PROTECTIVE GROUPS, EVENTUALLY INCORPORATED IN A PROVISIONAL WAY FOR THE PROTECTION OF FUNCTIONAL GROUPS, AND THE PEPTIDE, SO OBTAINED, IS EVENTUALLY TRANSFORMED INTO ITS PHYSIOLOGICALLY COMPATIBLE SALT.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3842010A DE3842010A1 (en) | 1988-12-14 | 1988-12-14 | COMPETITIVE GONADOLIBERINE ANTAGONISTS |
Publications (1)
Publication Number | Publication Date |
---|---|
AR247572A1 true AR247572A1 (en) | 1995-01-31 |
Family
ID=6369104
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AR89315650A AR247572A1 (en) | 1988-12-14 | 1989-10-12 | Competitive genadoliberin antagonists |
Country Status (16)
Country | Link |
---|---|
US (1) | US5071836A (en) |
EP (1) | EP0373545B1 (en) |
JP (1) | JPH02258798A (en) |
KR (1) | KR0142195B1 (en) |
AR (1) | AR247572A1 (en) |
AT (1) | ATE101622T1 (en) |
AU (1) | AU620184B2 (en) |
CA (1) | CA2005420C (en) |
DE (2) | DE3842010A1 (en) |
DK (1) | DK630289A (en) |
ES (1) | ES2061908T3 (en) |
IE (1) | IE62873B1 (en) |
IL (1) | IL92661A (en) |
NZ (1) | NZ231716A (en) |
PT (1) | PT92557B (en) |
ZA (1) | ZA899509B (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5455232A (en) * | 1992-02-04 | 1995-10-03 | Piljac; Goran | Pharmaceutical preparation based on rhamnolipid |
JP4511042B2 (en) | 1998-08-07 | 2010-07-28 | メルク セローノ ソシエテ アノニム | FSH mimics for the treatment of infertility |
EP1380582B1 (en) * | 1998-08-07 | 2006-06-14 | Applied Research Systems ARS Holding N.V. | FSH mimetics for the treatment of infertility |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PH11571A (en) * | 1973-10-03 | 1978-03-31 | American Home Prod | P-gui-d-phe-trp-ser-tyr-d-ala-leu-arg-pro-gly-nh2,its non-toxic salts and method of use thereof |
DE2617646C2 (en) * | 1976-04-22 | 1986-07-31 | Hoechst Ag, 6230 Frankfurt | Nonapeptide-amides and decapeptide-amides with gonadoliberin activity, processes for their preparation and pharmaceutical preparations containing these compounds |
FI832053L (en) * | 1982-06-10 | 1983-12-11 | Syntex Inc | NONAPEPTID- OCH DEKAPEPTIDANALOGER AV LHRH ANVAENDBARA SOM LHRH-ANTAGONISTER SAMT DERAS FRAMSTAELLNINGSFOERFARANDE |
US4504467A (en) * | 1983-10-21 | 1985-03-12 | Eli Lilly And Company | Glycopeptide derivatives |
US4530920A (en) * | 1983-11-07 | 1985-07-23 | Syntex (U.S.A.) Inc. | Nonapeptide and decapeptide analogs of LHRH, useful as LHRH agonist |
US4569927A (en) * | 1984-02-23 | 1986-02-11 | The Salk Institute For Biological Studies | GnRH Antagonists IV |
DE3634435A1 (en) * | 1986-10-09 | 1988-04-14 | Hoechst Ag | ANALOGA OF GONADOLIBERIN WITH IMPROVED SOLUBILITY, METHOD FOR THE PRODUCTION THEREOF, THE CONTAINERS THEREOF AND THEIR USE |
DK163689A (en) * | 1988-04-08 | 1989-10-30 | Sandoz Ag | PEPTIDE DERIVATIVES |
-
1988
- 1988-12-14 DE DE3842010A patent/DE3842010A1/en not_active Withdrawn
-
1989
- 1989-10-12 AR AR89315650A patent/AR247572A1/en active
- 1989-12-09 DE DE89122757T patent/DE58906995D1/en not_active Expired - Fee Related
- 1989-12-09 ES ES89122757T patent/ES2061908T3/en not_active Expired - Lifetime
- 1989-12-09 AT AT89122757T patent/ATE101622T1/en not_active IP Right Cessation
- 1989-12-09 EP EP89122757A patent/EP0373545B1/en not_active Expired - Lifetime
- 1989-12-12 KR KR1019890018352A patent/KR0142195B1/en not_active IP Right Cessation
- 1989-12-12 US US07/448,904 patent/US5071836A/en not_active Expired - Fee Related
- 1989-12-12 IL IL9266189A patent/IL92661A/en unknown
- 1989-12-12 NZ NZ231716A patent/NZ231716A/en unknown
- 1989-12-13 JP JP1321603A patent/JPH02258798A/en active Pending
- 1989-12-13 AU AU46113/89A patent/AU620184B2/en not_active Ceased
- 1989-12-13 DK DK630289A patent/DK630289A/en not_active Application Discontinuation
- 1989-12-13 ZA ZA899509A patent/ZA899509B/en unknown
- 1989-12-13 CA CA002005420A patent/CA2005420C/en not_active Expired - Fee Related
- 1989-12-13 IE IE399089A patent/IE62873B1/en not_active IP Right Cessation
- 1989-12-13 PT PT92557A patent/PT92557B/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DK630289A (en) | 1990-06-15 |
EP0373545A2 (en) | 1990-06-20 |
CA2005420C (en) | 2000-01-18 |
AU4611389A (en) | 1990-06-21 |
KR0142195B1 (en) | 1998-07-01 |
IE893990L (en) | 1990-06-14 |
DE58906995D1 (en) | 1994-03-24 |
EP0373545A3 (en) | 1990-10-17 |
ZA899509B (en) | 1990-08-29 |
CA2005420A1 (en) | 1990-06-14 |
JPH02258798A (en) | 1990-10-19 |
ES2061908T3 (en) | 1994-12-16 |
NZ231716A (en) | 1991-12-23 |
KR900009693A (en) | 1990-07-05 |
AU620184B2 (en) | 1992-02-13 |
PT92557A (en) | 1990-06-29 |
ATE101622T1 (en) | 1994-03-15 |
IE62873B1 (en) | 1995-03-08 |
IL92661A (en) | 1994-05-30 |
DK630289D0 (en) | 1989-12-13 |
PT92557B (en) | 1995-08-09 |
US5071836A (en) | 1991-12-10 |
EP0373545B1 (en) | 1994-02-16 |
IL92661A0 (en) | 1990-08-31 |
DE3842010A1 (en) | 1990-06-21 |
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