AR241182A1 - Un procedimiento para preparar n-(2-metoxifenil)-piperazinil-alcanoil anilidas. - Google Patents

Un procedimiento para preparar n-(2-metoxifenil)-piperazinil-alcanoil anilidas.

Info

Publication number
AR241182A1
AR241182A1 AR84295676A AR29567684A AR241182A1 AR 241182 A1 AR241182 A1 AR 241182A1 AR 84295676 A AR84295676 A AR 84295676A AR 29567684 A AR29567684 A AR 29567684A AR 241182 A1 AR241182 A1 AR 241182A1
Authority
AR
Argentina
Prior art keywords
alcanoyl
halo
formula
sulfamoil
alcoxi
Prior art date
Application number
AR84295676A
Other languages
English (en)
Original Assignee
Recordati Chem Pharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Recordati Chem Pharm filed Critical Recordati Chem Pharm
Application granted granted Critical
Publication of AR241182A1 publication Critical patent/AR241182A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/66—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

UN PROCEDIMIENTO PARA PREPARAR N-(2-METOXIFENIL)-PIPERAZINIL-ALCANOIL- ANILIDAS O SUS SALES FARMACEUTICAMENTE ACEPTABLES, DE FORMULA (I), DONDE N ES 0, 1 O 2; R2 ES H, ALCOXI, HALO, TRIFLUORMETILO, SULFAMOILO; R4 ES H O ALCOXI, R3 ES H, ALCOXI; SULFAMOILO; ALQUIL-SULFONILO; AMINO; CARBOXI; CARBAMOILO; ALCOXI CARBONILO; ALCANOILO; ALQUILTIO; CIANO; HALO; NITRO; HIDROXIALQUILO; ALCANOIL-SULFAMOILO, ALCANOIL-AMINO; MONO O DIALQUIL- AMINOSULFONILO; FENILAMINOSULFONILO; GUANIDINOSULFONILO O SULFO, FORMANDO R2 Y R3 CONSIDERADOS CON R4, FORMAN UN GRUPO 3,4-METILEN-DIOXI, Y R ES H O ALQUILO. SE HACE REACCIONAR UN COMPUESTO DE FORMULA (II) DONDE X0 ES - (CH2)N-CRH-X O -CH=CR-H Y X ES HALO; N ES 0 O 1 CON 1-(2-METOXIFENIL)- PIPERAZINA EN UN SOLVENTE, OBTENIENDOSE LA FORMULA (I).
AR84295676A 1983-02-12 1984-02-09 Un procedimiento para preparar n-(2-metoxifenil)-piperazinil-alcanoil anilidas. AR241182A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB838303946A GB8303946D0 (en) 1983-02-12 1983-02-12 Antihypertensive n-piperazinylalkanoylanilides

Publications (1)

Publication Number Publication Date
AR241182A1 true AR241182A1 (es) 1992-01-31

Family

ID=10537908

Family Applications (1)

Application Number Title Priority Date Filing Date
AR84295676A AR241182A1 (es) 1983-02-12 1984-02-09 Un procedimiento para preparar n-(2-metoxifenil)-piperazinil-alcanoil anilidas.

Country Status (23)

Country Link
US (1) US4940711A (es)
EP (1) EP0120558B1 (es)
JP (1) JPS59152379A (es)
KR (1) KR910000451B1 (es)
AR (1) AR241182A1 (es)
AT (1) ATE41150T1 (es)
AU (1) AU565208B2 (es)
CA (1) CA1254894A (es)
DE (1) DE3476998D1 (es)
DK (1) DK162640C (es)
ES (1) ES8507529A1 (es)
FI (1) FI80025C (es)
GB (1) GB8303946D0 (es)
GR (1) GR81460B (es)
HU (1) HU191270B (es)
IE (1) IE56652B1 (es)
IL (1) IL70733A (es)
MX (1) MX156049A (es)
NZ (1) NZ206823A (es)
PH (1) PH20244A (es)
PT (1) PT78081B (es)
SG (1) SG34889G (es)
ZA (1) ZA84316B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8303946D0 (en) * 1983-02-12 1983-03-16 Recordati Chem Pharm Antihypertensive n-piperazinylalkanoylanilides
JPS61134382A (ja) * 1984-12-04 1986-06-21 Kyorin Pharmaceut Co Ltd 新規なスルファモイル安息香酸誘導体およびその製造法
IT1190375B (it) * 1985-06-20 1988-02-16 Recordati Chem Pharm N-benzidrildiazacicloalchil-alcanilidi ad attivita' antianafilattica ed antibroncospastica
DE3642497A1 (de) * 1986-12-12 1988-06-23 Hoechst Ag Substituierte aminopropionsaeureamide, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung sowie die bei der herstellung anfallenden neuen zwischenprodukte
JP2712222B2 (ja) * 1988-01-29 1998-02-10 三菱化学株式会社 抗不安薬
DK203990D0 (da) * 1990-08-24 1990-08-24 Novo Nordisk As Piperazinylderivater
US5605896A (en) * 1992-02-25 1997-02-25 Recordati S.A., Chemical And Pharmaceutical Company Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities
US5474994A (en) * 1992-05-26 1995-12-12 Recordati S.A., Chemical And Pharmaceutical Company Bicyclic heterocyclic derivatives having α1 -adrenergic and 5HT1A
IT1254469B (it) * 1992-02-25 1995-09-25 Recordati Chem Pharm Derivati benzopiranici e benzotiopiranici
IT1258315B (it) * 1992-04-10 1996-02-22 Recordati Chem Pharm Derivati del flavone
JP6664632B2 (ja) * 2013-09-30 2020-03-13 国立大学法人 東京大学 アディポネクチン受容体活性化化合物
AU2015299055C1 (en) * 2014-08-06 2021-05-06 Ascendis Pharma A/S Prodrugs comprising an aminoalkyl glycine linker
US20180305334A1 (en) * 2015-10-14 2018-10-25 Aquinnah Pharmaceuticals, Inc. Compounds, compositions and methods of use against stress granules

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB912788A (en) * 1959-11-16 1962-12-12 Miles Lab Phenylpiperazinylacyl anilines
DE1670200A1 (de) * 1967-03-22 1972-03-02 Byk Gulden Lomberg Chem Fab Neue arylsubstituierte Piperazinylcarbonsaeureanilide und Verfahren zu deren Herstellung
JPS5064282A (es) * 1973-10-17 1975-05-31
JPS5849550B2 (ja) * 1974-02-07 1983-11-05 住友化学工業株式会社 シンキナアニリンユウドウタイ ノ セイホウ
GB1574019A (en) * 1977-01-14 1980-09-03 Joullie International Sa Therapeutically useful 3,4,5-trimethoxybenzene derivatives
US4202978A (en) * 1978-02-08 1980-05-13 Hoffmann-La Roche Inc. (S)-1-[2-(4-(2-Hydroxy-s-(1-alkylaminopropoxy)phenylalkyl]-4-phenylpiperazines
JPS58154573A (ja) * 1982-03-09 1983-09-14 Mitsubishi Chem Ind Ltd アルキレンジオキシベンゼン誘導体及びその酸付加塩
GB8303946D0 (en) * 1983-02-12 1983-03-16 Recordati Chem Pharm Antihypertensive n-piperazinylalkanoylanilides

Also Published As

Publication number Publication date
DK162640B (da) 1991-11-25
DK48584A (da) 1984-08-13
DK48584D0 (da) 1984-02-03
IL70733A0 (en) 1984-04-30
GB8303946D0 (en) 1983-03-16
PT78081B (en) 1986-04-17
ATE41150T1 (de) 1989-03-15
KR840007593A (ko) 1984-12-08
JPS59152379A (ja) 1984-08-31
FI840478A (fi) 1984-08-13
MX156049A (es) 1988-06-21
DE3476998D1 (de) 1989-04-13
NZ206823A (en) 1987-07-31
HU191270B (en) 1987-01-28
EP0120558A1 (en) 1984-10-03
FI80025B (fi) 1989-12-29
GR81460B (es) 1984-12-11
ES529642A0 (es) 1985-09-01
DK162640C (da) 1992-04-13
IL70733A (en) 1987-10-30
ZA84316B (en) 1985-02-27
US4940711A (en) 1990-07-10
AU2449484A (en) 1984-08-16
FI840478A0 (fi) 1984-02-06
ES8507529A1 (es) 1985-09-01
JPH0434549B2 (es) 1992-06-08
IE840207L (en) 1984-08-14
KR910000451B1 (en) 1991-01-25
PH20244A (en) 1986-11-10
AU565208B2 (en) 1987-09-10
PT78081A (en) 1984-03-01
CA1254894A (en) 1989-05-30
SG34889G (en) 1989-10-13
EP0120558B1 (en) 1989-03-08
FI80025C (fi) 1990-04-10
IE56652B1 (en) 1991-10-23

Similar Documents

Publication Publication Date Title
AR241182A1 (es) Un procedimiento para preparar n-(2-metoxifenil)-piperazinil-alcanoil anilidas.
ES8703142A1 (es) Proceso para preparar un derivado del bencimidazol.
AR245705A1 (es) Un proceso para preparar leucotrienos-antagonistas y sus sales.
ES8604927A1 (es) Procedimiento para la preparacion de nuevos compuestos fluoroalcoxilicos
AU518470B2 (en) 2-(2-alkoxyethyl)-2:-hydroxy-6,7-benzomorphanes
SE8404019D0 (sv) Oftalmiskt medel
FI864017A (fi) 3-vinyl och 3-etynyl- -karbolinderivat, deras framstaellning och deras anvaendning som laekemedel.
MX173422B (es) Imidazo-(2,1-b)benzotiazoles y procedimiento para su preparacion
JPS5359675A (en) Aminoalcohol derivatives
ES532337A0 (es) Procedimiento para la preparacion de 6-aril-3 (2h)piridazinonas
SE8001818L (sv) Merkaptoacyldihydropyrazolkarboxylsyraderivat
FR2409755A1 (fr) Medicaments a base de nouvelles indolo (2,3-a) quinolizidines
ES531063A0 (es) Procedimiento para la preparacion de un nuevo compuesto heterociclico
DK111982A (da) N-(2,2,2-trifluorethyl)-n-alkylazolyloxyeddikesureamider,fremgangsmaade og mellemprodukter til deres fremstilling og deres anvendelse som herbicider
NO901652D0 (no) Angstdempende midler.
BR8208033A (pt) Processo quimico
ES464483A1 (es) Procedimiento para la obtencion de ortoaminoacetofenonas.
ES427185A1 (es) Un metodo de preparacion de butiramidas de oxi-iminocarba- moilaficidas y butiratos de oxi-iminocarbamoilo.
ES8406156A1 (es) Procedimiento para la preparacion de n-pteridinil-ureas(como divisional de la patente numero 521.331)
SE7902724L (sv) Substituerade n-iminometylpiperidiner
DK160051C (da) N-methyl-n-silylcarbamat, fremgangsmaade til bekaempelse af skadedyr under anvendelse deraf samt skadedyrsbekaempelsesmiddel indeholdende forbindelsen
ATE65986T1 (de) Propanolabkoemmlinge.
ES544709A0 (es) Procedimiento para la obtencion de iminosulfonamidas
ES8606245A1 (es) Procedimiento para preparar fenoxianilinas y piridiloxianilinas sustituidas
JPS52106861A (en) Substituted benzamides