AR126939A1 - HIGH MOLECULAR WEIGHT MODIFIED dsRNA COMPOSITIONS RELATED TO BIOCIDES - Google Patents
HIGH MOLECULAR WEIGHT MODIFIED dsRNA COMPOSITIONS RELATED TO BIOCIDESInfo
- Publication number
- AR126939A1 AR126939A1 ARP220102359A ARP220102359A AR126939A1 AR 126939 A1 AR126939 A1 AR 126939A1 AR P220102359 A ARP220102359 A AR P220102359A AR P220102359 A ARP220102359 A AR P220102359A AR 126939 A1 AR126939 A1 AR 126939A1
- Authority
- AR
- Argentina
- Prior art keywords
- dsrnas
- molecular weight
- high molecular
- fertility
- reduces
- Prior art date
Links
- 102000040650 (ribonucleotides)n+m Human genes 0.000 title abstract 6
- 108091032973 (ribonucleotides)n+m Proteins 0.000 title abstract 6
- 239000000203 mixture Substances 0.000 title abstract 3
- 239000003139 biocide Substances 0.000 title 1
- 238000000034 method Methods 0.000 abstract 8
- 241000238631 Hexapoda Species 0.000 abstract 4
- 230000035558 fertility Effects 0.000 abstract 3
- 241000196324 Embryophyta Species 0.000 abstract 2
- 241000233866 Fungi Species 0.000 abstract 2
- 206010053759 Growth retardation Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 231100000001 growth retardation Toxicity 0.000 abstract 2
- 238000012986 modification Methods 0.000 abstract 2
- 230000004048 modification Effects 0.000 abstract 2
- 241001465180 Botrytis Species 0.000 abstract 1
- 241000223195 Fusarium graminearum Species 0.000 abstract 1
- 101710163270 Nuclease Proteins 0.000 abstract 1
- 241000895647 Varroa Species 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 238000010189 synthetic method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
- A01N63/60—Isolated nucleic acids
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P23/00—Chemosterilants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P7/00—Arthropodicides
- A01P7/02—Acaricides
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P7/00—Arthropodicides
- A01P7/04—Insecticides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2330/00—Production
- C12N2330/30—Production chemically synthesised
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Plant Pathology (AREA)
- Genetics & Genomics (AREA)
- Pest Control & Pesticides (AREA)
- Environmental Sciences (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Insects & Arthropods (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Dentistry (AREA)
- Virology (AREA)
- Agronomy & Crop Science (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Saccharide Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se describen los ARN de doble hebra modificados químicamente después de la transcripción (ARNbcM) que tienen una modificación polialquiloxilo de peso molecular elevado en la posición 2-OH. Esta modificación proporciona una mayor biodisponibilidad del compuesto, mejor estabilidad del compuesto y proporciona una mayor estabilidad frente al nucleasas. Los ARNbcM se pueden producir de manera rentable de una manera fácilmente escalable. Se describen composiciones de ARNbcM que tienen nucleótidos modificados químicamente, de modo que los ARNbcM se modifican para contener polímeros de polialquiloxilo de peso molecular elevado. Se describen métodos sintéticos para hacer eficientemente estos ARNbcM y métodos de uso de ARNbcM. Reivindicación 43: Un método de modificación de la expresión de un polinucleótido de interés en cualquiera de los siguientes: un insecto, un ácaro, un hongo o una mala hierba que comprende administrar una composición de una cualquiera de las reivindicaciones 1 - 9. Reivindicación 48: El método de las reivindicaciones 43 - 47, donde la expresión modificada aumenta la mortalidad o induce retraso en el crecimiento, o detiene el desarrollo de estadios o reduce la fertilidad del insecto diana. Reivindicación 49: El método de una cualquiera de las reivindicaciones 43 - 48, donde la expresión modificada reduce la fertilidad de los insectos lepidópteros. Reivindicación 51: El método de una cualquiera de las reivindicaciones 43 - 48, donde la expresión aumenta la mortalidad o induce retraso en el crecimiento, o detiene el desarrollo de estadios o reduce la fertilidad de los insectos coleópteros. Reivindicación 53: El método de la reivindicación 43, donde la mala hierba es Palmer Amaranth. Reivindicación 54: El método de la reivindicación 43, donde el hongo es Fusarium Graminearum o Botrytis. Reivindicación 55: El método de la reivindicación 43, donde el ácaro es ácaro Varroa.Described are post-transcriptionally chemically modified double-stranded RNAs (dsRNAs) that have a high molecular weight polyalkyloxyl modification at the 2-OH position. This modification provides greater bioavailability of the compound, better stability of the compound and provides greater stability against nucleases. dsRNAs can be produced cost-effectively in an easily scalable manner. Disclosed are MdsRNA compositions that have chemically modified nucleotides, such that the MdsRNAs are modified to contain high molecular weight polyalkyloxy polymers. Synthetic methods to efficiently make these dsRNAs and methods of using dsRNAs are described. Claim 43: A method of modifying the expression of a polynucleotide of interest in any of the following: an insect, a mite, a fungus or a weed comprising administering a composition of any one of claims 1 - 9. Claim 48 : The method of claims 43 - 47, wherein the modified expression increases mortality or induces growth retardation, or stops stage development or reduces fertility of the target insect. Claim 49: The method of any one of claims 43-48, wherein the modified expression reduces the fertility of lepidopteran insects. Claim 51: The method of any one of claims 43 - 48, wherein the expression increases mortality or induces growth retardation, or arrests the development of stages or reduces the fertility of coleopteran insects. Claim 53: The method of claim 43, wherein the weed is Palmer Amaranth. Claim 54: The method of claim 43, wherein the fungus is Fusarium Graminearum or Botrytis. Claim 55: The method of claim 43, wherein the mite is Varroa mite.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163239165P | 2021-08-31 | 2021-08-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR126939A1 true AR126939A1 (en) | 2023-11-29 |
Family
ID=83508899
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP220102359A AR126939A1 (en) | 2021-08-31 | 2022-08-31 | HIGH MOLECULAR WEIGHT MODIFIED dsRNA COMPOSITIONS RELATED TO BIOCIDES |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP4396348A2 (en) |
| CN (1) | CN118302524A (en) |
| AR (1) | AR126939A1 (en) |
| CA (1) | CA3228823A1 (en) |
| WO (1) | WO2023034849A2 (en) |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000075306A2 (en) * | 1999-04-30 | 2000-12-14 | Cyclops Genome Sciences Limited | Method for producing double stranded polynucleotides |
| US20040167090A1 (en) * | 2003-02-21 | 2004-08-26 | Monahan Sean D. | Covalent modification of RNA for in vitro and in vivo delivery |
| CA2562022C (en) | 2004-04-09 | 2016-01-26 | Monsanto Technology Llc | Compositions and methods for control of insect infestations in plants |
| US20100279408A1 (en) * | 2006-11-27 | 2010-11-04 | Enzon Pharmaceuticals, Inc. | Polymeric short interfering rna conjugates |
| US20130047297A1 (en) | 2010-03-08 | 2013-02-21 | Robert D. Sammons | Polynucleotide molecules for gene regulation in plants |
| US9428791B2 (en) * | 2012-08-14 | 2016-08-30 | The Board Of Trustees Of The Leland Stanford Junior University | Probes of RNA structure and methods for using the same |
| HUE053033T2 (en) | 2013-06-19 | 2021-06-28 | Apse Llc | Compositions and methods using capsids resistant to hydrolases |
| CN105518136A (en) | 2013-07-10 | 2016-04-20 | 巴斯夫欧洲公司 | RNAI for the control of phytopathogenic fungi and oomycetes by inhibiting the expression of CYP51 genes |
| CA2959402A1 (en) | 2014-09-17 | 2016-03-24 | Pioneer Hi-Bred International, Inc. | Compositions and methods to control insect pests |
| US10131911B2 (en) | 2016-11-07 | 2018-11-20 | nanoSUR LLC | Post-transcriptionally chemically modified double strand RNAs |
| CA3061721A1 (en) | 2017-05-01 | 2018-11-08 | Donald Danforth Plant Science Center | Rnai approach for crop pest protection |
| CN111033816B (en) | 2017-08-28 | 2022-09-13 | 株式会社村田制作所 | Nonaqueous electrolyte battery and communication device |
| US11572557B2 (en) * | 2018-01-29 | 2023-02-07 | The Board Of Trustees Of The Leland Stanford Junior University | Photoreversible acylation reagents |
| CN112566925A (en) | 2018-08-13 | 2021-03-26 | 先锋国际良种公司 | Novel insecticidal toxin receptors and methods of use |
| EP3983077A4 (en) * | 2019-06-17 | 2023-12-20 | Alnylam Pharmaceuticals, Inc. | Delivery of oligonucleotides to the striatum |
| DE102019212345B4 (en) | 2019-08-19 | 2024-02-08 | Robert Bosch Gmbh | Electromechanically driven brake pressure generator |
-
2022
- 2022-08-31 CN CN202280059222.3A patent/CN118302524A/en active Pending
- 2022-08-31 EP EP22783223.5A patent/EP4396348A2/en active Pending
- 2022-08-31 WO PCT/US2022/075740 patent/WO2023034849A2/en active Application Filing
- 2022-08-31 CA CA3228823A patent/CA3228823A1/en active Pending
- 2022-08-31 AR ARP220102359A patent/AR126939A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA3228823A1 (en) | 2023-03-09 |
| EP4396348A2 (en) | 2024-07-10 |
| CN118302524A (en) | 2024-07-05 |
| WO2023034849A3 (en) | 2023-05-19 |
| WO2023034849A2 (en) | 2023-03-09 |
| WO2023034849A8 (en) | 2024-03-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| UY37657A (en) | COMPOSITIONS THAT INCLUDE A DERIVATIVE OF ARIL OXADIAZOL FUNGICIDE | |
| CY1124422T1 (en) | PYRAZOLE COMPOUNDS AND METHOD FOR THE PREPARATION AND USE OF THE COMPOUNDS | |
| CO2018005384A2 (en) | Oxadiazoles substituted to fight phytopathogenic fungi | |
| AR062187A1 (en) | INSECTICIATED COMPOSITION | |
| CO2019014948A2 (en) | Fungicidal compositions | |
| CO2021015049A2 (en) | Fungicidal compositions | |
| CO2024004617A2 (en) | An agrochemical combination | |
| AR126939A1 (en) | HIGH MOLECULAR WEIGHT MODIFIED dsRNA COMPOSITIONS RELATED TO BIOCIDES | |
| CO2020015030A2 (en) | Fungicidal composition | |
| UY38798A (en) | COMBINATIONS, MIXTURES AND FUNGICIDAL COMPOSITIONS AND USES OF THEM | |
| CL2018002634A1 (en) | Use of non-prolific cyclic amino acids to increase the tolerance of plants to osmotic stress conditions. | |
| BR112019001158A2 (en) | succinate forms and bruton tyrosine kinase inhibitor compositions | |
| CO2023006911A2 (en) | fungicidal compositions | |
| CO2022016858A2 (en) | fungicidal compositions | |
| UY37029A (en) | COMPOSITIONS AND METHODS TO REDUCE NEMATODES | |
| ECSP22040087A (en) | STABLE COMPOSITIONS OF FUNGICIDE COMPOUNDS | |
| CR20190362A (en) | Pest attractant compositions comprising theaspirane | |
| Silva et al. | Rural education in a historiographical perpspective in journals on the History of Education | |
| Gabriel et al. | Contact-independent microbial control using biologically-derived volatile organic compounds | |
| Siedlecki et al. | Hidden in a fortress?-a distinctive Mucoromycota community of red wood ants’ mounds | |
| AR103922A1 (en) | MICROBICIDE COMPOSITION | |
| Lima et al. | Structure and forest dynamics under the effect of timber management in FLONA Tapajos. | |
| Peruch et al. | Citric biomass and fungicides associated to leaf removal in yellow sigatoka disease control for banana" Prata". | |
| Custódio et al. | Ataque aos bens culturais: prejuízo histórico-cultural causado no episódio de 8 de janeiro de 2023, em Brasília | |
| UY39252A (en) | FUNGICIDE COMPOSITIONS AND THEIR USE IN AGRICULTURE OR HORTICULTURE |