AR126447A1 - INHIBIDORES DE PI3Ka Y MÉTODOS DE USO DE LOS MISMOS - Google Patents
INHIBIDORES DE PI3Ka Y MÉTODOS DE USO DE LOS MISMOSInfo
- Publication number
- AR126447A1 AR126447A1 ARP220101841A ARP220101841A AR126447A1 AR 126447 A1 AR126447 A1 AR 126447A1 AR P220101841 A ARP220101841 A AR P220101841A AR P220101841 A ARP220101841 A AR P220101841A AR 126447 A1 AR126447 A1 AR 126447A1
- Authority
- AR
- Argentina
- Prior art keywords
- methods
- pi3ka
- compounds
- compositions
- disclosure
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000011664 signaling Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente divulgación se refiere a nuevos compuestos y composiciones farmacéuticas de los mismos, y a métodos para inhibir la actividad de las enzimas PI3Ka con los compuestos y composiciones de la divulgación. La presente divulgación se refiere, además, pero sin limitación, a métodos para tratar trastornos asociados con la señalización de PI3Ka con los compuestos y las composiciones de la divulgación.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163203220P | 2021-07-13 | 2021-07-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR126447A1 true AR126447A1 (es) | 2023-10-11 |
Family
ID=84919704
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP220101841A AR126447A1 (es) | 2021-07-13 | 2022-07-13 | INHIBIDORES DE PI3Ka Y MÉTODOS DE USO DE LOS MISMOS |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP4370124A1 (es) |
| CN (1) | CN117881683A (es) |
| AR (1) | AR126447A1 (es) |
| AU (1) | AU2022311952A1 (es) |
| CA (1) | CA3225285A1 (es) |
| TW (1) | TW202317579A (es) |
| WO (1) | WO2023288242A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117683036A (zh) * | 2022-09-09 | 2024-03-12 | 上海璎黎药业有限公司 | 一种含氮杂环化合物、其药物组合物及应用 |
| WO2024097721A1 (en) | 2022-11-02 | 2024-05-10 | Petra Pharma Corporation | Targeting allosteric and orthosteric pockets of phosphoinositide 3-kinase (pi3k) for the treatment of disease |
| WO2024118810A1 (en) * | 2022-11-30 | 2024-06-06 | Protego Biopharma, Inc. | Cyclic pyrazole diamide ire1/xbp1s activators |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3368B1 (ar) * | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
| PL3865484T3 (pl) * | 2015-07-07 | 2024-04-22 | H. Lundbeck A/S | Inhibitor PDE9 ze szkieletem imidazopirazynonowym do leczenia chorób obwodowych |
| CA3082976A1 (en) * | 2017-11-24 | 2019-05-31 | Sumitomo Dainippon Pharma Co., Ltd. | 6,7-dihydropyrazolo[1,5-a]pyrazinone derivative and medical use thereof |
| WO2020257790A1 (en) * | 2019-06-20 | 2020-12-24 | University Of Kentucky Research Foundation | Pharmaceutically active pyrazolo-pyridone modulators of dcn1/2-mediated cullin neddylation |
-
2022
- 2022-07-13 CA CA3225285A patent/CA3225285A1/en active Pending
- 2022-07-13 EP EP22843033.6A patent/EP4370124A1/en active Pending
- 2022-07-13 CN CN202280059784.8A patent/CN117881683A/zh active Pending
- 2022-07-13 AU AU2022311952A patent/AU2022311952A1/en active Pending
- 2022-07-13 TW TW111126296A patent/TW202317579A/zh unknown
- 2022-07-13 WO PCT/US2022/073672 patent/WO2023288242A1/en active Application Filing
- 2022-07-13 AR ARP220101841A patent/AR126447A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN117881683A (zh) | 2024-04-12 |
| EP4370124A1 (en) | 2024-05-22 |
| TW202317579A (zh) | 2023-05-01 |
| CA3225285A1 (en) | 2023-01-19 |
| WO2023288242A1 (en) | 2023-01-19 |
| AU2022311952A1 (en) | 2024-01-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CL2023002276A1 (es) | Inhibidores de cdk y métodos de uso de estos | |
| CL2021002882A1 (es) | Inhibidores de fgfr y métodos de uso de los mismos | |
| CL2022002985A1 (es) | Inhibidores de pi3k y métodos de uso de los mismos | |
| AR126447A1 (es) | INHIBIDORES DE PI3Ka Y MÉTODOS DE USO DE LOS MISMOS | |
| CL2022000751A1 (es) | Inhibidores de la fosfatasa shp2 y métodos para su uso (divisional de la solicitud no. 202002419) | |
| ECSP22087539A (es) | Inhibidores de kras tricíclicos fusionados | |
| MX2021010625A (es) | Derivado de pirazina y aplicacion del mismo en la inhibicion de shp2. | |
| CL2020000856A1 (es) | Isoquinolinas como inhibidores de hpk1. (divisional solicitud 201902734) | |
| CL2020002146A1 (es) | Derivados de n-(fenil)-2-(fenil)pirimidina-4-carboxamida y compuestos relacionados como inhibidores hpki para tratar el cáncer. | |
| CO2020014217A2 (es) | Moduladores de enzimas modificadoras de metilo, composiciones y usos de estos | |
| DOP2021000234A (es) | Pirroles triciclicos condensados como moduladores de alfa-1 antitripsina | |
| BR112022010754A2 (pt) | Análogos de rapamicina e usos dos mesmos | |
| DOP2023000145A (es) | Inhibidores de cdk2 y métodos de uso de los mismos | |
| CO2024001285A2 (es) | Compuestos tricíclicos como inhibidores de kras | |
| EA202190462A1 (ru) | Индольные и азаиндольные ингибиторы ферментов pad | |
| UY39588A (es) | Pirazolotiazol carboxamidas y usos de estas como inhibidores de pdgfr | |
| CL2021003292A1 (es) | Inhibidores de prmt5. | |
| WO2023220131A3 (en) | PI3Kα INHIBITORS AND METHODS OF USE THEREOF | |
| EA201990109A1 (ru) | Митохондриальные ингибиторы для лечения пролиферативных нарушений | |
| CO2022017969A2 (es) | Compuestos de imidazopiridazina con actividad como inhibidores de alk2 | |
| AR124860A1 (es) | Inhibidores de cdk y métodos de uso de estos | |
| BR112023015721A2 (pt) | Derivados tricíclicos úteis como inibidores de parp7 | |
| EA202192517A1 (ru) | Ингибиторы fgfr и способы их применения | |
| AR126389A1 (es) | Compuestos tricíclicos como inhibidores de kras | |
| MX2022004565A (es) | Tienopirimidonas como inhibidores de trpa1. |