AR125211A1 - TRISPECIFIC ANTIBODIES DIRECTED TO CD79B, CD20 AND CD3 - Google Patents

TRISPECIFIC ANTIBODIES DIRECTED TO CD79B, CD20 AND CD3

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Publication number
AR125211A1
AR125211A1 ARP220100699A ARP220100699A AR125211A1 AR 125211 A1 AR125211 A1 AR 125211A1 AR P220100699 A ARP220100699 A AR P220100699A AR P220100699 A ARP220100699 A AR P220100699A AR 125211 A1 AR125211 A1 AR 125211A1
Authority
AR
Argentina
Prior art keywords
antibodies
antigen
binding fragments
cd79b
multispecific
Prior art date
Application number
ARP220100699A
Other languages
Spanish (es)
Inventor
Rajkumar Ganesan
Anna Kuchnio
Cassandra L Lowenstein
Ulrike Philippar
Sanjaya Singh
Nele Vloemans
Danlin Yang
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of AR125211A1 publication Critical patent/AR125211A1/en

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  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

En la presente descripción se proporcionan anticuerpos multiespecíficos, que incluyen anticuerpos triespecíficos que se unen a CD79b, CD20 y CD3, y anticuerpos biespecíficos que se unen a CD79b y CD3, y fragmentos de unión al antígeno multiespecíficos de estos. Además, se describen polinucleótidos relacionados que tienen la capacidad de codificar anticuerpos multiespecíficos o fragmentos de unión al antígeno multiespecíficos proporcionados, células que expresan anticuerpos multiespecíficos o fragmentos de unión al antígeno multiespecíficos proporcionados, así como vectores asociados y anticuerpos multiespecíficos o fragmentos de unión al antígeno multiespecíficos marcados de forma detectable. Adicionalmente, se describen métodos para producir y usar los anticuerpos multiespecíficos y los fragmentos de unión al antígeno multiespecíficos proporcionados. En la presente descripción se proporcionan además anticuerpos aislados que se unen a CD79b y fragmentos de unión al antígeno de estos. Además, se describen polinucleótidos relacionados que tienen la capacidad de codificar anticuerpos específicos para CD79b o fragmentos de unión al antígeno proporcionados, células que expresan los anticuerpos específicos para CD79b o fragmentos de unión al antígeno proporcionados, así como vectores asociados y anticuerpos específicos para CD79b o fragmentos de unión al antígeno etiquetados de forma detectable. Adicionalmente, se describen métodos para producir y usar los anticuerpos específicos para CD79b y los fragmentos de unión al antígeno proporcionados.Multispecific antibodies are provided herein, including trispecific antibodies that bind CD79b, CD20, and CD3, and bispecific antibodies that bind CD79b and CD3, and multispecific antigen-binding fragments thereof. In addition, related polynucleotides having the ability to encode multispecific antibodies or provided multispecific antigen-binding fragments, cells expressing multispecific antibodies or provided multispecific antigen-binding fragments, as well as associated vectors and multispecific antibodies or antigen-binding fragments are disclosed. detectably labeled multispecies. Additionally, methods for producing and using the provided multispecific antibodies and multispecific antigen-binding fragments are described. Further provided herein are isolated antibodies that bind to CD79b and antigen-binding fragments thereof. In addition, related polynucleotides are described which have the ability to encode antibodies specific for CD79b or provided antigen-binding fragments, cells expressing the antibodies specific for CD79b or provided antigen-binding fragments, as well as associated vectors and antibodies specific for CD79b or provided. detectably labeled antigen-binding fragments. Additionally, methods for producing and using the provided CD79b-specific antibodies and antigen-binding fragments are described.

ARP220100699A 2021-03-24 2022-03-23 TRISPECIFIC ANTIBODIES DIRECTED TO CD79B, CD20 AND CD3 AR125211A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US202163165501P 2021-03-24 2021-03-24

Publications (1)

Publication Number Publication Date
AR125211A1 true AR125211A1 (en) 2023-06-21

Family

ID=86988848

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP220100699A AR125211A1 (en) 2021-03-24 2022-03-23 TRISPECIFIC ANTIBODIES DIRECTED TO CD79B, CD20 AND CD3

Country Status (1)

Country Link
AR (1) AR125211A1 (en)

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