AR117014A1 - Proceso para la síntesis de lactamas - Google Patents

Proceso para la síntesis de lactamas

Info

Publication number
AR117014A1
AR117014A1 ARP190103262A ARP190103262A AR117014A1 AR 117014 A1 AR117014 A1 AR 117014A1 AR P190103262 A ARP190103262 A AR P190103262A AR P190103262 A ARP190103262 A AR P190103262A AR 117014 A1 AR117014 A1 AR 117014A1
Authority
AR
Argentina
Prior art keywords
lactam
product
ammonia
synthesis
salt
Prior art date
Application number
ARP190103262A
Other languages
English (en)
Inventor
David William Thornthwaite
Neil James Parry
Panagiotis Kotsakis
David Anthony Dawkins
Original Assignee
Unilever Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unilever Nv filed Critical Unilever Nv
Publication of AR117014A1 publication Critical patent/AR117014A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/38—2-Pyrrolones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members

Abstract

Un proceso para la síntesis de lactamas adecuado para su uso en composiciones antimicrobianas, antibiopelícula y bacteriostáticas. Reivindicación 1: Un proceso para la síntesis de una lactama, caracterizado porque comprende las etapas de: (a) una condensación de aldol entre un iniciador de acetona y ácido glioxálico; (b) tratar el o los productos de la etapa (a) con cloruro de tionilo; (c) hacer reaccionar el producto de la etapa (b) con amoníaco o una amina primaria, o una sal del mismo, para proporcionar una lactama; en donde la etapa (c) implica la adición de amoníaco o una amina primaria, o sal del mismo, al producto de la etapa (b). Reivindicación 2: El proceso de acuerdo con la reivindicación 1, caracterizado porque la etapa (c) usa amoníaco, opcionalmente en donde la etapa (c) usa amoníaco acuoso concentrado. Reivindicación 3: El proceso de acuerdo con cualquier reivindicación precedente, caracterizado porque el proceso comprende además: (d) deshidratación del producto de lactama de la etapa (c) para proporcionar una lactama que tiene un grupo exometileno.
ARP190103262A 2018-11-08 2019-11-07 Proceso para la síntesis de lactamas AR117014A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP18205110 2018-11-08

Publications (1)

Publication Number Publication Date
AR117014A1 true AR117014A1 (es) 2021-07-07

Family

ID=64267631

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP190103262A AR117014A1 (es) 2018-11-08 2019-11-07 Proceso para la síntesis de lactamas

Country Status (7)

Country Link
US (1) US11401240B2 (es)
EP (1) EP3877363B1 (es)
CN (1) CN112969685B (es)
AR (1) AR117014A1 (es)
BR (1) BR112021008900A2 (es)
WO (1) WO2020094403A1 (es)
ZA (1) ZA202102742B (es)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9300894D0 (en) * 1992-02-07 1993-03-10 Zeneca Ltd Oxime derivatives
US5948917A (en) * 1996-03-26 1999-09-07 Nippon Soda Co., Ltd. 3-(isoxazol-5-yl)-substituted benzoic acid derivative and method for production thereof
US20030162924A1 (en) 2000-02-25 2003-08-28 Marcel Vos Metal-free binders for self-polishing antifouling paints
WO2007030389A2 (en) 2005-09-06 2007-03-15 Novus International Inc. Marine antifouling coating compositions
CN101410372A (zh) * 2006-01-24 2009-04-15 拜欧希格诺有限公司 新内酰胺类
CN107920977A (zh) * 2015-08-20 2018-04-17 荷兰联合利华有限公司 内酰胺组合物
US10888087B2 (en) 2015-08-20 2021-01-12 Conopco, Inc. Lactam solubility
EP3337451B1 (en) 2015-08-20 2018-12-26 Unilever PLC Improved lactam solubility
WO2018091222A1 (en) 2016-11-17 2018-05-24 Unilever Plc Lactam compositions
CN108658973A (zh) 2017-03-28 2018-10-16 中国海洋大学 一种内酰胺类化合物及其制备方法和作为海洋防污剂的用途

Also Published As

Publication number Publication date
EP3877363A1 (en) 2021-09-15
CN112969685B (zh) 2023-12-08
EP3877363B1 (en) 2023-07-26
US20210395199A1 (en) 2021-12-23
WO2020094403A1 (en) 2020-05-14
ZA202102742B (en) 2022-10-26
CN112969685A (zh) 2021-06-15
BR112021008900A2 (pt) 2021-08-10
US11401240B2 (en) 2022-08-02

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