AR112284A1 - Combinación que comprende palbociclib y ácido 6-(2,4-diclorofenil)-5-[4-[(3s)-1-(3-fluoropropil)pirrolidin-3-il]oxifenil]-8,9-dihidro-7h-benzo[7]anuleno-2-carboxílico - Google Patents
Combinación que comprende palbociclib y ácido 6-(2,4-diclorofenil)-5-[4-[(3s)-1-(3-fluoropropil)pirrolidin-3-il]oxifenil]-8,9-dihidro-7h-benzo[7]anuleno-2-carboxílicoInfo
- Publication number
- AR112284A1 AR112284A1 ARP180102058A AR112284A1 AR 112284 A1 AR112284 A1 AR 112284A1 AR P180102058 A ARP180102058 A AR P180102058A AR 112284 A1 AR112284 A1 AR 112284A1
- Authority
- AR
- Argentina
- Prior art keywords
- acid
- annulene
- fluoropropyl
- pyrrolidin
- benzo
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Se proporcionan en la presente memoria una combinación de palbociclib y del ácido 6-(2,4-diclorofenil)-5-[4-[(3S)-1-(3-fluoropropil)pirrolidin-3-il]oxifenil]-8,9-dihidro-7H-benzo[7]anuleno-2-carboxílico o una de sus sales farmacéuticamente aceptables, una composición farmacéutica que contiene dicha combinación, y sus usos terapéuticos, en particular para el tratamiento del cáncer, incluyendo el cáncer de mama. Reivindicación 5: Una composición farmacéutica que comprende ácido 6-(2,4-diclorofenil)-5-[4-[(3S)-1-(3-fluoropropil)pirrolidin-3-il]oxifenil]-8,9-dihidro-7H-benzo[7]anuleno-2-carboxílico, o una de sus sales farmacéuticamente aceptables, y palbociclib, y al menos un excipiente farmacéuticamente aceptable. Reivindicación 9: Compuesto ácido 6-(2,4-diclorofenil)-5-[4-[(3S)-1-(3-fluoropropil)pirrolidin-3-il]oxifenil]-8,9-dihidro-7H-benzo[7]anuleno-2-carboxílico o una de sus sales farmacéuticamente aceptables para usar en el tratamiento de cáncer por coadministración con palbociclib.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762536121P | 2017-07-24 | 2017-07-24 | |
EP17305998.1A EP3434272A1 (en) | 2017-07-25 | 2017-07-25 | Combination comprising palbociclib and 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylic acid |
Publications (1)
Publication Number | Publication Date |
---|---|
AR112284A1 true AR112284A1 (es) | 2019-10-09 |
Family
ID=59569252
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP180102058 AR112284A1 (es) | 2017-07-24 | 2018-07-24 | Combinación que comprende palbociclib y ácido 6-(2,4-diclorofenil)-5-[4-[(3s)-1-(3-fluoropropil)pirrolidin-3-il]oxifenil]-8,9-dihidro-7h-benzo[7]anuleno-2-carboxílico |
Country Status (29)
Country | Link |
---|---|
US (2) | US11260057B2 (es) |
EP (2) | EP3434272A1 (es) |
JP (1) | JP6741897B1 (es) |
KR (1) | KR20200031622A (es) |
CN (1) | CN111107851B (es) |
AR (1) | AR112284A1 (es) |
AU (1) | AU2018308871A1 (es) |
BR (1) | BR112020001398A2 (es) |
CA (1) | CA3070754A1 (es) |
CO (1) | CO2020000240A2 (es) |
DK (1) | DK3658147T3 (es) |
ES (1) | ES2906279T3 (es) |
HR (1) | HRP20212030T1 (es) |
HU (1) | HUE057271T2 (es) |
IL (1) | IL272166B2 (es) |
LT (1) | LT3658147T (es) |
MA (1) | MA49673B1 (es) |
MY (1) | MY195271A (es) |
PH (1) | PH12020500091A1 (es) |
PL (1) | PL3658147T3 (es) |
PT (1) | PT3658147T (es) |
RS (1) | RS62837B1 (es) |
RU (1) | RU2764116C2 (es) |
SG (1) | SG11202000367RA (es) |
SI (1) | SI3658147T1 (es) |
TW (1) | TWI768087B (es) |
UY (1) | UY37818A (es) |
WO (1) | WO2019020559A1 (es) |
ZA (1) | ZA202000145B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3434272A1 (en) * | 2017-07-25 | 2019-01-30 | Sanofi | Combination comprising palbociclib and 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylic acid |
MX2021002666A (es) * | 2018-09-07 | 2021-07-16 | Sanofi Sa | Proceso para la preparacion de 6-(2,4-diclorofenil)-5-[4-[(3s)-1-( 3-fluoropropil)pirrolidin-3-il]oxifenil]-8,9-dihidro-7h-benzo[7]a nulen-2-carboxilato de metilo. |
JP2022531898A (ja) * | 2019-05-09 | 2022-07-12 | サノフイ | 転移性または進行性***がん患者において使用するための6-(2,4-ジクロロフェニル)-5-[4-[(3s)-1-(3-フルオロプロピル)ピロリジン-3-イル]オキシフェニル]-8,9-ジヒドロ-7h-ベンゾ[7]アヌレン-2-カルボン酸 |
CA3160897A1 (en) * | 2019-12-09 | 2021-06-17 | Sanofi | Crystalline form of a 7h-benzo[7]annulene-2-carboxylic acid derivative |
TW202146007A (zh) * | 2020-02-27 | 2021-12-16 | 法商賽諾菲公司 | 包含阿培利司(alpelisib)與6-(2,4-二氯苯基)-5-[4-[(3s)-1-(3-氟丙基)吡咯啶-3-基]氧苯基]-8,9-二氫-7h-苯并[7]輪烯-2-羧酸之組合 |
IL303041A (en) * | 2020-11-23 | 2023-07-01 | Sanofi Sa | Combinations containing abamciclib, and 6-(2,4-DICHLOROPHENYL)-5-[4-[(3S)-1-(3-FLUOROPROPYL)PYRROLIDIN-3-YL]OXYPHENYL]-8,9-DIHYDRO-7H-BENZO [7]ANNULENE-2-CARBOXYLIC ACID |
TW202302084A (zh) * | 2021-03-02 | 2023-01-16 | 法商賽諾菲公司 | 以安森司坦和帕博西尼治療乳癌 |
TW202304425A (zh) * | 2021-04-12 | 2023-02-01 | 法商賽諾菲公司 | 包含瑞博西尼和安森司群(amcenestrant)的組合 |
KR20230130261A (ko) | 2022-03-03 | 2023-09-12 | 인하대학교 산학협력단 | 암의 예방 또는 치료용 조성물 |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992015579A1 (en) | 1991-03-08 | 1992-09-17 | Rhone-Poulenc Rorer International (Holdings) Inc. | Multicyclic tertiary amine polyaromatic squalene synthetase inhibitors |
DE19833786A1 (de) | 1998-07-18 | 2000-01-20 | Schering Ag | Benzocycloheptene, Verfahren zu ihrer Herstellung, pharmazeutische Präparate, die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln |
EP1229036B1 (en) | 2001-01-24 | 2005-01-12 | CHIESI FARMACEUTICI S.p.A. | 2H-1-benzopyran derivatives, processes for their preparation and pharmaceutical compositions thereof |
WO2003016270A2 (en) | 2001-08-11 | 2003-02-27 | Bristol-Myers Squibb Pharma Company | Selective estrogen receptor modulators |
DK1501819T3 (da) | 2002-04-24 | 2011-01-10 | Merck Sharp & Dohme | Østrogenreceptormodulatorer |
JP4500689B2 (ja) | 2002-12-26 | 2010-07-14 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 選択的エストロゲン受容体モジュレーター |
CA2571587C (en) | 2004-06-25 | 2013-02-12 | Janssen Pharmaceutica, N.V. | Quaternary salt ccr2 antagonists |
JP5354775B2 (ja) | 2005-06-14 | 2013-11-27 | ベイラー ユニバーシティ | チューブリン結合活性を有するコンブレタスタチンアナログ |
US8127618B1 (en) | 2007-05-18 | 2012-03-06 | Pacesetter, Inc. | Implantable micro-electromechanical system sensor |
EP2048126A1 (de) | 2007-10-11 | 2009-04-15 | Bayer Schering Pharma AG | Benzocycloheptanderivate als selektiv wirksame Estrogene |
DE102010030538A1 (de) | 2010-06-25 | 2011-12-29 | Bayer Schering Pharma Aktiengesellschaft | 6,7-Dihydro-5H-benzo[7]annulen-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln |
GB2483736B (en) | 2010-09-16 | 2012-08-29 | Aragon Pharmaceuticals Inc | Estrogen receptor modulators and uses thereof |
JP5886873B2 (ja) | 2010-12-24 | 2016-03-16 | メルク・シャープ・エンド・ドーム・ベー・フェー | N置換アゼチジン誘導体 |
DE102011087987A1 (de) | 2011-12-08 | 2013-06-13 | Bayer Intellectual Property Gmbh | 6,7-Dihydro-5H-benzo[7]annulen-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln |
CA2861939A1 (en) | 2011-12-30 | 2013-07-04 | Centaurus Biopharma Co., Ltd. | Novel arylalkene derivatives and use thereof as selective estrogen receptor modulators |
CN102584687A (zh) | 2011-12-30 | 2012-07-18 | 北京赛林泰医药技术有限公司 | 作为选择性***受体调节剂的乙烯衍生物 |
HUE057061T2 (hu) * | 2013-08-14 | 2022-04-28 | Novartis Ag | Kombinációs terápia rák kezelésére |
WO2015028409A1 (de) | 2013-08-27 | 2015-03-05 | Bayer Pharma Aktiengesellschaft | 6,7-dihydro-5h-benzo[7]annulen-derivate, verfahren zu ihrer herstellung, pharmazeutische präparate die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln |
WO2016097072A1 (en) | 2014-12-18 | 2016-06-23 | F. Hoffmann-La Roche Ag | TETRAHYDRO-PYRIDO[3,4-b]INDOLE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF |
EP3233828B1 (en) | 2014-12-18 | 2020-03-04 | F. Hoffmann-La Roche AG | Estrogen receptor modulators and uses thereof |
WO2016146591A1 (en) * | 2015-03-16 | 2016-09-22 | Astrazeneca Ab | Combination treatment |
AR104068A1 (es) * | 2015-03-26 | 2017-06-21 | Hoffmann La Roche | Combinaciones de un compuesto inhibidor de fosfoinosítido 3-cinasa y un compuesto inhibidor de cdk4/6 para el tratamiento del cáncer |
IL255148B2 (en) * | 2015-04-29 | 2023-04-01 | Radius Pharmaceuticals Inc | 1901 rad for use in a method to inhibit a cancerous growth or induce tumor regression in a patient who is resistant to the drug and/or has cancer positive for an estrogen receptor alpha mutation |
CN106924210A (zh) * | 2015-12-29 | 2017-07-07 | 北京新领先医药科技发展有限公司 | 一种含有帕布昔利布的胶囊剂及其制备方法 |
JP6425852B1 (ja) | 2016-02-15 | 2018-11-21 | サノフイSanofi | エストロゲン受容体調節剤としての6,7−ジヒドロ−5h−ベンゾ[7]アヌレン誘導体 |
WO2018091153A1 (en) | 2016-11-17 | 2018-05-24 | Sanofi | Novel substituted n-(3-fluoropropyl)-pyrrolidine compounds, processes for their preparation and therapeutic uses thereof |
EP3434272A1 (en) * | 2017-07-25 | 2019-01-30 | Sanofi | Combination comprising palbociclib and 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylic acid |
MX2021002666A (es) | 2018-09-07 | 2021-07-16 | Sanofi Sa | Proceso para la preparacion de 6-(2,4-diclorofenil)-5-[4-[(3s)-1-( 3-fluoropropil)pirrolidin-3-il]oxifenil]-8,9-dihidro-7h-benzo[7]a nulen-2-carboxilato de metilo. |
CA3119742A1 (en) * | 2018-11-16 | 2020-05-22 | Arqule, Inc. | Pharmaceutical combination for treatment of cancer |
-
2017
- 2017-07-25 EP EP17305998.1A patent/EP3434272A1/en not_active Ceased
-
2018
- 2018-07-23 RS RS20220068A patent/RS62837B1/sr unknown
- 2018-07-23 WO PCT/EP2018/069901 patent/WO2019020559A1/en unknown
- 2018-07-23 HU HUE18740615A patent/HUE057271T2/hu unknown
- 2018-07-23 IL IL272166A patent/IL272166B2/en unknown
- 2018-07-23 ES ES18740615T patent/ES2906279T3/es active Active
- 2018-07-23 HR HRP20212030TT patent/HRP20212030T1/hr unknown
- 2018-07-23 BR BR112020001398-6A patent/BR112020001398A2/pt active Search and Examination
- 2018-07-23 LT LTEPPCT/EP2018/069901T patent/LT3658147T/lt unknown
- 2018-07-23 KR KR1020207002003A patent/KR20200031622A/ko not_active Application Discontinuation
- 2018-07-23 EP EP18740615.2A patent/EP3658147B1/en active Active
- 2018-07-23 MY MYPI2020000179A patent/MY195271A/en unknown
- 2018-07-23 PL PL18740615T patent/PL3658147T3/pl unknown
- 2018-07-23 MA MA49673A patent/MA49673B1/fr unknown
- 2018-07-23 CA CA3070754A patent/CA3070754A1/en active Pending
- 2018-07-23 SI SI201830528T patent/SI3658147T1/sl unknown
- 2018-07-23 US US16/634,089 patent/US11260057B2/en active Active
- 2018-07-23 DK DK18740615.2T patent/DK3658147T3/da active
- 2018-07-23 RU RU2020107416A patent/RU2764116C2/ru active
- 2018-07-23 SG SG11202000367RA patent/SG11202000367RA/en unknown
- 2018-07-23 AU AU2018308871A patent/AU2018308871A1/en not_active Abandoned
- 2018-07-23 PT PT187406152T patent/PT3658147T/pt unknown
- 2018-07-23 CN CN201880048755.5A patent/CN111107851B/zh active Active
- 2018-07-23 JP JP2020503737A patent/JP6741897B1/ja active Active
- 2018-07-24 TW TW107125442A patent/TWI768087B/zh active
- 2018-07-24 UY UY0001037818A patent/UY37818A/es not_active Application Discontinuation
- 2018-07-24 AR ARP180102058 patent/AR112284A1/es unknown
-
2020
- 2020-01-09 ZA ZA2020/00145A patent/ZA202000145B/en unknown
- 2020-01-10 PH PH12020500091A patent/PH12020500091A1/en unknown
- 2020-01-13 CO CONC2020/0000240A patent/CO2020000240A2/es unknown
-
2022
- 2022-01-19 US US17/579,187 patent/US20220362248A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR112284A1 (es) | Combinación que comprende palbociclib y ácido 6-(2,4-diclorofenil)-5-[4-[(3s)-1-(3-fluoropropil)pirrolidin-3-il]oxifenil]-8,9-dihidro-7h-benzo[7]anuleno-2-carboxílico | |
CO2019007810A2 (es) | Compuestos de amino-triazolopiridina y su uso en el tratamiento del cáncer | |
CO2019015090A2 (es) | Métodos de tratamiento para la fibrosis cística | |
CU20160109A7 (es) | Compuestos de indazol como inhibidores de irak4 | |
NI201700101A (es) | Composiciones farmacéuticas que comprenden n - (3, 5 - dimetoxifenil) - n'- (1-metiletil) - n - [3-(1-metil-1h-pirazol-4-il) quinoxalina-6-il]etano-1,2-diamina | |
CO2018002060A2 (es) | Compuestos farmacéuticos | |
CL2017000469A1 (es) | Derivados de tetrahidronaftaleno que inhiben la proteina mcl-1 | |
CL2019000056A1 (es) | Sales y formas cristalinas del ácido 2-(3r,5r,6s)-5-(3-clorofenil)-6-(4-clorofenil)-1-(s)-1(isopropilsufonil)-3-metilbutan-2-il)-3-metil-2-oxopiperidin-3-il)acético; proceso de preparación de una de las sales; composición farmacéutica que comprende; útiles para tratar cáncer. (solicitud divisional 201503589) | |
CR20150628A (es) | Derivados de la pirazolopirrolidina y su uso en el tratamiento de enfermedades | |
CO2018004857A2 (es) | Derivados de dihidroimidazopirazinona usados en el tratamiento del cáncer | |
AR059948A1 (es) | Formas farmaceuticas y metodos de tratamiento que usan un inhibidor de la tirosinacinasa | |
CL2015002608A1 (es) | Compuesto de amino-pirazol y usos medicinales relacionados. | |
GT200600096A (es) | Composicion farmaceutica para el tratamiento del cancer | |
CR20140086A (es) | Tratamientos de combinación para hepatitis c | |
AR103680A1 (es) | Inhibidores selectivos de bace1 | |
CO6491060A2 (es) | Compuestos y composiciones para el tratamiento de enfermedades parasitarias | |
NI201800071A (es) | Compuestos de isoindol | |
DOP2016000254A (es) | Formulaciones farmeceuticas de inhibidor de la quinasa pan-raf, procedimientos para su preparacion, y metodos de uso. | |
AR104068A1 (es) | Combinaciones de un compuesto inhibidor de fosfoinosítido 3-cinasa y un compuesto inhibidor de cdk4/6 para el tratamiento del cáncer | |
AR094707A1 (es) | Compuesto de quinazolin-4-amina, composición farmacéutica que lo comprende y su uso para el tratamiento de una enfermedad mediada por la quinasa rip2 | |
AR128459A2 (es) | Composición farmacéutica sólida comprimida por rodillo y el proceso para su fabricación | |
CL2018000430A1 (es) | Compuesto de hidroxitriazina y uso médico relacionado. | |
CO2022002731A2 (es) | Formas en estado sólido de (s)-2-(((s)-6,8-diflúor-1,2,3,4-tetrahidronaftalen-2-il)amino)-n-(1-(2-metil-1-(neopentilamino)propan-2-il)-1h-imidazol-4-il)pentanamida y usos de la misma | |
AR109168A1 (es) | Sales de derivados de 2,6-dimetilpirimidona y sus usos | |
BR112015023078A2 (pt) | inibidores de pirrolopirimindina cdk9 quinase |