AR110680A1 - BISPECIFIC ANTIBODIES THAT JOIN COAGULATION FACTOR IX AND COAGULATION FACTOR X - Google Patents
BISPECIFIC ANTIBODIES THAT JOIN COAGULATION FACTOR IX AND COAGULATION FACTOR XInfo
- Publication number
- AR110680A1 AR110680A1 ARP170103261A ARP170103261A AR110680A1 AR 110680 A1 AR110680 A1 AR 110680A1 AR P170103261 A ARP170103261 A AR P170103261A AR P170103261 A ARP170103261 A AR P170103261A AR 110680 A1 AR110680 A1 AR 110680A1
- Authority
- AR
- Argentina
- Prior art keywords
- fxz
- antibodies
- fixa
- coagulation factor
- binding portion
- Prior art date
Links
Abstract
La presente descripción proporciona anticuerpos que se unen selectivamente a formas específicas de factores de coagulación, en particular, anticuerpos que se unen específicamente al factor IX activado (FIXa) en donde el anticuerpo anti-FIXa o una porción de unión a antígeno del mismo se une preferentemente a FIXa en presencia de FIXa y zimógeno de factor IX (FIXz), y anticuerpos que se unen específicamente al zimógeno de factor X (FXz) en donde el anticuerpo anti-FXz o la porción de unión a antígeno del mismo se une preferentemente a FXz en presencia de FXz y factor X activado (FXa). También se proporcionan moléculas biespecíficas (por ejemplo, anticuerpos) que comprenden, por ejemplo, un anticuerpo anti-FIXa o una porción de unión a antígeno del mismo y/o un anticuerpo anti-FXz o una porción de unión. a antígeno del mismo. La descripción también. proporciona composiciones que codifican los anticuerpos descritos y moléculas, vectores, células, composiciones farmacéuticas y de diagnóstico, kits, métodos de fabricación, métodos de uso e inmunoconjugados biespecíficos.The present disclosure provides antibodies that selectively bind to specific forms of coagulation factors, in particular, antibodies that specifically bind to activated factor IX (FIXa) wherein the anti-FIXa antibody or an antigen-binding portion thereof binds. preferably to FIXa in the presence of FIXa and factor IX zymogen (FIXz), and antibodies that specifically bind to the factor X zymogen (FXz) wherein the anti-FXz antibody or the antigen binding portion thereof preferably binds to FXz in the presence of FXz and activated factor X (FXa). Bispecific molecules are also provided (eg, antibodies) comprising, for example, an anti-FIXa antibody or an antigen binding portion thereof and / or an anti-FXz antibody or a binding portion. to antigen thereof. The description too. provides compositions encoding the described antibodies and molecules, vectors, cells, pharmaceutical and diagnostic compositions, kits, manufacturing methods, use methods and bispecific immunoconjugates.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662425921P | 2016-11-23 | 2016-11-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR110680A1 true AR110680A1 (en) | 2019-04-24 |
Family
ID=66326302
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP170103261A AR110680A1 (en) | 2016-11-23 | 2017-11-23 | BISPECIFIC ANTIBODIES THAT JOIN COAGULATION FACTOR IX AND COAGULATION FACTOR X |
Country Status (1)
| Country | Link |
|---|---|
| AR (1) | AR110680A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116333145A (en) * | 2023-04-14 | 2023-06-27 | 北京基科晟斯医药科技有限公司 | Antibodies that bind activated factor IX |
-
2017
- 2017-11-23 AR ARP170103261A patent/AR110680A1/en unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116333145A (en) * | 2023-04-14 | 2023-06-27 | 北京基科晟斯医药科技有限公司 | Antibodies that bind activated factor IX |
| CN116333145B (en) * | 2023-04-14 | 2023-11-07 | 北京基科晟斯医药科技有限公司 | Antibodies that bind activated factor IX |
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