AR109293A1 - IRN AGENTS FOR INFECTION WITH THE HEPATITIS B VIRUS - Google Patents

IRN AGENTS FOR INFECTION WITH THE HEPATITIS B VIRUS

Info

Publication number
AR109293A1
AR109293A1 ARP170102210A ARP170102210A AR109293A1 AR 109293 A1 AR109293 A1 AR 109293A1 AR P170102210 A ARP170102210 A AR P170102210A AR P170102210 A ARP170102210 A AR P170102210A AR 109293 A1 AR109293 A1 AR 109293A1
Authority
AR
Argentina
Prior art keywords
hbv
agents
hepatitis
disclosed
gene expression
Prior art date
Application number
ARP170102210A
Other languages
Spanish (es)
Inventor
Darren H Wakefield
David B Rozema
Lauren J Almeida
David L Lewis
Tao Pei
Bruce D Given
Christine I Wooddell
Rui Zhu
Zhen Li
Original Assignee
Arrowhead Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arrowhead Pharmaceuticals Inc filed Critical Arrowhead Pharmaceuticals Inc
Publication of AR109293A1 publication Critical patent/AR109293A1/en

Links

Landscapes

  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se dan a conocer composiciones y métodos para la inhibición de la expresión génica del virus de la Hepatitis B. Se dan a conocer agentes de interferencia de ARN (iARN) para la inhibición de la expresión de genes de virus de la Hepatitis B. Los agentes iARN VHB que se describen en la presente memoria pueden dirigirse a células, tales como hepatocitos, por ejemplo, utilizando ligandos de orientación conjugados. También se dan a conocer composiciones farmacéuticas que comprenden uno o más agentes iARN VHB opcionalmente con uno o más agentes terapéuticos adicionales. La entrega de los agentes iARN VHB descritos al hígado infectado in vivo permite la inhibición de la expresión génica de VHB y el tratamiento de enfermedades y condiciones asociadas con la infección por VHB.Compositions and methods for the inhibition of Hepatitis B virus gene expression are disclosed. RNA interference agents (RNAI) for the inhibition of Hepatitis B virus gene expression are disclosed. HBV iRNA described herein can be directed to cells, such as hepatocytes, for example, using conjugated targeting ligands. Pharmaceutical compositions comprising one or more HBV iRNA agents optionally with one or more additional therapeutic agents are also disclosed. The delivery of the HBV iRNA agents described to the infected liver in vivo allows inhibition of HBV gene expression and the treatment of diseases and conditions associated with HBV infection.

ARP170102210A 2016-08-04 2017-08-04 IRN AGENTS FOR INFECTION WITH THE HEPATITIS B VIRUS AR109293A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662370754P 2016-08-04 2016-08-04

Publications (1)

Publication Number Publication Date
AR109293A1 true AR109293A1 (en) 2018-11-14

Family

ID=64498538

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP170102210A AR109293A1 (en) 2016-08-04 2017-08-04 IRN AGENTS FOR INFECTION WITH THE HEPATITIS B VIRUS

Country Status (1)

Country Link
AR (1) AR109293A1 (en)

Similar Documents

Publication Publication Date Title
ECSP19015395A (en) IRNA AGENTS FOR INFECTION CAUSED BY HEPATITIS B VIRUS
WO2017027350A3 (en) Rnai therapy for hepatitis b virus infection
AR118719A2 (en) OLIGONUCLEOTIDES TO REDUCE THE EXPRESSION OF PD-L1
CY1125263T1 (en) COMPOSITIONS AND METHODS FOR INHIBITING GENE EXPRESSION OF LPA
CL2017000780A1 (en) Compositions and methods to silence the expression of the hepatitis b gene virus
PE20170262A1 (en) OLIGOMERS AND CONJUGATES OF OLIGOMERS
JOP20210208A1 (en) Rnai agents for hepatitis b virus infection
EA201692318A1 (en) COMPOSITIONS AND METHODS FOR INHIBITING THE EXPRESSION OF THE ALPHA-1-ANTITRIPSINE GENE
MX2015014816A (en) Microrna compounds and methods for modulating mir-122.
AR109293A1 (en) IRN AGENTS FOR INFECTION WITH THE HEPATITIS B VIRUS
BR112014030623A2 (en) composition, combination and their uses
EA201990427A1 (en) RNAi AGENTS AGAINST INFECTION CAUSED BY HEPATITIS B VIRUS
AR105611A1 (en) RNAi THERAPY FOR HEPATITIS B VIRUS INFECTION
AR113454A1 (en) IARN AGENTS AND COMPOSITIONS TO INHIBIT RECIPIENT EXPRESSION OF ASIALOGLYCOPROTEIN 1
EA202192191A1 (en) RNAi AGENTS AGAINST HEPATITIS B VIRUS INFECTION
CL2022002496A1 (en) iRNA agents for infection caused by hepatitis b virus (divisional application 201900278)
AR106227A1 (en) COMPOSITIONS AND METHODS TO INHIBIT THE GENE EXPRESSION OF THE APO APOLIPOPROTEIN GENE (a) (LPA)
AR102614A1 (en) HEPATITIS D VIRUS (HDV) RNAi COMPOSITIONS AND METHODS FOR USE