AR107973A1 - 6-hidroxi-4-oxo-1,4-dihidropirimidin-5-carboxamidas como agonista de apj - Google Patents
6-hidroxi-4-oxo-1,4-dihidropirimidin-5-carboxamidas como agonista de apjInfo
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- AR107973A1 AR107973A1 ARP170100736A ARP170100736A AR107973A1 AR 107973 A1 AR107973 A1 AR 107973A1 AR P170100736 A ARP170100736 A AR P170100736A AR P170100736 A ARP170100736 A AR P170100736A AR 107973 A1 AR107973 A1 AR 107973A1
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- Prior art keywords
- substituted
- independently selected
- case
- cr7r7
- alkyl
- Prior art date
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/557—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. orotic acid
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
Reivindicación 1: Un compuesto caracterizado porque tiene la fórmula (1), o un estereoisómero, un enantiómero, un diastereoisómero, un tautómero o una sal de aquel aceptable desde el punto de vista farmacéutico, en donde: alk es C₁₋₆ alquilo sustituido con 0 - 5 Rᵉ; el anillo B se selecciona independientemente de C₃₋₆ cicloalquilo, C₃₋₆ cicloalquenilo, arilo, carbociclilo bicíclico y heteroarilo de 6 miembros; R¹, en cada caso, se selecciona independientemente de H, halógeno, NO₂, -(CH₂)ₙORᵇ, (CH₂)ₙS(O)ₚRᶜ, -(CH₂)ₙC(=O)Rᵇ, -(CH₂)ₙNRᵃRᵃ, -(CH₂)ₙCN, -(CH₂)ₙC(=O)NRᵃRᵃ, -(CH₂)ₙNRᵃC(=O)Rᵇ, -(CH₂)ₙNRᵃC(=O)NRᵃRᵃ, -(CH₂)ₙNRᵃC(=O)ORᵇ, -(CH₂)ₙOC(=O)NRᵃRᵃ, -(CH₂)ₙC(=O)ORᵇ, -(CH₂)ₙS(O)ₚNRᵃRᵃ, -(CH₂)ₙNRᵃS(O)ₚNRᵃRᵃ, -(CH₂)ₙNRᵃS(O)ₚRᶜ, C₁₋₄ alquilo sustituido con 0 - 3 Rᵉ, -(CH₂)ₙ-C₃₋₆ carbociclilo sustituido con 0 - 3 Rᵉ y -(CH₂)ₙ-carbociclilo sustituido con 0 - 3 Rᵉ; R² se selecciona independientemente de C₁₋₅ alquilo sustituido con 0 - 3 Rᵉ; C₂₋₅ alquenilo sustituido con 0 - 3 Rᵉ, arilo sustituido con 0 - 3 Rᵉ, heteroarilo sustituido con 0 - 3 Rᵉ y C₃₋₆ cicloalquilo sustituido con 0 - 3 Rᵉ; siempre que, cuando R² es C₁₋₅ alquilo, el átomo de carbono y los grupos unidos a este, salvo el que está unido al anillo de pirimidina, se puedan reemplazar por O, N y S; R³ se selecciona independientemente de H y C₁₋₅ alquilo; R⁴ se selecciona independientemente de -(CR⁷R⁷)ₙ-R⁶, -(CR⁷R⁷)ₙOR⁶, -(CR⁷R⁷)ₙS(O)ₚR⁶, -(CR⁷R⁷)ₙC(=O)R⁶, -(CR⁷R⁷)ₙNRᵃR⁶, -(CR⁷R⁷)ₙNRᵃC(=O)R⁶, -(CR⁷R⁷)ₙS(O)ₚNRᵃR⁶ y -(CR⁷R⁷)ₙNRᵃS(O)ₚR⁶; de manera alternativa, R³ y R⁴, junto con el átomo de nitrógeno al que están unidos, forman un anillo heterocíclico o un anillo espiro heterocíclico que comprende átomos de carbono y 1 a 4 heteroátomos adicionales seleccionados de NR⁵ᵃ, O y S, y sustituidos con 0 - 5 R⁵; R⁵, en cada caso, se selecciona independientemente de OH, halógeno, -(CR⁷R⁷)ₙ-R⁶, -OR⁶, -S(O)ₚR⁶, -C(=O)R⁶, -NRᵃR⁶, -C(=O)NRᵃR⁶, -NRᵃC(=O)R⁶, -NRᵃC(=O)OR⁶, -OC(=O)NRᵃR⁶, -C(=O)OR⁶, -S(O)ₚNRᵃR⁶, -NRᵃS(O)ₚNRᵃR⁶ y -NRᵃS(O)ₚR⁶; R⁵ᵃ, en cada caso, se selecciona independientemente de -C(=O)OR⁶, C(=O)NRᵃR⁶, -(CR⁷R⁷)ₙ-R⁶, -C(=O)-R⁶ y -S(O)ₚR⁶; R⁶, en cada caso, se selecciona independientemente de -(CR⁷R⁷)ₙ-C₃₋₁₀ carbociclilo y -(CR⁷R⁷)ₙ-heteroarilo, cada uno sustituido con 0 - 3 R⁸; R⁷, en cada caso, se selecciona independientemente de H, C₁₋₄ alquilo y (CH₂)ₙ-C₃₋₁₂ carbociclilo sustituido con 0 - 3 Rᵉ; R⁸, en cada caso, se selecciona independientemente de H, halógeno, -(CH₂)ₙORᵇ, (CH₂)ₙS(O)ₚRᶜ, -(CH₂)ₙC(=O)Rᵇ, -(CH₂)ₙNRᵃRᵃ, (CH₂)ₙCN, -(CH=)ₙC(=O)NRᵃRᵃ, -(CH₂)ₙNRᵃC(=O)Rᵇ, -(CH₂)ₙNRᵃC(=O)NRᵃRᵃ, -(CH₂)ₙNRᵃC(=O)ORᵇ, -(CH₂)ₙOC(=O)NRᵃRᵃ, -(CH₂)ₙC(=O)ORᵇ, -(CH₂)ₙS(O)ₚNRᵃRᵃ, -(CH₂)ₙNRᵃS(O)ₚNRᵃRᵃ, -(CH₂)ₙNRᵃS(O)ₚRᶜ, C₁₋₅ alquilo sustituido con 0 - 3 Rᵉ, (CH₂)ₙ-C₃₋₆ carbociclilo sustituido con 0 - 3 Rᵉ y -(CH₂)ₙ-heterociclilo sustituido con 0 - 3 Rᵉ; Rᵃ, en cada caso, se selecciona independientemente de H, C₁₋₆ alquilo sustituido con 0 - 5 Rᵉ, C₂₋₆ alquenilo sustituido con 0 - 5 Rᵉ, C₂₋₆ alquinilo sustituido con 0 - 5 Rᵉ, -(CH₂)ₙ-C₃₋₁₀ carbociclilo sustituido con 0 - 5 Rᵉ y -(CH₂)ₙ-heterociclilo sustituido con 0 - 5 Rᵉ; o Rᵃ y Rᵃ, junto con el átomo de nitrógeno al que están unidos, forman un anillo heterocíclico sustituido con 0 - 5 Rᵉ; Rᵇ, en cada caso, se selecciona independientemente de H, C₁₋₆ alquilo sustituido con 0 - 5 Rᵉ, C₂₋₆ alquenilo sustituido con 0 - 5 Rᵉ, C₂₋₆ alquinilo sustituido con 0 - 5 Rᵉ, -(CH₂)ₙ-C₃₋₁₀ carbociclilo sustituido con 0 - 5 Rᵉ y -(CH₂)ₙ-heterociclilo sustituido con 0 - 5 Rᵉ; Rᶜ, en cada caso, se selecciona independientemente de C₁₋₆, alquilo sustituido con 0 - 5 Rᵉ, C₂₋₆ alquenilo sustituido con 0 - 5 Rᵉ, C₂₋₆ alquinilo sustituido con 0 - 5 Rᵉ, C₃₋₆ carbociclilo y heterociclilo; Rᵈ, en cada caso, se selecciona independientemente de H y C₁₋₄ alquilo sustituido con 0 - 5 Rᵉ; Rᵉ, en cada caso, se selecciona independientemente de F, Cl, Br, CN, NO₂, =O, CO₂H, C₁₋₆ alquilo sustituido con 0 - 5 Rᶠ, C₂₋₆ alquenilo, C₂₋₆ alquinilo, -(CH₂)ₙ-C₃₋₆ cicloalquilo, -(CH₂)ₙ-C₄₋₆, heterociclilo, -(CH₂)ₙ-arilo, -(CH₂)ₙ-heteroarilo, -(CH₂)ₙORᶠ, S(O)ₚRᶠ, C(=O)NRᶠRᶠ, NRᶠC(=O)Rᶠ, S(O)ₚNRᶠRᶠ, NRᶠS(O)ₚRᶠ, NRᶠC(=O)ORᶠ, OC(=O)NRᶠRᶠ y -(CH₂)ₙNRᶠRᶠ; Rᶠ, en cada caso, se selecciona independientemente de H, F, Cl, Br, CN, OH, C₁₋₅ alquilo (de manera óptima, sustituido con halógeno y OH), C₃₋₆ cicloalquilo y fenilo, o Rᶠ y Rᶠ, junto con el átomo de nitrógeno al que están unidos, forman un anillo heterocíclico opcionalmente sustituido con C₁₋₄ alquilo; n en cada caso, se selecciona independientemente de 0, 1, 2, 3 y 4; y p en cada caso, se selecciona independientemente de 0, 1 y 2.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US201662312780P | 2016-03-24 | 2016-03-24 |
Publications (1)
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AR107973A1 true AR107973A1 (es) | 2018-07-04 |
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ARP170100736A AR107973A1 (es) | 2016-03-24 | 2017-03-23 | 6-hidroxi-4-oxo-1,4-dihidropirimidin-5-carboxamidas como agonista de apj |
Country Status (22)
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US (2) | US10106528B2 (es) |
EP (1) | EP3433247B1 (es) |
JP (1) | JP6716711B2 (es) |
KR (1) | KR102433280B1 (es) |
CN (1) | CN109195963B (es) |
AR (1) | AR107973A1 (es) |
AU (1) | AU2017238504B2 (es) |
BR (1) | BR112018068341A2 (es) |
CA (1) | CA3018346A1 (es) |
CL (1) | CL2018002671A1 (es) |
CO (1) | CO2018011105A2 (es) |
EA (1) | EA037162B1 (es) |
ES (1) | ES2895124T3 (es) |
IL (1) | IL261904B (es) |
MA (1) | MA43761A (es) |
MX (1) | MX2018011194A (es) |
MY (1) | MY189454A (es) |
SG (1) | SG11201808163WA (es) |
TW (1) | TWI744301B (es) |
UY (1) | UY37169A (es) |
WO (1) | WO2017165640A1 (es) |
ZA (1) | ZA201806356B (es) |
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HUE045546T2 (hu) | 2015-06-03 | 2020-01-28 | Bristol Myers Squibb Co | 4-hidroxi-3-(heteroaril)piridin-2-on APJ agonisták felhasználásra cardiovascularis megbetegedések kezelésében |
SG10201908839QA (en) | 2015-10-14 | 2019-10-30 | Bristol Myers Squibb Co | 2,4-dihydroxy-nicotinamides as apj agonists |
ES2858312T3 (es) | 2015-12-04 | 2021-09-30 | Bristol Myers Squibb Co | Agonistas del receptor de apelina y métodos de uso |
PE20181487A1 (es) | 2015-12-16 | 2018-09-18 | Bristol Myers Squibb Co | Heteroarilhidroxipirimidinonas como agonistas del receptor de apelina (apj) |
WO2017165640A1 (en) * | 2016-03-24 | 2017-09-28 | Bristol-Myers Squibb Company | 6-hydroxy-4-oxo-1,4-dihydropyrimidine-5-carboxamides as apj agonists |
US9988369B2 (en) | 2016-05-03 | 2018-06-05 | Amgen Inc. | Heterocyclic triazole compounds as agonists of the APJ receptor |
ES2863903T3 (es) | 2016-06-14 | 2021-10-13 | Bristol Myers Squibb Co | 6-hidroxi-5-(fenil/heteroarilsulfonil)pirimidin-4(1H)-ona como agonistas de APJ |
JP6962941B2 (ja) | 2016-06-14 | 2021-11-05 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | Apj受容体アゴニストとしての4−ヒドロキシ−3−スルホニルピリジン−2(1h)−オン |
EP3526198B1 (en) | 2016-10-14 | 2020-08-12 | Bristol-Myers Squibb Company | 3-sulfonyl-5-aminopyridine-2,4-diol apj agonists |
WO2018093580A1 (en) | 2016-11-16 | 2018-05-24 | Amgen Inc. | Triazole pyridyl compounds as agonists of the apj receptor |
WO2018093577A1 (en) | 2016-11-16 | 2018-05-24 | Amgen Inc. | Cycloalkyl substituted triazole compounds as agonists of the apj receptor |
WO2018097945A1 (en) | 2016-11-16 | 2018-05-31 | Amgen Inc. | Heteroaryl-substituted triazoles as apj receptor agonists |
EP3541802A1 (en) | 2016-11-16 | 2019-09-25 | Amgen Inc. | Alkyl substituted triazole compounds as agonists of the apj receptor |
EP3541792B1 (en) | 2016-11-16 | 2020-12-23 | Amgen Inc. | Triazole furan compounds as agonists of the apj receptor |
US10906890B2 (en) | 2016-11-16 | 2021-02-02 | Amgen Inc. | Triazole phenyl compounds as agonists of the APJ receptor |
MA50509A (fr) | 2017-11-03 | 2021-06-02 | Amgen Inc | Agonistes de triazole fusionnés du récepteur apj |
EP3788037A1 (en) | 2018-05-01 | 2021-03-10 | Amgen Inc. | Substituted pyrimidinones as agonists of the apj receptor |
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- 2017-03-23 JP JP2018549910A patent/JP6716711B2/ja active Active
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- 2017-03-23 TW TW106109801A patent/TWI744301B/zh active
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IL261904A (en) | 2018-10-31 |
TW201736362A (zh) | 2017-10-16 |
WO2017165640A1 (en) | 2017-09-28 |
CN109195963A (zh) | 2019-01-11 |
MX2018011194A (es) | 2019-01-10 |
TWI744301B (zh) | 2021-11-01 |
EA201892123A1 (ru) | 2019-02-28 |
EP3433247A1 (en) | 2019-01-30 |
ZA201806356B (en) | 2021-05-26 |
MY189454A (en) | 2022-02-14 |
CO2018011105A2 (es) | 2018-10-22 |
US10590113B2 (en) | 2020-03-17 |
AU2017238504B2 (en) | 2021-05-27 |
US20170275272A1 (en) | 2017-09-28 |
KR20180129836A (ko) | 2018-12-05 |
CN109195963B (zh) | 2021-04-23 |
JP2019509319A (ja) | 2019-04-04 |
US10106528B2 (en) | 2018-10-23 |
SG11201808163WA (en) | 2018-10-30 |
ES2895124T3 (es) | 2022-02-17 |
EP3433247B1 (en) | 2021-09-08 |
EA037162B1 (ru) | 2021-02-12 |
BR112018068341A2 (pt) | 2019-01-15 |
IL261904B (en) | 2020-09-30 |
JP6716711B2 (ja) | 2020-07-01 |
KR102433280B1 (ko) | 2022-08-17 |
CL2018002671A1 (es) | 2019-01-25 |
AU2017238504A1 (en) | 2018-11-15 |
US20190002441A1 (en) | 2019-01-03 |
CA3018346A1 (en) | 2017-09-28 |
UY37169A (es) | 2017-09-29 |
MA43761A (fr) | 2021-05-05 |
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