AR106166A1 - Formulaciones de aminoácidos de liberación modificada administradas por vía oral - Google Patents
Formulaciones de aminoácidos de liberación modificada administradas por vía oralInfo
- Publication number
- AR106166A1 AR106166A1 ARP160102947A ARP160102947A AR106166A1 AR 106166 A1 AR106166 A1 AR 106166A1 AR P160102947 A ARP160102947 A AR P160102947A AR P160102947 A ARP160102947 A AR P160102947A AR 106166 A1 AR106166 A1 AR 106166A1
- Authority
- AR
- Argentina
- Prior art keywords
- amino acids
- gum
- release
- modified
- formulation
- Prior art date
Links
- 150000001413 amino acids Chemical class 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 title abstract 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 abstract 2
- 235000010443 alginic acid Nutrition 0.000 abstract 2
- 239000000783 alginic acid Substances 0.000 abstract 2
- 229920000615 alginic acid Polymers 0.000 abstract 2
- 229960001126 alginic acid Drugs 0.000 abstract 2
- 150000004781 alginic acids Chemical class 0.000 abstract 2
- 239000001768 carboxy methyl cellulose Substances 0.000 abstract 2
- 235000010418 carrageenan Nutrition 0.000 abstract 2
- 239000000679 carrageenan Substances 0.000 abstract 2
- 229920001525 carrageenan Polymers 0.000 abstract 2
- 229940113118 carrageenan Drugs 0.000 abstract 2
- 229920001577 copolymer Polymers 0.000 abstract 2
- 238000009472 formulation Methods 0.000 abstract 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 abstract 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 abstract 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 abstract 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 abstract 2
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 abstract 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 abstract 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 abstract 1
- 229920002126 Acrylic acid copolymer Polymers 0.000 abstract 1
- 239000001856 Ethyl cellulose Substances 0.000 abstract 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 abstract 1
- 229920002907 Guar gum Polymers 0.000 abstract 1
- 229920000084 Gum arabic Polymers 0.000 abstract 1
- 229920000569 Gum karaya Polymers 0.000 abstract 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 abstract 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 abstract 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 abstract 1
- 229920000161 Locust bean gum Polymers 0.000 abstract 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 abstract 1
- 241000934878 Sterculia Species 0.000 abstract 1
- 229920001615 Tragacanth Polymers 0.000 abstract 1
- BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 abstract 1
- 235000010489 acacia gum Nutrition 0.000 abstract 1
- 239000000205 acacia gum Substances 0.000 abstract 1
- 239000004469 amino acid formulation Substances 0.000 abstract 1
- 239000000305 astragalus gummifer gum Substances 0.000 abstract 1
- 235000013871 bee wax Nutrition 0.000 abstract 1
- 239000012166 beeswax Substances 0.000 abstract 1
- 239000004203 carnauba wax Substances 0.000 abstract 1
- 235000013869 carnauba wax Nutrition 0.000 abstract 1
- 229920002301 cellulose acetate Polymers 0.000 abstract 1
- 229960000541 cetyl alcohol Drugs 0.000 abstract 1
- 238000007922 dissolution test Methods 0.000 abstract 1
- BYNVYIUJKRRNNC-UHFFFAOYSA-N docosanoic acid;propane-1,2,3-triol Chemical compound OCC(O)CO.CCCCCCCCCCCCCCCCCCCCCC(O)=O BYNVYIUJKRRNNC-UHFFFAOYSA-N 0.000 abstract 1
- 235000019325 ethyl cellulose Nutrition 0.000 abstract 1
- 229920001249 ethyl cellulose Polymers 0.000 abstract 1
- 235000010417 guar gum Nutrition 0.000 abstract 1
- 239000000665 guar gum Substances 0.000 abstract 1
- 229960002154 guar gum Drugs 0.000 abstract 1
- 239000008172 hydrogenated vegetable oil Substances 0.000 abstract 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 abstract 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 abstract 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 abstract 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 abstract 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 abstract 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 abstract 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 abstract 1
- 235000010494 karaya gum Nutrition 0.000 abstract 1
- 239000000231 karaya gum Substances 0.000 abstract 1
- 229940039371 karaya gum Drugs 0.000 abstract 1
- 235000010420 locust bean gum Nutrition 0.000 abstract 1
- 239000000711 locust bean gum Substances 0.000 abstract 1
- 229920000609 methyl cellulose Polymers 0.000 abstract 1
- 235000010981 methylcellulose Nutrition 0.000 abstract 1
- 239000001923 methylcellulose Substances 0.000 abstract 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 abstract 1
- 235000010987 pectin Nutrition 0.000 abstract 1
- 239000001814 pectin Substances 0.000 abstract 1
- 229920001277 pectin Polymers 0.000 abstract 1
- 229960000292 pectin Drugs 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 235000010413 sodium alginate Nutrition 0.000 abstract 1
- 239000000661 sodium alginate Substances 0.000 abstract 1
- 229940005550 sodium alginate Drugs 0.000 abstract 1
- 235000002639 sodium chloride Nutrition 0.000 abstract 1
- 235000010493 xanthan gum Nutrition 0.000 abstract 1
- 239000000230 xanthan gum Substances 0.000 abstract 1
- 229920001285 xanthan gum Polymers 0.000 abstract 1
- 229940082509 xanthan gum Drugs 0.000 abstract 1
Classifications
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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- A21D—TREATMENT, e.g. PRESERVATION, OF FLOUR OR DOUGH, e.g. BY ADDITION OF MATERIALS; BAKING; BAKERY PRODUCTS; PRESERVATION THEREOF
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- A21D13/80—Pastry not otherwise provided for elsewhere, e.g. cakes, biscuits or cookies
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- A21D2/00—Treatment of flour or dough by adding materials thereto before or during baking
- A21D2/08—Treatment of flour or dough by adding materials thereto before or during baking by adding organic substances
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
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- Physics & Mathematics (AREA)
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- Nanotechnology (AREA)
- Mycology (AREA)
- Polymers & Plastics (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
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Abstract
Reivindicación 1: Una formulación de aminoácidos administrada por vía oral, caracterizada porque comprende uno o más aminoácidos de liberación modificada, en donde una formulación que comprende 2 g de los aminoácidos de liberación modificada no libera más de un x% de los aminoácidos de liberación modificada en 30 minutos en una prueba de disolución efectuada en un aparato de paletas <711> USP 39 NF 34, a 37ºC, en 450 ó 500 ml de ácido clorhídrico 0,1 N (pH 1,2), y velocidad de paleta de 50 rpm, en donde x% es 90%, 80%, 70%, 60%, 50% o aún 40%. Reivindicación 31: La formulación de cualquiera de las reivindicaciones precedentes, caracterizada porque los aminoácidos de liberación modificada además comprenden uno o más excipientes modificadores de liberación seleccionados del grupo que consiste en etilcelulosa, dibehenato de glicerilo, acetato de celulosa, copolímeros de acetato de vinilo / cloruro de vinilo, copolímeros de acrilato/metacrilato, óxido de polietileno, hidroxipropilmetilcelulosa, carragenina, ácido algínico y sales del mismo, hidroxietilcelulosa, hidroxipropilcelulosa, goma de karaya, goma de acacia, goma tragacanto, goma de algarroba, goma guar, goma de xantán, carboximetilcelulosa sódica, metilcelulosa, cera de abejas, cera carnaúba, alcohol cetílico, aceites vegetales hidrogenados, alcohol estearílico, copolímeros ácido acrílico, alginato de sodio, carragenina, ácido algínico, pectina, carboximetilcelulosa sódica o una combinación de los mismos.
Applications Claiming Priority (1)
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US201562233695P | 2015-09-28 | 2015-09-28 |
Publications (1)
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AR106166A1 true AR106166A1 (es) | 2017-12-20 |
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ARP160102947A AR106166A1 (es) | 2015-09-28 | 2016-09-28 | Formulaciones de aminoácidos de liberación modificada administradas por vía oral |
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US (3) | US11419837B2 (es) |
EP (2) | EP3355856B1 (es) |
CN (2) | CN114699397A (es) |
AR (1) | AR106166A1 (es) |
AU (2) | AU2016330261B2 (es) |
CA (1) | CA2998276A1 (es) |
CL (1) | CL2018000811A1 (es) |
CO (1) | CO2018003224A2 (es) |
DK (1) | DK3355856T3 (es) |
EA (1) | EA038018B1 (es) |
ES (1) | ES2925902T3 (es) |
HK (1) | HK1254555A1 (es) |
HR (1) | HRP20220933T1 (es) |
HU (1) | HUE059603T2 (es) |
IL (3) | IL285695B2 (es) |
JO (1) | JO3543B1 (es) |
LT (1) | LT3355856T (es) |
MX (1) | MX2018003497A (es) |
MY (1) | MY187358A (es) |
PH (1) | PH12018501072A1 (es) |
PL (1) | PL3355856T3 (es) |
PT (1) | PT3355856T (es) |
SA (1) | SA518391206B1 (es) |
SI (1) | SI3355856T1 (es) |
TW (1) | TWI729005B (es) |
UY (1) | UY36920A (es) |
WO (1) | WO2017055997A1 (es) |
ZA (1) | ZA201801927B (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
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JO3543B1 (ar) | 2015-09-28 | 2020-07-05 | Applied Pharma Res | تراكيب حمض أميني إصدار معدل تعطى عن طريق الفم |
KR20200126404A (ko) * | 2018-03-01 | 2020-11-06 | 463아이피 파트너즈, 엘엘씨 | 마이크로캡슐화 제품, 이의 투명한 용액, 및 제조 방법 |
AR115581A1 (es) * | 2018-06-20 | 2021-02-03 | Axcella Health Inc | Métodos de preparación de composiciones de aminoácidos |
US11701335B2 (en) * | 2018-08-31 | 2023-07-18 | Apr Applied Pharma Research S.A. | Methods of normalizing amino acid metabolism |
IT201900013473A1 (it) * | 2019-07-31 | 2021-01-31 | Vetagro Int S R L | Composizioni comprendenti amminoacidi e un ulteriore componente per l'apporto di amminoacidi ad un animale monogastrico quale uomo o maiale |
CA3155042A1 (en) * | 2019-10-17 | 2021-04-22 | Thomas Durig | A dispersible extended release granule composition, and a process for preparing same |
CN110946839A (zh) * | 2019-12-31 | 2020-04-03 | 烟台万润药业有限公司 | 一种补充硒、维生素c的咀嚼片及其制备方法 |
CN111821272A (zh) * | 2020-08-11 | 2020-10-27 | 河北科星药业有限公司 | 犬用复方氨基酸肠溶片及其制备方法 |
CN111956644A (zh) * | 2020-08-18 | 2020-11-20 | 河北科星药业有限公司 | 一种犬用复方氨基酸肠溶胶囊及其制备方法 |
CN116531334B (zh) * | 2023-01-13 | 2023-09-15 | 山东国邦药业有限公司 | 一种盐酸多西环素颗粒剂及其制备方法 |
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---|---|---|---|---|
GB1217365A (en) * | 1967-02-23 | 1970-12-31 | Labatt Ltd John | Controlled release feed additives for ruminants |
US5026721A (en) * | 1989-06-05 | 1991-06-25 | Dudrick Stanley J | Amino acid nutritional supplement and regimen for enhancing physical performance through sound nutrition |
US20110196039A9 (en) * | 1994-10-05 | 2011-08-11 | Kaesemeyer Wayne H | Controlled release arginine formulations |
US20020004072A1 (en) * | 1999-05-06 | 2002-01-10 | Peter G. Thomas | "composition providing a sustained release of l-histidine and methods of manufacture thereof" |
US20040213838A1 (en) | 2003-04-24 | 2004-10-28 | Mazer Terrence B. | Medical food tablets containing free amino acids |
ITFI20050215A1 (it) * | 2005-10-13 | 2007-04-14 | Valpharma Internat S P A | Composizione nutrizionale a base di amminoacidi |
EP1897451A1 (en) * | 2006-09-08 | 2008-03-12 | SHS International Ltd. | Tasteless nutritional supplement containing free amino acids |
WO2011043647A1 (en) * | 2009-10-09 | 2011-04-14 | N.V. Nutricia | Amino acid composition with improved dispersibility |
US20120039999A1 (en) * | 2010-08-11 | 2012-02-16 | Ashish Chatterji | Pharmaceutical compositions of metabotropic glutamate 5 receptor (mglu5) antagonists |
EP2468261A1 (en) * | 2010-12-02 | 2012-06-27 | UCB Pharma GmbH | Formulation of lacosamide |
WO2012072256A2 (en) * | 2010-12-02 | 2012-06-07 | Ucb Pharma Gmbh | Once daily formulation of lacosamide |
CN102861011B (zh) * | 2012-10-12 | 2014-11-05 | 杜博 | 18种氨基酸的药物组合物及制剂 |
WO2016112170A1 (en) | 2015-01-07 | 2016-07-14 | Corr-Jensen Inc. | Compositions and methods for enhancing athletic performance |
JO3543B1 (ar) | 2015-09-28 | 2020-07-05 | Applied Pharma Res | تراكيب حمض أميني إصدار معدل تعطى عن طريق الفم |
US11701335B2 (en) | 2018-08-31 | 2023-07-18 | Apr Applied Pharma Research S.A. | Methods of normalizing amino acid metabolism |
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- 2016-09-27 CN CN201680069481.9A patent/CN108289835B/zh active Active
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