AR101840A1 - ANTIGENS OF THE HUMAN PAPILOMA VIRUS HIGHER WITH HIGHER IMMUNE PROPERTIES, AND VACCINE THAT CONTAINS THEM - Google Patents
ANTIGENS OF THE HUMAN PAPILOMA VIRUS HIGHER WITH HIGHER IMMUNE PROPERTIES, AND VACCINE THAT CONTAINS THEMInfo
- Publication number
- AR101840A1 AR101840A1 ARP150102901A ARP150102901A AR101840A1 AR 101840 A1 AR101840 A1 AR 101840A1 AR P150102901 A ARP150102901 A AR P150102901A AR P150102901 A ARP150102901 A AR P150102901A AR 101840 A1 AR101840 A1 AR 101840A1
- Authority
- AR
- Argentina
- Prior art keywords
- protein
- human papillomavirus
- seq
- gene
- gene encoding
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20023—Virus like particles [VLP]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20051—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20071—Demonstrated in vivo effect
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/22—Vectors comprising a coding region that has been codon optimised for expression in a respective host
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
Reivindicación 1: Un gen aislado que codifica la proteína de la cápside mayor del virus del papiloma humano, caracterizado porque dicho gen se selecciona entre SEQ ID Nº 2, SEQ ID Nº 3, SEQ ID Nº 4 y SEQ ID Nº 5. Reivindicación 2: Un vector que comprende el gen que codifica la proteína de la cápside mayor del virus del papiloma humano, caracterizado porque dicho gen se selecciona entre SEQ ID Nº 2, SEQ ID Nº 3, SEQ ID Nº 4, SEQ ID Nº 5, y su combinación. Reivindicación 6: Una célula huésped caracterizada porque comprende el vector tal como se reivindica en la reivindicación 2. Reivindicación 11: Una vacuna contra el virus del papiloma humano, caracterizada porque comprende al menos un gen que codifica la proteína del cápside entre las reivindicadas en la reivindicación 1, que puede generar una respuesta inmunitaria contra el antígeno del HPV. Reivindicación 16: Un método para preparar la vacuna contra el virus del papiloma humano tal como se reivindica en la reivindicación 11, caracterizado porque comprende los siguientes pasos: a) síntesis del gen que codifica la proteína de la cápside mayor del virus del papiloma humano; b) construcción del vector de expresión para el gen que codifica la proteína de la cápside mayor del virus del papiloma humano; c) selección del clon con un número alto de copias del gen transformado de dicha proteína del virus del papiloma humano; d) análisis de expresión del gen transformado de dicha proteína del virus del papiloma humano; e) purificación de la proteína codificada por el gen de dicha proteína del virus del papiloma humano; f) preparación de solución a granel de VLPs de dicha proteína del virus del papiloma humano; g) caracterización de dicha proteína en la célula huésped; h) preparación de la vacuna que contiene dicha proteína del virus del papiloma humano.Claim 1: An isolated gene encoding the major capsid protein of the human papillomavirus, characterized in that said gene is selected from SEQ ID No. 2, SEQ ID No. 3, SEQ ID No. 4 and SEQ ID No. 5. Claim 2: A vector comprising the gene encoding the protein of the major capsid of the human papillomavirus, characterized in that said gene is selected from SEQ ID No. 2, SEQ ID No. 3, SEQ ID No. 4, SEQ ID No. 5, and their combination . Claim 6: A host cell characterized in that it comprises the vector as claimed in claim 2. Claim 11: A vaccine against the human papillomavirus, characterized in that it comprises at least one gene encoding the capsid protein between those claimed in the claim 1, which can generate an immune response against the HPV antigen. Claim 16: A method for preparing the vaccine against the human papillomavirus as claimed in claim 11, characterized in that it comprises the following steps: a) synthesis of the gene encoding the major capsid protein of the human papillomavirus; b) construction of the expression vector for the gene encoding the major capsid protein of the human papillomavirus; c) selection of the clone with a high copy number of the transformed gene of said human papillomavirus protein; d) expression analysis of the transformed gene of said human papillomavirus protein; e) purification of the protein encoded by the gene of said human papillomavirus protein; f) preparation of bulk solution of VLPs of said human papillomavirus protein; g) characterization of said protein in the host cell; h) preparation of the vaccine containing said human papillomavirus protein.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN2905MU2014 | 2014-09-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR101840A1 true AR101840A1 (en) | 2017-01-18 |
Family
ID=54843870
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP150102901A AR101840A1 (en) | 2014-09-11 | 2015-09-11 | ANTIGENS OF THE HUMAN PAPILOMA VIRUS HIGHER WITH HIGHER IMMUNE PROPERTIES, AND VACCINE THAT CONTAINS THEM |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP3191505A2 (en) |
JP (1) | JP2017528137A (en) |
CN (1) | CN107002085A (en) |
AR (1) | AR101840A1 (en) |
AU (1) | AU2015313756A1 (en) |
BR (1) | BR112017004181A2 (en) |
CA (1) | CA2958222A1 (en) |
EA (1) | EA201790365A1 (en) |
MA (1) | MA40624A (en) |
WO (1) | WO2016038625A2 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN117187262A (en) * | 2014-02-18 | 2023-12-08 | 上海泽润生物科技有限公司 | Recombinant human papilloma virus protein expression |
SG11201803209QA (en) | 2015-10-19 | 2018-05-30 | Cadila Healthcare Ltd | New adjuvant and vaccine composition containing the same |
CN109750049B (en) * | 2017-11-07 | 2023-08-18 | 上海泽润生物科技有限公司 | Recombinant human papillomavirus subtype 52 protein expression |
JP2021502822A (en) * | 2017-11-14 | 2021-02-04 | フラウンホファー ゲセルシャフト ツール フェールデルンク ダー アンゲヴァンテン フォルシュンク エー.ファオ. | Non-human papillomavirus for gene delivery in vitro and in vivo |
BR102020006846A2 (en) * | 2020-04-03 | 2021-12-07 | Imunoscan Engenharia Molecular Ltda | SYNTHETIC PEPTIDES MIMETIC TO HPV L1 PROTEIN, HPV DIAGNOSIS METHOD, HPV DIAGNOSIS SYSTEM, PHARMACEUTICAL COMPOSITION AND USE THEREOF IN HPV TREATMENT OR PROPHYLAXIS |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69631380T2 (en) * | 1995-11-15 | 2004-11-04 | Merck & Co., Inc. | SYNTHETIC HPV11 VIRUS-LIKE PARTICLES |
WO1998044944A2 (en) * | 1997-04-08 | 1998-10-15 | Merck & Co., Inc. | Stabilized human papillomavirus formulations |
EP1700911B1 (en) * | 1997-09-05 | 2016-04-06 | Medimmune, Inc. | In vitro method for disassembly/reassembly of papillomavirus virus-like particles (VLPs) |
MY140664A (en) * | 2003-09-29 | 2010-01-15 | Merck Sharp & Dohme | Optimized expression of hpv 45 l1 in yeast |
MY139500A (en) * | 2003-11-12 | 2009-10-30 | Merck Sharp & Dohme | Optimized expression of hpv 58 l1 in yeast |
JP4769247B2 (en) * | 2004-06-18 | 2011-09-07 | インディアン・イムノロジカルズ・リミテッド | Codon optimized HPV16L1 for Salmonella vaccine strain against human papillomavirus type 16 |
CN101487009B (en) * | 2008-01-15 | 2012-11-21 | 上海泽润生物科技有限公司 | Method for preparing vaccine for anti-HPV 16 infection by pichia yeast expression system |
CN101835797A (en) * | 2007-11-23 | 2010-09-15 | 上海泽润生物科技有限公司 | Human papilloma virus major capsid protein L 1 gene and uses thereof |
BRPI0916732B1 (en) * | 2008-07-31 | 2021-06-29 | Glaxosmithkline Biologicals S.A. | VACCINE FOR THE PREVENTION OF DISEASE OR INFECTION RELATED TO HUMAN PAPILLOMAVIRUS (HPV) COMPRISING PARTICLES SIMILAR TO THE HPV 16 AND HPV 18 VIRUSES |
PL2444103T3 (en) * | 2009-06-19 | 2018-05-30 | Eyegene Inc. | Vaccine for cervical cancer |
CN102154325B (en) * | 2011-01-01 | 2013-08-21 | 上海生物制品研究所有限责任公司 | Vaccine against human papillomavirus (HPV) as well as preparation method and application thereof |
BR112013029143A2 (en) * | 2011-05-13 | 2017-07-11 | Folia Biotech Inc | in vitro process for the preparation of virus-like particles and their use, papaya mosaic virus-like virus particle, pharmaceutical composition and method for enhancing an immune response to an antigen and for stimulating the innate immune response in an individual |
ES2762230T3 (en) * | 2011-06-24 | 2020-05-22 | Merck Sharp & Dohme | HPV vaccine formulations comprising an aluminum adjuvant and production methods thereof |
KR101559622B1 (en) * | 2012-07-30 | 2015-10-13 | 중앙대학교 산학협력단 | An Efficient Method for Purifying Virus-Like Particles of Human Papillomavirus |
CN103667319B (en) * | 2012-09-10 | 2017-09-26 | 同济大学 | The trivalent vaccine and its preparation method and purposes of anti-human papilloma virus (anti-HPV) |
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2015
- 2015-09-11 CA CA2958222A patent/CA2958222A1/en not_active Abandoned
- 2015-09-11 MA MA040624A patent/MA40624A/en unknown
- 2015-09-11 WO PCT/IN2015/000355 patent/WO2016038625A2/en active Application Filing
- 2015-09-11 AR ARP150102901A patent/AR101840A1/en unknown
- 2015-09-11 JP JP2017513424A patent/JP2017528137A/en active Pending
- 2015-09-11 BR BR112017004181A patent/BR112017004181A2/en not_active Application Discontinuation
- 2015-09-11 EP EP15808033.3A patent/EP3191505A2/en not_active Withdrawn
- 2015-09-11 EA EA201790365A patent/EA201790365A1/en unknown
- 2015-09-11 CN CN201580049136.4A patent/CN107002085A/en active Pending
- 2015-09-11 AU AU2015313756A patent/AU2015313756A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP3191505A2 (en) | 2017-07-19 |
BR112017004181A2 (en) | 2017-12-05 |
AU2015313756A1 (en) | 2017-03-09 |
EA201790365A1 (en) | 2017-07-31 |
MA40624A (en) | 2016-03-17 |
WO2016038625A3 (en) | 2016-04-28 |
WO2016038625A2 (en) | 2016-03-17 |
JP2017528137A (en) | 2017-09-28 |
CN107002085A (en) | 2017-08-01 |
CA2958222A1 (en) | 2016-03-17 |
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