AR101565A1 - ANTI TIGIT ANTIBODIES - Google Patents

ANTI TIGIT ANTIBODIES

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Publication number
AR101565A1
AR101565A1 ARP150102630A ARP150102630A AR101565A1 AR 101565 A1 AR101565 A1 AR 101565A1 AR P150102630 A ARP150102630 A AR P150102630A AR P150102630 A ARP150102630 A AR P150102630A AR 101565 A1 AR101565 A1 AR 101565A1
Authority
AR
Argentina
Prior art keywords
seq
amino acid
acid sequence
variable region
chain variable
Prior art date
Application number
ARP150102630A
Other languages
Spanish (es)
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of AR101565A1 publication Critical patent/AR101565A1/en

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  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente solicitud se refiere a anticuerpos anti TIGIT (inmunorreceptor de linfocitos T con dominios Ig e ITIM -motivo de inhibición basado en tirosina inmunorreceptor-), así como al uso de estos anticuerpos en el tratamiento de enfermedades tales como cáncer y enfermedad infecciosa. Reivindicación 1: Un anticuerpo o fragmento de unión a antígeno del mismo que se une con TIGIT humano, en el que el anticuerpo o fragmento de unión a antígeno se selecciona del grupo que consiste en: a) un anticuerpo o fragmento de unión a antígeno que comprende: una CDR1 de región variable de cadena pesada que comprende la secuencia de aminoácidos de SEC ID Nº 1, una CDR2 de región variable de cadena pesada que comprende la secuencia de aminoácidos de SEC ID Nº: 2, una CDR3 de región variable de cadena pesada que comprende la secuencia de aminoácidos de SEC ID Nº 3, 79, 80, 81, 82, 83 ó 140, una CDR1 de región variable de cadena ligera que comprende la secuencia de aminoácidos de SEC ID Nº 4, una CDR2 de región variable de cadena ligera que comprende la secuencia de aminoácidos de SEC ID Nº 5, 65, 66, 67, 68, 69, 70, 71, 72, 73 ó 41, y una CDR3 de región variable de cadena ligera que comprende la secuencia de aminoácidos de SEC ID Nº 6, 74, 20 75, 76, 77, 78 ó 142; b) un anticuerpo o fragmento de unión a antígeno que comprende: una CDR1 de región variable de cadena pesada que comprende la secuencia de aminoácidos de SEC ID Nº 57, una CDR2 de región variable de cadena pesada que comprende la secuencia de aminoácidos de SEC ID Nº 58, una CDR3 de región variable de cadena pesada que comprende la secuencia de aminoácidos de SEC ID Nº 59, una CDR1 de región variable de cadena ligera que comprende la secuencia de aminoácidos de SEC ID Nº 60, una CDR2 de región variable de cadena ligera que comprende la secuencia de aminoácidos de SEC ID Nº: 61, y una CDR3 de región variable de cadena ligera que comprende la secuencia de aminoácidos de SEC ID Nº 62; y c) un anticuerpo o fragmento de unión a antígeno que comprende: una CDR1 de región variable de cadena pesada que comprende la secuencia de aminoácidos de SEC ID Nº 88, una CDR2 de región variable de cadena pesada que comprende la secuencia de aminoácidos de SEC ID Nº 89, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 134, 135 ó 147, una CDR3 de región variable de cadena pesada que comprende la secuencia de aminoácidos de SEC ID Nº 90, 153, 154, 155, 156, 157, 158, 159, 160, 161, 162, 163, 164, 165, 166 ó 167, una CDR1 de región variable de cadena ligera que comprende la secuencia de aminoácidos de SEC ID Nº 91, una CDR2 de región variable de cadena ligera que comprende la secuencia de aminoácidos de SEC ID Nº 92, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122 ó 148, y una CDR3 de región variable de cadena ligera que comprende la secuencia de aminoácidos de SEC ID Nº 93.The present application refers to anti TIGIT antibodies (T lymphocyte immunoreceptor with Ig and ITIM domains - immunosuppressive tyrosine-based inhibition -), as well as the use of these antibodies in the treatment of diseases such as cancer and infectious disease. Claim 1: An antibody or antigen binding fragment thereof that binds to human TIGIT, wherein the antibody or antigen binding fragment is selected from the group consisting of: a) an antibody or antigen binding fragment that comprises: a heavy chain variable region CDR1 comprising the amino acid sequence of SEQ ID No. 1, a heavy chain variable region CDR2 comprising the amino acid sequence of SEQ ID NO: 2, a chain variable region CDR3 heavy comprising the amino acid sequence of SEQ ID NO: 3, 79, 80, 81, 82, 83 or 140, a light chain variable region CDR1 comprising the amino acid sequence of SEQ ID No. 4, a variable region CDR2 light chain comprising the amino acid sequence of SEQ ID NO. 5, 65, 66, 67, 68, 69, 70, 71, 72, 73 or 41, and a light chain variable region CDR3 comprising the amino acid sequence of SEQ ID NO. 6, 74, 20 75, 76, 77, 78 or 142; b) an antibody or antigen binding fragment comprising: a heavy chain variable region CDR1 comprising the amino acid sequence of SEQ ID No. 57, a heavy chain variable region CDR2 comprising the amino acid sequence of SEQ ID No. 58, a heavy chain variable region CDR3 comprising the amino acid sequence of SEQ ID No. 59, a light chain variable region CDR1 comprising the amino acid sequence of SEQ ID No. 60, a chain variable region CDR2 light comprising the amino acid sequence of SEQ ID NO: 61, and a light chain variable region CDR3 comprising the amino acid sequence of SEQ ID NO: 62; and c) an antibody or antigen binding fragment comprising: a heavy chain variable region CDR1 comprising the amino acid sequence of SEQ ID No. 88, a heavy chain variable region CDR2 comprising the amino acid sequence of SEQ ID No. 89, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 134, 135 or 147, a heavy chain variable region CDR3 that comprises the amino acid sequence of SEQ ID NO: 90, 153, 154, 155, 156, 157, 158, 159, 160, 161, 162, 163, 164, 165, 166 or 167, a light chain variable region CDR1 which comprises the amino acid sequence of SEQ ID No. 91, a light chain variable region CDR2 comprising the amino acid sequence of SEQ ID No. 92, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121 , 122 or 148, and a light chain variable region CDR3 comprising the amino acid sequence of SEQ ID NO: 93.

ARP150102630A 2014-08-19 2015-08-14 ANTI TIGIT ANTIBODIES AR101565A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462038912P 2014-08-19 2014-08-19

Publications (1)

Publication Number Publication Date
AR101565A1 true AR101565A1 (en) 2016-12-28

Family

ID=58694403

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP150102630A AR101565A1 (en) 2014-08-19 2015-08-14 ANTI TIGIT ANTIBODIES
ARP200102706A AR120118A2 (en) 2014-08-19 2020-09-29 ANTI-TIGIT ANTIBODIES

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP200102706A AR120118A2 (en) 2014-08-19 2020-09-29 ANTI-TIGIT ANTIBODIES

Country Status (2)

Country Link
AR (2) AR101565A1 (en)
EC (1) ECSP17016755A (en)

Also Published As

Publication number Publication date
ECSP17016755A (en) 2017-03-31
AR120118A2 (en) 2022-02-02

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