AR101479A1 - Derivados de 6-alquinil-piridina - Google Patents

Derivados de 6-alquinil-piridina

Info

Publication number
AR101479A1
AR101479A1 ARP150102551A ARP150102551A AR101479A1 AR 101479 A1 AR101479 A1 AR 101479A1 AR P150102551 A ARP150102551 A AR P150102551A AR P150102551 A ARP150102551 A AR P150102551A AR 101479 A1 AR101479 A1 AR 101479A1
Authority
AR
Argentina
Prior art keywords
alkyl
substituted
halogen
hydrogen
groups
Prior art date
Application number
ARP150102551A
Other languages
English (en)
Inventor
Reiser Ulrich
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of AR101479A1 publication Critical patent/AR101479A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Abstract

Su uso como miméticos de SMAC, composiciones farmacéuticas que los contienen y su uso como un medicamento para el tratamiento y/o la prevención de enfermedades caracterizadas por la proliferación celular excesiva o anormal y condiciones asociadas como cáncer. Reivindicación 1: Un compuesto caracterizado por la fórmula (1) en donde R¹ se selecciona de hidrógeno, -alquilo C₁₋₃ y halógeno; R² se selecciona de hidrógeno, -alquilo C₁₋₃ y halógeno; R³ se selecciona de fenilo o un heteroarilo de 9 a 14 miembros, en donde cada uno de estos grupos está opcionalmente sustituido con R⁵ o R³ es un resto de fenilo fusionado con un heterocicloalquilo de 5 - 6 miembros, en donde cada uno de estos grupos está sustituido, de modo opcional e independiente, con uno o varios R⁶; R⁴ un heteroarilo de 5 ó 6 miembros sustituido con -alquilo C₁₋₃, u -O-alquilo C₁₋₃; R⁵ es -alquilo C₁₋₃; R⁶ es =O ó -alquilo C₁₋₃; o sus sales.
ARP150102551A 2014-08-11 2015-08-07 Derivados de 6-alquinil-piridina AR101479A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP14180554 2014-08-11

Publications (1)

Publication Number Publication Date
AR101479A1 true AR101479A1 (es) 2016-12-21

Family

ID=51300621

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP150102551A AR101479A1 (es) 2014-08-11 2015-08-07 Derivados de 6-alquinil-piridina

Country Status (34)

Country Link
US (4) US9481673B2 (es)
EP (1) EP3180339B1 (es)
JP (1) JP6250226B2 (es)
KR (1) KR102445744B1 (es)
CN (2) CN106573930B (es)
AP (1) AP2017009718A0 (es)
AR (1) AR101479A1 (es)
AU (1) AU2015303308B2 (es)
BR (1) BR112017002498B1 (es)
CA (1) CA2956123C (es)
CL (1) CL2017000326A1 (es)
CO (1) CO2017001226A2 (es)
CY (1) CY1121273T1 (es)
DK (1) DK3180339T3 (es)
EA (1) EA031424B1 (es)
ES (1) ES2711763T3 (es)
HR (1) HRP20190336T1 (es)
HU (1) HUE043915T2 (es)
IL (1) IL249844B (es)
LT (1) LT3180339T (es)
ME (1) ME03303B (es)
MX (1) MX2017001835A (es)
NZ (1) NZ728073A (es)
PE (1) PE20170193A1 (es)
PH (1) PH12017500231A1 (es)
PL (1) PL3180339T3 (es)
PT (1) PT3180339T (es)
RS (1) RS58355B1 (es)
SG (1) SG11201700999YA (es)
SI (1) SI3180339T1 (es)
TR (1) TR201902023T4 (es)
TW (1) TWI723959B (es)
UA (1) UA118887C2 (es)
WO (1) WO2016023858A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR101479A1 (es) * 2014-08-11 2016-12-21 Boehringer Ingelheim Int Derivados de 6-alquinil-piridina
WO2017198734A1 (en) * 2016-05-19 2017-11-23 Boehringer Ingelheim International Gmbh Process for the manufacture of 6-alkynyl-pyridine derivatives
CN110475567A (zh) * 2017-03-31 2019-11-19 勃林格殷格翰国际有限公司 抗癌组合疗法
JP2022511437A (ja) 2018-11-26 2022-01-31 デバイオファーム インターナショナル エス．エー． Ｈｉｖ感染の組み合わせ治療
TW202043466A (zh) 2019-01-25 2020-12-01 德商百靈佳殷格翰國際股份有限公司 編碼ccl21之重組棒狀病毒
JP2022550037A (ja) 2019-09-25 2022-11-30 デバイオファーム インターナショナル エス．エー． 局所進行性扁平上皮癌を有する患者の治療のための投与レジメン
TW202210499A (zh) 2020-06-03 2022-03-16 德商百靈佳殷格翰國際股份有限公司 編碼CD80胞外域Fc融合蛋白之重組桿形病毒

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060234360A1 (en) * 2005-04-13 2006-10-19 Paola Branduardi Ascorbic acid production from D-glucose in yeast
CN101193908B (zh) 2005-06-08 2012-04-11 诺瓦提斯公司 有机化合物
WO2007101347A1 (en) 2006-03-07 2007-09-13 Aegera Therapeutics Inc. Bir domain binding compounds
CA2670728A1 (en) * 2006-12-07 2008-06-19 Novartis Ag Pyridine derivatives used as xiap inhibitors
US8859541B2 (en) * 2012-02-27 2014-10-14 Boehringer Ingelheim International Gmbh 6-alkynylpyridines
US9249151B2 (en) 2013-08-23 2016-02-02 Boehringer Ingelheim International Gmbh Bis-amido pyridines
US9278978B2 (en) 2013-08-23 2016-03-08 Boehringer Ingelheim International Gmbh 6-Alkynyl Pyridine
AR101479A1 (es) * 2014-08-11 2016-12-21 Boehringer Ingelheim Int Derivados de 6-alquinil-piridina

Also Published As

Publication number Publication date
PT3180339T (pt) 2019-02-27
HRP20190336T1 (hr) 2019-05-03
UA118887C2 (uk) 2019-03-25
LT3180339T (lt) 2019-02-25
EA031424B1 (ru) 2018-12-28
US20170020859A1 (en) 2017-01-26
AU2015303308A1 (en) 2017-02-02
BR112017002498B1 (pt) 2022-10-11
US10413536B2 (en) 2019-09-17
PH12017500231A1 (en) 2017-07-03
CA2956123A1 (en) 2016-02-18
CL2017000326A1 (es) 2017-10-20
PL3180339T3 (pl) 2019-05-31
EA201790349A1 (ru) 2017-07-31
DK3180339T3 (en) 2019-03-04
TWI723959B (zh) 2021-04-11
SG11201700999YA (en) 2017-03-30
JP6250226B2 (ja) 2017-12-20
CN106573930A (zh) 2017-04-19
SI3180339T1 (sl) 2019-03-29
IL249844A0 (en) 2017-03-30
MX2017001835A (es) 2017-04-27
BR112017002498A2 (pt) 2017-12-05
HUE043915T2 (hu) 2019-09-30
EP3180339B1 (en) 2018-12-05
TR201902023T4 (tr) 2019-03-21
CN111440164A (zh) 2020-07-24
TW201619156A (zh) 2016-06-01
RS58355B1 (sr) 2019-03-29
EP3180339A1 (en) 2017-06-21
ME03303B (me) 2019-07-20
US9801871B2 (en) 2017-10-31
IL249844B (en) 2019-03-31
WO2016023858A1 (en) 2016-02-18
US20190358218A1 (en) 2019-11-28
AP2017009718A0 (en) 2017-01-31
NZ728073A (en) 2022-10-28
KR102445744B1 (ko) 2022-09-20
US20180015082A1 (en) 2018-01-18
US20160039814A1 (en) 2016-02-11
CN106573930B (zh) 2020-03-03
CN111440164B (zh) 2023-02-17
CO2017001226A2 (es) 2017-05-10
ES2711763T3 (es) 2019-05-07
JP2017524013A (ja) 2017-08-24
CA2956123C (en) 2023-02-14
KR20170036095A (ko) 2017-03-31
PE20170193A1 (es) 2017-03-25
CY1121273T1 (el) 2020-05-29
AU2015303308B2 (en) 2020-01-30
US9481673B2 (en) 2016-11-01

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