AR099671A1 - ANHIBINE OF INHIBINE a, CODIFYING GENE OF INHIBINE a, CODIFYING GENE OF FUSION PROTEIN, PROCESS OF OBTAINING THE INHIBINE ANTIGEN a, ANTIGEN COMPOSITION, USE OF THE INHIBINE ANTIGEN a AND USE OF THE ANTIGEN COMPOSITION - Google Patents
ANHIBINE OF INHIBINE a, CODIFYING GENE OF INHIBINE a, CODIFYING GENE OF FUSION PROTEIN, PROCESS OF OBTAINING THE INHIBINE ANTIGEN a, ANTIGEN COMPOSITION, USE OF THE INHIBINE ANTIGEN a AND USE OF THE ANTIGEN COMPOSITIONInfo
- Publication number
- AR099671A1 AR099671A1 ARP150100658A ARP150100658A AR099671A1 AR 099671 A1 AR099671 A1 AR 099671A1 AR P150100658 A ARP150100658 A AR P150100658A AR P150100658 A ARP150100658 A AR P150100658A AR 099671 A1 AR099671 A1 AR 099671A1
- Authority
- AR
- Argentina
- Prior art keywords
- inhibine
- antigen
- inhibin
- fusion protein
- composition
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmacology & Pharmacy (AREA)
- Gynecology & Obstetrics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente se refiere a una proteína inhibina a modificada, sus fragmentos antigénicos y proteína de fusión comprendiendo la misma, así como a una composición antigénica comprendiendo inhibina a modificada y/o un fragmento antigénico de la misma y/o una proteína de fusión comprendiendo inhibina a modificada, al proceso de producción de la proteína inhibina a modificada, sus fragmentos antigénicos y proteína de fusión comprendiendo la misma, y al uso de la inhibina a modificada, sus fragmentos antigénicos; o proteína de fusión comprendiendo inhibina a, y al uso de la composición antigénica en el aumento de la ovulación de animales, especialmente mamíferos y aves. La presente se fundamenta en la modificación de la secuencia madura de la subunidad a de la inhibina de Bos taurus, específicamente en el segmento de la extremidad C-terminal que, además de la modificación de algunos aminoácidos, pasa a tener las dos regiones más inmunogénicas en ese segmento. Gen codificante.This refers to an inhibin to modified protein, its antigenic fragments and fusion protein comprising the same, as well as to an antigenic composition comprising inhibin to modified and / or an antigenic fragment thereof and / or a fusion protein comprising inhibin. to modified, to the process of production of the inhibin to modified protein, its antigenic fragments and fusion protein comprising the same, and to the use of the inhibin to modified, its antigenic fragments; or fusion protein comprising inhibin a, and the use of the antigenic composition in the increase of ovulation of animals, especially mammals and birds. This is based on the modification of the mature sequence of the a subunit of Bos taurus inhibin, specifically in the segment of the C-terminal limb that, in addition to the modification of some amino acids, happens to have the two most immunogenic regions in that segment. Coding gene.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR102014005376A BR102014005376A2 (en) | 2014-03-07 | 2014-03-07 | inhibin alpha antigen, inhibin alpha coding gene, fusion protein encoding gene, process of obtaining inhibin alpha antigen, antigenic composition, use of inhibin alpha antigen, and use of antigenic composition |
Publications (1)
Publication Number | Publication Date |
---|---|
AR099671A1 true AR099671A1 (en) | 2016-08-10 |
Family
ID=54054284
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP150100658A AR099671A1 (en) | 2014-03-07 | 2015-03-05 | ANHIBINE OF INHIBINE a, CODIFYING GENE OF INHIBINE a, CODIFYING GENE OF FUSION PROTEIN, PROCESS OF OBTAINING THE INHIBINE ANTIGEN a, ANTIGEN COMPOSITION, USE OF THE INHIBINE ANTIGEN a AND USE OF THE ANTIGEN COMPOSITION |
Country Status (4)
Country | Link |
---|---|
AR (1) | AR099671A1 (en) |
BR (1) | BR102014005376A2 (en) |
UY (1) | UY36020A (en) |
WO (1) | WO2015131254A1 (en) |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1341617C (en) * | 1984-06-08 | 2011-06-28 | Henry George Burger | Inhibin isolated from ovarian follicular fluid |
KR940004077B1 (en) * | 1985-04-18 | 1994-05-11 | 바이오테크놀로지 오스트레일리아 프로프라이어터리 리밋티드 | Recombinantinhbin |
US5215893A (en) * | 1985-10-03 | 1993-06-01 | Genentech, Inc. | Nucleic acid encoding the ba chain prodomains of inhibin and method for synthesizing polypeptides using such nucleic acid |
NZ217727A (en) * | 1985-10-03 | 1990-05-28 | Genentech Inc | Nucleic acid encoding alpha or b chain of inhibin, its production and compositions containing it |
US4864019A (en) * | 1985-11-08 | 1989-09-05 | The Salk Institute For Biological Studies | Antibodies to inhibin and conjugates produced therefrom |
ES2065673T3 (en) * | 1990-01-08 | 1995-02-16 | Genentech Inc | PROCEDURE TO INCREASE FERTILITY IN FEMALES. |
US20040220098A1 (en) * | 1994-02-28 | 2004-11-04 | Satterlee Daniel G. | Inhibin compositions and methods of enhancing fertility and growth |
PT804219E (en) * | 1994-02-28 | 2002-12-31 | Agritech Technologies Ltd | INIBINE COMPOSITIONS AND METHODS FOR THEIR USE |
JPH07238097A (en) * | 1994-09-07 | 1995-09-12 | Masao Igarashi | Igg antibody comprising inhibin as antigen |
JP2899534B2 (en) * | 1994-12-09 | 1999-06-02 | 全国農業協同組合連合会 | Method of inducing superovulation in cattle |
JP2006523180A (en) * | 2002-11-07 | 2006-10-12 | アグリテック テクノロジー リミテッド | Novel inhibin-related multi-antigen peptide composition that promotes productivity in birds |
BRPI0506043A (en) * | 2005-07-12 | 2007-03-13 | Univ Fed Do Rio Grande Do Sul | animal evaluation and selection process |
CN101407781A (en) * | 2008-12-01 | 2009-04-15 | 华中农业大学 | Inhibin DNA vaccine capable of improving animal fertility, and preparation and use thereof |
-
2014
- 2014-03-07 BR BR102014005376A patent/BR102014005376A2/en not_active Application Discontinuation
-
2015
- 2015-03-04 WO PCT/BR2015/050025 patent/WO2015131254A1/en active Application Filing
- 2015-03-05 AR ARP150100658A patent/AR099671A1/en unknown
- 2015-03-05 UY UY0001036020A patent/UY36020A/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
UY36020A (en) | 2015-09-30 |
WO2015131254A1 (en) | 2015-09-11 |
BR102014005376A2 (en) | 2016-02-10 |
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