AR099557A1 - Fgf-18 en trasplantes de injertos y procedimientos de ingeniería de tejido - Google Patents
Fgf-18 en trasplantes de injertos y procedimientos de ingeniería de tejidoInfo
- Publication number
- AR099557A1 AR099557A1 ARP150100506A ARP150100506A AR099557A1 AR 099557 A1 AR099557 A1 AR 099557A1 AR P150100506 A ARP150100506 A AR P150100506A AR P150100506 A ARP150100506 A AR P150100506A AR 099557 A1 AR099557 A1 AR 099557A1
- Authority
- AR
- Argentina
- Prior art keywords
- cartilage
- fgf
- procedures
- culture
- transfers
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 102000003977 fibroblast growth factor 18 Human genes 0.000 title abstract 3
- 108090000370 fibroblast growth factor 18 Proteins 0.000 title abstract 3
- 210000000845 cartilage Anatomy 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 2
- 210000001519 tissue Anatomy 0.000 abstract 2
- 206010007710 Cartilage injury Diseases 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 208000015100 cartilage disease Diseases 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 239000002782 chondrocyte implant Substances 0.000 abstract 1
- 230000002648 chondrogenic effect Effects 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- 238000004264 monolayer culture Methods 0.000 abstract 1
- 230000001172 regenerating effect Effects 0.000 abstract 1
- 238000002054 transplantation Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3612—Cartilage, synovial fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
- A61L27/3645—Connective tissue
- A61L27/3654—Cartilage, e.g. meniscus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0655—Chondrocytes; Cartilage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/24—Materials or treatment for tissue regeneration for joint reconstruction
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/119—Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2513/00—3D culture
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Botany (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Rheumatology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
Abstract
La presente solicitud proporciona métodos relacionados con la medicina regenerativa para el tratamiento de los trastornos del cartílago y el daño al cartílago en particular. Más particularmente se refiere a un compuesto FGF-18 para utilizar en la ingeniería del tejido y en los procedimientos de injertos, tales como el trasplante osteocondral o del cartílago o el implante de condrocito análogo (ACI). Reivindicación 1: Un proceso para producir un material de cartílago trasplantable para la ingeniería de tejidos, en el que dicho procedimiento comprende las etapas de cultivar células condrogénicas, ya sea en cultivo en monocapa o en un cultivo en 3D, en un medio de cultivo que contiene un compuesto FGF-18 durante un tiempo suficiente para permitir la formación de un material de cartílago trasplantable.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14000599 | 2014-02-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR099557A1 true AR099557A1 (es) | 2016-08-03 |
Family
ID=50151087
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP150100506A AR099557A1 (es) | 2014-02-20 | 2015-02-20 | Fgf-18 en trasplantes de injertos y procedimientos de ingeniería de tejido |
Country Status (17)
Country | Link |
---|---|
US (2) | US20170056554A1 (es) |
EP (1) | EP3107591B1 (es) |
JP (1) | JP6495934B2 (es) |
KR (1) | KR102437057B1 (es) |
CN (1) | CN106232153B (es) |
AR (1) | AR099557A1 (es) |
AU (1) | AU2015220781B2 (es) |
BR (1) | BR112016018704B1 (es) |
CA (1) | CA2938795A1 (es) |
ES (1) | ES2676318T3 (es) |
IL (1) | IL247105B (es) |
MX (1) | MX2016010873A (es) |
NZ (1) | NZ723169A (es) |
RU (1) | RU2682159C2 (es) |
SG (1) | SG11201606696UA (es) |
WO (1) | WO2015124735A1 (es) |
ZA (1) | ZA201605549B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6431082B2 (ja) | 2014-02-20 | 2018-11-28 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | Fgf−18化合物の投与計画 |
AR099556A1 (es) | 2014-02-20 | 2016-08-03 | Merck Patent Gmbh | Implante que contiene fgf-18 |
CN107058217A (zh) * | 2017-01-22 | 2017-08-18 | 广州赛莱拉干细胞科技股份有限公司 | 一种软骨细胞的增殖培养基及增殖培养方法 |
US20200128812A1 (en) * | 2017-03-17 | 2020-04-30 | Merck Patent Gmbh | Cartilage preservation media |
CN113244413B (zh) * | 2021-06-28 | 2021-10-26 | 深圳市瑞吉生物科技有限公司 | 一种mRNA剂型的骨关节炎药物制剂及其制备方法和应用 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6511958B1 (en) * | 1997-08-14 | 2003-01-28 | Sulzer Biologics, Inc. | Compositions for regeneration and repair of cartilage lesions |
US20140193468A1 (en) * | 2001-03-23 | 2014-07-10 | Histogenics Corporation | Methods for preparation of neo-cartilage constructs |
WO2004032849A2 (en) * | 2002-10-07 | 2004-04-22 | Zymogenetics, Inc. | Methods of administering fgf18 |
UA99818C2 (ru) * | 2006-08-25 | 2012-10-10 | Эйрэс Трейдинг С.А. | Лечение заболеваний хряща |
WO2008023063A2 (en) * | 2006-08-25 | 2008-02-28 | Ares Trading S.A. | Treatment of cartilage disorders with fgf-18 |
JP5388233B2 (ja) * | 2011-01-19 | 2014-01-15 | 富士ソフト株式会社 | 再生軟骨の軟骨特性を評価する方法 |
-
2015
- 2015-02-20 JP JP2016553431A patent/JP6495934B2/ja active Active
- 2015-02-20 RU RU2016137290A patent/RU2682159C2/ru active
- 2015-02-20 ES ES15705823.1T patent/ES2676318T3/es active Active
- 2015-02-20 US US15/120,136 patent/US20170056554A1/en not_active Abandoned
- 2015-02-20 CN CN201580020522.0A patent/CN106232153B/zh active Active
- 2015-02-20 KR KR1020167025249A patent/KR102437057B1/ko active IP Right Grant
- 2015-02-20 AU AU2015220781A patent/AU2015220781B2/en active Active
- 2015-02-20 NZ NZ723169A patent/NZ723169A/en unknown
- 2015-02-20 CA CA2938795A patent/CA2938795A1/en active Pending
- 2015-02-20 MX MX2016010873A patent/MX2016010873A/es active IP Right Grant
- 2015-02-20 BR BR112016018704-0A patent/BR112016018704B1/pt active IP Right Grant
- 2015-02-20 EP EP15705823.1A patent/EP3107591B1/en active Active
- 2015-02-20 SG SG11201606696UA patent/SG11201606696UA/en unknown
- 2015-02-20 AR ARP150100506A patent/AR099557A1/es unknown
- 2015-02-20 WO PCT/EP2015/053639 patent/WO2015124735A1/en active Application Filing
-
2016
- 2016-08-04 IL IL247105A patent/IL247105B/en active IP Right Grant
- 2016-08-10 ZA ZA2016/05549A patent/ZA201605549B/en unknown
-
2022
- 2022-06-16 US US17/842,762 patent/US20220378981A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
BR112016018704A2 (pt) | 2017-10-17 |
KR20160124149A (ko) | 2016-10-26 |
KR102437057B1 (ko) | 2022-08-26 |
WO2015124735A1 (en) | 2015-08-27 |
AU2015220781B2 (en) | 2018-05-24 |
NZ723169A (en) | 2023-05-26 |
EP3107591A1 (en) | 2016-12-28 |
CN106232153B (zh) | 2020-01-17 |
US20220378981A1 (en) | 2022-12-01 |
CA2938795A1 (en) | 2015-08-27 |
MX2016010873A (es) | 2016-11-17 |
EP3107591B1 (en) | 2018-04-18 |
BR112016018704B1 (pt) | 2021-01-05 |
IL247105A0 (en) | 2016-09-29 |
RU2682159C2 (ru) | 2019-03-15 |
IL247105B (en) | 2020-02-27 |
CN106232153A (zh) | 2016-12-14 |
AU2015220781A1 (en) | 2016-09-01 |
RU2016137290A3 (es) | 2018-09-07 |
JP2017508523A (ja) | 2017-03-30 |
ZA201605549B (en) | 2018-12-19 |
US20170056554A1 (en) | 2017-03-02 |
ES2676318T3 (es) | 2018-07-18 |
JP6495934B2 (ja) | 2019-04-03 |
SG11201606696UA (en) | 2016-09-29 |
RU2016137290A (ru) | 2018-03-23 |
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