AR096980A1 - CYCLIC POLIPEPTIDES FOR THE CARDIAC INSUFFICIENCY TREATMENT - Google Patents
CYCLIC POLIPEPTIDES FOR THE CARDIAC INSUFFICIENCY TREATMENTInfo
- Publication number
- AR096980A1 AR096980A1 ARP140102680A ARP140102680A AR096980A1 AR 096980 A1 AR096980 A1 AR 096980A1 AR P140102680 A ARP140102680 A AR P140102680A AR P140102680 A ARP140102680 A AR P140102680A AR 096980 A1 AR096980 A1 AR 096980A1
- Authority
- AR
- Argentina
- Prior art keywords
- polypeptides
- heart failure
- cyclic
- diabetes
- polipeptides
- Prior art date
Links
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Un polipéptido cíclico de la fórmula (1): X¹-R-X³-X⁴-L-S-X⁷-X⁸-X⁹-X¹⁰-X¹¹-X¹²-X¹³ (1) o una amida, un éster o una sal del mismo, o un bioconjugado del mismo, en donde X¹, X³, X⁴, X⁷, X⁸, X⁹, X¹⁰, X¹¹, X¹² y X¹³ se definen en la presente. Los polipéptidos son agonistas del receptor APJ. Un método para la fabricación de los polipéptidos o bioconjugados de los mismos, y sus usos terapéuticos tales como el tratamiento o la prevención de insuficiencia cardiaca aguda descompensada (IDAC), insuficiencia cardiaca crónica, hipertensión pulmonar, fibrilación atrial, síndrome de Brugada, taquicardia ventricular, aterosclerosis, hipertensión, restenosis, enfermedades cardiovasculares isquémicas, cardiomiopatía, fibrosis cardiaca, arritmia, retención de agua, diabetes (incluyendo diabetes gestacional), obesidad, enfermedad arterial periférica, accidentes cerebrovasculares, ataques isquémicos temporales, lesiones cerebrales traumáticas, esclerosis lateral amiotrófica, lesiones por quemaduras (incluyendo quemaduras solares) y preeclampsia. Una combinación de agentes farmacológicamente activos y una composición farmacéutica.A cyclic polypeptide of the formula (1): X¹-R-X³-X⁴-LS-X⁷-X⁸-X⁹-X¹⁰-X¹¹-X¹²-X¹³ (1) or an amide, an ester or a salt thereof, or a bioconjugate thereof, wherein X¹, X³, X⁴, X⁷, X⁸, X⁹, X¹⁰, X¹¹, X¹² and X¹³ are defined herein. Polypeptides are agonists of the APJ receptor. A method for the manufacture of polypeptides or bioconjugates thereof, and their therapeutic uses such as the treatment or prevention of decompensated acute heart failure (IDAC), chronic heart failure, pulmonary hypertension, atrial fibrillation, Brugada syndrome, ventricular tachycardia , atherosclerosis, hypertension, restenosis, ischemic cardiovascular diseases, cardiomyopathy, cardiac fibrosis, arrhythmia, water retention, diabetes (including gestational diabetes), obesity, peripheral arterial disease, strokes, temporary ischemic attacks, traumatic brain injuries, amyotrophic lateral sclerosis, burn injuries (including sunburn) and preeclampsia. A combination of pharmacologically active agents and a pharmaceutical composition.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361858263P | 2013-07-25 | 2013-07-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR096980A1 true AR096980A1 (en) | 2016-02-10 |
Family
ID=56125378
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP140102680A AR096980A1 (en) | 2013-07-25 | 2014-07-21 | CYCLIC POLIPEPTIDES FOR THE CARDIAC INSUFFICIENCY TREATMENT |
Country Status (2)
| Country | Link |
|---|---|
| AR (1) | AR096980A1 (en) |
| MA (1) | MA38864A1 (en) |
-
2014
- 2014-07-21 AR ARP140102680A patent/AR096980A1/en unknown
- 2014-07-21 MA MA38864A patent/MA38864A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MA38864A1 (en) | 2017-11-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |