AR096848A1 - Derivados de indazol con actividad antagonista del receptor de la hormona concentradora de melanina (mch) - Google Patents
Derivados de indazol con actividad antagonista del receptor de la hormona concentradora de melanina (mch)Info
- Publication number
- AR096848A1 AR096848A1 ARP140102528A ARP140102528A AR096848A1 AR 096848 A1 AR096848 A1 AR 096848A1 AR P140102528 A ARP140102528 A AR P140102528A AR P140102528 A ARP140102528 A AR P140102528A AR 096848 A1 AR096848 A1 AR 096848A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- group
- independently
- hydrogen atom
- ring
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Se proporciona un compuesto que tiene una acción antagonista del receptor de la hormona concentradora de melanina y que es útil como agente para la profilaxis o el tratamiento de la obesidad y similares. Reivindicación 1: Un compuesto representado por la fórmula (1), caracterizado porque el anillo Ar es un anillo aromático además sustituido en forma opcional; L¹ es O, S(O)ₘ₁, NR³A o CR³BR³C; L² es O, S(O)ₘ₂, NR⁴A o CR⁴BR⁴C; (con la exclusión de la combinación en que L¹ sea distinto de CR³BR³C y L² sea distinto de CR⁴BR⁴C); m1 y m2 son cada uno en forma independiente un número entero de 0 a 2; R³A y R⁴A son cada uno en forma independiente un átomo de hidrógeno o un grupo hidrocarburo sustituido en forma opcional; R³B, R³C, R⁴B y R⁴C son cada uno en forma independiente un átomo de hidrógeno o un sustituyente; cuando L¹ es CR³BR³C y el anillo Ar tiene sustituyente(s), R³B y el sustituyente se encuentran unidos en forma opcional entre sí para formar un anillo sustituido en forma opcional; X¹, X² y X³ son cada uno en forma independiente CR⁵ o N; R⁵ es un átomo de hidrógeno, un átomo de halógeno, un grupo ciano, un grupo alquilo C₁₋₆ sustituido en forma opcional, un grupo alcoxi C₁₋₆ sustituido en forma opcional o un grupo cicloalquilo C₃₋₁₀ sustituido en forma opcional; R¹ es un grupo alquilo C₁₋₆ sustituido en forma opcional o un grupo cíclico sustituido en forma opcional; R² es un átomo de halógeno, un grupo alquilo C₁₋₆ sustituido en forma opcional o un grupo cíclico sustituido en forma opcional; Y¹, Y² e Y³ son cada uno en forma independiente CR⁶ o N; y R⁶ es un átomo de hidrógeno, un átomo de halógeno, un grupo alquilo C₁₋₆ sustituido en forma opcional, un grupo alcoxi C₁₋₆ sustituido en forma opcional o un grupo cicloalquilo C₃₋₁₀ sustituido en forma opcional; o una sal del mismo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2013143940 | 2013-07-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR096848A1 true AR096848A1 (es) | 2016-02-03 |
Family
ID=51220851
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP140102528A AR096848A1 (es) | 2013-07-09 | 2014-07-08 | Derivados de indazol con actividad antagonista del receptor de la hormona concentradora de melanina (mch) |
Country Status (9)
Country | Link |
---|---|
US (1) | US9199963B2 (es) |
EP (1) | EP3019487A1 (es) |
JP (1) | JP2016523809A (es) |
CN (1) | CN105358544A (es) |
AR (1) | AR096848A1 (es) |
CA (1) | CA2917490A1 (es) |
TW (1) | TW201536767A (es) |
UY (1) | UY35650A (es) |
WO (1) | WO2015005489A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9365540B2 (en) * | 2012-01-12 | 2016-06-14 | Takeda Pharmaceutical Company Limited | Benzimidazole derivatives as MCH receptor antagonists |
EP2848621A4 (en) * | 2012-05-10 | 2016-06-01 | Takeda Pharmaceutical | AROMATIC CYCLIC COMPOUND |
JP2023506917A (ja) | 2019-12-20 | 2023-02-20 | バイエル・アクチエンゲゼルシヤフト | 置換チオフェンカルボキサミド、チオフェンカルボン酸およびその誘導体 |
HUP2200222A1 (hu) | 2022-06-17 | 2023-12-28 | Richter Gedeon Nyrt | MCHR1 antagonisták a Prader-Willi szindróma kezelésére |
Family Cites Families (46)
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US5849708A (en) | 1995-06-06 | 1998-12-15 | Joslin Diabetes Center, Inc. | Promotion of eating behavior |
CN1072649C (zh) | 1995-09-13 | 2001-10-10 | 武田药品工业株式会社 | 苯并氧杂吖庚因化合物,其生产方法和用途 |
EP0848060A3 (en) | 1996-12-11 | 2000-02-02 | Smithkline Beecham Corporation | Novel human 11CB splice variant |
CA2302992C (en) | 1997-09-05 | 2011-11-01 | Targeted Genetics Corporation | Methods for generating high titer helper-free preparations of recombinant aav vectors |
EP1042498A4 (en) | 1997-12-03 | 2003-05-07 | Smithkline Beecham Corp | METHOD FOR SEARCHING FOR AN AGONIST OR ANTAGONIST OF THE HUMAN 11 CB SPLICE VARIANT |
WO2000049170A1 (en) | 1999-02-18 | 2000-08-24 | Smithkline Beecham Corporation | MURINE 11cby RECEPTOR |
AR035016A1 (es) | 1999-08-25 | 2004-04-14 | Takeda Chemical Industries Ltd | Composicion de azol promotor de produccion/secrecion de neurotrofina, compuesto prodroga del mismo, composicion farmaceutica que lo comprende y uso del mismo para preparar esta ultima. |
CA2407149C (en) | 2000-04-28 | 2010-10-12 | Takeda Chemical Industries, Ltd. | Melanin-concentrating hormone antagonist |
EP1302462A4 (en) | 2000-07-17 | 2007-07-18 | Takeda Pharmaceutical | Sulphonic derivatives, process for their preparation and their use |
JP2005523237A (ja) | 2001-10-01 | 2005-08-04 | 大正製薬株式会社 | Mch受容体アンタゴニスト |
US7101845B2 (en) | 2002-01-31 | 2006-09-05 | Joslin Diabetes Center, Inc. | Methods of modulating β cell function |
ES2334990T3 (es) | 2002-02-14 | 2010-03-18 | Pharmacia Corporation | Piridinonas sustituidas como moduladores de p38 map quinasa. |
US20060183789A1 (en) | 2002-09-25 | 2006-08-17 | Lavanya Rajachandran | Methods for preventing and treating obesity in patients with mc4 receptor mutations |
WO2004039365A1 (en) | 2002-11-01 | 2004-05-13 | Takeda Pharmaceutical Company Limited | Agent for preventing or treating neuropathy |
AU2003277576A1 (en) | 2002-11-08 | 2004-06-07 | Takeda Pharmaceutical Company Limited | Receptor function controlling agent |
AU2003284596A1 (en) | 2002-11-22 | 2004-06-18 | Takeda Pharmaceutical Company Limited | Imidazole derivative, process for producing the same, and use |
CA2527691C (en) | 2003-05-30 | 2013-01-22 | Takeda Pharmaceutical Company Limited | Condensed ring compound |
CL2004002050A1 (es) | 2003-08-13 | 2005-06-03 | Pharmacia Corp Sa Organizada B | Compuestos derivados de piridinonas sustituidas; su uso en el tratamiento de afecciones causadas o exacerbadas por actividad p38 map kinasa y/o tnf no regulada, tales como inflamaciones, tumores, sida y otros. |
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WO2005040824A2 (en) | 2003-10-24 | 2005-05-06 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with g protein-coupled receptor 24 (gpr24) |
WO2005058823A1 (ja) | 2003-12-17 | 2005-06-30 | Takeda Pharmaceutical Company Limited | ウレア誘導体、その製造法及び用途 |
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EP1698624B1 (en) | 2003-12-26 | 2012-06-27 | Takeda Pharmaceutical Company Limited | Phenylpropanoic acid derivatives |
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US9365540B2 (en) * | 2012-01-12 | 2016-06-14 | Takeda Pharmaceutical Company Limited | Benzimidazole derivatives as MCH receptor antagonists |
-
2014
- 2014-07-08 TW TW103123436A patent/TW201536767A/zh unknown
- 2014-07-08 AR ARP140102528A patent/AR096848A1/es unknown
- 2014-07-08 UY UY35650A patent/UY35650A/es not_active Application Discontinuation
- 2014-07-08 CN CN201480039259.5A patent/CN105358544A/zh active Pending
- 2014-07-08 CA CA2917490A patent/CA2917490A1/en not_active Abandoned
- 2014-07-08 EP EP14742376.8A patent/EP3019487A1/en not_active Withdrawn
- 2014-07-08 JP JP2016500830A patent/JP2016523809A/ja active Pending
- 2014-07-08 US US14/325,564 patent/US9199963B2/en not_active Expired - Fee Related
- 2014-07-08 WO PCT/JP2014/068651 patent/WO2015005489A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
US9199963B2 (en) | 2015-12-01 |
UY35650A (es) | 2015-02-27 |
JP2016523809A (ja) | 2016-08-12 |
US20150018373A1 (en) | 2015-01-15 |
EP3019487A1 (en) | 2016-05-18 |
CA2917490A1 (en) | 2015-01-15 |
CN105358544A (zh) | 2016-02-24 |
WO2015005489A1 (en) | 2015-01-15 |
TW201536767A (zh) | 2015-10-01 |
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