AR089020A1 - ANTICOAGULATING REVERSION AGENTS - Google Patents
ANTICOAGULATING REVERSION AGENTSInfo
- Publication number
- AR089020A1 AR089020A1 ARP120104474A ARP120104474A AR089020A1 AR 089020 A1 AR089020 A1 AR 089020A1 AR P120104474 A ARP120104474 A AR P120104474A AR P120104474 A ARP120104474 A AR P120104474A AR 089020 A1 AR089020 A1 AR 089020A1
- Authority
- AR
- Argentina
- Prior art keywords
- different
- same
- compound
- anticoagulating
- absent
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Abstract
Reivindicación 1: Un compuesto de la fórmula (1): Y-M-X-L-A-L-X-M-Y (1) o una sal farmacéuticamente aceptable de la misma, donde: A es un anillo carbocíclico o heterocíclico, aromático o no aromático, sustituido o no sustituido o un resto lineal; L y L son iguales o diferentes y son enlaces; X y X son iguales o diferentes y están ausentes o son un grupo funcional que une el enlace L a M y el enlace L a M, respectivamente; M y M son iguales o diferentes y están ausentes o son un enlace que une X a Y y X a Y, respectivamente; e Y e Y son iguales o diferentes y son un resto que contiene uno o más átomos o grupos catiónicos o uno o más grupos que se vuelven catiónicos en condiciones fisiológicas. Reivindicación 6: El compuesto de la reivindicación 1, donde el compuesto está representado por la fórmula (2) o una sal farmacéuticamente aceptable de este.Claim 1: A compound of the formula (1): Y-M-X-L-A-L-X-M-Y (1) or a pharmaceutically acceptable salt thereof, wherein: A is a carbocyclic or heterocyclic, aromatic or non-aromatic, substituted or unsubstituted ring or a linear moiety; L and L are the same or different and are links; X and X are the same or different and are absent or are a functional group that links the L to M link and the L to M link, respectively; M and M are the same or different and are absent or are a bond linking X to Y and X to Y, respectively; e Y e Y are the same or different and are a residue that contains one or more cationic atoms or groups or one or more groups that become cationic under physiological conditions. Claim 6: The compound of claim 1, wherein the compound is represented by formula (2) or a pharmaceutically acceptable salt thereof.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161564559P | 2011-11-29 | 2011-11-29 | |
| US201261614292P | 2012-03-22 | 2012-03-22 | |
| US201261641698P | 2012-05-02 | 2012-05-02 | |
| US201261666291P | 2012-06-29 | 2012-06-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR089020A1 true AR089020A1 (en) | 2014-07-23 |
Family
ID=47430065
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120104474A AR089020A1 (en) | 2011-11-29 | 2012-11-29 | ANTICOAGULATING REVERSION AGENTS |
Country Status (35)
| Country | Link |
|---|---|
| US (4) | US9522892B2 (en) |
| EP (1) | EP2785700B1 (en) |
| JP (1) | JP6134731B2 (en) |
| KR (1) | KR101892330B1 (en) |
| CN (1) | CN104080772B (en) |
| AP (1) | AP2014007662A0 (en) |
| AR (1) | AR089020A1 (en) |
| AU (1) | AU2012345975B2 (en) |
| BR (1) | BR112014012892B1 (en) |
| CA (1) | CA2856540C (en) |
| CL (1) | CL2014001399A1 (en) |
| CO (1) | CO6990738A2 (en) |
| CR (1) | CR20140310A (en) |
| CY (1) | CY1117414T1 (en) |
| DK (1) | DK2785700T3 (en) |
| EA (1) | EA027603B1 (en) |
| EC (1) | ECSP14006696A (en) |
| ES (1) | ES2569674T3 (en) |
| HK (1) | HK1202858A1 (en) |
| HR (1) | HRP20160513T1 (en) |
| HU (1) | HUE027452T2 (en) |
| IL (1) | IL232788B (en) |
| ME (1) | ME02424B (en) |
| MX (1) | MX349514B (en) |
| PE (1) | PE20141295A1 (en) |
| PH (1) | PH12014501176B1 (en) |
| PL (1) | PL2785700T3 (en) |
| PT (1) | PT2785700E (en) |
| RS (1) | RS54738B1 (en) |
| SG (1) | SG11201402713WA (en) |
| SI (1) | SI2785700T1 (en) |
| SM (1) | SMT201600161B (en) |
| UA (1) | UA116336C2 (en) |
| WO (1) | WO2013082210A1 (en) |
| ZA (1) | ZA201404793B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9999690B2 (en) | 2013-11-08 | 2018-06-19 | Perosphere Pharmaceuticals Inc. | Labeled compounds and methods of imaging, diagnosing cartilage disorders and diseases, and monitoring cartilage health using labeled and unlabeled compounds |
| PE20200719A1 (en) * | 2017-11-13 | 2020-07-21 | Maximum Fidelity Surgical Simulations Llc | RECONSTITUTION OF POSTMORTEM CIRCULATION, SPECIALIZED METHODS AND PROCEDURES |
| MA53010A (en) | 2018-06-29 | 2021-05-05 | Incyte Corp | FORMULATIONS OF AN AXL / MER INHIBITOR |
| US11716989B2 (en) | 2019-04-16 | 2023-08-08 | Maximum Fidelity Surgical Simulations, LLC | Cadaver preservation systems and methods |
| US11915610B2 (en) | 2019-05-15 | 2024-02-27 | Maximum Fidelity Surgical Simulations, LLC | Cadaverous heart model |
| CN112010930B (en) * | 2019-05-28 | 2022-08-02 | 首都医科大学 | RGD modified pentacyclic piperazinedione and preparation and application thereof |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3678157A (en) * | 1968-10-23 | 1972-07-18 | Oreal | Hair treatment compositions containing polycondensable compounds |
| IL115420A0 (en) * | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
| US6069232A (en) * | 1995-10-02 | 2000-05-30 | Hoechst Marion Roussel, Inc. | Polyfluoroalkyl tryptophan tripeptide thrombin inhibitors |
| US6080852A (en) | 1996-06-27 | 2000-06-27 | The Perkin-Elmer Corporation | 4,7-dichlororhodamine dyes |
| WO1998016547A1 (en) | 1996-10-11 | 1998-04-23 | Cor Therapeutics, Inc. | SELECTIVE FACTOR Xa INHIBITORS |
| NZ500029A (en) * | 1997-04-07 | 2001-02-23 | Axys Pharm Inc | Compounds and compositions of carboxamide derivatives associated with the treatment of rheumatoid arthritis, conjunctivitis and/ or syncytial virus infections |
| FR2781221B1 (en) * | 1998-07-17 | 2000-10-13 | Lafon Labor | ALPHA SUBSTITUTED PIPERAZINONES |
| CA2320730A1 (en) * | 1998-12-23 | 2000-07-06 | Renhua Li | Thrombin or factor xa inhibitors |
| CA2373610A1 (en) | 1999-05-19 | 2000-11-23 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents |
| EP1377554A1 (en) * | 1999-06-16 | 2004-01-07 | University Of Iowa Research Foundation | Antagonism of immunostimulatory cpg-oligonucleotides by 4-aminoquinolines and other weak bases |
| AU2001253363A1 (en) | 2000-04-17 | 2001-10-30 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted 1,4-quinones useful for selective inhibition of the coagulation cascade |
| WO2002002519A2 (en) * | 2000-06-29 | 2002-01-10 | Bristol-Myers Squibb Pharma Company | THROMBIN OR FACTOR Xa INHIBITORS |
| WO2003029216A1 (en) | 2001-10-03 | 2003-04-10 | Pharmacia Corporation | 6-membered heterocyclic compounds useful for selective inhibition of the coagulation cascade |
| EP1487788A1 (en) * | 2002-03-27 | 2004-12-22 | Glaxo Group Limited | Diaminoacid-aminoacid-polyamine based gemini surfactant compounds |
| WO2003099324A1 (en) * | 2002-05-23 | 2003-12-04 | Chugai Seiyaku Kabushiki Kaisha | Agent neutralizint tissue factor inhibitor and agent neutralizing activated blood coagulation factor viii preparation |
| GB0214122D0 (en) * | 2002-06-19 | 2002-07-31 | Eastman Kodak Co | High contrast photographic element containing a polyhydrazide nucleating agent |
| SE0400014D0 (en) * | 2004-01-08 | 2004-01-08 | Astrazeneca Ab | Heterocyclic derivatives |
| US20060045865A1 (en) | 2004-08-27 | 2006-03-02 | Spherics, Inc. | Controlled regional oral delivery |
| EP3824902A1 (en) * | 2007-09-28 | 2021-05-26 | Portola Pharmaceuticals, Inc. | Antidotes for factor xa inhibitors and methods of using the same |
| GB2476643B (en) | 2009-12-23 | 2012-11-14 | Haomamedica Ltd | 1,4-Dihydro-1,4-dioxonaphtalene derivatives as anticoagulants |
| AR079944A1 (en) | 2010-01-20 | 2012-02-29 | Boehringer Ingelheim Int | NEUTRALIZING ANTIBODY OF THE ACTIVITY OF AN ANTICOAGULANT |
| AP2013007046A0 (en) | 2011-03-30 | 2013-08-31 | Boehringer Ingelheim Int | Anticoagulant antidotes |
-
2012
- 2012-11-29 PE PE2014000763A patent/PE20141295A1/en active IP Right Grant
- 2012-11-29 SG SG11201402713WA patent/SG11201402713WA/en unknown
- 2012-11-29 EP EP12806229.6A patent/EP2785700B1/en active Active
- 2012-11-29 AU AU2012345975A patent/AU2012345975B2/en active Active
- 2012-11-29 HU HUE12806229A patent/HUE027452T2/en unknown
- 2012-11-29 CN CN201280060950.2A patent/CN104080772B/en active Active
- 2012-11-29 MX MX2014006349A patent/MX349514B/en active IP Right Grant
- 2012-11-29 US US13/688,442 patent/US9522892B2/en active Active
- 2012-11-29 UA UAA201404997A patent/UA116336C2/en unknown
- 2012-11-29 AR ARP120104474A patent/AR089020A1/en active IP Right Grant
- 2012-11-29 SI SI201230558A patent/SI2785700T1/en unknown
- 2012-11-29 WO PCT/US2012/066938 patent/WO2013082210A1/en active Application Filing
- 2012-11-29 KR KR1020147016304A patent/KR101892330B1/en active IP Right Grant
- 2012-11-29 AP AP2014007662A patent/AP2014007662A0/en unknown
- 2012-11-29 DK DK12806229.6T patent/DK2785700T3/en active
- 2012-11-29 BR BR112014012892-8A patent/BR112014012892B1/en active IP Right Grant
- 2012-11-29 PL PL12806229.6T patent/PL2785700T3/en unknown
- 2012-11-29 EA EA201490823A patent/EA027603B1/en unknown
- 2012-11-29 PT PT128062296T patent/PT2785700E/en unknown
- 2012-11-29 JP JP2014544857A patent/JP6134731B2/en active Active
- 2012-11-29 RS RS20160318A patent/RS54738B1/en unknown
- 2012-11-29 CA CA2856540A patent/CA2856540C/en active Active
- 2012-11-29 ME MEP-2016-95A patent/ME02424B/en unknown
- 2012-11-29 ES ES12806229.6T patent/ES2569674T3/en active Active
-
2014
- 2014-05-26 IL IL232788A patent/IL232788B/en active IP Right Grant
- 2014-05-26 PH PH12014501176A patent/PH12014501176B1/en unknown
- 2014-05-27 CL CL2014001399A patent/CL2014001399A1/en unknown
- 2014-06-26 EC ECIEPI20146696A patent/ECSP14006696A/en unknown
- 2014-06-26 CO CO14137450A patent/CO6990738A2/en unknown
- 2014-06-26 CR CR20140310A patent/CR20140310A/en unknown
- 2014-06-27 ZA ZA2014/04793A patent/ZA201404793B/en unknown
-
2015
- 2015-04-01 HK HK15103329.9A patent/HK1202858A1/en unknown
-
2016
- 2016-04-25 CY CY20161100338T patent/CY1117414T1/en unknown
- 2016-05-13 HR HRP20160513TT patent/HRP20160513T1/en unknown
- 2016-06-08 SM SM201600161T patent/SMT201600161B/en unknown
- 2016-11-10 US US15/348,348 patent/US9877961B2/en active Active
-
2017
- 2017-10-06 US US15/726,497 patent/US20180207152A1/en not_active Abandoned
-
2020
- 2020-12-10 US US17/117,559 patent/US20210169874A1/en not_active Abandoned
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |