AR087655A1 - Sulfoxidos de piperidino-dihidrotienopirimidina y su uso para tratar epoc y asma - Google Patents

Sulfoxidos de piperidino-dihidrotienopirimidina y su uso para tratar epoc y asma

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Publication number
AR087655A1
AR087655A1 ARP120103115A ARP120103115A AR087655A1 AR 087655 A1 AR087655 A1 AR 087655A1 AR P120103115 A ARP120103115 A AR P120103115A AR P120103115 A ARP120103115 A AR P120103115A AR 087655 A1 AR087655 A1 AR 087655A1
Authority
AR
Argentina
Prior art keywords
ring
formula
asthma
piperidine
salts
Prior art date
Application number
ARP120103115A
Other languages
English (en)
Inventor
A J Puozet Pascale
Nickolaus Peter
Werthmann Ulrike
P Frutos Rogelio
Yang Bing
Shiou-Kim Soojin
Alan Mulder Jason
Patel Nitinchandra
H Senanayake Chris
G Tampone Thomas
Wei Xudong
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46924393&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR087655(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of AR087655A1 publication Critical patent/AR087655A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/12—Mucolytics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P11/16—Central respiratory analeptics
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    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Otolaryngology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Psychology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Sulfóxidos de piperidino-dihidrotienopirimidina de fórmula (1), en donde el Anillo A es un anillo aromático de 6 miembros que puede comprender opcionalmente uno o dos átomos de nitrógeno y en donde R es Cl y en donde R puede estar ubicado en la posición para, meta u orto del Anillo A, en donde S* es un átomo de azufre que representa un centro quiral, y todas las sales aceptables para uso farmacéutico, enantiómeros y racematos, hidratos y solvatos de los mismos y el uso de estos compuestos para el tratamiento de enfermedades inflamatorias o alérgicas del tracto respiratorio tales como EPOC o asma. Reivindicación 1: Compuesto caracterizado porque tiene la fórmula (1) en donde el Anillo A es un anillo aromático de 6 miembros que puede comprender opcionalmente uno o dos átomos de nitrógeno y en donde R es Cl y en donde R puede estar ubicado en la posición para, meta u orto del Anillo A, en donde S* es un átomo de azufre que representa un centro quiral, y todas las sales aceptables para uso farmacéutico del mismo, enantiómeros y racematos del mismo. Reivindicación 35: El intermediario caracterizado porque tiene la fórmula (2) y sus sales. Reivindicación 36: El intermediario caracterizado porque tiene la fórmula (3) en donde S* significa un átomo de azufre que representa un centro quiral, y sus sales.
ARP120103115A 2011-08-24 2012-08-23 Sulfoxidos de piperidino-dihidrotienopirimidina y su uso para tratar epoc y asma AR087655A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161526861P 2011-08-24 2011-08-24

Publications (1)

Publication Number Publication Date
AR087655A1 true AR087655A1 (es) 2014-04-09

Family

ID=46924393

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP120103115A AR087655A1 (es) 2011-08-24 2012-08-23 Sulfoxidos de piperidino-dihidrotienopirimidina y su uso para tratar epoc y asma
ARP220100644A AR125150A2 (es) 2011-08-24 2022-03-18 Sulfóxidos de piperidino-dihidrotienopirimidina y su uso para tratar epoc y asma

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP220100644A AR125150A2 (es) 2011-08-24 2022-03-18 Sulfóxidos de piperidino-dihidrotienopirimidina y su uso para tratar epoc y asma

Country Status (26)

Country Link
US (3) US20130059866A1 (es)
EP (1) EP2748156B1 (es)
JP (1) JP5851038B2 (es)
KR (1) KR101959194B1 (es)
CN (1) CN103889970B (es)
AP (1) AP2014007401A0 (es)
AR (2) AR087655A1 (es)
AU (1) AU2012298599B2 (es)
BR (2) BR122022002799B1 (es)
CA (1) CA2846183C (es)
CL (1) CL2014000296A1 (es)
CO (1) CO6900138A2 (es)
DK (1) DK2748156T3 (es)
EA (1) EA024033B1 (es)
EC (1) ECSP14013254A (es)
ES (1) ES2563028T3 (es)
HU (1) HUE028531T2 (es)
IL (1) IL230592A0 (es)
MX (1) MX358651B (es)
PE (1) PE20141532A1 (es)
PL (1) PL2748156T3 (es)
TN (1) TN2014000081A1 (es)
TW (1) TWI597283B (es)
UY (1) UY34285A (es)
WO (1) WO2013026797A1 (es)
ZA (1) ZA201400792B (es)

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US20230181590A1 (en) 2021-12-09 2023-06-15 Boehringer Ingelheim International Gmbh New oral pharmaceutical composition and dose regimen for the therapy of progressive fibrosing interstitial lung diseases
CA3236757A1 (en) 2021-12-09 2023-06-15 Boehringer Ingelheim International Gmbh New therapeutic combinations for the treatment of progressive fibrosing interstitial lung diseases
US20230286950A1 (en) * 2022-02-04 2023-09-14 Aclaris Therapeutics, Inc. Methods of synthesizing deuterated substituted pyridinone-pyridinyl compounds
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WO2023232135A1 (zh) * 2022-06-02 2023-12-07 西藏海思科制药有限公司 Pde4b抑制剂及其用途
WO2023241684A1 (zh) * 2022-06-16 2023-12-21 武汉人福创新药物研发中心有限公司 Pde4b抑制剂
TW202413371A (zh) * 2022-06-16 2024-04-01 大陸商武漢人福創新藥物研發中心有限公司 作為pde4b抑制劑的含氮雜環類化合物
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US8609670B2 (en) 2013-12-17
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