AR086738A1 - USE OF AN ANTIBODY ANTI-CD20 OF GREAT CYTOTOXICITY FOR ANTIBODY DEPENDENT CELLULAR MEDIATION (ADCC) IN THE TREATMENT OF WALDENSTRÖM DISEASE - Google Patents
USE OF AN ANTIBODY ANTI-CD20 OF GREAT CYTOTOXICITY FOR ANTIBODY DEPENDENT CELLULAR MEDIATION (ADCC) IN THE TREATMENT OF WALDENSTRÖM DISEASEInfo
- Publication number
- AR086738A1 AR086738A1 ARP120102258A ARP120102258A AR086738A1 AR 086738 A1 AR086738 A1 AR 086738A1 AR P120102258 A ARP120102258 A AR P120102258A AR P120102258 A ARP120102258 A AR P120102258A AR 086738 A1 AR086738 A1 AR 086738A1
- Authority
- AR
- Argentina
- Prior art keywords
- antibody
- waldenström
- adcc
- disease
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
Anticuerpo monoclonal dirigido contra el antígeno CD20. Dicho anticuerpo posee una gran citotoxicidad para la mediación celular dependiente de anticuerpos (ADCC) y/o tiene capacidad para activar las células efectoras con mayor expresión de FcgRlll, y que poseen una región Fc en la cual al menos un 60% de los oligosacáridos no están fucosilados, para su uso en el tratamiento de la enfermedad de Waldenström. Reivindicación 1: Anticuerpo monoclonal dirigido contra el antígeno CD20, caracterizado porque dicho anticuerpo tiene citotoxicidad mediada por células dependiente de anticuerpos (ADCC) y/o una capacidad para activar las células efectoras que expresan FcgRlll incrementada, y posee una región Fc en donde al menos 60% de los oligosacáridos son no fucosilados, para su utilización en el tratamiento de la enfermedad de Waldenström.Monoclonal antibody directed against the CD20 antigen. Said antibody has a high cytotoxicity for antibody-dependent cell mediation (ADCC) and / or has the capacity to activate effector cells with greater FcgRlll expression, and which possess an Fc region in which at least 60% of the oligosaccharides do not are fucosylated, for use in the treatment of Waldenström disease. Claim 1: Monoclonal antibody directed against the CD20 antigen, characterized in that said antibody has antibody-dependent cell-mediated cytotoxicity (ADCC) and / or an ability to activate effector cells expressing increased FcgRlll, and possesses an Fc region where at least 60% of oligosaccharides are non-fucosylated, for use in the treatment of Waldenström disease.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1101931A FR2976811A1 (en) | 2011-06-22 | 2011-06-22 | USE OF A HIGH ADCC ANTI-CD20 ANTIBODY FOR THE TREATMENT OF WALDENSTROM'S DISEASE |
Publications (1)
Publication Number | Publication Date |
---|---|
AR086738A1 true AR086738A1 (en) | 2014-01-22 |
Family
ID=46508094
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP120102258A AR086738A1 (en) | 2011-06-22 | 2012-06-22 | USE OF AN ANTIBODY ANTI-CD20 OF GREAT CYTOTOXICITY FOR ANTIBODY DEPENDENT CELLULAR MEDIATION (ADCC) IN THE TREATMENT OF WALDENSTRÖM DISEASE |
Country Status (4)
Country | Link |
---|---|
AR (1) | AR086738A1 (en) |
FR (1) | FR2976811A1 (en) |
TW (1) | TW201309728A (en) |
WO (1) | WO2012175874A1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR3012453B1 (en) | 2013-10-31 | 2015-11-13 | Lab Francais Du Fractionnement | CHIMERIC PROTEIN FOR THE TREATMENT OF AMYLOSIS |
CN111363043B (en) * | 2020-04-09 | 2021-07-23 | 福州迈新生物技术开发有限公司 | anti-CD 20 protein monoclonal antibody, cell line, preparation method and application thereof |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2261229A3 (en) | 1998-04-20 | 2011-03-23 | GlycArt Biotechnology AG | Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity |
ES2568899T3 (en) | 1999-04-09 | 2016-05-05 | Kyowa Hakko Kirin Co., Ltd. | Procedure to control the activity of an immunofunctional molecule |
AU7950400A (en) | 1999-10-19 | 2001-04-30 | Kyowa Hakko Kogyo Co. Ltd. | Process for producing polypeptide |
FR2807767B1 (en) | 2000-04-12 | 2005-01-14 | Lab Francais Du Fractionnement | MONOCLONAL ANTIBODIES ANTI-D |
ES2252261T3 (en) | 2000-06-28 | 2006-05-16 | Glycofi, Inc. | METHODS TO PRODUCE MODIFIED GLICOPROTEINS. |
US6946292B2 (en) | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
US7317091B2 (en) | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
ATE503829T1 (en) | 2002-04-09 | 2011-04-15 | Kyowa Hakko Kirin Co Ltd | CELL WITH REDUCED OR DELETED ACTIVITY OF A PROTEIN INVOLVED IN GDP-FUCOSE TRANSPORT |
US7425449B2 (en) | 2002-04-30 | 2008-09-16 | The Regents Of The University Of California | Site specific Listeria integration vectors and methods for using the same |
US20060235208A1 (en) | 2002-09-27 | 2006-10-19 | Xencor, Inc. | Fc variants with optimized properties |
US6994292B2 (en) | 2002-10-18 | 2006-02-07 | The Procter & Gamble Company | Dispensing apparatus for web material |
EP1587921B1 (en) | 2003-01-22 | 2010-07-28 | GlycArt Biotechnology AG | Fusion constructs and use of same to produce antibodies with increased fc receptor binding affinity and effector function |
US20050160485A1 (en) | 2003-03-18 | 2005-07-21 | Kyowa Hakko Kogyo Co., Ltd. | Mouse in which genome is modified |
US20060134105A1 (en) | 2004-10-21 | 2006-06-22 | Xencor, Inc. | IgG immunoglobulin variants with optimized effector function |
CA2542125A1 (en) | 2003-10-09 | 2005-04-21 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing antibody composition by using rna inhibiting the function of .alpha.1,6-fucosyltransferase |
EA202091901A1 (en) | 2003-11-05 | 2020-11-24 | Роше Гликарт Аг | ANTIBODIES WITH INCREASED AFFINITY TO BINDING WITH THE Fc-RECEPTOR AND EFFECTORAL FUNCTION |
US20060223147A1 (en) | 2004-08-05 | 2006-10-05 | Kyowa Hakko Kogyo Co., Ltd., | Process for producing glycoprotein composition |
US8546543B2 (en) | 2004-11-12 | 2013-10-01 | Xencor, Inc. | Fc variants that extend antibody half-life |
US8367805B2 (en) | 2004-11-12 | 2013-02-05 | Xencor, Inc. | Fc variants with altered binding to FcRn |
FR2879204B1 (en) | 2004-12-15 | 2007-02-16 | Lab Francais Du Fractionnement | CYTOTOXIC ANTIBODY AGAINST HEMATOPOIETIC B-TYPE HEMATOPOIETIC PROLIFERATIONS |
AU2006255085A1 (en) | 2005-06-03 | 2006-12-14 | Genentech, Inc. | Method of producing antibodies with modified fucosylation level |
DK1945666T3 (en) | 2005-10-21 | 2013-07-01 | Genzyme Corp | Antibodies with enhanced antibody-dependent cellular cytotoxicity activity, methods for their preparation and use thereof |
SI1945665T1 (en) | 2005-10-21 | 2012-03-30 | Genzyme Corp | Antibody-based therapeutics with enhanced adcc activity |
US20090060921A1 (en) * | 2006-01-17 | 2009-03-05 | Biolex Therapeutics, Inc. | Glycan-optimized anti-cd20 antibodies |
WO2007099988A1 (en) | 2006-02-28 | 2007-09-07 | Kyowa Hakko Kogyo Co., Ltd. | α-1,6-FUCOSYLTRANSFERASE MUTANT AND USE THEREOF |
FR2915398B1 (en) * | 2007-04-25 | 2012-12-28 | Lab Francais Du Fractionnement | "SET OF MEANS FOR THE TREATMENT OF MALIGNANT PATHOLOGY, AUTOIMMUNE DISEASE OR INFECTIOUS DISEASE" |
EP1985633A1 (en) * | 2007-04-26 | 2008-10-29 | LFB Biotechnologies | Kit of parts for the treatment of cancer or infectious diseases |
AU2009242453B2 (en) | 2008-05-02 | 2014-12-04 | Seagen Inc. | Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation |
TWI409079B (en) * | 2009-08-14 | 2013-09-21 | Roche Glycart Ag | Combination therapy of an afucosylated cd20 antibody with bendamustine |
AU2011283694B2 (en) | 2010-07-29 | 2017-04-13 | Xencor, Inc. | Antibodies with modified isoelectric points |
-
2011
- 2011-06-22 FR FR1101931A patent/FR2976811A1/en not_active Withdrawn
-
2012
- 2012-06-20 WO PCT/FR2012/051395 patent/WO2012175874A1/en active Application Filing
- 2012-06-22 AR ARP120102258A patent/AR086738A1/en unknown
- 2012-06-22 TW TW101122468A patent/TW201309728A/en unknown
Also Published As
Publication number | Publication date |
---|---|
TW201309728A (en) | 2013-03-01 |
FR2976811A1 (en) | 2012-12-28 |
WO2012175874A1 (en) | 2012-12-27 |
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