AR086653A1 - COMPOUNDS FOR REDUCTION OF PRODUCTION OF B-AMYLOID - Google Patents

COMPOUNDS FOR REDUCTION OF PRODUCTION OF B-AMYLOID

Info

Publication number
AR086653A1
AR086653A1 ARP120101953A ARP120101953A AR086653A1 AR 086653 A1 AR086653 A1 AR 086653A1 AR P120101953 A ARP120101953 A AR P120101953A AR P120101953 A ARP120101953 A AR P120101953A AR 086653 A1 AR086653 A1 AR 086653A1
Authority
AR
Argentina
Prior art keywords
alkyl
haloalkyl
cycloalkyl
group
compounds
Prior art date
Application number
ARP120101953A
Other languages
Spanish (es)
Inventor
Yong Wu
Jason M Jin-Guernon
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AR086653A1 publication Critical patent/AR086653A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

Los compuestos de la fórmula (1), que incluyen sales aceptables para el uso farmacéutico de los mismos, se exponen en la presente, donde R1 y R2 son independientemente hidrógeno, alquilo C1-6 o cicloalquilo; o R1 y R2 pueden unirse juntos en un anillo mediante la adición de -(CH2)m-, en donde m es 3, 4, ó 5; R3 es hidrógeno, alquilo C1-3, haloalquilo C1-3 o ciclopropilo; Y y Z son independientemente un grupo arilo C6-10 o un grupo heterocíclico de 5 a 10 miembros que además puede sustituirse con de 0 a 3 sustituyentes seleccionados del grupo de halógeno, hidroxi, amino, alquilamino C1-4, dialquilamino C1-4, haloalquilo C1-4, CN, alquilo C1-6 o cicloalquilo, alcoxi C1-6, - C=O-alquilo C1-4, -SO2-alquilo C1-4, y alquinilo C2-4; A se selecciona de los grupos de fenilo, bencilo, furanilo, oxazolilo, tiazolilo, isoxazolilo, isotiazolilo, oxadiazolilo, triazolilo, imidazolilo, pirazolilo, piridilo, pirimidinilo, pirazinilo, y piridazinilo que además pueden sustituirse con de 0 a 3 sustituyentes seleccionados del grupo de halógeno, hidroxi, amino, alquilamino C1-4, dialquilamino C1-4, haloalquilo C1-4, hidroxialquilo C1-6, CN, alquilo C1-6 o cicloalquilo, alcoxi C1-6, y alquinilo C2-4; L es -NHCO-, es un enlace simple; y L y Z juntos pueden estar ausentes.The compounds of the formula (1), which include salts acceptable for pharmaceutical use thereof, are set forth herein, where R 1 and R 2 are independently hydrogen, C 1-6 alkyl or cycloalkyl; or R1 and R2 can be joined together in a ring by the addition of - (CH2) m-, where m is 3, 4, or 5; R3 is hydrogen, C1-3 alkyl, C1-3 haloalkyl or cyclopropyl; Y and Z are independently a C6-10 aryl group or a 5-10 membered heterocyclic group which can also be substituted with 0 to 3 substituents selected from the halogen, hydroxy, amino, C1-4 alkylamino, C1-4 dialkylamino group, C1-4 haloalkyl, CN, C1-6 alkyl or cycloalkyl, C1-6 alkoxy, -C = O-C1-4 alkyl, -SO2-C1-4 alkyl, and C2-4 alkynyl; A is selected from the groups of phenyl, benzyl, furanyl, oxazolyl, thiazolyl, isoxazolyl, isothiazolyl, oxadiazolyl, triazolyl, imidazolyl, pyrazolyl, pyridyl, pyrimidinyl, pyrazinyl, and pyridazinyl which can also be substituted with 0 to 3 substituents selected from the group halogen, hydroxy, amino, C1-4 alkylamino, C1-4 dialkylamino, C1-4 haloalkyl, C1-6 hydroxyalkyl, CN, C1-6 alkyl or cycloalkyl, C1-6 alkoxy, and C2-4 alkynyl; L is -NHCO-, it is a simple link; and L and Z together may be absent.

ARP120101953A 2011-06-03 2012-06-01 COMPOUNDS FOR REDUCTION OF PRODUCTION OF B-AMYLOID AR086653A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161492856P 2011-06-03 2011-06-03

Publications (1)

Publication Number Publication Date
AR086653A1 true AR086653A1 (en) 2014-01-15

Family

ID=46275993

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP120101953A AR086653A1 (en) 2011-06-03 2012-06-01 COMPOUNDS FOR REDUCTION OF PRODUCTION OF B-AMYLOID

Country Status (1)

Country Link
AR (1) AR086653A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9550762B2 (en) 2014-08-08 2017-01-24 Amgen, Inc. Cyclopropyl fused thiazin-2-amine compounds as beta-secretase inhibitors and methods of use
US9611261B2 (en) 2013-03-08 2017-04-04 Amgen Inc. Perfluorinated cyclopropyl fused 1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use
US11926616B2 (en) 2018-03-08 2024-03-12 Incyte Corporation Aminopyrazine diol compounds as PI3K-γ inhibitors

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9611261B2 (en) 2013-03-08 2017-04-04 Amgen Inc. Perfluorinated cyclopropyl fused 1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use
US9550762B2 (en) 2014-08-08 2017-01-24 Amgen, Inc. Cyclopropyl fused thiazin-2-amine compounds as beta-secretase inhibitors and methods of use
US11926616B2 (en) 2018-03-08 2024-03-12 Incyte Corporation Aminopyrazine diol compounds as PI3K-γ inhibitors

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