AR086476A2 - Metodos de produccion de una proteina de interes heterologa en una celula, para aumentar la productividad celular especifica de una proteina de interes de membrana o secretada en una celula, para aumentar la eficacia de transfeccion de una celula que expresa una proteina de interes de membrana o secretada en una celula y para identificar un modulador de la funcion de proteina con dominio start, vectores de expresion, celulas, proteinas, composiciones farmaceuticas y sus usos - Google Patents
Metodos de produccion de una proteina de interes heterologa en una celula, para aumentar la productividad celular especifica de una proteina de interes de membrana o secretada en una celula, para aumentar la eficacia de transfeccion de una celula que expresa una proteina de interes de membrana o secretada en una celula y para identificar un modulador de la funcion de proteina con dominio start, vectores de expresion, celulas, proteinas, composiciones farmaceuticas y sus usosInfo
- Publication number
- AR086476A2 AR086476A2 ARP120101384A ARP120101384A AR086476A2 AR 086476 A2 AR086476 A2 AR 086476A2 AR P120101384 A ARP120101384 A AR P120101384A AR P120101384 A ARP120101384 A AR P120101384A AR 086476 A2 AR086476 A2 AR 086476A2
- Authority
- AR
- Argentina
- Prior art keywords
- protein
- cell
- interest
- secreted
- increase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Communicable Diseases (AREA)
Abstract
Un método de producción de una proteína de interés heteróloga en una célula que comprende a) aumentar la expresión o actividad de una proteína que tiene una secuencia de amino ácidos que comprende un dominio de transferencia de lípido relacionado con la proteína reguladora de la esteroidogénesis aguda (START) o un derivado o mutante del mismo, en donde la proteína que tiene una secuencia de aminoácidos no comprende proteína de transferencia de ceramida (CERT), en donde el derivado no es una molécula de polipéptido al menos 70% idéntica en secuencia con la secuencia original CERT o su secuencia complementaria o dicho derivado no es una secuencia CERT homóloga de un organismo diferente y en donde dicho mutante no se basa en modificaciones dirigidas de secuencias CERT por sustitución, inserción o eliminación de uno a diez aminoácidos; y b) efectuar la expresión de dicha proteína de interés. Métodos para aumentar la productividad celular específica de una proteína de interés de membrana o secretada en una célula, para aumentar la eficacia de transfección de una célula que expresa una proteína de interés de membrana o secretada en una célula y para identificar un modulador de la función de proteína con dominio START, vectores de expresión, células, proteínas, composiciones farmacéuticas y sus usos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07103406A EP1964922A1 (en) | 2007-03-02 | 2007-03-02 | Improvement of protein production |
EP07104226 | 2007-03-15 | ||
EP07116358 | 2007-09-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR086476A2 true AR086476A2 (es) | 2013-12-18 |
Family
ID=39639553
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP080100873A AR065573A1 (es) | 2007-03-02 | 2008-02-29 | Metodo de produccion de proteinas heterologas por expresion de una proteina con dominio de trasnferencia de lipido relacionada con proteina reguladora de la esteroidogenesis aguda start. |
ARP120101384A Pending AR086476A2 (es) | 2007-03-02 | 2012-04-20 | Metodos de produccion de una proteina de interes heterologa en una celula, para aumentar la productividad celular especifica de una proteina de interes de membrana o secretada en una celula, para aumentar la eficacia de transfeccion de una celula que expresa una proteina de interes de membrana o secretada en una celula y para identificar un modulador de la funcion de proteina con dominio start, vectores de expresion, celulas, proteinas, composiciones farmaceuticas y sus usos |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP080100873A AR065573A1 (es) | 2007-03-02 | 2008-02-29 | Metodo de produccion de proteinas heterologas por expresion de una proteina con dominio de trasnferencia de lipido relacionada con proteina reguladora de la esteroidogenesis aguda start. |
Country Status (24)
Country | Link |
---|---|
US (4) | US8221999B2 (es) |
EP (3) | EP2126093B1 (es) |
JP (1) | JP5467415B2 (es) |
KR (1) | KR20100015363A (es) |
AR (2) | AR065573A1 (es) |
AU (1) | AU2008223874B2 (es) |
BR (1) | BRPI0808542A2 (es) |
CA (1) | CA2677925A1 (es) |
CY (1) | CY1113710T1 (es) |
DK (1) | DK2126093T3 (es) |
EA (1) | EA018190B1 (es) |
ES (1) | ES2397274T3 (es) |
HK (1) | HK1136314A1 (es) |
HR (1) | HRP20121077T1 (es) |
IL (1) | IL200030A0 (es) |
MX (1) | MX2009009156A (es) |
MY (1) | MY148472A (es) |
NZ (1) | NZ580043A (es) |
PL (1) | PL2126093T3 (es) |
PT (1) | PT2126093E (es) |
SG (1) | SG182160A1 (es) |
SI (1) | SI2126093T1 (es) |
TW (1) | TWI419902B (es) |
WO (1) | WO2008107388A1 (es) |
Families Citing this family (61)
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EP2126093B1 (en) | 2007-03-02 | 2012-10-10 | Boehringer Ingelheim Pharma GmbH & Co. KG | Improvement of protein production |
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CN110592044B (zh) * | 2019-07-26 | 2021-06-22 | 中国农业科学院蔬菜花卉研究所 | 蛋白激酶Fused编码基因及其在防治小菜蛾中的应用 |
CN111100865B (zh) * | 2020-01-07 | 2022-03-18 | 江南大学 | 一种提高酿酒酵母丁醇耐受能力的方法 |
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US5521297A (en) * | 1993-06-04 | 1996-05-28 | Salk Institute Biotechnology/Industrial Associates | Nucleic acids encoding human metabotropic glutamate receptors |
US5869250A (en) * | 1996-12-02 | 1999-02-09 | The University Of North Carolina At Chapel Hill | Method for the identification of peptides that recognize specific DNA sequences |
DE60025704T2 (de) * | 1999-02-24 | 2006-09-07 | Juan Saus | Das goodpasture-antigen bindende protein |
EP1514933A1 (en) * | 1999-07-08 | 2005-03-16 | Research Association for Biotechnology | Secretory protein or membrane protein |
US6972324B2 (en) * | 2001-05-18 | 2005-12-06 | Boehringer Ingelheim Pharmaceuticals, Inc. | Antibodies specific for CD44v6 |
JP2005515157A (ja) * | 2001-05-25 | 2005-05-26 | トマス ジェファソン ユニバーシティ | 多様な治療様式のための主成分としての選択的スプライスフォーム |
EP1560931B1 (en) * | 2002-11-14 | 2011-07-27 | Dharmacon, Inc. | Functional and hyperfunctional sirna |
US7326768B2 (en) * | 2003-02-05 | 2008-02-05 | Juan Saus | Goodpasture antigen-binding protein isoforms and protein misfolded-mediated disorders |
AU2004248165A1 (en) | 2003-06-11 | 2004-12-23 | Biogen Idec Ma Inc. | Method to increase protein production in culture |
US7244616B2 (en) * | 2003-06-27 | 2007-07-17 | Bayer Pharmaceuticals Corporation | Use of molecular chaperones for the enhanced production of secreted, recombinant proteins in mammalian cells |
JP2005035926A (ja) | 2003-07-14 | 2005-02-10 | Japan Science & Technology Agency | セラミド輸送を促進する薬剤、該薬剤を製造する塩基配列、セラミド遊離を促進する活性の測定方法、及びセラミドの膜間移動を促進する活性の測定方法 |
AU2005248147A1 (en) * | 2004-05-11 | 2005-12-08 | Alphagen Co., Ltd. | Polynucleotides for causing RNA interference and method for inhibiting gene expression using the same |
AU2006262603B2 (en) | 2005-06-20 | 2011-01-06 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
EP2126093B1 (en) | 2007-03-02 | 2012-10-10 | Boehringer Ingelheim Pharma GmbH & Co. KG | Improvement of protein production |
US20090018099A1 (en) * | 2007-03-02 | 2009-01-15 | Hitto Kaufmann | Protein production |
WO2010128032A1 (en) | 2009-05-05 | 2010-11-11 | Boehringer Ingelheim International Gmbh | Cho / cert cell lines |
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