AR083901A1 - COMPOUND 8-OXO-9- [3- (1H-BENCIMIDAZOL-2-ILOXI) -FENYL] -4,5,6,7,8,9-HEXAHYDRO-2H-PIRROLO [3,4-B] QUINOLINA-3 -THE CARBOXYLATE, SALT, PREPARATION PROCEDURES, MEDICINES AND PHARMACEUTICAL COMPOSITIONS - Google Patents

COMPOUND 8-OXO-9- [3- (1H-BENCIMIDAZOL-2-ILOXI) -FENYL] -4,5,6,7,8,9-HEXAHYDRO-2H-PIRROLO [3,4-B] QUINOLINA-3 -THE CARBOXYLATE, SALT, PREPARATION PROCEDURES, MEDICINES AND PHARMACEUTICAL COMPOSITIONS

Info

Publication number
AR083901A1
AR083901A1 ARP110104285A ARP110104285A AR083901A1 AR 083901 A1 AR083901 A1 AR 083901A1 AR P110104285 A ARP110104285 A AR P110104285A AR P110104285 A ARP110104285 A AR P110104285A AR 083901 A1 AR083901 A1 AR 083901A1
Authority
AR
Argentina
Prior art keywords
compound
formula
hexahydro
carboxylate
oxo
Prior art date
Application number
ARP110104285A
Other languages
Spanish (es)
Inventor
Natalie Arokiassamy
Pascal Billot
Jean Carry
Patrick Christophe-Clavieres
Franois Clerc
Veronique Crocq-Stuerga
Sylvette Lachaud
Philippe Lienard
Jerome Menegotto
Laurent Schio
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of AR083901A1 publication Critical patent/AR083901A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

Los compuestos se utilizan en terapéutica, principalmente como inhibidores selectivos de las quinasas Aurora A y B, y para su utilización como anticancerosos.Reivindicación 1: Compuesto 8-oxo-9-[3-(1H-bencimidazol-2-iloxi)-fenil]-4,5,6,7,8,9-hexahidro-2H-pirrolo[3,4-b]quinolina-3-carboxilato de etilo o compuesto F de fórmula (1), estando este compuesto de fórmula (1) en forma: de compuesto I sal sulfato de dicho compuesto de fórmula (1); o de compuesto II co-cristal de dicho producto de fórmula (1); o de formulación que contiene dicho compuesto de fórmula (1) o dicho compuesto I sal sulfato del producto de fórmula (1) o dicho compuesto II co-cristal del producto de fórmula (1) tales como se han definido anteriormente.The compounds are used in therapeutics, primarily as selective inhibitors of Aurora A and B kinases, and for use as anticancer drugs. Claim 1: Compound 8-oxo-9- [3- (1 H -benzimidazol-2-yloxy) -phenyl ] -4,5,6,7,8,9-hexahydro-2H-pyrrolo [3,4-b] ethyl quinoline-3-carboxylate or compound F of formula (1), this compound being of formula (1) in the form: of compound I sulfate salt of said compound of formula (1); or of compound II co-crystal of said product of formula (1); or of formulation containing said compound of formula (1) or said compound I sulfate salt of the product of formula (1) or said compound II co-crystal of the product of formula (1) as defined above.

ARP110104285A 2010-11-17 2011-11-17 COMPOUND 8-OXO-9- [3- (1H-BENCIMIDAZOL-2-ILOXI) -FENYL] -4,5,6,7,8,9-HEXAHYDRO-2H-PIRROLO [3,4-B] QUINOLINA-3 -THE CARBOXYLATE, SALT, PREPARATION PROCEDURES, MEDICINES AND PHARMACEUTICAL COMPOSITIONS AR083901A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1059456A FR2967413A1 (en) 2010-11-17 2010-11-17 COMPOUND 8-OXO-9- [3- (1H-BENZIMIDAZOL-2-YLOXY) -PHENYL] -4,5,6,7,8,9-HEXAHYDRO-2H-PYRROLO [3,4-B] QUINOLIN-3 - ETHYL CARBOXYLATE, SALT, CRYSTALLINE FORM, CO-CRYSTAL, FORMULATION, METHODS OF PREPARATION, MEDICAMENT APPLICATION, PHARMACEUTICAL COMPOSITIONS, AND NOVEL USE, IN PARTICULAR AS THE INHIBITOR OF AURORA KINASES.

Publications (1)

Publication Number Publication Date
AR083901A1 true AR083901A1 (en) 2013-04-10

Family

ID=43759999

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP110104285A AR083901A1 (en) 2010-11-17 2011-11-17 COMPOUND 8-OXO-9- [3- (1H-BENCIMIDAZOL-2-ILOXI) -FENYL] -4,5,6,7,8,9-HEXAHYDRO-2H-PIRROLO [3,4-B] QUINOLINA-3 -THE CARBOXYLATE, SALT, PREPARATION PROCEDURES, MEDICINES AND PHARMACEUTICAL COMPOSITIONS

Country Status (5)

Country Link
AR (1) AR083901A1 (en)
FR (1) FR2967413A1 (en)
TW (1) TW201307339A (en)
UY (1) UY33738A (en)
WO (1) WO2012066486A1 (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1746097T3 (en) * 2005-07-20 2010-05-25 Aventis Pharma Sa 1,4-dihydropyridine-fused heterocyclic rings, process for their preparation, use and compositions containing them
FR2945535B1 (en) * 2009-05-18 2011-06-10 Sanofi Aventis ANTICANCER COMPOUND AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

Also Published As

Publication number Publication date
FR2967413A1 (en) 2012-05-18
WO2012066486A1 (en) 2012-05-24
TW201307339A (en) 2013-02-16
UY33738A (en) 2012-06-29

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