AR083114A1 - Produccion de anticuerpos de fucosa baja en celulas de rata h4-ii-e - Google Patents
Produccion de anticuerpos de fucosa baja en celulas de rata h4-ii-eInfo
- Publication number
- AR083114A1 AR083114A1 ARP110103517A ARP110103517A AR083114A1 AR 083114 A1 AR083114 A1 AR 083114A1 AR P110103517 A ARP110103517 A AR P110103517A AR P110103517 A ARP110103517 A AR P110103517A AR 083114 A1 AR083114 A1 AR 083114A1
- Authority
- AR
- Argentina
- Prior art keywords
- rat hepatoma
- cells
- production
- addition
- glycoproteins
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/067—Hepatocytes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
Una célula de hepatoma de rata, preferiblemente una célula H4-II-E de hepatoma de rata, que transporta un ADN que codifica un anticuerpo o proteína de fusión Fc y que tiene baja actividad de fucosilación para añadir fucosa a estructuras glicosidicas tales como glicanos biantena, por ejemplo, N-acetilglucosamina. Además, un método para producir glicoproteínas de fucosa baja especialmente anticuerpos o proteínas de fusión Fc en células de hepatoma de rata, preferiblemente en células H4-II-E de hepatoma de rata. Además, la identificación y generación de nuevas líneas celulares huésped que puedan sintetizar glicoproteínas con propiedades beneficiosas, mejorando la eficacia terapéutica y/o la semivida en el suero del producto comparado con productos de líneas celulares huésped usadas comúnmente.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10180321 | 2010-09-27 | ||
EP11156848 | 2011-03-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR083114A1 true AR083114A1 (es) | 2013-01-30 |
Family
ID=45891992
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP110103517A AR083114A1 (es) | 2010-09-27 | 2011-09-26 | Produccion de anticuerpos de fucosa baja en celulas de rata h4-ii-e |
Country Status (5)
Country | Link |
---|---|
US (1) | US20120258496A1 (es) |
EP (1) | EP2622066A1 (es) |
CN (1) | CN103534347A (es) |
AR (1) | AR083114A1 (es) |
WO (1) | WO2012041768A1 (es) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9062106B2 (en) | 2011-04-27 | 2015-06-23 | Abbvie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
US9150645B2 (en) | 2012-04-20 | 2015-10-06 | Abbvie, Inc. | Cell culture methods to reduce acidic species |
US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
JP2015528802A (ja) * | 2012-07-18 | 2015-10-01 | グリコトープ ゲーエムベーハー | フコシル化が低い抗her2抗体を用いた新規治療処置 |
US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
US20140106405A1 (en) * | 2012-10-15 | 2014-04-17 | Bristol-Myers Squibb Company | Mammalian cell culture processes for protein production |
CA2905010A1 (en) | 2013-03-12 | 2014-09-18 | Abbvie Inc. | Human antibodies that bind human tnf-alpha and methods of preparing the same |
US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
US9499614B2 (en) | 2013-03-14 | 2016-11-22 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides |
LT3027651T (lt) * | 2013-08-01 | 2019-04-10 | Five Prime Therapeutics, Inc. | Afukozilinti anti-fgfr2iiib antikūnai |
EP3052640A2 (en) | 2013-10-04 | 2016-08-10 | AbbVie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
WO2015057910A1 (en) | 2013-10-16 | 2015-04-23 | Oncobiologics, Inc. | Buffer formulations for enhanced antibody stability |
US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
WO2015073884A2 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
FR3025515B1 (fr) | 2014-09-05 | 2016-09-09 | Lab Francais Du Fractionnement | Procede de purification d'un anticorps monoclonal |
PL3212230T3 (pl) | 2014-10-29 | 2021-07-26 | Seagen Inc. | Dawkowanie i podawanie niefukozylowanych przeciwciał anty-CD40 |
WO2016118707A1 (en) | 2015-01-21 | 2016-07-28 | Oncobiologics, Inc. | Modulation of charge variants in a monoclonal antibody composition |
FR3034420A1 (fr) | 2015-03-31 | 2016-10-07 | Lab Francais Du Fractionnement | Anticorps monoclonaux anti-cd303 |
TWI791422B (zh) | 2015-11-23 | 2023-02-11 | 美商戊瑞治療有限公司 | 用於癌症治療之單獨fgfr2抑制劑或與免疫刺激劑組合 |
US20190161543A1 (en) | 2016-01-06 | 2019-05-30 | Outlook Therapeutics, Inc. | Modulation of afucosylated species in a monoclonal antibody composition |
MX2018009341A (es) | 2016-02-03 | 2019-05-15 | Oncobiologics Inc | Formulaciones tamponadas para una mayor estabilidad de anticuerpos. |
FR3060395B1 (fr) | 2016-12-16 | 2019-05-24 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Combinaison d'anticorps anti-cd303 et anti-her2 |
FR3060394B1 (fr) | 2016-12-16 | 2019-05-24 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Combinaison d'anticorps anti-cd303 et anti-amhrii |
CN110621336B (zh) | 2017-05-16 | 2024-05-14 | 戊瑞治疗有限公司 | 癌症治疗中抗fgfr2抗体与化学治疗剂的组合 |
US10280217B2 (en) * | 2017-09-19 | 2019-05-07 | American Air Liquide, Inc. | Cell culture additives and their use for increased bioprotein production from cells |
EP3498293A1 (en) | 2017-12-15 | 2019-06-19 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Treatment of monogenic diseases with an anti-cd45rc antibody |
EP3626265A1 (en) | 2018-09-21 | 2020-03-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Anti-human cd45rc antibodies and uses thereof |
KR20210104837A (ko) * | 2018-12-19 | 2021-08-25 | 씨젠 인크. | 항체의 제어된 푸코실화 |
AU2020211728A1 (en) | 2019-01-23 | 2021-08-12 | Encefa | CD31 competitors and uses thereof |
WO2023041717A1 (en) | 2021-09-16 | 2023-03-23 | Aboleris Pharma | Anti-human cd45rc binding domains and uses thereof |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3150340B2 (ja) | 1990-11-13 | 2001-03-26 | イムネクス コーポレイション | 二機能選択可能融合遺伝子 |
JPH09500783A (ja) | 1993-05-21 | 1997-01-28 | ターゲッティッド ジェネティクス コーポレイション | シトシンデアミナーゼ(cd)遺伝子に基づく二機能性選択融合遺伝子 |
ATE427966T1 (de) * | 1997-02-11 | 2009-04-15 | Immunomedics Inc | Stimulation einer immunantwort durch antikírper, welche mit dem alpha-galaktosylepitop markiert sind |
ES2379977T3 (es) * | 2001-05-24 | 2012-05-07 | Zymogenetics, Inc. | Proteínas de fusión de taci-inmunoglobulina |
KR20050000380A (ko) * | 2002-04-09 | 2005-01-03 | 교와 핫꼬 고교 가부시끼가이샤 | 게놈이 개변된 세포 |
EP1567652B1 (de) | 2002-11-29 | 2007-08-22 | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG | Neue neomycin-phosphotransferase-gene und verfahren zur selektion von hochproduzierenden rekombinanten zellen |
CN1829533A (zh) * | 2003-05-30 | 2006-09-06 | 阿莱克申药物公司 | 包含改造恒定区的抗体和融合蛋白 |
EP1635872A4 (en) * | 2003-05-30 | 2008-01-02 | Alexion Pharma Inc | ANTIBODIES AND FUSION PROTEINS COMPRISING MODIFIED CONSTANT REGIONS |
US20090208500A1 (en) * | 2005-06-03 | 2009-08-20 | Genentech, Inc. | Method of producing antibodies with improved function |
US20080124760A1 (en) | 2006-07-26 | 2008-05-29 | Barbara Enenkel | Regulatory Nucleic Acid Elements |
EP2142569A2 (en) * | 2007-03-28 | 2010-01-13 | Biogen Idec, Inc. | Non-fucosylated antibodies |
AU2008275649B2 (en) * | 2007-07-12 | 2013-09-05 | Sangamo Therapeutics, Inc. | Methods and compositions for inactivating alpha 1,6 fucosyltransferase (FUT 8) gene expression |
-
2011
- 2011-09-22 US US13/239,654 patent/US20120258496A1/en not_active Abandoned
- 2011-09-23 WO PCT/EP2011/066554 patent/WO2012041768A1/en active Application Filing
- 2011-09-23 EP EP11763630.8A patent/EP2622066A1/en not_active Withdrawn
- 2011-09-23 CN CN201180056942.6A patent/CN103534347A/zh active Pending
- 2011-09-26 AR ARP110103517A patent/AR083114A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
CN103534347A (zh) | 2014-01-22 |
EP2622066A1 (en) | 2013-08-07 |
US20120258496A1 (en) | 2012-10-11 |
WO2012041768A1 (en) | 2012-04-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR083114A1 (es) | Produccion de anticuerpos de fucosa baja en celulas de rata h4-ii-e | |
BR112019007288A2 (pt) | proteína heterodimérica biespecífica, composições de ácido nucleico e de vetor de expressão, vetor de expressão, célula hospedeira, e, métodos para produzir proteína heterodimérica biespecífica e para tratar câncer em um paciente | |
BR112014018630A2 (pt) | alvejamento de glicanos de sulfato de condroitina | |
MX2019010583A (es) | Anticuerpos contra ligando 1 de muerte programada. | |
MX354717B (es) | Moleculas de union novedosas con actividad antitumoral. | |
BR112015019603A2 (pt) | Moléculas de ácido nucleico isoladas, molécula de polipeptídeo isolada, molécula isolada de car, domínio de ligação anti-egfrviii, vetor, célula e uso de uma quantidade eficaz da mesma e métodos para produção de uma célula e para a produção de uma população de células modificadas por rna | |
MX2014005108A (es) | Constructos de polipeptidos y sus usos. | |
BR112015013525A2 (pt) | método para produção de uma proteína de fusão, bem como composição compreendendo uma proteína de fusão | |
WO2019008123A3 (en) | CELLS, VERTEBRATES, POPULATIONS AND METHODS | |
PH12015500284A1 (en) | Interleukin-10 fusion proteins and uses thereof | |
AR095660A1 (es) | Métodos de fabricación para el control el contenido de lisina c-terminal, galactosa y ácido siálico en proteínas recombinantes | |
PH12014501970A1 (en) | Antibodies to bradykinin b1 receptor ligands | |
MX2013007853A (es) | Polipeptidos que tienen actividad de celobiohidrolasa y polinucleotidos que codifican los mismos. | |
MX337919B (es) | Polipeptidos que tienen actividad de celobiohidrolasa y polinucleotidos que codifican los mismos. | |
GB201008682D0 (en) | Epitope tag for affinity based applications | |
MX2020011334A (es) | Cultivo celular metabolicamente optimizado. | |
BR112014008694A2 (pt) | moléculas de ácido nucleico policistrônico recombinante | |
AR085302A1 (es) | Metodo de produccion de anticuerpos sialilados | |
WO2014093894A3 (en) | Dna antibody constructs and method of using same | |
MX2013008903A (es) | Metodos de desarrollo de variantes de terpeno sintasa. | |
MX2013007720A (es) | Polipeptidos que tienen actividad celobiohidrolasa y polinucleotidos que codifican para los mismos. | |
EP4282881A3 (en) | Antibodies against csf-1r | |
BR112015022529A2 (pt) | meios de cultura de células e processos de produção de anticorpo | |
EP2576626A4 (en) | FUNCTIONAL AND STABLE CLASS I CELLOBIOHYDROLASTIC ENZYMES | |
MX2021000934A (es) | Linfocitos t que contienen nef y métodos para producirlos. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |