AR081906A1 - Metodo para injertar celulas de tejidos solidos, reparar tejidos, para localizar celulas, metodo de crioconservacion, injerto de tejido - Google Patents

Metodo para injertar celulas de tejidos solidos, reparar tejidos, para localizar celulas, metodo de crioconservacion, injerto de tejido

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Publication number
AR081906A1
AR081906A1 ARP110101582A ARP110101582A AR081906A1 AR 081906 A1 AR081906 A1 AR 081906A1 AR P110101582 A ARP110101582 A AR P110101582A AR P110101582 A ARP110101582 A AR P110101582A AR 081906 A1 AR081906 A1 AR 081906A1
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AR
Argentina
Prior art keywords
cells
growth factor
mixture
internal organ
combining
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ARP110101582A
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English (en)
Inventor
Lola M Reid
Oswaldo Lozoya
Rachael Turner
David Gerber
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Univ North Carolina
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Publication date
Application filed by Univ North Carolina filed Critical Univ North Carolina
Publication of AR081906A1 publication Critical patent/AR081906A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/407—Liver; Hepatocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/734—Alginic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/39—Pancreas; Islets of Langerhans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/42—Respiratory system, e.g. lungs, bronchi or lung cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/28—Materials or treatment for tissue regeneration for liver reconstruction
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    • C12N2537/00—Supports and/or coatings for cell culture characterised by physical or chemical treatment
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • General Health & Medical Sciences (AREA)
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  • Developmental Biology & Embryology (AREA)
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Abstract

Reivindicación 1: Un método para injertar células de un órgano interno en un sujeto cuyo órgano interno se encuentra en una condición enferma o disfuncional, donde dicho método comprende: a) obtener células normales de un órgano interno de un donante; b) combinar las células con uno o más biomateriales formadores de geles para formar una mezcla; c) opcionalmente, combinar la mezcla con un medio de nutrientes, moléculas de señalización, proteínas de la matriz extracelular o una combinación de los mismos; d) introducir la mezcla del paso (b) en el sujeto, en donde una porción sustancial de las células introducidas en el paso (d) residirá en o sobre al menos una porción del órgano interno in vivo.Reivindicación 2: El método de acuerdo con la reivindicación 1, en donde las células normales son células madre, progenitores obligados o células maduras. Reivindicación 7: El método de acuerdo con la reivindicación 1, en donde el donante es un donante no autólogo. Reivindicación 9: El método de acuerdo con la reivindicación 1, en donde las células adicionales comprenden angioblastos, células endoteliales, precursores de células estrelladas, células estrelladas, células estromáticas, células madre epiteliales, células parenquimáticas maduras o combinaciones de las mismas. Reivindicación 10: El método de acuerdo con la reivindicación 1, en donde dichos uno o más biomateriales comprenden colágenos, lamininas, moléculas de adhesión, proteoglucanos, hialuronanos, cadenas de glucosaminoglucano, quitosán, alginato y polímeros sintéticos, biodegradables y biocompatibles, o combinaciones de los mismos. Reivindicación 11: El método de acuerdo con la reivindicación 1, en donde las moléculas de señalización comprenden el factor de crecimiento de fibroblastos, el factor de crecimiento de hepatocitos, el factor de crecimiento epidérmico, el factor de crecimiento de células del endotelio vascular (VEGF), el factor de crecimiento tipo insulina I, el factor de crecimiento tipo insulina II (IGF-II), oncostatina-M, el factor inhibidor de leucemia (LIF), interleuquinas, el factor de crecimiento transformante-b (TGF-b), HGF, transferrina, insulina, transferrina/fe, tri-iodotironina, T3, glucagon, glucocorticoides, hormonas de crecimiento, estrógenos, andrógenos, hormonas de las tiroides y combinaciones de los mismos. Reivindicación 21: Un método de crioconservación de células que comprende: a) obtener células para ser transplantadas; b) combinar las células con biomateriales formadores de geles para formar una mezcla; c) opcionalmente, combinar la mezcla con uno o más de medios de nutrientes isotónicas, moléculas de señalización y componentes de la matriz extracelular; d) congelar la mezcla.
ARP110101582A 2010-05-07 2011-05-06 Metodo para injertar celulas de tejidos solidos, reparar tejidos, para localizar celulas, metodo de crioconservacion, injerto de tejido AR081906A1 (es)

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US33244110P 2010-05-07 2010-05-07

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Country Status (18)

Country Link
US (1) US20110274666A1 (es)
EP (1) EP2566567A4 (es)
JP (4) JP6177687B2 (es)
KR (4) KR102289168B1 (es)
CN (2) CN111281890A (es)
AR (1) AR081906A1 (es)
AU (1) AU2011247984B2 (es)
BR (1) BR112012028265B1 (es)
CA (2) CA3146949A1 (es)
CL (1) CL2012003085A1 (es)
CR (1) CR20120603A (es)
IL (3) IL222857A (es)
MX (3) MX359678B (es)
NZ (2) NZ603913A (es)
RU (1) RU2736955C2 (es)
SG (2) SG10201503582YA (es)
TW (3) TW202006136A (es)
WO (1) WO2011140428A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013010045A1 (en) 2011-07-12 2013-01-17 Biotime Inc. Novel methods and formulations for orthopedic cell therapy
US8961617B2 (en) * 2012-03-08 2015-02-24 Liventa Bioscience, Inc. Amnion and chorion constructs and uses thereof in abdominal surgery
US9533013B2 (en) 2013-03-13 2017-01-03 University Of North Carolina At Chapel Hill Method of treating pancreatic and liver conditions by endoscopic-mediated (or laparoscopic-mediated) transplantation of stem cells into/onto bile duct walls of particular regions of the biliary tree
EP2886644A1 (en) * 2013-12-20 2015-06-24 Kallistem Process for implementing in vitro spermatogenesis and associated device
US10765705B2 (en) 2014-11-24 2020-09-08 Prime Merger Sub, Llc Visco-supplement compositions, and methods of use thereof
US20160213714A1 (en) * 2015-01-23 2016-07-28 Everon Biosciences, Inc. Induction of cellular senescence for tissue therapies
CN106148266A (zh) * 2015-04-20 2016-11-23 烟台赛泽生物技术有限公司 一种免疫细胞用培养基及该培养基的添加剂
JP2016209303A (ja) * 2015-05-08 2016-12-15 レジエンス株式会社 肝組織を再生するための製剤
US20170369849A1 (en) * 2016-05-11 2017-12-28 The University Of North Carolina At Chapel Hill Compositions and methods for bioengineered tissues
EP3520746A4 (en) * 2016-09-30 2020-05-06 Taipei Veterans General Hospital ANTIFREEZE AGENT FOR PROTECTING BIOLOGICAL TISSUE DURING FREEZING TREATMENT AND PREPARATION METHOD THEREOF
US20180295834A1 (en) * 2017-04-06 2018-10-18 The University Of North Carolina At Chapel Hill Cryopreservation method
TW201902467A (zh) * 2017-06-12 2019-01-16 北卡羅來納大學教堂山 用於細胞植入的補釘移植物組成物
JP2020050625A (ja) * 2018-09-27 2020-04-02 株式会社北里コーポレーション 卵巣組織の移植方法および卵胞活性化方法
JP7350505B2 (ja) * 2019-02-15 2023-09-26 イビデン株式会社 生体試料を含む固化体
WO2023042875A1 (ja) * 2021-09-16 2023-03-23 富士フイルム株式会社 ゲル形成キット及びその利用
JP7440987B2 (ja) 2021-12-28 2024-02-29 株式会社ポル・メド・テック 移植材料の製造方法、及び移植材料
WO2024043306A1 (ja) * 2022-08-24 2024-02-29 株式会社ヴィータ 蛍光標識用組成物、蛍光プローブ、注入剤、シリンジ充填物、医療器具、医療用繊維素材、蛍光標識用組成物の製造方法、及び医療用繊維素材の製造方法

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6231881B1 (en) * 1992-02-24 2001-05-15 Anton-Lewis Usala Medium and matrix for long-term proliferation of cells
US20040138329A1 (en) * 1992-04-20 2004-07-15 Board Of Regents Of The University Of Texas System Gels for encapsulation of biological materials
EP0655910A4 (en) * 1992-07-29 1996-02-28 Univ Washington USE OF A POCKET FOR THE IMPLANTATION OF LIVING CELLS.
US5709854A (en) * 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
US5681587A (en) * 1995-10-06 1997-10-28 Desmos, Inc. Growth of adult pancreatic islet cells
US6482231B1 (en) * 1995-11-20 2002-11-19 Giovanni Abatangelo Biological material for the repair of connective tissue defects comprising mesenchymal stem cells and hyaluronic acid derivative
WO1997045533A1 (en) * 1996-05-28 1997-12-04 The Regents Of The University Of Michigan Engineering oral tissues
US6224893B1 (en) * 1997-04-11 2001-05-01 Massachusetts Institute Of Technology Semi-interpenetrating or interpenetrating polymer networks for drug delivery and tissue engineering
JP3014343B2 (ja) * 1997-06-06 2000-02-28 科学技術振興事業団 肝細胞の培養方法
IT1293484B1 (it) * 1997-06-11 1999-03-01 Fidia Advanced Biopolymers Srl Materiale biologico comprendente una efficiente coltura di cellule e una matrice tridimensionale biocompatibile e biodegradabile
US6129911A (en) * 1998-07-10 2000-10-10 Rhode Island Hospital, A Lifespan Partner Liver stem cell
DK1147179T3 (da) * 1999-01-19 2009-03-09 Univ North Carolina Humane lever-progenitorer
US6592623B1 (en) * 1999-08-31 2003-07-15 Virginia Commonwealth University Intellectual Property Foundation Engineered muscle
US6365385B1 (en) * 1999-03-22 2002-04-02 Duke University Methods of culturing and encapsulating pancreatic islet cells
DE60017900T2 (de) * 1999-04-30 2006-04-06 Massachusetts General Hospital, Boston Herstellung von dreidimensionalem vaskularisierten gewebe mittels der verwendung von zweidimensionalen mikrohergestellten formen
WO2001005955A2 (en) * 1999-07-14 2001-01-25 The Board Of Trustees Of The Leland Stanford Junior University Animals comprising human hepatocellular tissue
US6960576B2 (en) 1999-09-13 2005-11-01 Bristol-Myers Squibb Pharma Company Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production
RU2165263C1 (ru) * 2000-06-23 2001-04-20 Зыбин Дмитрий Владимирович Способ лечения сахарного диабета
US7291673B2 (en) * 2000-06-02 2007-11-06 Eidgenossiche Technische Hochschule Zurich Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
US6435190B1 (en) * 2000-06-14 2002-08-20 Syde A. Taheri Autogenous cell patch cardio myoplasty and advanced muscle graft implantation system
MY130475A (en) * 2000-08-25 2007-06-29 Contura As Polyacrylamide hydrogel and its use as an endoprosthesis
US7074424B2 (en) * 2000-11-28 2006-07-11 Genzyme Corporation Polyalkylene glycol viscosity-enhancing polymeric formulations
US20030077566A1 (en) * 2001-09-10 2003-04-24 Palasz Andrzej T. Method for cryopreserving mammalian cells and tissues
WO2004012791A2 (en) * 2002-08-06 2004-02-12 Genvec, Inc. Improved injection system
AU2003284875A1 (en) * 2002-10-17 2004-05-04 Vacanti, Joseph P. Biological scaffolding material
JP2006525006A (ja) * 2003-05-08 2006-11-09 セルアーティス アーベー 閉塞ストローガラス化方法を利用するヒト胚盤胞由来幹細胞の低温保存法
US20050100877A1 (en) * 2003-09-02 2005-05-12 University Of North Carolina At Chapel Hill Biodegradable polymer-ligand conjugates and their uses in isolation of cellular subpolulations and in cryopreservation, culture and transplantation of cells
CN1863903A (zh) * 2003-09-19 2006-11-15 新南部创新有限公司 分离肝细胞的方法
US20080176205A1 (en) * 2003-12-04 2008-07-24 University Of Utah Research Foundation Process and Formulation to Improve Viability of Stored Cells and Tissue
US7884185B2 (en) * 2004-07-28 2011-02-08 University Of Delaware Hydrogels and uses thereof
US8828433B2 (en) * 2005-04-19 2014-09-09 Advanced Cardiovascular Systems, Inc. Hydrogel bioscaffoldings and biomedical device coatings
EP1954804A4 (en) * 2005-11-16 2009-03-04 Univ North Carolina EXTRACELLULAR MATRIX COMPONENTS FOR EXTENDING OR DIFFERENTIATING HEPATIC PRECURSORS
US20090186335A1 (en) * 2006-05-30 2009-07-23 Palasz Andre T Method of preparing unilamellar vesicles for the cryopreservation and culture of germ cells and embryos
TW200817019A (en) * 2006-07-10 2008-04-16 Univ Columbia De novo formation and regeneration of vascularized tissue from tissue progenitor cells and vascular progenitor cells
AU2007297611B2 (en) * 2006-09-21 2013-02-07 Purdue Research Foundation Collagen preparation and method of isolation
WO2008101215A1 (en) * 2007-02-16 2008-08-21 Varian Medical Systems Technologies, Inc. Preparative regimen for engraftment, growth and differentiation of non-hematopoeitic cells in vivo
CN101855340A (zh) * 2007-03-06 2010-10-06 北卡罗来纳大学查珀尔希尔分校 用于细胞维持、扩增和/或分化的透明质酸、其他基质成分、激素和生长因子的复合物
US20080311045A1 (en) * 2007-06-06 2008-12-18 Biovaluation & Analysis, Inc. Polymersomes for Use in Acoustically Mediated Intracellular Drug Delivery in vivo
IN2010KN00157A (es) * 2007-06-15 2015-08-28 Univ North Carolina
GB0713079D0 (en) * 2007-07-05 2007-08-15 Ucl Business Plc biomaterial scaffolds with defined stiffness
WO2009022339A1 (en) * 2007-08-15 2009-02-19 Ramot At Tel Aviv University Ltd. Polypeptides, matrices, hydrogels and methods of using same for tissue regeneration and repair
EP2190562A2 (en) * 2007-08-20 2010-06-02 Do-Coop Technologies Ltd Enriched nanostructure composition
EP3338549A1 (en) * 2007-11-20 2018-06-27 Pioneer Surgical Orthobiologics, Inc. Cryopreservation of cells using cross-linked bioactive hydrogel matrix particles
CN101618235A (zh) * 2008-07-01 2010-01-06 中国人民解放军军事医学科学院基础医学研究所 一种基于opf水凝胶为液态支架的可注射性心肌组织工程产品
EP2341953B1 (en) * 2008-09-04 2018-11-21 The General Hospital Corporation Hydrogels for vocal cord and soft tissue augmentation and repair
US20100092533A1 (en) * 2008-10-15 2010-04-15 Joshua Stopek Bioabsorbable Surgical Composition
EP2221362A1 (en) * 2009-02-19 2010-08-25 Naturin GmbH & Co Method for the cryopreservation of cells, artificial cell constructs or three-dimensional complex tissues assemblies

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