AR080692A1 - Compuestos, composiciones y metodos para la administracion no toxica de antiprogestinas - Google Patents
Compuestos, composiciones y metodos para la administracion no toxica de antiprogestinasInfo
- Publication number
- AR080692A1 AR080692A1 ARP110100899A ARP110100899A AR080692A1 AR 080692 A1 AR080692 A1 AR 080692A1 AR P110100899 A ARP110100899 A AR P110100899A AR P110100899 A ARP110100899 A AR P110100899A AR 080692 A1 AR080692 A1 AR 080692A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- acyl
- alkoxy
- hydrogen
- group
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/36—Antigestagens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
- C07J7/0045—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa not substituted in position 16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
- C07J7/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa substituted in position 16
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Reproductive Health (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Gynecology & Obstetrics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pregnancy & Childbirth (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
El objeto es pertinente para el campo del tratamiento de las afecciones dependientes de hormonas. Se divulgan compuestos y métodos para tratar estas afecciones. Se divulgan métodos para tratar la endometriosis, la dismenorrea, el cáncer del seno, los fibromas uterinos y la hiperproliferacion endometrial. Reivindicacion 1: Un compuesto caracterizado porque tiene la formula general (1) o una sal aceptable desde el punto de vista farmacéutico de este, donde R1 se selecciona del grupo que incluye: alquilo; alquenilo; cicloalquilo; cicloalquenilo; arilo; H; CH3SO; CH3SO2 acilo; alcoxi; tioalcoxi; tioalquilo, aciloxi; Si(CH3)3; el resto de formula (2) donde X e Y son acilo; aziridinilo, azirinilo, azetidinilo, pirrolidinilo, etoxipirrolidinilo, metoxipirrolidinilo, piperidinilo, etoxipiperidinilo, morfolinilo, etoximorfolinilo, oxazinilo, piperazinilo, metilpiperazinilo, etilpiperazinilo y diazinilo; R2 se selecciona del grupo que incluye: hidrogeno, halogeno, alquilo, acilo, hidroxilo, alcoxi, aciloxi, carbonato de alquilo, cipioniloxi, S-alquilo, S-CN, S-acilo y -OC(O)R6 donde R6 es alquilo, alcoxialquilo o alcoxi; R3 se selecciona del grupo que incluye: alquilo, hidroxi, alcoxi y aciloxi con la condicion de que sea distinto de acetoxi o propinilo; R4 es hidrogeno o alquilo; y X se selecciona del grupo que incluye: =O, N-OR5 donde R5 es hidrogeno o alquilo, OH, CH2, OAIk1 y OCOAlk2, donde Alk1 y Alk2 son alquilo C1-8 o aralalquilo C7-15, con la condicion de que si R1 está en la posicion para y es -OCH3, -SCH3, -NC4H8, -NC5H10, -NC4H8O, -CHO, -CH(OH)CH3, -COCH3, -O(CH2)2NC4H8 o -O(CH2)2NC5H10, X sea distinto de =O o =N-OR5, donde R5 es hidrogeno o alquilo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31626310P | 2010-03-22 | 2010-03-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR080692A1 true AR080692A1 (es) | 2012-05-02 |
Family
ID=44343114
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP110100899A AR080692A1 (es) | 2010-03-22 | 2011-03-18 | Compuestos, composiciones y metodos para la administracion no toxica de antiprogestinas |
Country Status (24)
Country | Link |
---|---|
US (3) | US20130018027A1 (es) |
EP (2) | EP3865502A1 (es) |
JP (4) | JP5894143B2 (es) |
KR (2) | KR20130009990A (es) |
CN (3) | CN107260745A (es) |
AR (1) | AR080692A1 (es) |
AU (4) | AU2010348967C1 (es) |
BR (2) | BR112012023281A2 (es) |
CA (1) | CA2793712A1 (es) |
CL (1) | CL2012002544A1 (es) |
CO (1) | CO6602170A2 (es) |
CR (1) | CR20120514A (es) |
EA (1) | EA023743B1 (es) |
EC (1) | ECSP12012226A (es) |
IL (2) | IL221820B (es) |
MX (1) | MX2012010327A (es) |
MY (1) | MY164622A (es) |
NI (2) | NI201200142A (es) |
NZ (1) | NZ602525A (es) |
SG (3) | SG183924A1 (es) |
TW (1) | TWI581797B (es) |
UA (1) | UA110030C2 (es) |
WO (1) | WO2011119194A1 (es) |
ZA (1) | ZA201207688B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015171319A1 (en) * | 2014-05-05 | 2015-11-12 | Repros Therapeutics Inc. | Formulations and methods for vaginal delivery of antiprogestins |
KR20170084086A (ko) | 2014-11-17 | 2017-07-19 | 아르노 테라퓨틱스 인코포레이티드 | 오나프리스톤 연장-방출 조성물 및 방법 |
CA2998924A1 (en) | 2015-09-25 | 2017-03-30 | Context Biopharma Inc. | Methods of making onapristone intermediates |
US10548905B2 (en) | 2015-12-15 | 2020-02-04 | Context Biopharma Inc. | Amorphous onapristone compositions and methods of making the same |
CA3015781C (en) * | 2016-02-24 | 2024-04-23 | Eastern Virginia Medical School | An improved formulation of long-acting levonorgestrel butanoate injectable depot suspension |
US20180148471A1 (en) | 2016-11-30 | 2018-05-31 | Arno Therapeutics, Inc. | Methods for onapristone synthesis dehydration and deprotection |
Family Cites Families (66)
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FR2521565B1 (fr) | 1982-02-17 | 1985-07-05 | Dior Sa Parfums Christian | Melange pulverulent de constituants lipidiques et de constituants hydrophobes, procede pour le preparer, phases lamellaires lipidiques hydratees et procede de fabrication, compositions pharmaceutiques ou cosmetiques comportant des phases lamellaires lipidiques hydratees |
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2010
- 2010-12-23 US US13/636,119 patent/US20130018027A1/en not_active Abandoned
- 2010-12-23 CN CN201710457367.XA patent/CN107260745A/zh active Pending
- 2010-12-23 CN CN201710457607.6A patent/CN107260746A/zh active Pending
- 2010-12-23 KR KR1020127027413A patent/KR20130009990A/ko active Application Filing
- 2010-12-23 AU AU2010348967A patent/AU2010348967C1/en not_active Ceased
- 2010-12-23 JP JP2013501240A patent/JP5894143B2/ja not_active Expired - Fee Related
- 2010-12-23 BR BR112012023281A patent/BR112012023281A2/pt not_active IP Right Cessation
- 2010-12-23 MY MYPI2012004016A patent/MY164622A/en unknown
- 2010-12-23 SG SG2012065801A patent/SG183924A1/en unknown
- 2010-12-23 UA UAA201212075A patent/UA110030C2/uk unknown
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