AR078676A1 - Derivados de etiniltiazol-2-sustituido y usos de los mismos - Google Patents

Derivados de etiniltiazol-2-sustituido y usos de los mismos

Info

Publication number: AR078676A1
Authority: AR; Argentina
Prior art keywords: alkyl; cycloalkyl; aryl; heterocyclyl; heteroaryl
Prior art date: 2009-10-20

Application number

ARP100103814A

Other languages

English (en)

Spanish (es)

Original Assignee

Lundbeck & Co As H

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-10-20

Filing date

2010-10-19

Publication date

2011-11-23

2010-10-19 Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H

2011-11-23 Publication of AR078676A1 publication Critical patent/AR078676A1/es

Links

125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 8
125000003118 aryl group Chemical group 0.000 abstract 6
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
125000000753 cycloalkyl group Chemical group 0.000 abstract 5
229910052736 halogen Inorganic materials 0.000 abstract 5
150000002367 halogens Chemical class 0.000 abstract 5
125000001072 heteroaryl group Chemical group 0.000 abstract 5
125000000623 heterocyclic group Chemical group 0.000 abstract 5
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 4
JNCMHMUGTWEVOZ-UHFFFAOYSA-N F[CH]F Chemical group F[CH]F JNCMHMUGTWEVOZ-UHFFFAOYSA-N 0.000 abstract 4
108010081348 HRT1 protein Hairy Chemical group 0.000 abstract 4
102100021881 Hairy/enhancer-of-split related with YRPW motif protein 1 Human genes 0.000 abstract 4
229910052799 carbon Inorganic materials 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 4
125000000217 alkyl group Chemical group 0.000 abstract 3
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 2
125000002252 acyl group Chemical group 0.000 abstract 2
125000004093 cyano group Chemical group *C#N 0.000 abstract 2
125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 2
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 1
FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical group C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 abstract 1
125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
238000006467 substitution reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Thiazole And Isothizaole Compounds (AREA)

ARP100103814A 2009-10-20 2010-10-19 Derivados de etiniltiazol-2-sustituido y usos de los mismos AR078676A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US25345209P	2009-10-20	2009-10-20

Publications (1)

Publication Number	Publication Date
AR078676A1 true AR078676A1 (es)	2011-11-23

Family

ID=43879766

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ARP100103814A AR078676A1 (es)	2009-10-20	2010-10-19	Derivados de etiniltiazol-2-sustituido y usos de los mismos

Country Status (9)

Country	Link
US (2)	US8440837B2 (pt)
EP (1)	EP2490541A4 (pt)
JP (1)	JP2013508386A (pt)
KR (1)	KR20120088737A (pt)
CN (1)	CN102573493A (pt)
AR (1)	AR078676A1 (pt)
BR (1)	BR112012009311A2 (pt)
TW (1)	TW201124391A (pt)
WO (1)	WO2011050063A1 (pt)

Families Citing this family (7)

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WO2011075699A2 (en)	2009-12-18	2011-06-23	Sunovion Pharmaceuticals Inc.	Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof
EP2705024B1 (en)	2011-05-03	2015-12-16	Merck Sharp & Dohme Corp.	Alkyne benzotriazole derivatives
CN103827104A (zh) *	2011-09-16	2014-05-28	H.隆德贝克有限公司	双碳环和三碳环乙炔基衍生物及其应用
WO2013066152A1 (en) *	2011-10-31	2013-05-10	N.V. Nutricia	Method for improving executive function
KR101656634B1 (ko) *	2012-10-18	2016-09-09	에프. 호프만-라 로슈 아게	mGluR5 수용체 활성의 조절제로서 에틴일 유도체
CN104211639A (zh) *	2013-06-05	2014-12-17	中国科学院上海药物研究所	一类炔基杂环类化合物及其应用
WO2015091645A1 (en)	2013-12-18	2015-06-25	Basf Se	Azole compounds carrying an imine-derived substituent

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US4788207A (en) *	1988-02-29	1988-11-29	Fmc Corporation	Photoactivated miticidal and insecticidal ethynylthiazoles
US4990520A (en) *	1990-02-02	1991-02-05	American Cyanamid Company	2-,4- or 5-substituted thiazole derivatives
WO1996033181A1 (en) *	1995-04-21	1996-10-24	Daiichi Pharmaceutical Co., Ltd.	Ethynylthiazole derivative
US6645990B2 (en) *	2000-08-15	2003-11-11	Amgen Inc.	Thiazolyl urea compounds and methods of uses
WO2002080928A1 (en) *	2001-04-03	2002-10-17	Merck & Co., Inc.	N-substituted nonaryl-heterocyclo amidyl nmda/nr2b antagonists
CA2583572C (en) *	2004-10-07	2016-07-12	Merck & Co., Inc.	Thiazolyl mglur5 antagonists and methods for their use
WO2006074884A1 (en) *	2005-01-14	2006-07-20	F.Hoffmann-La Roche Ag	Thiazole-4-carboxamide derivatives as mglur5 antagonists
DOP2006000051A (es)	2005-02-24	2006-08-31	Lilly Co Eli	Inhibidores de vegf-r2 y métodos
WO2006091506A2 (en)	2005-02-24	2006-08-31	Bayer Pharmaceuticals Corporation	Neuropeptide y4 receptor agonists
CN101193891A (zh) *	2005-04-12	2008-06-04	明治制果株式会社	2位硫乙烯基系碳青霉烯衍生物
WO2006109823A1 (ja)	2005-04-12	2006-10-19	Meiji Seika Kaisha, Ltd.	２位チオエテニル系カルバペネム誘導体
WO2006121860A2 (en)	2005-05-06	2006-11-16	Bayer Pharmaceuticals Corporation	Glucagon-like peptide 1 (glp-1) receptor agonists and their pharmacological methods of use
DE102006012655B4 (de)	2006-01-10	2008-12-24	Siemens Ag	Verfahren zum Bereitstellen einer Dienstqualität in einem WiMAX-Kommunikationsnetzwerk und Verfahren zum Auswählen einer Zugangs-Transportressourcenkontrollfunktion durch eine Richtlinienentscheidungsfunktion in einem Kommunikationsnetzwerk
JPWO2008053913A1 (ja)	2006-11-02	2010-02-25	塩野義製薬株式会社	Ｍｍｐ−１３を選択的に阻害するスルホニルウレア誘導体
JP2010513403A (ja) *	2006-12-20	2010-04-30	ノバルティスアーゲー	Ｓｃｄ阻害剤としての２−置換５員ヘテロ環
WO2010007482A2 (en)	2008-07-16	2010-01-21	Glenmark Pharmaceuticals S.A.	Thiazole derivatives as stearoyl coa desaturase inhibitors
JPWO2010007943A1 (ja) *	2008-07-17	2012-01-05	旭化成ファーマ株式会社	含窒素複素環化合物
CA2735794A1 (en) *	2008-09-08	2010-03-11	Merck Frosst Canada Ltd.	Heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase
US20110184027A1 (en) *	2008-09-25	2011-07-28	Glenmark Pharmaceuticals S.A.	Tissue selective stearoyl-coa desaturase 1 inhibitors and cell based screening assay for their identification
EP2563358A4 (en) *	2010-04-30	2013-09-25	Merck Sharp & Dohme	INHIBITORS OF PHOSPHOINOSITIDE-DEPENDENT KINASE 1 (PDK1)

2010
- 2010-10-11 TW TW099134560A patent/TW201124391A/zh unknown
- 2010-10-19 AR ARP100103814A patent/AR078676A1/es unknown
- 2010-10-20 US US12/908,588 patent/US8440837B2/en not_active Expired - Fee Related
- 2010-10-20 KR KR1020127011772A patent/KR20120088737A/ko not_active Application Discontinuation
- 2010-10-20 JP JP2012535335A patent/JP2013508386A/ja active Pending
- 2010-10-20 CN CN2010800471508A patent/CN102573493A/zh active Pending
- 2010-10-20 BR BR112012009311A patent/BR112012009311A2/pt not_active IP Right Cessation
- 2010-10-20 EP EP10825591.0A patent/EP2490541A4/en not_active Withdrawn
- 2010-10-20 WO PCT/US2010/053379 patent/WO2011050063A1/en active Application Filing
2013
- 2013-04-16 US US13/863,663 patent/US20130231321A1/en not_active Abandoned

Also Published As

Publication number	Publication date
KR20120088737A (ko)	2012-08-08
US8440837B2 (en)	2013-05-14
EP2490541A1 (en)	2012-08-29
US20110092475A1 (en)	2011-04-21
TW201124391A (en)	2011-07-16
CN102573493A (zh)	2012-07-11
JP2013508386A (ja)	2013-03-07
US20130231321A1 (en)	2013-09-05
EP2490541A4 (en)	2013-04-10
BR112012009311A2 (pt)	2015-09-22
WO2011050063A1 (en)	2011-04-28

Legal Events

Date	Code	Title	Description
2013-10-29	FB	Suspension of granting procedure

Publication	Publication Date	Title
AR078676A1 (es)	2011-11-23	Derivados de etiniltiazol-2-sustituido y usos de los mismos
PH12016501007A1 (en)	2016-07-18	Substituted benzamides and methods of use thereof
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AR105845A1 (es)	2017-11-15	Compuestos de heteroarilo bicíclicos fusionados como moduladores de la función irak4
ECSP099755A (es)	2009-12-28	Derivados de pirrolopiridina y su uso como inhibidores de bace
AR081058A1 (es)	2012-06-06	Derivados de arilmetoxi isoindolina, composiciones que los comprenden y su uso en el tratamiento del cancer.
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