AR075511A2 - Polipeptidos bopag (glicoproteina asociada a la prenez en bovinos) y acidos nucleicos que los codifican - Google Patents
Polipeptidos bopag (glicoproteina asociada a la prenez en bovinos) y acidos nucleicos que los codificanInfo
- Publication number
- AR075511A2 AR075511A2 ARP100100469A ARP100100469A AR075511A2 AR 075511 A2 AR075511 A2 AR 075511A2 AR P100100469 A ARP100100469 A AR P100100469A AR P100100469 A ARP100100469 A AR P100100469A AR 075511 A2 AR075511 A2 AR 075511A2
- Authority
- AR
- Argentina
- Prior art keywords
- bopag
- pag
- pregnancy
- animal
- polypeptides
- Prior art date
Links
- 108020004707 nucleic acids Proteins 0.000 title abstract 2
- 102000039446 nucleic acids Human genes 0.000 title abstract 2
- 150000007523 nucleic acids Chemical class 0.000 title abstract 2
- 229920001184 polypeptide Polymers 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 4
- 230000035935 pregnancy Effects 0.000 abstract 4
- 238000001514 detection method Methods 0.000 abstract 3
- 102100024003 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 Human genes 0.000 abstract 1
- 102000003886 Glycoproteins Human genes 0.000 abstract 1
- 108090000288 Glycoproteins Proteins 0.000 abstract 1
- 101100380306 Homo sapiens ASAP1 gene Proteins 0.000 abstract 1
- 108091034117 Oligonucleotide Proteins 0.000 abstract 1
- 101150003633 PAG2 gene Proteins 0.000 abstract 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 230000001900 immune effect Effects 0.000 abstract 1
- 239000008267 milk Substances 0.000 abstract 1
- 210000004080 milk Anatomy 0.000 abstract 1
- 235000013336 milk Nutrition 0.000 abstract 1
- 210000003296 saliva Anatomy 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
- 210000002700 urine Anatomy 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/471—Pregnancy proteins, e.g. placenta proteins, alpha-feto-protein, pregnancy specific beta glycoprotein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/36—Gynecology or obstetrics
- G01N2800/368—Pregnancy complicated by disease or abnormalities of pregnancy, e.g. preeclampsia, preterm labour
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/973—Simultaneous determination of more than one analyte
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Reproductive Health (AREA)
- Zoology (AREA)
- Gynecology & Obstetrics (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Pregnancy & Childbirth (AREA)
- Toxicology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Se provee un método para detectar la prenez en un animal euterio que comprende la obtencion de una muestra del animal; y la deteccion de por lo menos uno de los antígenos asociados con la prenez (PAG), caracterizado porque el PAG está presente al comienzo de la prenez y ausente a los dos meses de post-paricion aproximadamente, con Io cual la presencia de la PAG indica que el animal está prenado. La PAG se puede seleccionar del grupo formado por PAG2, PAG4, PAG5, PAG6, PAG7 y PAG9. En realizaciones más preferidas, la PAG puede ser, independientemente, BoPAG2, BoPAG4, BoPAG5, BoPAG6, BoPAG7, BoPAG9, boPAG7v; boPAG9v; boPAG 15; boPAG 16; boPAG 17; boPAG 18; boPAG 19; boPAG 20 o boPAG 21 y la muestra puede ser de saliva, suero, sangre, Ieche u orina. La deteccion comprende una deteccion inmunologica. También se contempla un método para elaborar un anticuerpo monoclonal contra BoPAG2, BoPAG4, BoPAG5, BoPAG6, BoPAG7, BoPAG9, boPAG 7v; boPAG9v, boPAG 15; boPAG 16; boPAG 17; boPAG 18; boPAG 19; boPAG 20 o boPAG 21. Se provee también un método para identificar una glicoproteína asociada con la prenez (PAG) que es un indicador temprano de prenez en un animal euterio. Se describen asimismo los polipéptidos PAG y los ácidos nucleicos que los codifican. También se contemplan oligonucleotidos que comprenden por lo menos 15 pares de bases consecutivas de cualquier secuencia que codifica PAG, o un complemento de la misma. Se provee además un kit [juego] para llevar a cabo dicho método.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7878398P | 1998-03-20 | 1998-03-20 | |
| US10618898P | 1998-10-28 | 1998-10-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR075511A2 true AR075511A2 (es) | 2011-04-06 |
Family
ID=26760935
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990101227A AR015549A1 (es) | 1998-03-20 | 1999-03-19 | Método para inferir la prenez en un animal bovino. |
| ARP070105068A AR063820A2 (es) | 1998-03-20 | 2007-11-14 | Anticuerpo purificado y kit para detectar la prenez en un animal bovino |
| ARP100100469A AR075511A2 (es) | 1998-03-20 | 2010-02-17 | Polipeptidos bopag (glicoproteina asociada a la prenez en bovinos) y acidos nucleicos que los codifican |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990101227A AR015549A1 (es) | 1998-03-20 | 1999-03-19 | Método para inferir la prenez en un animal bovino. |
| ARP070105068A AR063820A2 (es) | 1998-03-20 | 2007-11-14 | Anticuerpo purificado y kit para detectar la prenez en un animal bovino |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US6869770B1 (es) |
| EP (2) | EP2295978A3 (es) |
| AR (3) | AR015549A1 (es) |
| AU (1) | AU768018C (es) |
| CA (1) | CA2323812C (es) |
| NZ (1) | NZ507033A (es) |
| WO (1) | WO1999047934A2 (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR015549A1 (es) | 1998-03-20 | 2001-05-02 | Univ Missouri | Método para inferir la prenez en un animal bovino. |
| RU2284035C2 (ru) * | 2001-06-19 | 2006-09-20 | Айдахо Рисерч Фаундейшн | Определение статуса беременности |
| WO2003028582A2 (en) * | 2001-09-28 | 2003-04-10 | Aspenbio, Inc. | Bovine pregnancy test |
| EP1468288A4 (en) * | 2001-11-20 | 2006-03-15 | Univ Missouri | COMPOSITIONS AND METHODS FOR PRECISE PRECISE DIAGNOSIS OF PREGNANCY |
| CA2483958A1 (en) * | 2002-05-02 | 2003-11-13 | Aspenbio, Inc. | Pregnancy detection |
| US7604950B2 (en) | 2004-04-29 | 2009-10-20 | Monsanto Technology Llc | Methods for early detection of pregnancy in cows |
| US20080026384A1 (en) * | 2005-09-30 | 2008-01-31 | Hansen Thomas R | Methods and compositions for the detection of bovine pregnancy |
| HUE034401T2 (en) * | 2007-12-13 | 2018-02-28 | Monsanto Technology Llc | Preparations and methods for early pregnancy diagnosis |
| WO2009126889A1 (en) * | 2008-04-10 | 2009-10-15 | The Curators Of The University Of Missouri | Assays for detecting pregnancy- associated glycoproteins |
| US8541187B2 (en) | 2011-03-01 | 2013-09-24 | Bio Tracking, LLC | Systems and methods for detecting animal pregnancy |
| WO2017123599A1 (en) * | 2016-01-11 | 2017-07-20 | University Of Tennessee Research Foundation | Pregnancy associated glycoprotein (pag) genes as markers of bull fertility |
| KR102189893B1 (ko) * | 2017-11-15 | 2020-12-11 | (주)에스엘에스바이오 | bPAG1에 특이적으로 결합하는 항체 및 이의 용도 |
| CN111596073B (zh) * | 2020-06-04 | 2023-05-02 | 昆明天沃生物科技有限公司 | 一种检测羊早期妊娠的方法 |
| CN113960025A (zh) * | 2021-10-12 | 2022-01-21 | 北京农学院 | 一种奶牛早期妊娠的检测方法 |
| KR20230065047A (ko) * | 2021-11-04 | 2023-05-11 | 주식회사 나노바이오라이프 | 소 임신 진단 항체와 이를 이용한 조기 임신 진단키트 개발 |
| CN114134123B (zh) * | 2021-12-02 | 2023-05-05 | 深圳市爱医生物科技有限公司 | 妊娠相关糖蛋白的单克隆抗体及其在牛早期怀孕检测中的应用 |
| CN114047336A (zh) * | 2021-12-13 | 2022-02-15 | 大连医科大学 | 一种用于辅助诊断复发性流产的生物标志物及其应用 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US3939350A (en) | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4196265A (en) | 1977-06-15 | 1980-04-01 | The Wistar Institute | Method of producing antibodies |
| US4208479A (en) * | 1977-07-14 | 1980-06-17 | Syva Company | Label modified immunoassays |
| US4271140A (en) * | 1978-01-23 | 1981-06-02 | Baxter Travenol Laboratories, Inc. | Method and composition for double receptor, specific binding assays |
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4277437A (en) | 1978-04-05 | 1981-07-07 | Syva Company | Kit for carrying out chemically induced fluorescence immunoassay |
| US4367110A (en) | 1979-07-02 | 1983-01-04 | Toppan Printing Co. | Decorative laminate and a manufacturing method therefor |
| US4452901A (en) | 1980-03-20 | 1984-06-05 | Ciba-Geigy Corporation | Electrophoretically transferring electropherograms to nitrocellulose sheets for immuno-assays |
| US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
| US4755460A (en) * | 1984-07-06 | 1988-07-05 | The Regents Of The Univ. Of Minnesota | Bovine antigen glycoprotein, related antibody, and use in detection of pregnancy in cattle |
| US4895804A (en) * | 1984-07-06 | 1990-01-23 | University Of Minnesota | Bovine antigen glycoprotein, related antibody, and use in detection of pregnancy in cattle |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4668621A (en) | 1985-04-22 | 1987-05-26 | Wake Forest University | Detecting blood clotting factors with immobilized fibrinogen and labeled fibrinogen |
| US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| US4932207A (en) | 1988-12-28 | 1990-06-12 | Sundstrand Corporation | Segmented seal plate for a turbine engine |
| DE19733505A1 (de) | 1997-08-01 | 1999-02-04 | Knoll Ag | Schnell wirksames Analgeticum |
| EP1053473A4 (en) * | 1998-02-02 | 2003-08-13 | Concepto Diagnostics Inc | METHOD AND DEVICE FOR DETECTING THE CONCEPT OF ANIMALS |
| AR015549A1 (es) * | 1998-03-20 | 2001-05-02 | Univ Missouri | Método para inferir la prenez en un animal bovino. |
| WO2003028582A2 (en) | 2001-09-28 | 2003-04-10 | Aspenbio, Inc. | Bovine pregnancy test |
| EP1468288A4 (en) * | 2001-11-20 | 2006-03-15 | Univ Missouri | COMPOSITIONS AND METHODS FOR PRECISE PRECISE DIAGNOSIS OF PREGNANCY |
| WO2009126889A1 (en) * | 2008-04-10 | 2009-10-15 | The Curators Of The University Of Missouri | Assays for detecting pregnancy- associated glycoproteins |
-
1999
- 1999-03-19 AR ARP990101227A patent/AR015549A1/es active IP Right Grant
- 1999-03-19 WO PCT/US1999/006038 patent/WO1999047934A2/en active IP Right Grant
- 1999-03-19 EP EP10183539A patent/EP2295978A3/en not_active Withdrawn
- 1999-03-19 AU AU31028/99A patent/AU768018C/en not_active Expired
- 1999-03-19 NZ NZ507033A patent/NZ507033A/en not_active IP Right Cessation
- 1999-03-19 US US09/273,164 patent/US6869770B1/en not_active Expired - Lifetime
- 1999-03-19 EP EP99912715A patent/EP1141727A2/en not_active Withdrawn
- 1999-03-19 CA CA2323812A patent/CA2323812C/en not_active Expired - Lifetime
-
2003
- 2003-09-04 US US10/655,547 patent/US20050100975A1/en not_active Abandoned
-
2006
- 2006-10-24 US US11/552,454 patent/US7763432B2/en not_active Expired - Fee Related
-
2007
- 2007-11-14 AR ARP070105068A patent/AR063820A2/es not_active Application Discontinuation
-
2010
- 2010-02-17 AR ARP100100469A patent/AR075511A2/es active IP Right Grant
- 2010-06-28 US US12/825,223 patent/US8182999B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2323812A1 (en) | 1999-09-23 |
| EP2295978A3 (en) | 2012-06-06 |
| AR063820A2 (es) | 2009-02-18 |
| US7763432B2 (en) | 2010-07-27 |
| US20070166773A1 (en) | 2007-07-19 |
| AU768018B2 (en) | 2003-11-27 |
| US20100331206A1 (en) | 2010-12-30 |
| AU768018C (en) | 2004-09-30 |
| WO1999047934A3 (en) | 2001-07-19 |
| NZ507033A (en) | 2004-06-25 |
| CA2323812C (en) | 2011-05-10 |
| AR015549A1 (es) | 2001-05-02 |
| AU3102899A (en) | 1999-10-11 |
| US20050100975A1 (en) | 2005-05-12 |
| US8182999B2 (en) | 2012-05-22 |
| EP1141727A2 (en) | 2001-10-10 |
| US6869770B1 (en) | 2005-03-22 |
| WO1999047934A2 (en) | 1999-09-23 |
| EP2295978A2 (en) | 2011-03-16 |
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