AR075239A1 - Tratamiento del cancer de pulmon con un inhibidor de la parp en combinacion con un inhibidor de un factor de crecimiento. composicion farmaceutica. uso - Google Patents
Tratamiento del cancer de pulmon con un inhibidor de la parp en combinacion con un inhibidor de un factor de crecimiento. composicion farmaceutica. usoInfo
- Publication number
- AR075239A1 AR075239A1 ARP100100305A ARP100100305A AR075239A1 AR 075239 A1 AR075239 A1 AR 075239A1 AR P100100305 A ARP100100305 A AR P100100305A AR P100100305 A ARP100100305 A AR P100100305A AR 075239 A1 AR075239 A1 AR 075239A1
- Authority
- AR
- Argentina
- Prior art keywords
- inhibitor
- growth factor
- combination
- parp inhibitor
- nitro
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Reivindicacion 1: Una composicion farmacéutica que comprende por lo menos un inhibidor de la PARP en combinacion con por lo menos un inhibidor de un factor de crecimiento, donde dicho inhibidor de la PARP es de la formula (1), o un metabolito del mismo en la cual R1, R2, R3, R4 y R5 son independientemente seleccionados del grupo que consiste en hidrogeno, hidroxi, amino, nitro, nitroso, yodo, alquilo C1-6, alcoxi C1-6, cicloalquilo C3-7 y fenilo, donde por lo menos dos de los cinco sustituyentes R1, R2, R3, R4 y R5 son siempre hidrogeno, por lo menos uno de los cinco sustituyentes son siempre nitro y por lo menos un sustituyente situado adyacente a un nitro es siempre yodo, o una sal, solvato, isomero o tautomero del mismo y donde el inhibidor del factor de crecimiento es seleccionado del grupo que consiste en AEE788, GW-974, BIBW 2992, catumaxomab, vacuna EGF, icotinib, leflunomida, necitumumab, neratinib, pertuzumab, PF-299804, zalutumumab, CNTF, tanezumab, dalotuzumab, AMG-479, rilotumumab, lanreotida, OSI 906, pasireotide, PF-2341066, MetMab, XL-184, aflibercept, apatinib, BIBF-1120, PAM-1, XL-999, brivanib, fluocinolona, midostaurina, motesanib, OTS-102, OSI-632, vatalanib, pazopanib, BMS-690514, ramucirumab, ridoforolimus, tivozanib, alacizumab pegol, PD173074, PHA 665752, DMQ, SU4312, K252a, X-647, VEGF-Trap-Eye, pirfenidona, masitinib y nilotinib. Reivindicacion 3: El uso de la composicion de acuerdo con la reivindicacion 1 para la elaboracion de un medicamento para el tratamiento del cáncer de pulmon. Reivindicacion 5: El uso de acuerdo con la reivindicacion 3 o 4, en el cual se obtiene por lo menos un efecto terapéutico, donde dicho por lo menos un efecto terapéutico es la reduccion del tamano de un tumor pulmonar, la reduccion de metástasis, la remision total, remision parcial, la estabilidad de la enfermedad o una respuesta patologica completa. Reivindicacion 27: El uso de acuerdo con la reivindicacion 3 u 8, que además comprende administrar al paciente uno o más del grupo que consiste en una ciclodextrina, un tensioactivo, y un cosolvente en combinacion con el inhibidor de la PARP.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14997709P | 2009-02-04 | 2009-02-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR075239A1 true AR075239A1 (es) | 2011-03-16 |
Family
ID=42542374
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP100100305A AR075239A1 (es) | 2009-02-04 | 2010-02-04 | Tratamiento del cancer de pulmon con un inhibidor de la parp en combinacion con un inhibidor de un factor de crecimiento. composicion farmaceutica. uso |
Country Status (14)
Country | Link |
---|---|
US (1) | US20120130144A1 (es) |
EP (1) | EP2393364A4 (es) |
JP (1) | JP2012516895A (es) |
KR (1) | KR20110113648A (es) |
CN (1) | CN102307475A (es) |
AR (1) | AR075239A1 (es) |
AU (1) | AU2010210636A1 (es) |
CA (1) | CA2751397A1 (es) |
IL (1) | IL214366A0 (es) |
MX (1) | MX2011008221A (es) |
RU (1) | RU2011136641A (es) |
SG (1) | SG173198A1 (es) |
TW (1) | TW201032796A (es) |
WO (1) | WO2010091140A1 (es) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2405566C2 (ru) | 2005-02-03 | 2010-12-10 | Дзе Дженерал Хоспитал Корпорейшн | Способ лечения рака, устойчивого к гефитинибу |
ZA200800907B (en) | 2005-07-18 | 2010-04-28 | Bipar Sciences Inc | Treatment of cancer |
PE20070763A1 (es) | 2005-11-04 | 2007-08-08 | Wyeth Corp | COMBINACIONES ANTINEOPLASICAS DE UN INHIBIDOR DE mTOR, TRASTUZUMAB Y/O HKI-272 |
US8143447B2 (en) | 2006-09-05 | 2012-03-27 | Bipar Sciences, Inc. | Treatment of cancer |
WO2008030891A2 (en) | 2006-09-05 | 2008-03-13 | Bipar Sciences, Inc. | Inhibition of fatty acid synthesis by parp inhibitors and methods of treatment thereof |
US8022216B2 (en) | 2007-10-17 | 2011-09-20 | Wyeth Llc | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
MX365008B (es) | 2008-06-17 | 2019-05-20 | Wyeth Llc | Combinaciones antineoplasticas que contienen hki-272 y vinorelbina. |
JP5681108B2 (ja) | 2008-08-04 | 2015-03-04 | ワイス・エルエルシー | 4−アニリノ−3−シアノキノリンとカペシタビンの抗新生物薬の組合せ |
ES2561495T3 (es) | 2009-04-06 | 2016-02-26 | Wyeth Llc | Régimen de tratamiento que utiliza neratinib contra cáncer de mama |
FI20115640A0 (fi) | 2011-06-22 | 2011-06-22 | Turun Yliopisto | Yhdistelmähoito |
US20150182490A1 (en) * | 2012-06-26 | 2015-07-02 | Del Mar Pharmaceuticals | Methods for treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or ahi1 dysregulations or mutations employing dianhydrogalactitol, diacetyldianhydrogalactitol, dibromodulcitol, or analogs or derivatives thereof |
JP6393682B2 (ja) | 2012-07-13 | 2018-09-19 | トゥルン イリオピスト | 併用療法iii |
WO2014170441A1 (en) * | 2013-04-19 | 2014-10-23 | Dna Therapeutics | Inhibition of dna damage repair by artificial activation of parp with oligonucleotide molecules |
WO2016054055A1 (en) * | 2014-09-29 | 2016-04-07 | Board Of Regent, The University Of Texas System | Prediction of response to parp inhibitors and combinational therapy targeting c-met and parp1 |
EP3253211A4 (en) * | 2015-02-05 | 2018-10-31 | Memorial Sloan Kettering Cancer Center | Compositions and methods for treatment of edema |
PT3325623T (pt) | 2015-07-23 | 2019-09-04 | Inst Curie | Utilização de uma combinação de molécula dbait e de inibidores de parp para o tratamento do cancro |
MX2018005071A (es) * | 2015-10-26 | 2018-11-29 | Medivation Tech Llc | Tratamiento del cancer de pulmon de celulas pequeñas con un inhibidor de parp. |
EP4071174A1 (en) * | 2016-02-15 | 2022-10-12 | AstraZeneca AB | Methods comprising fixed intermittent dosing of cediranib |
EP3549608A4 (en) * | 2016-12-01 | 2020-08-12 | Jiangsu Hengrui Medicine Co., Ltd. | USE OF A COMBINATION OF A VEGFR INHIBITOR AND PARP INHIBITOR IN THE MANUFACTURING OF A MEDICINAL PRODUCT FOR TREATMENT OF STOMACH CANCER |
CN106906184B (zh) * | 2017-02-27 | 2021-04-23 | 广东昭泰体内生物医药科技有限公司 | 一种促进肺癌细胞生长的方法 |
WO2018162439A1 (en) | 2017-03-08 | 2018-09-13 | Onxeo | New predictive biomarker for the sensitivity to a treatment of cancer with a dbait molecule |
BR112019024135A2 (pt) | 2017-05-18 | 2020-06-02 | Tesaro, Inc. | Terapias de combinação para o tratamento de câncer |
EP3655418A4 (en) | 2017-06-22 | 2021-05-19 | Triact Therapeutics, Inc. | METHOD OF TREATMENT OF GLIOBLASTOMA |
EP3687501A4 (en) | 2017-09-29 | 2021-06-23 | Triact Therapeutics, Inc. | INIPARIB FORMS AND USES THEREOF |
WO2019067978A1 (en) * | 2017-09-30 | 2019-04-04 | Tesaro, Inc. | POLYTHERAPIES FOR THE TREATMENT OF CANCER |
SG11202002499TA (en) | 2017-10-06 | 2020-04-29 | Tesaro Inc | Combination therapies and uses thereof |
BR112020010435A2 (pt) * | 2017-12-06 | 2020-11-24 | Jiangsu Hengrui Medicine Co., Ltd. | uso de inibidor da parp no tratamento de câncer de ovário ou câncer de mama resistente à quimioterapia |
JP2021515580A (ja) | 2018-03-13 | 2021-06-24 | オンクセオOnxeo | がんの治療における獲得耐性に対抗するdbait分子 |
JP7372253B2 (ja) | 2018-04-05 | 2023-10-31 | ノビガ・リサーチ・エービー | 癌の治療における使用のためのチューブリン重合阻害剤とポリ(adp-リボース)ポリメラーゼ(parp)阻害剤との新規組合せ |
TW202110448A (zh) * | 2019-05-28 | 2021-03-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | Parp抑制劑聯合vegfr抑制劑用於治療卵巢癌或乳腺癌的用途 |
KR102267662B1 (ko) * | 2019-11-19 | 2021-06-22 | 한국화학연구원 | 벤즈아미드 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물 |
CN110917199A (zh) * | 2019-11-22 | 2020-03-27 | 上海市肺科医院 | 一种小分子化合物在制备肺癌化疗增敏药物中的应用 |
WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
CN114292895A (zh) * | 2022-02-10 | 2022-04-08 | 上海交通大学医学院附属第九人民医院 | 检测对parp抑制剂耐受的物质在制备评估肺癌患者对质子放疗敏感性的产品中的用途 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050287120A1 (en) * | 1997-03-21 | 2005-12-29 | Fisher Paul B | Cancer - targeted viral vectors |
JPWO2002055076A1 (ja) * | 2001-01-04 | 2004-05-13 | 第一製薬株式会社 | シクロデキストリン製剤 |
CA2524305C (en) * | 2003-05-01 | 2015-12-08 | Imclone Systems Incorporated | Fully human antibodies directed against the human insulin-like growth factor-1 receptor |
ZA200800907B (en) * | 2005-07-18 | 2010-04-28 | Bipar Sciences Inc | Treatment of cancer |
US20080262062A1 (en) * | 2006-11-20 | 2008-10-23 | Bipar Sciences, Inc. | Method of treating diseases with parp inhibitors |
KR101591656B1 (ko) * | 2007-01-10 | 2016-02-19 | 엠에스디 이탈리아 에스.알.엘. | 폴리(adp-리보오스) 폴리머라아제(parp) 억제제로서의 아미드 치환된 인다졸 |
-
2010
- 2010-02-04 SG SG2011055266A patent/SG173198A1/en unknown
- 2010-02-04 RU RU2011136641/13A patent/RU2011136641A/ru not_active Application Discontinuation
- 2010-02-04 EP EP10739097A patent/EP2393364A4/en not_active Withdrawn
- 2010-02-04 WO PCT/US2010/023137 patent/WO2010091140A1/en active Application Filing
- 2010-02-04 CA CA2751397A patent/CA2751397A1/en not_active Withdrawn
- 2010-02-04 AU AU2010210636A patent/AU2010210636A1/en not_active Withdrawn
- 2010-02-04 MX MX2011008221A patent/MX2011008221A/es unknown
- 2010-02-04 KR KR1020117020246A patent/KR20110113648A/ko not_active Application Discontinuation
- 2010-02-04 TW TW099103380A patent/TW201032796A/zh unknown
- 2010-02-04 CN CN2010800065364A patent/CN102307475A/zh not_active Withdrawn
- 2010-02-04 US US13/146,865 patent/US20120130144A1/en not_active Abandoned
- 2010-02-04 JP JP2011549246A patent/JP2012516895A/ja not_active Abandoned
- 2010-02-04 AR ARP100100305A patent/AR075239A1/es unknown
-
2011
- 2011-07-31 IL IL214366A patent/IL214366A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
US20120130144A1 (en) | 2012-05-24 |
MX2011008221A (es) | 2011-08-17 |
CN102307475A (zh) | 2012-01-04 |
TW201032796A (en) | 2010-09-16 |
SG173198A1 (en) | 2011-09-29 |
IL214366A0 (en) | 2011-09-27 |
AU2010210636A1 (en) | 2011-09-22 |
EP2393364A1 (en) | 2011-12-14 |
CA2751397A1 (en) | 2010-08-12 |
RU2011136641A (ru) | 2013-03-10 |
JP2012516895A (ja) | 2012-07-26 |
KR20110113648A (ko) | 2011-10-17 |
WO2010091140A1 (en) | 2010-08-12 |
EP2393364A4 (en) | 2013-03-13 |
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